Helical Nonfouling Polypeptides for Biomedical Applications

Chong Zhang; Hua Lu

doi:10.1007/s10118-022-2688-2

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Helical Nonfouling Polypeptides for Biomedical Applications

FEATURE ARTICLE | Updated：2022-04-26

- Helical Nonfouling Polypeptides for Biomedical Applications
- Chinese Journal of Polymer Science Vol. 40, Issue 5, Pages: 433-446(2022)
- Affiliations：
  
  a.Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen 518055, China
  b.Beijing National Laboratory for Molecular Sciences, Center for Soft Matter Science and Engineering, Key Laboratory of Polymer Chemistry and Physics of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China
- Author bio：
  
  chemhualu@pku.edu.cn
- Funds：
- DOI：10.1007/s10118-022-2688-2
  CLC：
- Received：10 December 2021，
  
  Revised：2021-12-29，
  
  Accepted：30 December 2021，
  
  Online First：02 March 2022，
  
  Published：01 May 2022
- Accepted：
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Zhang, C.; Lu, H. Helical nonfouling polypeptides for biomedical applications. Chinese J. Polym. Sci. 2022, 40, 433–446

Chong Zhang, Hua Lu. Helical Nonfouling Polypeptides for Biomedical Applications[J]. Chinese Journal of Polymer Science, 2022, 40(5): 433-446.
Zhang, C.; Lu, H. Helical nonfouling polypeptides for biomedical applications. Chinese J. Polym. Sci. 2022, 40, 433–446 DOI： 10.1007/s10118-022-2688-2.

Chong Zhang, Hua Lu. Helical Nonfouling Polypeptides for Biomedical Applications[J]. Chinese Journal of Polymer Science, 2022, 40(5): 433-446. DOI： 10.1007/s10118-022-2688-2.

摘要

The state-of-the-art of

-helical polypeptides for biomedical applications

with a special emphasis on the manipulation of helix-to-coil dynamic transition

conformation-associated anti-biofouling surfaces

cellular uptake regulation

and reducing immunogenicity of polypeptide-protein conjugates are reviewed.

Abstract

Synthetic polypeptides

also known as poly(

-amino acid)s (P

AAs)

are biomimetic and biodegradable polymers holding great potential for a variety of biomedical applications. Possessing the same peptide bonds as natural proteins

polypeptides can also adopt typical well-defined secondary structures including

-helix

which have been shown to significantly impact the physicochemical properties and biological outcomes of materials. In this feature article

we review the state-of-the-art progresses of

-helical polypeptides for biomedical applications

with a special emphasis on the manipulation of helix-to-coil dynamic transition

conformation-associated anti-biofouling coatings

cellular uptake regulation

and reducing immunogenicity of polypeptide-protein conjugates. Finally

perspectives on outstanding challenges remained in this field and some important future directions are discussed.

关键词

Keywords

references

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