Biological Stimuli-responsive Polymer Systems: Design, Construction and Controlled Self-assembly

Miao-Miao Xu; Ren-Jie Liu; Qiang Yan

doi:10.1007/s10118-018-2080-4

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Biological Stimuli-responsive Polymer Systems: Design, Construction and Controlled Self-assembly

REVIEWS | Updated：2021-02-18

- Biological Stimuli-responsive Polymer Systems: Design, Construction and Controlled Self-assembly
- Chinese Journal of Polymer Science Vol. 36, Issue 3, Pages: 347-365(2018)
- Affiliations：
  
  1.Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai 200433, China
- Author bio：
  
  Qiang Yan, E-mail yanq@fudan.edu.cn
- Funds：
- DOI：10.1007/s10118-018-2080-4
  CLC：
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Miao-Miao Xu, Ren-Jie Liu, Qiang Yan. Biological Stimuli-responsive Polymer Systems: Design, Construction and Controlled Self-assembly. [J]. Chinese Journal of Polymer Science 36(3):347-365(2018)
DOI：

Miao-Miao Xu, Ren-Jie Liu, Qiang Yan. Biological Stimuli-responsive Polymer Systems: Design, Construction and Controlled Self-assembly. [J]. Chinese Journal of Polymer Science 36(3):347-365(2018) DOI： 10.1007/s10118-018-2080-4.

摘要

Abstract

Biological stimuli-responsive polymers have increasingly attracted attention in recent years because it can satisfy many requirements of applications related with human body while traditional systems do not meet. Due to the importance of this burgeoning field, great efforts have been devoted and, up to now, polymer chemists have made a remarkable success in this prospective research topic. In this review, we systematically generalize the present state of biological stimuli-responsive polymer systems. We highlight several representative examples to specify the current problems and look ahead a clear sense of direction in this area.

关键词

Keywords

Biological stimuliResponsive polymerControlled self-assemblyBiomedicine

references

R. J. Williams , A. M. Smith , R. Collins , N. Hodson , A. K. Das . Enzyme-assisted self-assembly under thermodynamic control . Nat. Nanotechnol. , 2009 . 26 (3 ):19 -24 . http://dro.deakin.edu.au/view/DU:30047889http://dro.deakin.edu.au/view/DU:30047889, .

L. Zhai . Stimuli-responsive polymer films. Chem . Soc. Rev. , 2013 . 42 (17 ):7148 -7160 . DOI:10.1039/c3cs60023hhttp://doi.org/10.1039/c3cs60023h.

M. S. Shim , Y. J. Kwon . Stimuli-responsive polymers and nanomaterials for gene delivery and imaging applications . Adv. Drug Deliv. Rev. , 2012 . 64 (11 ):1046 -1059 . DOI:10.1016/j.addr.2012.01.018http://doi.org/10.1016/j.addr.2012.01.018.

K. Paek , H. Yang , J. Lee , J. Park , B. J. Kim . Efficient colorimetric pH sensor based on responsive polymer-quantum dot integrated graphene oxide . ACS Nano , 2014 . 8 (3 ):2848 -2056 . DOI:10.1021/nn406657bhttp://doi.org/10.1021/nn406657b.

D. Roy , J. N. Cambre , B. S. Sumerlin . Future perspectives and recent advances in stimuli-responsive materials . Prog. Polym. Sci. , 2010 . 35 (1-2 ):278 -301 . DOI:10.1016/j.progpolymsci.2009.10.008http://doi.org/10.1016/j.progpolymsci.2009.10.008.

M. Stuart , W. Huck , J. Genzer , M. Müller , C. Ober , M. Stamm , G. B. Sukhorukov , I. Szleifer , V. V. Tsukruk , M. Urban , F. Winnik , S. Zauscher , I. Luzinov , S. Minko . Emerging applications of stimuli-responsive polymer materials . Nat. Mater. , 2010 . 9 (2 ):101 -113 . DOI:10.1038/nmat2614http://doi.org/10.1038/nmat2614.

J. F. Lutz , O. Akdemir , A. Hoth . Point by point comparison of two thermosensitive polymers exhibiting a similar LCST:is the age of poly(NIPAM) over? J . Am. Chem. Soc. , 2006 . 128 (40 ):13046 -13047 . DOI:10.1021/ja065324nhttp://doi.org/10.1021/ja065324n.

Y. T. Li , B. S. Lokitz , C. L. Mccormick . Thermally responsive vesicles and their structural "locking" through polyelectrolyte complex formation . Angew. Chem. Int. Ed. , 2006 . 45 (35 ):5792 -5795 . DOI:10.1002/(ISSN)1521-3773http://doi.org/10.1002/(ISSN)1521-3773.

