Responsive Polymeric Nanoparticles for Biofilm-infection Control

Lin-Zhu Su; Yong Liu; Yuan-Feng Li; Ying-Li An; Lin-Qi Shi

doi:10.1007/s10118-021-2610-3

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Responsive Polymeric Nanoparticles for Biofilm-infection Control

FEATURE ARTICLE | Updated：2021-07-25

- Responsive Polymeric Nanoparticles for Biofilm-infection Control
- Chinese Journal of Polymer Science Vol. 39, Issue 11, Pages: 1376-1391(2021)
- Affiliations：
  
  a.State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Functional Polymer Materials, Ministry of Education, Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China
  b.Engineering Research Center of Clinical Functional Materials and Diagnosis & Treatment Devices of Zhejiang Province, Wenzhou Institute, University of Chinese Academy of Sciences; Oujiang Laboratory, Wenzhou 325000, China
- Author bio：
  
  y.liu@ucas.ac.cn (Y.L.)
  shilinqi@nankai.edu.cn (L.Q.S.)
- Funds：
- DOI：10.1007/s10118-021-2610-3
  CLC：
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Lin-Zhu Su, Yong Liu, Yuan-Feng Li, et al. Responsive Polymeric Nanoparticles for Biofilm-infection Control. [J]. Chinese Journal of Polymer Science 39(11):1376-1391(2021)
DOI：

Lin-Zhu Su, Yong Liu, Yuan-Feng Li, et al. Responsive Polymeric Nanoparticles for Biofilm-infection Control. [J]. Chinese Journal of Polymer Science 39(11):1376-1391(2021) DOI： 10.1007/s10118-021-2610-3.

摘要

Abstract

With the emergence of multidrug resistance (MDR) in many pathogens, bacterial infections are becoming a growing threat to public health. The frightening scenario is due largely to the formation of biofilms, in which the bacteria are extremely recalcitrant to the conventional antibiotic regimens. To address the emergence of MDR and biofilm-associated infections, numerous polymer-based materials have been designed and prepared recently. The subject of this perspective is the recent development of polymer-based materials that have been applied to combat multidrug-resistant pathogens, to prevent the formation of biofilms, or enhance the eradication efficacy to mature biofilms ,via, killing biofilm-bacteria or dispersing biofilms. The advantages and shortcomings of these polymer-based materials are discussed, as well as the challenges we are facing in the clinical translation of these systems.

关键词

Keywords

AntibacterialBiofilmMultidrug resistancePolymeric nanoparticlesStimuli-responsive

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