Biofilm Disruption Utilizing <italic style="font-style: italic">α</italic>/<italic style="font-style: italic">β</italic> Chimeric Polypeptide Molecular Brushes

Si Zhang; Xi-Mian Xiao; Fan Qi; Peng-Cheng Ma; Wei-Wei Zhang; Cheng-Zhi Dai; Dan-Feng Zhang; Run-Hui Liu

doi:10.1007/s10118-019-2278-0

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Biofilm Disruption Utilizing α/β Chimeric Polypeptide Molecular Brushes

ARTICLE | Updated：2021-02-18

- Biofilm Disruption Utilizing α/β Chimeric Polypeptide Molecular Brushes
- Chinese Journal of Polymer Science Vol. 37, Issue 11, Pages: 1105-1112(2019)
- Affiliations：
  
  State Key Laboratory of Bioreactor Engineering, Key Laboratory for Ultrafine Materials of Ministry of Education, Research Center for Biomedical Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China
- Author bio：
  
  rliu@ecust.edu.cn
- Funds：
- DOI：10.1007/s10118-019-2278-0
  CLC： M
- Received：13 March 2019，
  
  Revised：2019-4-13，
  
  Accepted：18 April 2019，
  
  Online First：17 June 2019，
  
  Published：2019-11
- Accepted：
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Zhang, S.; Xiao, X. M.; Qi, F.; Ma, P. C.; Zhang, W. W.; Dai, C. Z.; Zhang, D. F.; Liu, R. H. Biofilm disruption utilizing α/β chimeric polypeptide molecular brushes. Chinese J. Polym. Sci. 2019, 37, 1105–1112.

Si Zhang, Xi-Mian Xiao, Fan Qi, et al. Biofilm Disruption Utilizing α/β Chimeric Polypeptide Molecular Brushes[J]. Chinese Journal of Polymer Science, 2019, 37(11): 1105-1112. DOI: 10.1007/s10118-019-2278-0.
Zhang, S.; Xiao, X. M.; Qi, F.; Ma, P. C.; Zhang, W. W.; Dai, C. Z.; Zhang, D. F.; Liu, R. H. Biofilm disruption utilizing α/β chimeric polypeptide molecular brushes. Chinese J. Polym. Sci. 2019, 37, 1105–1112. DOI： 10.1007/s10118-019-2278-0.

Si Zhang, Xi-Mian Xiao, Fan Qi, et al. Biofilm Disruption Utilizing α/β Chimeric Polypeptide Molecular Brushes[J]. Chinese Journal of Polymer Science, 2019, 37(11): 1105-1112. DOI: 10.1007/s10118-019-2278-0. DOI：

摘要

Abstract

Gram-negative bacteria can cause serious infections and are well known problems in biomedical practices. Biofilms of gram-negative bacteria are notorious for their frequently encountered resistance toward antibiotics. We demonstrate that

chimeric polypeptide molecular brush (

CPMB) exerts potent activities against antibiotic-resistant gram-negative bacteria. MTT viability assay

bacterial colony counting

and live/dead staining all indicate that

CPMB not only inhibits biofilm formation of gram-negative

Pseudomonas aeruginosa

and

Acinetobacter baumannii

but also effectively disrupts mature biofilms that are highly resistant to one of the most active antibiotics—colistin. The superior antibacterial performance of the

CPMB implies its potential topical applications in treating biofilms.

关键词

Keywords

references

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⁰

Biofilm Disruption Utilizing α/β Chimeric Polypeptide Molecular Brushes

DOI：10.1007/s10118-019-2278-0

摘要

Abstract

关键词

Keywords

references