N. Ma , Y. Li , H. P. Xu , Z. Q. Wang , X. Zhang . Dual redox responsive assemblies formed from diselenide block copolymers . J. Am. Chem. Soc. , 2010 . 132 (2 ):442 -443 . DOI:10.1021/ja908124ghttp://doi.org/10.1021/ja908124g.

J. Rodriguez-Hernandez , S. Lecommandoux . Reversible inside-out micellization of pH-responsive and water-soluble vesicles based on polypeptide diblock copolymers . J. Am. Chem. Soc. , 2005 . 127 (7 ):2026 -2027 . DOI:10.1021/ja043920ghttp://doi.org/10.1021/ja043920g.

G. Y. Li , L. Q. Shi , R. J. Ma , Y. L. An , N. Huang . Formation of complex micelles with double-responsive channels from self-assembly of two diblock copolymers . Angew. Chem. Int. Ed. , 2006 . 45 (30 ):4959 -4962 . DOI:10.1002/(ISSN)1521-3773http://doi.org/10.1002/(ISSN)1521-3773.

J. Z. Du , X. J. Du , C. Q. Mao , J. Wang . Tailor-made dual pH-sensitive polymer-doxorubicin nanoparticles for efficient anticancer drug delivery . J. Am. Chem. Soc. , 2011 . 133 (44 ):17560 -17563 . DOI:10.1021/ja207150nhttp://doi.org/10.1021/ja207150n.

J. Q. Jiang , X. Tong , Y. Zhao . A new design for light-breakable polymer micelles . J. Am. Chem. Soc. , 2005 . 127 (123 ):8290 -8291 . http://pubs.acs.org/doi/pdfplus/10.1021/ja0521019?src=recsyshttp://pubs.acs.org/doi/pdfplus/10.1021/ja0521019?src=recsys, .

N. Fomina , C. Mcfearin , M. Sermsakdi , O. Edigin , A. Almutairi . UV and near-IR triggered release from polymeric nanoparticles . J. Am. Chem. Soc. , 2010 . 132 (28 ):9540 -9542 . DOI:10.1021/ja102595jhttp://doi.org/10.1021/ja102595j.

B. Yan , J. C. Boyer , N. R. Branda , Y. Zhao . Near-infrared light-triggered dissociation of block copolymer micelles using upconverting nanoparticles . J. Am. Chem. Soc. , 2011 . 133 (49 ):19714 -19717 . DOI:10.1021/ja209793bhttp://doi.org/10.1021/ja209793b.

X. Y. Tan , B. B. Li , X. G. Lu , F. Jia , C. Santori , P. Menon , H. Li , B. Zhang , J. J. Zhao , Zhang , . K . Light-triggered, self-immolative nucleic acid-drug nanostructures . J. Am. Chem. Soc. , 2015 . 137 (19 ):6112 -6115 . DOI:10.1021/jacs.5b00795http://doi.org/10.1021/jacs.5b00795.

X. R. Wang , J. M. Hu , G. H. Liu , J. Tian , H. J. Wang , M. Gong , S. Y. Liu . Reversibly switching bilayer permeability and release modules of photochromic polymersomes stabilized by cooperative noncovalent interactions . J. Am. Chem. Soc. , 2015 . 137 (48 ):15262 -15275 . DOI:10.1021/jacs.5b10127http://doi.org/10.1021/jacs.5b10127.

V.P. Torchilin . Multifunctional, stimuli-sensitive nanoparticulate systems for drug delivery . Nat. Rev. Drug Discov. , 2014 . 13 (11 ):813 -827 . DOI:10.1038/nrd4333http://doi.org/10.1038/nrd4333.

S. Y. Liu , N. C. Billingham , S. P. Armes . A schizophrenic water-soluble diblock copolymer . Angew. Chem. Int. Ed. , 2010 . 40 (12 ):2328 -2331 . http://onlinelibrary.wiley.com/doi/10.1002/1521-3757(20010618)113:12%3C2390::AID-ANGE2390%3E3.0.CO;2-J/abstracthttp://onlinelibrary.wiley.com/doi/10.1002/1521-3757(20010618)113:12%3C2390::AID-ANGE2390%3E3.0.CO;2-J/abstract, .

