

FOLLOWUS
Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai 200433, China
Qiang Yan, E-mail yanq@fudan.edu.cn
Received:01 October 2017,
Accepted:26 October 2017,
Online First:27 December 2017,
Published:05 March 2018
Scan QR Code
Miao-Miao Xu, Ren-Jie Liu, Qiang Yan. Biological Stimuli-responsive Polymer Systems: Design, Construction and Controlled Self-assembly[J]. Chinese Journal of Polymer Science, 2018, 36(3): 347-365.
Miao-Miao Xu, Ren-Jie Liu, Qiang Yan. Biological Stimuli-responsive Polymer Systems: Design, Construction and Controlled Self-assembly[J]. Chinese Journal of Polymer Science, 2018, 36(3): 347-365. DOI: 10.1007/s10118-018-2080-4.
Biological stimuli-responsive polymers have increasingly attracted attention in recent years because it can satisfy many requirements of applications related with human body while traditional systems do not meet. Due to the importance of this burgeoning field
great efforts have been devoted and
up to now
polymer chemists have made a remarkable success in this prospective research topic. In this review
we systematically generalize the present state of biological stimuli-responsive polymer systems. We highlight several representative examples to specify the current problems and look ahead a clear sense of direction in this area.
R. J. Williams , A. M. Smith , R. Collins , N. Hodson , A. K. Das . Enzyme-assisted self-assembly under thermodynamic control . Nat. Nanotechnol. , 2009 . 26 ( 3 ): 19 - 24 . http://dro.deakin.edu.au/view/DU:30047889 http://dro.deakin.edu.au/view/DU:30047889 , .
L. Zhai . Stimuli-responsive polymer films. Chem . Soc. Rev. , 2013 . 42 ( 17 ): 7148 - 7160 . DOI: 10.1039/c3cs60023h http://doi.org/10.1039/c3cs60023h .
M. S. Shim , Y. J. Kwon . Stimuli-responsive polymers and nanomaterials for gene delivery and imaging applications . Adv. Drug Deliv. Rev. , 2012 . 64 ( 11 ): 1046 - 1059 . DOI: 10.1016/j.addr.2012.01.018 http://doi.org/10.1016/j.addr.2012.01.018 .
K. Paek , H. Yang , J. Lee , J. Park , B. J. Kim . Efficient colorimetric pH sensor based on responsive polymer-quantum dot integrated graphene oxide . ACS Nano , 2014 . 8 ( 3 ): 2848 - 2056 . DOI: 10.1021/nn406657b http://doi.org/10.1021/nn406657b .
D. Roy , J. N. Cambre , B. S. Sumerlin . Future perspectives and recent advances in stimuli-responsive materials . Prog. Polym. Sci. , 2010 . 35 ( 1-2 ): 278 - 301 . DOI: 10.1016/j.progpolymsci.2009.10.008 http://doi.org/10.1016/j.progpolymsci.2009.10.008 .
M. Stuart , W. Huck , J. Genzer , M. Müller , C. Ober , M. Stamm , G. B. Sukhorukov , I. Szleifer , V. V. Tsukruk , M. Urban , F. Winnik , S. Zauscher , I. Luzinov , S. Minko . Emerging applications of stimuli-responsive polymer materials . Nat. Mater. , 2010 . 9 ( 2 ): 101 - 113 . DOI: 10.1038/nmat2614 http://doi.org/10.1038/nmat2614 .
J. F. Lutz , O. Akdemir , A. Hoth . Point by point comparison of two thermosensitive polymers exhibiting a similar LCST:is the age of poly(NIPAM) over? J . Am. Chem. Soc. , 2006 . 128 ( 40 ): 13046 - 13047 . DOI: 10.1021/ja065324n http://doi.org/10.1021/ja065324n .
Y. T. Li , B. S. Lokitz , C. L. Mccormick . Thermally responsive vesicles and their structural "locking" through polyelectrolyte complex formation . Angew. Chem. Int. Ed. , 2006 . 45 ( 35 ): 5792 - 5795 . DOI: 10.1002/(ISSN)1521-3773 http://doi.org/10.1002/(ISSN)1521-3773 .
N. Ma , Y. Li , H. P. Xu , Z. Q. Wang , X. Zhang . Dual redox responsive assemblies formed from diselenide block copolymers . J. Am. Chem. Soc. , 2010 . 132 ( 2 ): 442 - 443 . DOI: 10.1021/ja908124g http://doi.org/10.1021/ja908124g .
J. Rodriguez-Hernandez , S. Lecommandoux . Reversible inside-out micellization of pH-responsive and water-soluble vesicles based on polypeptide diblock copolymers . J. Am. Chem. Soc. , 2005 . 127 ( 7 ): 2026 - 2027 . DOI: 10.1021/ja043920g http://doi.org/10.1021/ja043920g .
