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Biofilm Disruption Utilizing
α /β Chimeric Polypeptide Molecular Brushes- Chinese Journal of Polymer Science Vol. 37, Issue 11, Pages: 1105-1112(2019)
- Affiliations：
1.State Key Laboratory of Bioreactor Engineering, Key Laboratory for Ultrafine Materials of Ministry of Education, Research Center for Biomedical Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China
- Author bio：
rliu@ecust.edu.cn
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DOI：10.1007/s10118-019-2278-0
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Si Zhang, Xi-Mian Xiao, Fan Qi, et al. Biofilm Disruption Utilizing
α /β Chimeric Polypeptide Molecular Brushes. [J]. Chinese Journal of Polymer Science 37(11):1105-1112(2019)Si Zhang, Xi-Mian Xiao, Fan Qi, et al. Biofilm Disruption Utilizing
α /β Chimeric Polypeptide Molecular Brushes. [J]. Chinese Journal of Polymer Science 37(11):1105-1112(2019) DOI： 10.1007/s10118-019-2278-0.
摘要
Abstract
Gram-negative bacteria can cause serious infections and are well known problems in biomedical practices. Biofilms of gram-negative bacteria are notorious for their frequently encountered resistance toward antibiotics. We demonstrate that ,α,/,β, chimeric polypeptide molecular brush (,α,/,β, CPMB) exerts potent activities against antibiotic-resistant gram-negative bacteria. MTT viability assay, bacterial colony counting, and live/dead staining all indicate that ,α,/,β, CPMB not only inhibits biofilm formation of gram-negative ,Pseudomonas aeruginosa, and ,Acinetobacter baumannii, but also effectively disrupts mature biofilms that are highly resistant to one of the most active antibiotics—colistin. The superior antibacterial performance of the ,α,/,β, CPMB implies its potential topical applications in treating biofilms.
关键词
Keywords
Molecular brushChimeric polypeptideBiofilmAntimicrobial resistanceHost defense peptide
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