B. Taghizadeh , S. Taranejoo , S. A. Monemian , Z. S. Moghaddam , K. Daliri , H. Derakhshankhah , Z. Derakhshan . Classification of stimuli-responsive polymers as anticancer drug delivery systems . Drug Deliv. , 2015 . 22 (2 ):145 -155 . DOI:10.3109/10717544.2014.887157http://doi.org/10.3109/10717544.2014.887157.

G. Y. Qing , M. M. Li , L. J. Deng , Z. Y. Lv , P. Ding , T. L. Sun . Smart drug release systems based on stimuli-responsive polymers . Mini-Rev. Med. Chem. , 2013 . 13 (9 ):1369 -1380 . DOI:10.2174/13895575113139990062http://doi.org/10.2174/13895575113139990062.

D. Kuckling , A. Doering , F. Krahl , K. F. Arndt . Stimuli-responsive polymer systems . Polym. Sci. A Comprehensive Ref. , 2012 . 12 (8 ):377 -413 . http://onlinelibrary.wiley.com/doi/10.1002/9781118747896.ch12/referenceshttp://onlinelibrary.wiley.com/doi/10.1002/9781118747896.ch12/references, .

Q. Yan , J. Y. Yuan . Synthesis and function of stimuli-responsive polymer systems . Chem. J. Chinese U. , 2012 . 33 (9 ):1877 -1885 . https://www.hindawi.com/journals/ijps/2016/6480259/cta/https://www.hindawi.com/journals/ijps/2016/6480259/cta/, .

E. Cabane , X. Y. Zhang , K. Langowska , C. G. Palivan , W. Meier . Stimuli-responsive polymers and their applications in nanomedicine . Biointerphase. , 2012 . 7 (1-4 ):9 -36 . https://link.springer.com/content/pdf/10.1007/s13758-011-0009-3.pdfhttps://link.springer.com/content/pdf/10.1007/s13758-011-0009-3.pdf, .

B. D. Boer , U. Stalmach , P. F. V. Hutten , V. K. Victor , G. Hadziioannou . Supramolecular self-assembly and opto-electronic properties of semiconducting block copolymers . Polymer , 2001 . 42 (21 ):9097 -9109 . DOI:10.1016/S0032-3861(01)00388-3http://doi.org/10.1016/S0032-3861(01)00388-3.

S. Mura , J. Nicolas , P. Couvreur . Stimuli-responsive nanocarriers for drug delivery . Nat. Mater. , 2013 . 12 (11 ):991 -1003 . DOI:10.1038/nmat3776http://doi.org/10.1038/nmat3776.

I. S. Kim , S. Y. Shin , Y. S. Kim , H. Y. Kim , H. S. Yoon . Expression of a glutathione reductase from Brassica rapasubsp. pekinensis enhanced cellular redox homeostasis by modulating antioxidant proteins in Escherichia coli . Mol. & Cells. , 2009 . 28 (5 ):479 -487 . https://www.cabdirect.org/cabdirect/abstract/20103000418https://www.cabdirect.org/cabdirect/abstract/20103000418, .

L. Y. Niu , Y. Z. Chen , H. R. Zheng , L. Z. Wu , B. C. Tung , Q. Z. Yang . Design strategies of fluorescent probes for selective detection among biothiols . Chem. Soc. Rev. , 2015 . 46 (17 ):6143 -6160 . http://onlinelibrary.wiley.com/doi/10.1002/chem.201300078/suppinfohttp://onlinelibrary.wiley.com/doi/10.1002/chem.201300078/suppinfo, .

S. Mocellin , V. Bronte , D. Nitti . Nitric oxide, a double edged sword in cancer biology:searching for therapeutic opportunities . Med. Res. Rev. , 2007 . 27 (3 ):317 -352 . DOI:10.1002/(ISSN)1098-1128http://doi.org/10.1002/(ISSN)1098-1128.

M. T. Gladwin , D. B. Kimshapiro . Vascular biology:Nitric oxide caught in traffic . Nature , 2012 . 491 (7424 ):344 -345 . DOI:10.1038/nature11640http://doi.org/10.1038/nature11640.

J. M. Hu , M. R. Whittaker , H. Duong , L. Yang , C. Boyer , T. P. Davi . Biomimetic polymers responsive to a biological signaling molecule:nitric oxide triggered reversible self-assembly of single macromolecular chains into nanoparticles . Angew. Chem. Int. Ed. , 2014 . 126 (3 ):7913 -1918 . http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1002/anie.201403147http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1002/anie.201403147, .

L. Li , P. Rose , P. K. Moore . Hydrogen sulfide and cell signaling . Annu. Rev. Pharmacol. , 2011 . 51 (1 ):169 -187 . DOI:10.1146/annurev-pharmtox-010510-100505http://doi.org/10.1146/annurev-pharmtox-010510-100505.