G. Y. Li , L. Q. Shi , R. J. Ma , Y. L. An , N. Huang . Formation of complex micelles with double-responsive channels from self-assembly of two diblock copolymers . Angew. Chem. Int. Ed. , 2006 . 45 ( 30 ): 4959 - 4962 . DOI: 10.1002/(ISSN)1521-3773 http://doi.org/10.1002/(ISSN)1521-3773 .
J. Z. Du , X. J. Du , C. Q. Mao , J. Wang . Tailor-made dual pH-sensitive polymer-doxorubicin nanoparticles for efficient anticancer drug delivery . J. Am. Chem. Soc. , 2011 . 133 ( 44 ): 17560 - 17563 . DOI: 10.1021/ja207150n http://doi.org/10.1021/ja207150n .
J. Q. Jiang , X. Tong , Y. Zhao . A new design for light-breakable polymer micelles . J. Am. Chem. Soc. , 2005 . 127 ( 123 ): 8290 - 8291 . http://pubs.acs.org/doi/pdfplus/10.1021/ja0521019?src=recsys http://pubs.acs.org/doi/pdfplus/10.1021/ja0521019?src=recsys , .
N. Fomina , C. Mcfearin , M. Sermsakdi , O. Edigin , A. Almutairi . UV and near-IR triggered release from polymeric nanoparticles . J. Am. Chem. Soc. , 2010 . 132 ( 28 ): 9540 - 9542 . DOI: 10.1021/ja102595j http://doi.org/10.1021/ja102595j .
B. Yan , J. C. Boyer , N. R. Branda , Y. Zhao . Near-infrared light-triggered dissociation of block copolymer micelles using upconverting nanoparticles . J. Am. Chem. Soc. , 2011 . 133 ( 49 ): 19714 - 19717 . DOI: 10.1021/ja209793b http://doi.org/10.1021/ja209793b .
X. Y. Tan , B. B. Li , X. G. Lu , F. Jia , C. Santori , P. Menon , H. Li , B. Zhang , J. J. Zhao , Zhang , . K . Light-triggered, self-immolative nucleic acid-drug nanostructures . J. Am. Chem. Soc. , 2015 . 137 ( 19 ): 6112 - 6115 . DOI: 10.1021/jacs.5b00795 http://doi.org/10.1021/jacs.5b00795 .
X. R. Wang , J. M. Hu , G. H. Liu , J. Tian , H. J. Wang , M. Gong , S. Y. Liu . Reversibly switching bilayer permeability and release modules of photochromic polymersomes stabilized by cooperative noncovalent interactions . J. Am. Chem. Soc. , 2015 . 137 ( 48 ): 15262 - 15275 . DOI: 10.1021/jacs.5b10127 http://doi.org/10.1021/jacs.5b10127 .
V.P. Torchilin . Multifunctional, stimuli-sensitive nanoparticulate systems for drug delivery . Nat. Rev. Drug Discov. , 2014 . 13 ( 11 ): 813 - 827 . DOI: 10.1038/nrd4333 http://doi.org/10.1038/nrd4333 .
S. Y. Liu , N. C. Billingham , S. P. Armes . A schizophrenic water-soluble diblock copolymer . Angew. Chem. Int. Ed. , 2010 . 40 ( 12 ): 2328 - 2331 . http://onlinelibrary.wiley.com/doi/10.1002/1521-3757(20010618)113:12%3C2390::AID-ANGE2390%3E3.0.CO;2-J/abstract http://onlinelibrary.wiley.com/doi/10.1002/1521-3757(20010618)113:12%3C2390::AID-ANGE2390%3E3.0.CO;2-J/abstract , .
B. Taghizadeh , S. Taranejoo , S. A. Monemian , Z. S. Moghaddam , K. Daliri , H. Derakhshankhah , Z. Derakhshan . Classification of stimuli-responsive polymers as anticancer drug delivery systems . Drug Deliv. , 2015 . 22 ( 2 ): 145 - 155 . DOI: 10.3109/10717544.2014.887157 http://doi.org/10.3109/10717544.2014.887157 .
G. Y. Qing , M. M. Li , L. J. Deng , Z. Y. Lv , P. Ding , T. L. Sun . Smart drug release systems based on stimuli-responsive polymers . Mini-Rev. Med. Chem. , 2013 . 13 ( 9 ): 1369 - 1380 . DOI: 10.2174/13895575113139990062 http://doi.org/10.2174/13895575113139990062 .
