Insight into Biophysicochemical Principles of Biopolymers through Simulation and Theory

Hai-Xiao Wan; Duo Xu; Xue-Wei Dong; Kai Yang; Li-Tang Yan

doi:10.1007/s10118-023-2954-y

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Insight into Biophysicochemical Principles of Biopolymers through Simulation and Theory

PERSPECTIVE | Updated：2023-08-24

- Insight into Biophysicochemical Principles of Biopolymers through Simulation and Theory
- Chinese Journal of Polymer Science Vol. 41, Issue 9, Pages: 1342-1354(2023)
- Affiliations：
  
  a.State Key Laboratory of Chemical Engineering, Department of Chemical Engineering, Tsinghua University, Beijing 100084, China
  b.Center for Soft Condensed Matter Physics and Interdisciplinary Research & School of Physical Science and Technology, Soochow University, Suzhou 215006, China
- Author bio：
  
  yangkai@suda.edu.cn (K.Y.)
  ltyan@mail.tsinghua.edu.cn (L.T.Y.)
- Funds：
- DOI：10.1007/s10118-023-2954-y
  CLC：
- Received：19 December 2022，
  
  Revised：2023-1-12，
  
  Accepted：16 January 2023，
  
  Online First：17 March 2023，
  
  Published：01 September 2023
- Accepted：
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Wan, H. X.; Xu, D.; Dong, X. W.; Yang, K.; Yan, L. T. Insight into biophysicochemical principles of biopolymers through simulation and theory. Chinese J. Polym. Sci. 2023, 41, 1342–1354

Hai-Xiao Wan, Duo Xu, Xue-Wei Dong, et al. Insight into Biophysicochemical Principles of Biopolymers through Simulation and Theory[J]. Chinese Journal of Polymer Science, 2023, 41(9): 1342-1354.
Wan, H. X.; Xu, D.; Dong, X. W.; Yang, K.; Yan, L. T. Insight into biophysicochemical principles of biopolymers through simulation and theory. Chinese J. Polym. Sci. 2023, 41, 1342–1354 DOI： 10.1007/s10118-023-2954-y.

Hai-Xiao Wan, Duo Xu, Xue-Wei Dong, et al. Insight into Biophysicochemical Principles of Biopolymers through Simulation and Theory[J]. Chinese Journal of Polymer Science, 2023, 41(9): 1342-1354. DOI： 10.1007/s10118-023-2954-y.

摘要

This article provides a conceptual framework demonstrating how the approaches of tailored computer simulations and theoretical analysis are harnessed to explore the physicochemical principles of biopolymer cellular interactions

allowing useful guidelines for advantageous and safe use of designer biomaterials.

Abstract

The development of biopolymers for biomedical applications has traditionally been based on new chemistries. However

there is growing recognition that the biological responses can be regulated by the physical as well as the chemical properties of biomaterials. Understanding the biophysicochemical principles regarding biopolymers is thereby of great importance in the generation of advanced biomaterials. Herein

this review article seeks to provide a conceptual framework demonstrating how the approaches of tailored computer simulations and theoretical analysis are harnessed to explore the physicochemical principles of biopolymer cellular interactions. We briefly introduce the theoretical and simulation methods used in this field

summarize the typical findings based on these approaches

and describe the correlations between theoretical results and experiments. Finally

the future prospects for the theoretical aspect of biopolymers and their biophysicochemical interactions are discussed. The knowledge might be critical from the perspective of advantageous and safe use of designer biomaterials.

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references

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