Y. Qiang , S. Wei . H2S gasotransmitter-responsive polymer vesicles . Chem. Sci. , 2015 . 7 (3 ):2100 -2105 . https://ncbi.nlm.nih.gov/pubmed/21608994https://ncbi.nlm.nih.gov/pubmed/21608994, .

H. Kimura . Physiological role of hydrogen sulfide and polysulfide in the central nervous system . Neurochem. Int. , 2013 . 63 (5 ):492 -497 . DOI:10.1016/j.neuint.2013.09.003http://doi.org/10.1016/j.neuint.2013.09.003.

P. Nagy , Z. Pálinkás , A. Nagy , B. Budai , I. Tóth , A. Vasas . Chemical aspects of hydrogen sulfide measurements in physiological samples . Biochim. Biophys. Acta , 2014 . 1840 (2 ):876 -891 . DOI:10.1016/j.bbagen.2013.05.037http://doi.org/10.1016/j.bbagen.2013.05.037.

O. Kabil , N. Motl , R. Banerjee . H2S and its role in redox signaling . Biochim. Biophys. Acta , 2014 . 1844 (8 ):1355 -1366 . DOI:10.1016/j.bbapap.2014.01.002http://doi.org/10.1016/j.bbapap.2014.01.002.

J. Zhang , X. Hao , W. Sang , Q. Yan . Hydrogen polysulfide biosignal-responsive polymersomes as a nanoplatform for distinguishing intracellular reactive sulfur species (RSS) . Small , 2017 . 13 (39 ):1701601 -1701608 . DOI:10.1002/smll.v13.39http://doi.org/10.1002/smll.v13.39.

G. Ferrersueta , R. Radi . Chemical biology of peroxynitrite:kinetics, diffusion, and radicals . ACS Chem. Biol. , 2009 . 4 (3 ):161 -177 . DOI:10.1021/cb800279qhttp://doi.org/10.1021/cb800279q.

C. Szabó , H. Ischiropoulos , R. Radi . Peroxynitrite:biochemistry, pathophysiology and development of therapeutics . Nat. Rev. Drug Discov. , 2007 . 6 (8 ):662 -680 . DOI:10.1038/nrd2222http://doi.org/10.1038/nrd2222.

Z. Chen , W. Ren , Q. E. Wright , H. W. Ai . Genetically encoded fluorescent probe for the selective detection of peroxynitrite . J. Am. Chem. Soc. , 2013 . 135 (40 ):14940 -14943 . DOI:10.1021/ja408011qhttp://doi.org/10.1021/ja408011q.

Z. J. Chen , Z. Tian , K. Kallio , A. L. Oleson , A. Ji , D. Borchardt , D. E. Jiang , S. J. Remington , H. W. Ai . The N-B interaction through a water bridge:understanding the chemoselectivity of a fluorescent protein based probe for peroxynitrite . J. Am. Chem. Soc. , 2016 . 138 (14 ):4900 -4907 . DOI:10.1021/jacs.6b01285http://doi.org/10.1021/jacs.6b01285.

T. Peng , N. K. Wong , X. M. Chen , Y. K. Chan , D. H. Ho , Z. N. Sun , J. J. Hu , J. G. Shen , H. El-Nezami , D. Yang . Molecular imaging of peroxynitrite with HKGreen-4 in live cells and tissues . J. Am. Chem. Soc. , 2014 . 136 (33 ):11728 -11734 . DOI:10.1021/ja504624qhttp://doi.org/10.1021/ja504624q.

T. Peng , D. Yang . HKGreen-3:a rhodol-based fluorescent probe for peroxynitrite . Org. Lett. , 2010 . 12 (21 ):4932 -4935 . DOI:10.1021/ol102182jhttp://doi.org/10.1021/ol102182j.

D. Yang , H. L. Wang , Z. N. Sun , N. W. Chung , J. G. Shen . A highly selective fluorescent probe for the detection and imaging of peroxynitrite in living cells . J. Am. Chem. Soc. , 2006 . 128 (18 ):6004 -6005 . DOI:10.1021/ja0603756http://doi.org/10.1021/ja0603756.

J. Zhang , J. Hu , W. Sang , J. B. Wang , Q. Yan . Peroxynitrite (ONOO-) redox signaling molecule-responsive polymersomes . ACS Macro Lett. , 2016 . 5 (8 ):919 -924 . DOI:10.1021/acsmacrolett.6b00474http://doi.org/10.1021/acsmacrolett.6b00474.