D. Kuckling , A. Doering , F. Krahl , K. F. Arndt . Stimuli-responsive polymer systems . Polym. Sci. A Comprehensive Ref. , 2012 . 12 ( 8 ): 377 - 413 . http://onlinelibrary.wiley.com/doi/10.1002/9781118747896.ch12/references http://onlinelibrary.wiley.com/doi/10.1002/9781118747896.ch12/references , .
Q. Yan , J. Y. Yuan . Synthesis and function of stimuli-responsive polymer systems . Chem. J. Chinese U. , 2012 . 33 ( 9 ): 1877 - 1885 . https://www.hindawi.com/journals/ijps/2016/6480259/cta/ https://www.hindawi.com/journals/ijps/2016/6480259/cta/ , .
E. Cabane , X. Y. Zhang , K. Langowska , C. G. Palivan , W. Meier . Stimuli-responsive polymers and their applications in nanomedicine . Biointerphase. , 2012 . 7 ( 1-4 ): 9 - 36 . https://link.springer.com/content/pdf/10.1007/s13758-011-0009-3.pdf https://link.springer.com/content/pdf/10.1007/s13758-011-0009-3.pdf , .
B. D. Boer , U. Stalmach , P. F. V. Hutten , V. K. Victor , G. Hadziioannou . Supramolecular self-assembly and opto-electronic properties of semiconducting block copolymers . Polymer , 2001 . 42 ( 21 ): 9097 - 9109 . DOI: 10.1016/S0032-3861(01)00388-3 http://doi.org/10.1016/S0032-3861(01)00388-3 .
S. Mura , J. Nicolas , P. Couvreur . Stimuli-responsive nanocarriers for drug delivery . Nat. Mater. , 2013 . 12 ( 11 ): 991 - 1003 . DOI: 10.1038/nmat3776 http://doi.org/10.1038/nmat3776 .
I. S. Kim , S. Y. Shin , Y. S. Kim , H. Y. Kim , H. S. Yoon . Expression of a glutathione reductase from Brassica rapasubsp. pekinensis enhanced cellular redox homeostasis by modulating antioxidant proteins in Escherichia coli . Mol. & Cells. , 2009 . 28 ( 5 ): 479 - 487 . https://www.cabdirect.org/cabdirect/abstract/20103000418 https://www.cabdirect.org/cabdirect/abstract/20103000418 , .
L. Y. Niu , Y. Z. Chen , H. R. Zheng , L. Z. Wu , B. C. Tung , Q. Z. Yang . Design strategies of fluorescent probes for selective detection among biothiols . Chem. Soc. Rev. , 2015 . 46 ( 17 ): 6143 - 6160 . http://onlinelibrary.wiley.com/doi/10.1002/chem.201300078/suppinfo http://onlinelibrary.wiley.com/doi/10.1002/chem.201300078/suppinfo , .
S. Mocellin , V. Bronte , D. Nitti . Nitric oxide, a double edged sword in cancer biology:searching for therapeutic opportunities . Med. Res. Rev. , 2007 . 27 ( 3 ): 317 - 352 . DOI: 10.1002/(ISSN)1098-1128 http://doi.org/10.1002/(ISSN)1098-1128 .
M. T. Gladwin , D. B. Kimshapiro . Vascular biology:Nitric oxide caught in traffic . Nature , 2012 . 491 ( 7424 ): 344 - 345 . DOI: 10.1038/nature11640 http://doi.org/10.1038/nature11640 .
J. M. Hu , M. R. Whittaker , H. Duong , L. Yang , C. Boyer , T. P. Davi . Biomimetic polymers responsive to a biological signaling molecule:nitric oxide triggered reversible self-assembly of single macromolecular chains into nanoparticles . Angew. Chem. Int. Ed. , 2014 . 126 ( 3 ): 7913 - 1918 . http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1002/anie.201403147 http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1002/anie.201403147 , .
L. Li , P. Rose , P. K. Moore . Hydrogen sulfide and cell signaling . Annu. Rev. Pharmacol. , 2011 . 51 ( 1 ): 169 - 187 . DOI: 10.1146/annurev-pharmtox-010510-100505 http://doi.org/10.1146/annurev-pharmtox-010510-100505 .
Y. Qiang , S. Wei . H 2 S gasotransmitter-responsive polymer vesicles . Chem. Sci. , 2015 . 7 ( 3 ): 2100 - 2105 . https://ncbi.nlm.nih.gov/pubmed/21608994 https://ncbi.nlm.nih.gov/pubmed/21608994 , .
H. Kimura . Physiological role of hydrogen sulfide and polysulfide in the central nervous system . Neurochem. Int. , 2013 . 63 ( 5 ): 492 - 497 . DOI: 10.1016/j.neuint.2013.09.003 http://doi.org/10.1016/j.neuint.2013.09.003 .
