FOLLOWUS
a.College of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, China
b.College of Chemical Engineering, Tianjin University, Tianjin 300072, China
c.Foshan (Southern China) Institute for New Materials, Foshan 528200, China
chm_liss@ujn.edu.cn (S.S.L.)
chm_zhuxl@ujn.edu.cn (X.L.Z.)
Published:1 May 2024,
Published Online:23 February 2024,
Received:17 November 2023,
Revised:22 December 2023,
Accepted:27 December 2023
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Li, X. D.; Li, S. S.; Jiang, X. B.; Zhu, X. L.; Kong, X. Z. Unconventional fluorescent and multi-responsive polysiloxane: synthesis, characterization and biological applications. Chinese J. Polym. Sci. 2024, 42, 579–590
Xiao-Di Li, Shu-Sheng Li, Xu-Bao Jiang, et al. Unconventional Fluorescent and Multi-responsive Polysiloxane: Synthesis, Characterization and Biological Applications. [J]. Chinese Journal of Polymer Science 42(5):579-590(2024)
Li, X. D.; Li, S. S.; Jiang, X. B.; Zhu, X. L.; Kong, X. Z. Unconventional fluorescent and multi-responsive polysiloxane: synthesis, characterization and biological applications. Chinese J. Polym. Sci. 2024, 42, 579–590 DOI: 10.1007/s10118-024-3091-y.
Xiao-Di Li, Shu-Sheng Li, Xu-Bao Jiang, et al. Unconventional Fluorescent and Multi-responsive Polysiloxane: Synthesis, Characterization and Biological Applications. [J]. Chinese Journal of Polymer Science 42(5):579-590(2024) DOI: 10.1007/s10118-024-3091-y.
Fluorescent and multi-responsive polysiloxane (FRPS) is synthesized. FRPS is not only highly sensitive to temperature
pH and CO
2
in water
but also showed an enhanced and stimuli-adjustable fluorescence emission. FRPS is used as physiological indicator for cell imaging
and for controlled release and trace detection of doxorubicin (DOX).
Owing to their high significance in fundamental study and diverse applications
stimuli-responsive and fluorescent polymers
particularly those with cluster-triggered emission (CTE) featured by non-conjugated chromophores
have drawn tremendous attention in recent years. In this work
fluorescent and multi-responsive polysiloxane (FRPS) was synthesized by hydrolytic condensation polymerization of 3-aminopropyl methyl diethoxysilane (APMS) with 3-(
N
-isopropyl propionamide) iminopropyl methyl diethoxysilane (APMS-NIP)
which was formed
in situ
through aza-Michael addition between APMS and
N
-isopropyl acrylamide. FRPS was not only highly sensitive to temperature
pH and CO
2
in water
but also showed an enhanced and stimuli-adjustable fluorescence emission. The effects of monomer feeding
pH and CO
2
on its lower critical solution temperature and fluorescent property were investigated. FRPS fluorescence emission was ascribed to CTE mechanism. In addition
FRPS was shown to be highly potential as physiological indicator for cell imaging
and for controlled release and trace detection of doxorubicin. This study provides therefore a type of stimuli-responsive and fluorescent material for potential applications in biomedical fields
and it is also of great significance for understanding of the fluorescence mechanism of polysiloxane-based stimuli-responsive polymers.
PolysiloxaneMulti-responsivenessCluster-triggered emissionCell imagingControlled drug release
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