A. K. Mustafa , M. M. Gadalla , S. H. Snyder . Signaling by gasotransmitters . Sci. Signal. , 2009 . 2 (68 ):DOI:10.1126/scisignal.268re2http://doi.org/10.1126/scisignal.268re2 .

C.A. Piantadosi . Carbon monoxide, reactive oxygen signaling, and oxidative stress . Free Radical Bio. & Med. , 2008 . 45 (5 ):562 -569 . http://online.liebertpub.com/doi/abs/10.1089/152308602753666316?src=recsyshttp://online.liebertpub.com/doi/abs/10.1089/152308602753666316?src=recsys, .

R. Motterlini , L. E. Otterbein . The therapeutic potential of carbon monoxide . Nat. Rev. Drug Discov. , 2010 . 9 (9 ):728 -743 . DOI:10.1038/nrd3228http://doi.org/10.1038/nrd3228.

D. Morse , J. Sethi . Carbon monoxide and human disease . Antioxidants & Redox Sign. , 2002 . 4 (2 ):331 -338 . http://www.liebertonline.com/doi/abs/10.1089/152308602753666389http://www.liebertonline.com/doi/abs/10.1089/152308602753666389, .

M. M. Xu , L. X. Liu , J. Hu , Q. Yan . CO-signaling molecule-responsive nanoparticles formed from palladiumcontaining block copolymers . ACS Macro Lett. , 2017 . 6 (4 ):458 -462 . DOI:10.1021/acsmacrolett.7b00042http://doi.org/10.1021/acsmacrolett.7b00042.

S. Biswas , K. Kinbara , T. Niwa , H. Taguchi , N. Ishii , S. Watanabe , K. Miyata , K. Kataoka , T. Aida . Biomolecular robotics for chemomechanically driven guest delivery fuelled by intracellular ATP . Nat. Chem. , 2013 . 5 (7 ):613 -620 . DOI:10.1038/nchem.1681http://doi.org/10.1038/nchem.1681.

K. Okuro , M. Sasaki , T. Aida . Boronic acid-appended molecular glues for ATP-responsive activity modulation of enzymes . J. Am. Chem. Soc. , 2016 . 138 (17 ):5527 -5530 . DOI:10.1021/jacs.6b02664http://doi.org/10.1021/jacs.6b02664.

R. Mo , T. Jiang , R. Disanto , W. Tai , Z. Gu . ATP-triggered anticancer drug delivery . Nat. Commun. , 2014 . 5 (1 ):3364 -3373 . http://www.nature.com/ncomms/2014/140311/ncomms4364/metrics/newshttp://www.nature.com/ncomms/2014/140311/ncomms4364/metrics/news, .

G. C. Yu , J. Zhou , J. Shen , G. P. Tang , F. H. Huang . Cationic pillar . Chem. Sci. , 2016 . 7 (7 ):4073 -4078 . DOI:10.1039/C6SC00531Dhttp://doi.org/10.1039/C6SC00531D.

Q. Yan , Y. Zhao . ATP-triggered biomimetic deformations of bioinspired receptor-containing polymer assemblies . Chem. Sci. , 2015 . 6 (7 ):4343 -4349 . DOI:10.1039/C5SC00965Khttp://doi.org/10.1039/C5SC00965K.

Z. Q. Guo , N. R. Song , J. H. Moon , M. Kim , E. J. Jun , J. Y. Choi , J. Y. Lee , C. W. Bielawski , J. L. Sessler , J. Y. Yoon . A Benzobisimidazolium-based fluorescent and colorimetric chemosensor for CO2 . J. Am. Chem. Soc. , 2012 . 134 (43 ):17846 -17849 . DOI:10.1021/ja306891chttp://doi.org/10.1021/ja306891c.

H. Wang , D. D. Chen , Y. H. Zhang , P. Liu , J. B. Shi , X. Feng , B. Tong , Y. P. Dong . A fluorescent probe with an aggregation-enhanced emission feature for real-time monitoring of low carbon dioxide levels . J. Mater. Chem. C , 2015 . 3 (29 ):7621 -7626 . DOI:10.1039/C5TC01280Ehttp://doi.org/10.1039/C5TC01280E.

R. N. Dansby-Sparks , J. Jin , S. J. Mechery , U. Sampathkumaran , T. W. Owen , B. D. Yu , K. Goswami , K. L. Hong , G. Grant , Z. L. Xue . Fluorescent dye-doped sol-gel sensor for highly sensitive carbon dioxide gas detection below atmospheric concentrations . Anal. Chem. , 2010 . 82 (2 ):593 -600 . DOI:10.1021/ac901890rhttp://doi.org/10.1021/ac901890r.