P. Nagy , Z. Pálinkás , A. Nagy , B. Budai , I. Tóth , A. Vasas . Chemical aspects of hydrogen sulfide measurements in physiological samples . Biochim. Biophys. Acta , 2014 . 1840 ( 2 ): 876 - 891 . DOI: 10.1016/j.bbagen.2013.05.037 http://doi.org/10.1016/j.bbagen.2013.05.037 .
O. Kabil , N. Motl , R. Banerjee . H 2 S and its role in redox signaling . Biochim. Biophys. Acta , 2014 . 1844 ( 8 ): 1355 - 1366 . DOI: 10.1016/j.bbapap.2014.01.002 http://doi.org/10.1016/j.bbapap.2014.01.002 .
J. Zhang , X. Hao , W. Sang , Q. Yan . Hydrogen polysulfide biosignal-responsive polymersomes as a nanoplatform for distinguishing intracellular reactive sulfur species (RSS) . Small , 2017 . 13 ( 39 ): 1701601 - 1701608 . DOI: 10.1002/smll.v13.39 http://doi.org/10.1002/smll.v13.39 .
G. Ferrersueta , R. Radi . Chemical biology of peroxynitrite:kinetics, diffusion, and radicals . ACS Chem. Biol. , 2009 . 4 ( 3 ): 161 - 177 . DOI: 10.1021/cb800279q http://doi.org/10.1021/cb800279q .
C. Szabó , H. Ischiropoulos , R. Radi . Peroxynitrite:biochemistry, pathophysiology and development of therapeutics . Nat. Rev. Drug Discov. , 2007 . 6 ( 8 ): 662 - 680 . DOI: 10.1038/nrd2222 http://doi.org/10.1038/nrd2222 .
Z. Chen , W. Ren , Q. E. Wright , H. W. Ai . Genetically encoded fluorescent probe for the selective detection of peroxynitrite . J. Am. Chem. Soc. , 2013 . 135 ( 40 ): 14940 - 14943 . DOI: 10.1021/ja408011q http://doi.org/10.1021/ja408011q .
Z. J. Chen , Z. Tian , K. Kallio , A. L. Oleson , A. Ji , D. Borchardt , D. E. Jiang , S. J. Remington , H. W. Ai . The N-B interaction through a water bridge:understanding the chemoselectivity of a fluorescent protein based probe for peroxynitrite . J. Am. Chem. Soc. , 2016 . 138 ( 14 ): 4900 - 4907 . DOI: 10.1021/jacs.6b01285 http://doi.org/10.1021/jacs.6b01285 .
T. Peng , N. K. Wong , X. M. Chen , Y. K. Chan , D. H. Ho , Z. N. Sun , J. J. Hu , J. G. Shen , H. El-Nezami , D. Yang . Molecular imaging of peroxynitrite with HKGreen-4 in live cells and tissues . J. Am. Chem. Soc. , 2014 . 136 ( 33 ): 11728 - 11734 . DOI: 10.1021/ja504624q http://doi.org/10.1021/ja504624q .
T. Peng , D. Yang . HKGreen-3:a rhodol-based fluorescent probe for peroxynitrite . Org. Lett. , 2010 . 12 ( 21 ): 4932 - 4935 . DOI: 10.1021/ol102182j http://doi.org/10.1021/ol102182j .
D. Yang , H. L. Wang , Z. N. Sun , N. W. Chung , J. G. Shen . A highly selective fluorescent probe for the detection and imaging of peroxynitrite in living cells . J. Am. Chem. Soc. , 2006 . 128 ( 18 ): 6004 - 6005 . DOI: 10.1021/ja0603756 http://doi.org/10.1021/ja0603756 .
J. Zhang , J. Hu , W. Sang , J. B. Wang , Q. Yan . Peroxynitrite (ONOO-) redox signaling molecule-responsive polymersomes . ACS Macro Lett. , 2016 . 5 ( 8 ): 919 - 924 . DOI: 10.1021/acsmacrolett.6b00474 http://doi.org/10.1021/acsmacrolett.6b00474 .
A. K. Mustafa , M. M. Gadalla , S. H. Snyder . Signaling by gasotransmitters . Sci. Signal. , 2009 . 2 ( 68 ): DOI: 10.1126/scisignal.268re2 http://doi.org/10.1126/scisignal.268re2 .
C.A. Piantadosi . Carbon monoxide, reactive oxygen signaling, and oxidative stress . Free Radical Bio. & Med. , 2008 . 45 ( 5 ): 562 - 569 . http://online.liebertpub.com/doi/abs/10.1089/152308602753666316?src=recsys http://online.liebertpub.com/doi/abs/10.1089/152308602753666316?src=recsys , .
