Helical Nonfouling Polypeptides for Biomedical Applications

Chong Zhang; Hua Lu

doi:10.1007/s10118-022-2688-2

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Helical Nonfouling Polypeptides for Biomedical Applications

FEATURE ARTICLE | Updated：2022-04-26

- Helical Nonfouling Polypeptides for Biomedical Applications
- Chinese Journal of Polymer Science Vol. 40, Issue 5, Pages: 433-446(2022)
- Affiliations：
  
  a.Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen 518055, China
  b.Beijing National Laboratory for Molecular Sciences, Center for Soft Matter Science and Engineering, Key Laboratory of Polymer Chemistry and Physics of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China
- Author bio：
  
  chemhualu@pku.edu.cn
- Funds：
- DOI：10.1007/s10118-022-2688-2
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Chong Zhang, Hua Lu. Helical Nonfouling Polypeptides for Biomedical Applications. [J]. Chinese Journal of Polymer Science 40(5):433-446(2022)
DOI：

Chong Zhang, Hua Lu. Helical Nonfouling Polypeptides for Biomedical Applications. [J]. Chinese Journal of Polymer Science 40(5):433-446(2022) DOI： 10.1007/s10118-022-2688-2.

摘要

The state-of-the-art of ,α,-helical polypeptides for biomedical applications, with a special emphasis on the manipulation of helix-to-coil dynamic transition, conformation-associated anti-biofouling surfaces, cellular uptake regulation, and reducing immunogenicity of polypeptide-protein conjugates are reviewed.

Abstract

Synthetic polypeptides, also known as poly(,α,-amino acid)s (P,α,AAs), are biomimetic and biodegradable polymers holding great potential for a variety of biomedical applications. Possessing the same peptide bonds as natural proteins, polypeptides can also adopt typical well-defined secondary structures including ,α,-helix, which have been shown to significantly impact the physicochemical properties and biological outcomes of materials. In this feature article, we review the state-of-the-art progresses of ,α,-helical polypeptides for biomedical applications, with a special emphasis on the manipulation of helix-to-coil dynamic transition, conformation-associated anti-biofouling coatings, cellular uptake regulation, and reducing immunogenicity of polypeptide-protein conjugates. Finally, perspectives on outstanding challenges remained in this field and some important future directions are discussed.

关键词

Keywords

Poly(α-amino acid) PolypeptideHelixNonfoulingPEPylation

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