J. Gutknecht , M. A. Bisson , F. C. Tosteson . Diffusion of carbon dioxide through lipid bilayer membranes:effects of carbonic anhydrase, bicarbonate and unstirred layers . J. Gen. Physiol. , 1977 . 69 (6 ):779 -794 . https://www.researchgate.net/publication/22732558_Diffusion_of_carbon_dioxide_through_lipid_bilayer_membranes_Effects_of_carbonic_anhydrase_bicarbonate_and_unstirred_layershttps://www.researchgate.net/publication/22732558_Diffusion_of_carbon_dioxide_through_lipid_bilayer_membranes_Effects_of_carbonic_anhydrase_bicarbonate_and_unstirred_layers, .

J. M. Tour , C. Kittrell , V. L. Colvin . Green carbon as a bridge to renewable energy . Nat. Mater. , 2010 . 9 (11 ):871 -874 . DOI:10.1038/nmat2887http://doi.org/10.1038/nmat2887.

Q. Yan , R. Zhou , C. K. Fu , H. J.; Yin Y. W. Zhang. , Y. W. Yin. , J. Y. Yuan . CO2-responsive polymeric vesicles that breathe . Angew. Chem. Int. Ed. , 2011 . 50 (21 ):4923 -4927 . DOI:10.1002/anie.v50.21http://doi.org/10.1002/anie.v50.21.

Q. Yan , Y. Zhao . CO2-stimulated diversiform deformations of polymer assemblies . J. Am. Chem. Soc. , 2013 . 135 (44 ):16300 -16303 . DOI:10.1021/ja408655nhttp://doi.org/10.1021/ja408655n.

Z. R. Guo , Y. J. Feng , Y. Wang , J. Y. Wang , Y. F. Wu , Y. M. Zhang . A novel smart polymer responsive to CO2 . Chem. Commun. , 2011 . 47 (33 ):9348 -9350 . DOI:10.1039/c1cc12388bhttp://doi.org/10.1039/c1cc12388b.

B. W. Liu , H. J. Zhou , S. T. Zhou , H. J. Zhang , A. C. Feng , C. M. Jian , J. Hu , W. P. Gao , J. Y. Yuan . Synthesis and self-assembly of CO2-temperature dual stimuli-responsive triblock copolymers . Macromolecules , 2014 . 47 (9 ):2938 -2946 . DOI:10.1021/ma5001404http://doi.org/10.1021/ma5001404.

J. Y. Choi , YK. Jin , H. J. Moon , M. H. Park , B. M. Jeong . CO2-and O2-sensitive fluorophenyl end-capped poly(ethylene glycol) . Macromol. Rapid Commun. , 2014 . 35 (1 ):66 -70 . DOI:10.1002/marc.201300700http://doi.org/10.1002/marc.201300700.

Q. Zhang , S. P. Zhu . Oxygen and carbon dioxide dual responsive nanoaggregates of fluoro-and amino-containing copolymer . ACS Macro Lett. , 2014 . 3 (8 ):743 -746 . DOI:10.1021/mz500377xhttp://doi.org/10.1021/mz500377x.

X. D. Xu , B. B. Lin , J. Feng , Y. Wang , S. X. Cheng , X. Z. Zhang , R. X. Zhuo . Biological glucose metabolism regulated peptide self-assembly as a simple visual biosensor for glucose detection . Macromol. Rapid Commun. , 2012 . 33 (5 ):426 -431 . DOI:10.1002/marc.201100689http://doi.org/10.1002/marc.201100689.

J. H. Ryu , S. Jiwpanich , R. Chacko , S. Bickerton . Surface-functionalizable polymer nanogels with facile hydrophobic guest encapsulation capabilities . J. Am. Chem. Soc. , 2010 . 132 (24 ):8246 -8247 . DOI:10.1021/ja102316ahttp://doi.org/10.1021/ja102316a.

R. Ja-Hyoung , R. T. Chacko , J. Siriporn , S. Bickerton , R. P. Babu . Thayumanavan. S. Self-cross-linked polymer nanogels:a versatile nanoscopic drug delivery platform . J. Am. Chem. Soc. , 2010 . 132 (48 ):17227 -17235 . DOI:10.1021/ja1069932http://doi.org/10.1021/ja1069932.