R. Motterlini , L. E. Otterbein . The therapeutic potential of carbon monoxide . Nat. Rev. Drug Discov. , 2010 . 9 ( 9 ): 728 - 743 . DOI: 10.1038/nrd3228 http://doi.org/10.1038/nrd3228 .
D. Morse , J. Sethi . Carbon monoxide and human disease . Antioxidants & Redox Sign. , 2002 . 4 ( 2 ): 331 - 338 . http://www.liebertonline.com/doi/abs/10.1089/152308602753666389 http://www.liebertonline.com/doi/abs/10.1089/152308602753666389 , .
M. M. Xu , L. X. Liu , J. Hu , Q. Yan . CO-signaling molecule-responsive nanoparticles formed from palladiumcontaining block copolymers . ACS Macro Lett. , 2017 . 6 ( 4 ): 458 - 462 . DOI: 10.1021/acsmacrolett.7b00042 http://doi.org/10.1021/acsmacrolett.7b00042 .
S. Biswas , K. Kinbara , T. Niwa , H. Taguchi , N. Ishii , S. Watanabe , K. Miyata , K. Kataoka , T. Aida . Biomolecular robotics for chemomechanically driven guest delivery fuelled by intracellular ATP . Nat. Chem. , 2013 . 5 ( 7 ): 613 - 620 . DOI: 10.1038/nchem.1681 http://doi.org/10.1038/nchem.1681 .
K. Okuro , M. Sasaki , T. Aida . Boronic acid-appended molecular glues for ATP-responsive activity modulation of enzymes . J. Am. Chem. Soc. , 2016 . 138 ( 17 ): 5527 - 5530 . DOI: 10.1021/jacs.6b02664 http://doi.org/10.1021/jacs.6b02664 .
R. Mo , T. Jiang , R. Disanto , W. Tai , Z. Gu . ATP-triggered anticancer drug delivery . Nat. Commun. , 2014 . 5 ( 1 ): 3364 - 3373 . http://www.nature.com/ncomms/2014/140311/ncomms4364/metrics/news http://www.nature.com/ncomms/2014/140311/ncomms4364/metrics/news , .
G. C. Yu , J. Zhou , J. Shen , G. P. Tang , F. H. Huang . Cationic pillar . Chem. Sci. , 2016 . 7 ( 7 ): 4073 - 4078 . DOI: 10.1039/C6SC00531D http://doi.org/10.1039/C6SC00531D .
Q. Yan , Y. Zhao . ATP-triggered biomimetic deformations of bioinspired receptor-containing polymer assemblies . Chem. Sci. , 2015 . 6 ( 7 ): 4343 - 4349 . DOI: 10.1039/C5SC00965K http://doi.org/10.1039/C5SC00965K .
Z. Q. Guo , N. R. Song , J. H. Moon , M. Kim , E. J. Jun , J. Y. Choi , J. Y. Lee , C. W. Bielawski , J. L. Sessler , J. Y. Yoon . A Benzobisimidazolium-based fluorescent and colorimetric chemosensor for CO 2 . J. Am. Chem. Soc. , 2012 . 134 ( 43 ): 17846 - 17849 . DOI: 10.1021/ja306891c http://doi.org/10.1021/ja306891c .
H. Wang , D. D. Chen , Y. H. Zhang , P. Liu , J. B. Shi , X. Feng , B. Tong , Y. P. Dong . A fluorescent probe with an aggregation-enhanced emission feature for real-time monitoring of low carbon dioxide levels . J. Mater. Chem. C , 2015 . 3 ( 29 ): 7621 - 7626 . DOI: 10.1039/C5TC01280E http://doi.org/10.1039/C5TC01280E .
R. N. Dansby-Sparks , J. Jin , S. J. Mechery , U. Sampathkumaran , T. W. Owen , B. D. Yu , K. Goswami , K. L. Hong , G. Grant , Z. L. Xue . Fluorescent dye-doped sol-gel sensor for highly sensitive carbon dioxide gas detection below atmospheric concentrations . Anal. Chem. , 2010 . 82 ( 2 ): 593 - 600 . DOI: 10.1021/ac901890r http://doi.org/10.1021/ac901890r .
J. Gutknecht , M. A. Bisson , F. C. Tosteson . Diffusion of carbon dioxide through lipid bilayer membranes:effects of carbonic anhydrase, bicarbonate and unstirred layers . J. Gen. Physiol. , 1977 . 69 ( 6 ): 779 - 794 . https://www.researchgate.net/publication/22732558_Diffusion_of_carbon_dioxide_through_lipid_bilayer_membranes_Effects_of_carbonic_anhydrase_bicarbonate_and_unstirred_layers https://www.researchgate.net/publication/22732558_Diffusion_of_carbon_dioxide_through_lipid_bilayer_membranes_Effects_of_carbonic_anhydrase_bicarbonate_and_unstirred_layers , .
