Responsive Polymeric Nanoparticles for Biofilm-infection Control

Lin-Zhu Su; Yong Liu; Yuan-Feng Li; Ying-Li An; Lin-Qi Shi

doi:10.1007/s10118-021-2610-3

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Responsive Polymeric Nanoparticles for Biofilm-infection Control

FEATURE ARTICLE | Updated：2021-07-25

- Responsive Polymeric Nanoparticles for Biofilm-infection Control
- Chinese Journal of Polymer Science Vol. 39, Issue 11, Pages: 1376-1391(2021)
- Affiliations：
  
  a.State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Functional Polymer Materials, Ministry of Education, Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China
  b.Engineering Research Center of Clinical Functional Materials and Diagnosis & Treatment Devices of Zhejiang Province, Wenzhou Institute, University of Chinese Academy of Sciences; Oujiang Laboratory, Wenzhou 325000, China
- Author bio：
  
  y.liu@ucas.ac.cn (Y.L.)
  shilinqi@nankai.edu.cn (L.Q.S.)
- Funds：
- DOI：10.1007/s10118-021-2610-3
  CLC：
- Received：25 April 2021，
  
  Revised：2021-5-17，
  
  Accepted：18 May 2021，
  
  Online First：25 July 2021，
  
  Published：18 September 2021
- Accepted：
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Su, L. Z.; Liu, Y.; Li, Y. F.; An, Y. L.; Shi, L. Q. Responsive Polymeric Nanoparticles for biofilm-infection control. Chinese J. Polym. Sci. 2021, 39, 1376–1391

Lin-Zhu Su, Yong Liu, Yuan-Feng Li, et al. Responsive Polymeric Nanoparticles for Biofilm-infection Control[J]. Chinese Journal of Polymer Science, 2021, 39(11): 1376-1391.
Su, L. Z.; Liu, Y.; Li, Y. F.; An, Y. L.; Shi, L. Q. Responsive Polymeric Nanoparticles for biofilm-infection control. Chinese J. Polym. Sci. 2021, 39, 1376–1391 DOI： 10.1007/s10118-021-2610-3.

Lin-Zhu Su, Yong Liu, Yuan-Feng Li, et al. Responsive Polymeric Nanoparticles for Biofilm-infection Control[J]. Chinese Journal of Polymer Science, 2021, 39(11): 1376-1391. DOI： 10.1007/s10118-021-2610-3.

摘要

Abstract

With the emergence of multidrug resistance (MDR) in many pathogens

bacterial infections are becoming a growing threat to public health. The frightening scenario is due largely to the formation of biofilms

in which the bacteria are extremely recalcitrant to the conventional antibiotic regimens. To address the emergence of MDR and biofilm-associated infections

numerous polymer-based materials have been designed and prepared recently. The subject of this perspective is the recent development of polymer-based materials that have been applied to combat multidrug-resistant pathogens

to prevent the formation of biofilms

or enhance the eradication efficacy to mature biofilms

via

killing biofilm-bacteria or dispersing biofilms. The advantages and shortcomings of these polymer-based materials are discussed

as well as the challenges we are facing in the clinical translation of these systems.

关键词

Keywords

references

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