S. Jiwpanich , J. H. Ryu , S. Bickerton . Thayumanavan. S. Non-covalent encapsulation stabilities in supramolecular nanoassemblies . J. Am. Chem. Soc. , 2010 . 132 (31 ):10683 -10685 . DOI:10.1021/ja105059ghttp://doi.org/10.1021/ja105059g.

W. R. Zhao , H. T. Zhang , Q. J. He , Y. S. Li , J. L. Gu , L. Li , H. Li , J. L. Shi . A glucose-responsive controlled release of insulin system based on enzyme multilayers-coated mesoporous silica particles . Chem. Commun. , 2011 . 47 (33 ):9459 -9461 . DOI:10.1039/c1cc12740chttp://doi.org/10.1039/c1cc12740c.

Q. Q. Guo , T. Q. Zhang , J. X. An , Z. M. Wu , Y. Zhao , X. M. Dai , X. G. Zhang , C. X. Li . Block versus random amphiphilic glycopolymer nanopaticles as glucose-responsive vehicles . Biomacromolecules , 2015 . 16 (10 ):3345 -3356 . DOI:10.1021/acs.biomac.5b01020http://doi.org/10.1021/acs.biomac.5b01020.

H. Kim , Y. J. Kang , S. Kang , K. T. Kim . Monosaccharideresponsive release of insulin from polymersomes of polyboroxole block copolymers at neutral pH . J. Am. Chem. Soc. , 2012 . 134 (9 ):4030 -4033 . DOI:10.1021/ja211728xhttp://doi.org/10.1021/ja211728x.

H. Wang , X. Wang , M. A. Winnik , I. Manners . Redox-mediated synthesis and encapsulation of inorganic nanoparticles in shell-cross-linked cylindrical polyferrocenylsilane block copolymer micelles . J. Am. Chem. Soc. , 2008 . 130 (39 ):12921 -12930 . DOI:10.1021/ja8028558http://doi.org/10.1021/ja8028558.

K. E. Broaders , S. Grandhe , J. M. Fréchet . A biocompatible oxidation-triggered carrier polymer with potential in therapeutics . J. Am. Chem. Soc. , 2011 . 133 (4 ):756 -758 . DOI:10.1021/ja110468vhttp://doi.org/10.1021/ja110468v.

R. Cheng , F. Feng , F. H. Meng , C. Deng , F. J. Jan , Z. Y. Zhong . Glutathione-responsive nano-vehicles as a promising platform for targeted intracellular drug and gene delivery . J. Control. Release , 2011 . 152 (1 ):2 -12 . DOI:10.1016/j.jconrel.2011.01.030http://doi.org/10.1016/j.jconrel.2011.01.030.

P. Kuppusamy , H. Li , G. Ilangovan , A. J. Cardounel , J. L. Zweier , K. Yamada , M. C. Krishna , J. B. Mitchell . Noninvasive imaging of tumor redox status and its modification by tissue glutathione levels . Cancer Res. , 2002 . 62 (1 ):307 -312 . http://cancerres.aacrjournals.org/content/62/1/307.abstract?cited-by=yes&legid=canres;62/1/307http://cancerres.aacrjournals.org/content/62/1/307.abstract?cited-by=yes&legid=canres;62/1/307, .

W. Chen , P. Zhong , F. H. Meng , R. Cheng , C. Deng , F. J. Jan , Z. Y. Zhong . Redox and pH-responsive degradable micelles for dually activated intracellular anticancer drug release . J. Control. Release , 2013 . 169 (3 ):171 -179 . DOI:10.1016/j.jconrel.2013.01.001http://doi.org/10.1016/j.jconrel.2013.01.001.

P. Han , S. C. Li , W. Cao , Y. Li , Z. W. Sun , Z. Q. Wang , H. P. Xu . Red light responsive diselenide-containing block copolymer micelles . J. Mater. Chem. , B2013 . 1 (6 ):740 -743 . DOI:10.1039/C2TB00186Ahttp://doi.org/10.1039/C2TB00186A.

R. J. Amir , S. Zhong , D. J. Pochan , C. J. Hawker . Enzymatically triggered self-assembly of block copolymers . J. Am. Chem. Soc. , 2009 . 131 (39 ):13949 -13951 . DOI:10.1021/ja9060917http://doi.org/10.1021/ja9060917.

P. Meers . Enzyme-activated targeting of liposomes . Adv. Drug Deliv. Rev. , 2001 . 53 (3 ):265 -272 . DOI:10.1016/S0169-409X(01)00205-8http://doi.org/10.1016/S0169-409X(01)00205-8.