J. M. Tour , C. Kittrell , V. L. Colvin . Green carbon as a bridge to renewable energy . Nat. Mater. , 2010 . 9 ( 11 ): 871 - 874 . DOI: 10.1038/nmat2887 http://doi.org/10.1038/nmat2887 .
Q. Yan , R. Zhou , C. K. Fu , H. J.; Yin Y. W. Zhang. , Y. W. Yin. , J. Y. Yuan . CO 2 -responsive polymeric vesicles that breathe . Angew. Chem. Int. Ed. , 2011 . 50 ( 21 ): 4923 - 4927 . DOI: 10.1002/anie.v50.21 http://doi.org/10.1002/anie.v50.21 .
Q. Yan , Y. Zhao . CO 2 -stimulated diversiform deformations of polymer assemblies . J. Am. Chem. Soc. , 2013 . 135 ( 44 ): 16300 - 16303 . DOI: 10.1021/ja408655n http://doi.org/10.1021/ja408655n .
Z. R. Guo , Y. J. Feng , Y. Wang , J. Y. Wang , Y. F. Wu , Y. M. Zhang . A novel smart polymer responsive to CO 2 . Chem. Commun. , 2011 . 47 ( 33 ): 9348 - 9350 . DOI: 10.1039/c1cc12388b http://doi.org/10.1039/c1cc12388b .
B. W. Liu , H. J. Zhou , S. T. Zhou , H. J. Zhang , A. C. Feng , C. M. Jian , J. Hu , W. P. Gao , J. Y. Yuan . Synthesis and self-assembly of CO 2 -temperature dual stimuli-responsive triblock copolymers . Macromolecules , 2014 . 47 ( 9 ): 2938 - 2946 . DOI: 10.1021/ma5001404 http://doi.org/10.1021/ma5001404 .
J. Y. Choi , YK. Jin , H. J. Moon , M. H. Park , B. M. Jeong . CO 2 -and O 2 -sensitive fluorophenyl end-capped poly(ethylene glycol) . Macromol. Rapid Commun. , 2014 . 35 ( 1 ): 66 - 70 . DOI: 10.1002/marc.201300700 http://doi.org/10.1002/marc.201300700 .
Q. Zhang , S. P. Zhu . Oxygen and carbon dioxide dual responsive nanoaggregates of fluoro-and amino-containing copolymer . ACS Macro Lett. , 2014 . 3 ( 8 ): 743 - 746 . DOI: 10.1021/mz500377x http://doi.org/10.1021/mz500377x .
X. D. Xu , B. B. Lin , J. Feng , Y. Wang , S. X. Cheng , X. Z. Zhang , R. X. Zhuo . Biological glucose metabolism regulated peptide self-assembly as a simple visual biosensor for glucose detection . Macromol. Rapid Commun. , 2012 . 33 ( 5 ): 426 - 431 . DOI: 10.1002/marc.201100689 http://doi.org/10.1002/marc.201100689 .
J. H. Ryu , S. Jiwpanich , R. Chacko , S. Bickerton . Surface-functionalizable polymer nanogels with facile hydrophobic guest encapsulation capabilities . J. Am. Chem. Soc. , 2010 . 132 ( 24 ): 8246 - 8247 . DOI: 10.1021/ja102316a http://doi.org/10.1021/ja102316a .
R. Ja-Hyoung , R. T. Chacko , J. Siriporn , S. Bickerton , R. P. Babu . Thayumanavan. S. Self-cross-linked polymer nanogels:a versatile nanoscopic drug delivery platform . J. Am. Chem. Soc. , 2010 . 132 ( 48 ): 17227 - 17235 . DOI: 10.1021/ja1069932 http://doi.org/10.1021/ja1069932 .
S. Jiwpanich , J. H. Ryu , S. Bickerton . Thayumanavan. S. Non-covalent encapsulation stabilities in supramolecular nanoassemblies . J. Am. Chem. Soc. , 2010 . 132 ( 31 ): 10683 - 10685 . DOI: 10.1021/ja105059g http://doi.org/10.1021/ja105059g .
W. R. Zhao , H. T. Zhang , Q. J. He , Y. S. Li , J. L. Gu , L. Li , H. Li , J. L. Shi . A glucose-responsive controlled release of insulin system based on enzyme multilayers-coated mesoporous silica particles . Chem. Commun. , 2011 . 47 ( 33 ): 9459 - 9461 . DOI: 10.1039/c1cc12740c http://doi.org/10.1039/c1cc12740c .
