Design of Biologically Active Macromolecular Ligands and Their Luminescent Complexes with Terbium Ions

Тatiana N. Nekrasova; Аndrei I. Fischer; Natalia А. Nesterova; Anatoliy V. Dobrodumov; Anzhelika V. Garshinina; Оlga D. Shuvaeva; Natalya V. Zakharova; Evgenii F. Panarin

doi:10.1007/s10118-024-3081-0

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Design of Biologically Active Macromolecular Ligands and Their Luminescent Complexes with Terbium Ions

RESEARCH ARTICLE | Updated：2024-04-12

- Design of Biologically Active Macromolecular Ligands and Their Luminescent Complexes with Terbium Ions
- Chinese Journal of Polymer Science Vol. 42, Issue 5, Pages: 604-611(2024)
- Affiliations：
  
  a.Institute of Macromolecular Compounds, Russian Academy of Sciences, 31 Bolshoy pr., St Petersburg 199004, Russia
  b.Smorodintsev Research Institute of Influenza, Russian Ministry of Health, 15/17 ul. prof. Popova, St Petersburg 197376, Russia
- Author bio：
  
  polar@macro.ru (T.N.N.)
  andreasfischer@mail.ru (A.I.F.)
- Funds：
- DOI：10.1007/s10118-024-3081-0
  CLC：
- Published：1 May 2024，
  
  Published Online：25 January 2024，
  
  Received：17 November 2023，
  
  Revised：2 December 2023，
  
  Accepted：15 December 2023
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Nekrasova, Т. N.; Fischer, А. I.; Nesterova, N. А.; Dobrodumov, A. V.; Garshinina, A. V.; Shuvaeva, О. D.; Zakharova, N. V.; Panarin, E. F. Design of biologically active macromolecular ligands and their luminescent complexes with terbium ions. Chinese J. Polym. Sci. 2024, 42, 604–611

Тatiana N. Nekrasova, Аndrei I. Fischer, Natalia А. Nesterova, et al. Design of Biologically Active Macromolecular Ligands and Their Luminescent Complexes with Terbium Ions. [J]. Chinese Journal of Polymer Science 42(5):604-611(2024)
Nekrasova, Т. N.; Fischer, А. I.; Nesterova, N. А.; Dobrodumov, A. V.; Garshinina, A. V.; Shuvaeva, О. D.; Zakharova, N. V.; Panarin, E. F. Design of biologically active macromolecular ligands and their luminescent complexes with terbium ions. Chinese J. Polym. Sci. 2024, 42, 604–611 DOI： 10.1007/s10118-024-3081-0.

Тatiana N. Nekrasova, Аndrei I. Fischer, Natalia А. Nesterova, et al. Design of Biologically Active Macromolecular Ligands and Their Luminescent Complexes with Terbium Ions. [J]. Chinese Journal of Polymer Science 42(5):604-611(2024) DOI： 10.1007/s10118-024-3081-0.

摘要

In the Tb

complexes with the vinylamide copolymers of pmethacrylamidobenzoic acid

water molecules located in the vicinity of carbonyl groups C=O and strongly bound by hydrogen bonds are partially included in the coordination sphere of Tb

. As a result

OH vibrations of the coordinated water molecules

which are the main process of luminescence quenching

are difficult. This leads to a significant increase in luminescence in compared with other copolymers.

Abstract

Water-soluble copolymers of

-methacrylamidobenzoic acid (MABA) with neutral comonomers (

-vinylpyrrolidone (VP)

-methyl-

-vinylacetamide (MVAA)

-methacryloyl glucosamine (MAG)) and anionic comononer sodium styrene sulfonate (NaSS) were synthesized by radical copolymerization. The interactions between the prepared copolymers and Tb

ions in aqueous solutions were studied; the significant influence of chemical structure of a comonomer on luminescence intensity of Tb

complexes with the copolymers was revealed. The luminescence intensity of Tb

complexes with the copolymers containing

-vinylamide units (VP

MVAA) is three times more intense than that observed for the complexes between Tb

and MAG-containing copolymers. In the case of NaSS-containing copolymers

the luminescence intensity is controlled by the values of binding constants between Tb

and MABA and the content of MABA units in a copolymer. The studied copolymers and their complexes with Tb

have low cytotoxicity and a pronounced antiviral activity against human respiratory syncytial virus.

关键词

Keywords

LuminescenceWater-soluble copolymersLanthanide complexesAntiviral activityCytotoxicity

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