J. Y. Rao , A. Khan . Enzyme sensitive synthetic polymer micelles based on the azobenzene motif . J. Am. Chem. Soc. , 2013 . 135 (38 ):14056 -14059 . DOI:10.1021/ja407514zhttp://doi.org/10.1021/ja407514z.

A. J. Harnoy , I. Rosenbaum , E. Tirosh , Y. Ebenstein , R. Shaharabani , R. Beck , R. J. Amir . Enzyme-responsive amphiphilic PEG-dendron hybrids and their assembly into smart micellar nanocarriers . J. Am. Chem. Soc. , 2014 . 136 (21 ):7531 -7534 . DOI:10.1021/ja413036qhttp://doi.org/10.1021/ja413036q.

A. J. Harnoy , M. Buzhor , E. Tirosh , R. Shaharabani , R. Beck , R. J. Amir . Modular synthetic approach for adjusting the disassembly rates of enzyme-responsive polymeric micelles . Biomacromolecules , 2017 . 18 (4 ):1218 -1228 . DOI:10.1021/acs.biomac.6b01906http://doi.org/10.1021/acs.biomac.6b01906.

S. Saxena , M. Jayakannan . Enzyme and pH dual responsive amino acid based biodegradable polymer nanocarrier for multidrug delivery to cancer cells . J. Polym. Sci., Part A:Polym. Chem. , 2016 . 54 (20 ):3279 -3293 . DOI:10.1002/pola.v54.20http://doi.org/10.1002/pola.v54.20.

C. Wang , Q. S. Chen , Z. Q. Wang , X. Zhang . An enzyme-responsive polymeric superamphiphile . Angew. Chem. Int. Ed. , 2010 . 49 (46 ):8612 -8615 . DOI:10.1002/anie.201004253http://doi.org/10.1002/anie.201004253.

Y. M. Li , G. H. Liu , X. R. Wang , J. M. Wu , S. Y. Liu . Enzyme-responsive polymeric vesicles for bacterial-strainselective delivery of antimicrobial agents . Angew. Chem. Int. Ed. , 2016 . 128 (5 ):1792 -1796 . DOI:10.1002/ange.201509401http://doi.org/10.1002/ange.201509401.

Y. M. Li , S. Y. Liu , Y. M. Li , S. Y. Liu . Enzyme-triggered transition from polymeric vesicles to core cross-linked micelles for selective release of antimicrobial agents . Acta Polymerica Sinica (in Chinese) , 2017 . (7 ):1178 -1190 . https://ncbi.nlm.nih.gov/pubmed/21608994https://ncbi.nlm.nih.gov/pubmed/21608994, .

N. C. Seeman . DNA in a material world . Nature , 2003 . 421 (6921 ):427 -431 . DOI:10.1038/nature01406http://doi.org/10.1038/nature01406.

F. A. Aldaye , A. L. Palmer , H. F. Sleiman . Assembling materials with DNA as the guide . Science , 2008 . 321 (5897 ):1795 -1799 . DOI:10.1126/science.1154533http://doi.org/10.1126/science.1154533.

C. K. Mclaughlin , G. D. Hamblin , H. F. Sleiman . Supramolecular DNA assembly . Chem. Soc. Rev. , 2011 . 40 (12 ):5647 -5656 . DOI:10.1039/c1cs15253jhttp://doi.org/10.1039/c1cs15253j.

T. G. W. Edwardson , K. M. M. Carneiro , C. K. Mclaughlin , C. J. Serpell , H. F. Sleiman . Site-specific positioning of dendritic alkyl chains on DNA cages enables their geometry-dependent self-assembly . Nat. Chem. , 2013 . 5 (10 ):868 -875 . DOI:10.1038/nchem.1745http://doi.org/10.1038/nchem.1745.

K. E. Bujold , J. Fakhoury , T. G. W. Edwardson , K. M. M. Carneiro , J. N. Briard , A. G. Godin , L. Amrein , G. D. Hamblin , L. C. Panasci , P. W. Wiseman , H. Sleiman . Sequenceresponsive unzipping DNA cubes with tunable cellular uptake profiles . Chem. Sci. , 2014 . 5 (6 ):2449 -2455 . DOI:10.1039/C4SC00646Ahttp://doi.org/10.1039/C4SC00646A.

G. I. Peterson , M. B. Larsen , A. J. Boydston , A. J. Boydston . Controlled depolymerization:stimuli-responsive self-immolative polymers . Macromolecules , 2012 . 45 (18 ):7317 -7328 . DOI:10.1021/ma300817vhttp://doi.org/10.1021/ma300817v.

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