Q. Q. Guo , T. Q. Zhang , J. X. An , Z. M. Wu , Y. Zhao , X. M. Dai , X. G. Zhang , C. X. Li . Block versus random amphiphilic glycopolymer nanopaticles as glucose-responsive vehicles . Biomacromolecules , 2015 . 16 ( 10 ): 3345 - 3356 . DOI: 10.1021/acs.biomac.5b01020 http://doi.org/10.1021/acs.biomac.5b01020 .
H. Kim , Y. J. Kang , S. Kang , K. T. Kim . Monosaccharideresponsive release of insulin from polymersomes of polyboroxole block copolymers at neutral pH . J. Am. Chem. Soc. , 2012 . 134 ( 9 ): 4030 - 4033 . DOI: 10.1021/ja211728x http://doi.org/10.1021/ja211728x .
H. Wang , X. Wang , M. A. Winnik , I. Manners . Redox-mediated synthesis and encapsulation of inorganic nanoparticles in shell-cross-linked cylindrical polyferrocenylsilane block copolymer micelles . J. Am. Chem. Soc. , 2008 . 130 ( 39 ): 12921 - 12930 . DOI: 10.1021/ja8028558 http://doi.org/10.1021/ja8028558 .
K. E. Broaders , S. Grandhe , J. M. Fréchet . A biocompatible oxidation-triggered carrier polymer with potential in therapeutics . J. Am. Chem. Soc. , 2011 . 133 ( 4 ): 756 - 758 . DOI: 10.1021/ja110468v http://doi.org/10.1021/ja110468v .
R. Cheng , F. Feng , F. H. Meng , C. Deng , F. J. Jan , Z. Y. Zhong . Glutathione-responsive nano-vehicles as a promising platform for targeted intracellular drug and gene delivery . J. Control. Release , 2011 . 152 ( 1 ): 2 - 12 . DOI: 10.1016/j.jconrel.2011.01.030 http://doi.org/10.1016/j.jconrel.2011.01.030 .
P. Kuppusamy , H. Li , G. Ilangovan , A. J. Cardounel , J. L. Zweier , K. Yamada , M. C. Krishna , J. B. Mitchell . Noninvasive imaging of tumor redox status and its modification by tissue glutathione levels . Cancer Res. , 2002 . 62 ( 1 ): 307 - 312 . http://cancerres.aacrjournals.org/content/62/1/307.abstract?cited-by=yes&legid=canres;62/1/307 http://cancerres.aacrjournals.org/content/62/1/307.abstract?cited-by=yes&legid=canres;62/1/307 , .
W. Chen , P. Zhong , F. H. Meng , R. Cheng , C. Deng , F. J. Jan , Z. Y. Zhong . Redox and pH-responsive degradable micelles for dually activated intracellular anticancer drug release . J. Control. Release , 2013 . 169 ( 3 ): 171 - 179 . DOI: 10.1016/j.jconrel.2013.01.001 http://doi.org/10.1016/j.jconrel.2013.01.001 .
N. Ma , Y. Li , H. P. Xu , Z. Q. Wang , X. Zhang . Dual redox responsive assemblies formed from diselenide block copolymers . J. Am. Chem. Soc. , 2010 . 132 ( 2 ): 442 - 443 . DOI: 10.1021/ja908124g http://doi.org/10.1021/ja908124g .
P. Han , S. C. Li , W. Cao , Y. Li , Z. W. Sun , Z. Q. Wang , H. P. Xu . Red light responsive diselenide-containing block copolymer micelles . J. Mater. Chem. , B2013 . 1 ( 6 ): 740 - 743 . DOI: 10.1039/C2TB00186A http://doi.org/10.1039/C2TB00186A .
R. J. Amir , S. Zhong , D. J. Pochan , C. J. Hawker . Enzymatically triggered self-assembly of block copolymers . J. Am. Chem. Soc. , 2009 . 131 ( 39 ): 13949 - 13951 . DOI: 10.1021/ja9060917 http://doi.org/10.1021/ja9060917 .
P. Meers . Enzyme-activated targeting of liposomes . Adv. Drug Deliv. Rev. , 2001 . 53 ( 3 ): 265 - 272 . DOI: 10.1016/S0169-409X(01)00205-8 http://doi.org/10.1016/S0169-409X(01)00205-8 .
J. Y. Rao , A. Khan . Enzyme sensitive synthetic polymer micelles based on the azobenzene motif . J. Am. Chem. Soc. , 2013 . 135 ( 38 ): 14056 - 14059 . DOI: 10.1021/ja407514z http://doi.org/10.1021/ja407514z .
