Light-responsive Self-Immolative <italic style="font-style: italic">L</italic>-glutamic Acid-based Polyester Nanoparticles for Controlled Drug Release <italic style="font-style: italic">via</italic> Passerini Three-Component Polymerization

Xiao-Fei Sun; Xu Zhang; Shu-Ping Song; Ya-Qun Yao; Yan Zhang; Cheng-Liang Wang; Jing-Jiang Sun; Qing-Fu Wang

doi:10.1007/s10118-024-3093-9

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Light-responsive Self-Immolative L-glutamic Acid-based Polyester Nanoparticles for Controlled Drug Release via Passerini Three-Component Polymerization

RESEARCH ARTICLE | Updated：2024-04-12

- Light-responsive Self-Immolative L-glutamic Acid-based Polyester Nanoparticles for Controlled Drug Release via Passerini Three-Component Polymerization
- Chinese Journal of Polymer Science Vol. 42, Issue 5, Pages: 570-578(2024)
- Affiliations：
  
  a.Key Laboratory of Rubber-plastics, Ministry of Education, School of Polymer Science and Engineering, Qingdao University of Science and Technology, Qingdao 266042, China
  b.Qingdao Research Academy of Environmental Science, Qingdao 266012, China
- Author bio：
  
  sunjij@qust.edu.cn (J.J.S.)
  wangqf@qust.edu.cn (Q.F.W.)
- Funds：
- DOI：10.1007/s10118-024-3093-9
  CLC：
- Published：1 May 2024，
  
  Published Online：4 March 2024，
  
  Received：22 November 2023，
  
  Revised：2 January 2024，
  
  Accepted：10 January 2024
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Sun, X. F.; Zhang, X.; Song, S. P.; Yao, Y. Q.; Zhang, Y.; Wang, C. L.; Sun, J. J.; Wang, Q. F. Light-responsive self-immolative L-glutamic acid-based polyester nanoparticles for controlled drug release via Passerini three-component polymerization. Chinese J. Polym. Sci. 2024, 42, 570–578

Xiao-Fei Sun, Xu Zhang, Shu-Ping Song, et al. Light-responsive Self-Immolative L-glutamic Acid-based Polyester Nanoparticles for Controlled Drug Release via Passerini Three-Component Polymerization. [J]. Chinese Journal of Polymer Science 42(5):570-578(2024)
Sun, X. F.; Zhang, X.; Song, S. P.; Yao, Y. Q.; Zhang, Y.; Wang, C. L.; Sun, J. J.; Wang, Q. F. Light-responsive self-immolative L-glutamic acid-based polyester nanoparticles for controlled drug release via Passerini three-component polymerization. Chinese J. Polym. Sci. 2024, 42, 570–578 DOI： 10.1007/s10118-024-3093-9.

Xiao-Fei Sun, Xu Zhang, Shu-Ping Song, et al. Light-responsive Self-Immolative L-glutamic Acid-based Polyester Nanoparticles for Controlled Drug Release via Passerini Three-Component Polymerization. [J]. Chinese Journal of Polymer Science 42(5):570-578(2024) DOI： 10.1007/s10118-024-3093-9.

摘要

Light-responsive polyesters (PLTDs) based on bio-based

-glutamic acid were synthesized by Passerini Three-Component Polymerization with molar masses up to 8500 g/mol and yields exceeding 90%. Doxorubicin-loaded nanoparticles (size = 193 nm

PDI = 0.018) were successfully prepared and the light-controlled drug release kinetic was thoroughly characterized.

Abstract

-glutamic acid (LA) is a bio-based

non-toxic

environmentally friendly material derived from biomass. The present study reports the application of Passerini three-component polymerization (P-3CP) for the straightforward preparation of LA-based light-responsive polyesters (PLTDs) under mild conditions. PLTDs with molar masses up to 8500 g/mol and high yields exceeding 90% are obtained. The chemical structures and light-responsive self-immolative behavior of PLTDs are comprehensively characterized by employing ultraviolet-visible (UV-Vis) spectroscopy

size exclusion chromatography (SEC)

nuclear magnetic resonance (NMR) spectroscopy

and liquid chromatography mass spectrometry (LC-MS). Meanwhile

monodisperse PLTD-based doxorubicin-loaded nanoparticles (PLTD-DOX-NP) (size=193 nm

PDI=0.018) are formulated by nanoprecipitation method. Upon light-induced depolymerization

the PLTD-DOX-NP undergoes rapid decomposition

resulting in a burst release of 80% cargo within 13 s. Furthermore

according to biological toxicity tests

the PLTD-NP possesses adequate biosafety

both before and after irradiation. Overall

the incorporation of P-3CP with biorenewable LA-based monomer adheres to the principles of green chemistry

significantly simplifying the synthetic pathway of light-responsive polymers.

关键词

Keywords

L-glutamic acidPasserini three-component polymerizationLight-responsivePolyesterNanoparticles

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Light-responsive Self-Immolative L-glutamic Acid-based Polyester Nanoparticles for Controlled Drug Release via Passerini Three-Component Polymerization

DOI：10.1007/s10118-024-3093-9

摘要

Abstract

关键词

Keywords

references