A. J. Harnoy , I. Rosenbaum , E. Tirosh , Y. Ebenstein , R. Shaharabani , R. Beck , R. J. Amir . Enzyme-responsive amphiphilic PEG-dendron hybrids and their assembly into smart micellar nanocarriers . J. Am. Chem. Soc. , 2014 . 136 ( 21 ): 7531 - 7534 . DOI: 10.1021/ja413036q http://doi.org/10.1021/ja413036q .
A. J. Harnoy , M. Buzhor , E. Tirosh , R. Shaharabani , R. Beck , R. J. Amir . Modular synthetic approach for adjusting the disassembly rates of enzyme-responsive polymeric micelles . Biomacromolecules , 2017 . 18 ( 4 ): 1218 - 1228 . DOI: 10.1021/acs.biomac.6b01906 http://doi.org/10.1021/acs.biomac.6b01906 .
S. Saxena , M. Jayakannan . Enzyme and pH dual responsive amino acid based biodegradable polymer nanocarrier for multidrug delivery to cancer cells . J. Polym. Sci., Part A:Polym. Chem. , 2016 . 54 ( 20 ): 3279 - 3293 . DOI: 10.1002/pola.v54.20 http://doi.org/10.1002/pola.v54.20 .
C. Wang , Q. S. Chen , Z. Q. Wang , X. Zhang . An enzyme-responsive polymeric superamphiphile . Angew. Chem. Int. Ed. , 2010 . 49 ( 46 ): 8612 - 8615 . DOI: 10.1002/anie.201004253 http://doi.org/10.1002/anie.201004253 .
Y. M. Li , G. H. Liu , X. R. Wang , J. M. Wu , S. Y. Liu . Enzyme-responsive polymeric vesicles for bacterial-strainselective delivery of antimicrobial agents . Angew. Chem. Int. Ed. , 2016 . 128 ( 5 ): 1792 - 1796 . DOI: 10.1002/ange.201509401 http://doi.org/10.1002/ange.201509401 .
Y. M. Li , S. Y. Liu , Y. M. Li , S. Y. Liu . Enzyme-triggered transition from polymeric vesicles to core cross-linked micelles for selective release of antimicrobial agents . Acta Polymerica Sinica (in Chinese) , 2017 . ( 7 ): 1178 - 1190 . https://ncbi.nlm.nih.gov/pubmed/21608994 https://ncbi.nlm.nih.gov/pubmed/21608994 , .
N. C. Seeman . DNA in a material world . Nature , 2003 . 421 ( 6921 ): 427 - 431 . DOI: 10.1038/nature01406 http://doi.org/10.1038/nature01406 .
F. A. Aldaye , A. L. Palmer , H. F. Sleiman . Assembling materials with DNA as the guide . Science , 2008 . 321 ( 5897 ): 1795 - 1799 . DOI: 10.1126/science.1154533 http://doi.org/10.1126/science.1154533 .
C. K. Mclaughlin , G. D. Hamblin , H. F. Sleiman . Supramolecular DNA assembly . Chem. Soc. Rev. , 2011 . 40 ( 12 ): 5647 - 5656 . DOI: 10.1039/c1cs15253j http://doi.org/10.1039/c1cs15253j .
T. G. W. Edwardson , K. M. M. Carneiro , C. K. Mclaughlin , C. J. Serpell , H. F. Sleiman . Site-specific positioning of dendritic alkyl chains on DNA cages enables their geometry-dependent self-assembly . Nat. Chem. , 2013 . 5 ( 10 ): 868 - 875 . DOI: 10.1038/nchem.1745 http://doi.org/10.1038/nchem.1745 .
K. E. Bujold , J. Fakhoury , T. G. W. Edwardson , K. M. M. Carneiro , J. N. Briard , A. G. Godin , L. Amrein , G. D. Hamblin , L. C. Panasci , P. W. Wiseman , H. Sleiman . Sequenceresponsive unzipping DNA cubes with tunable cellular uptake profiles . Chem. Sci. , 2014 . 5 ( 6 ): 2449 - 2455 . DOI: 10.1039/C4SC00646A http://doi.org/10.1039/C4SC00646A .
G. I. Peterson , M. B. Larsen , A. J. Boydston , A. J. Boydston . Controlled depolymerization:stimuli-responsive self-immolative polymers . Macromolecules , 2012 . 45 ( 18 ): 7317 - 7328 . DOI: 10.1021/ma300817v http://doi.org/10.1021/ma300817v .
0
Views
26
Downloads
0
CSCD
Publicity Resources
Related Articles
Related Author
Related Institution
京公网安备11010802046900号