Responsive Hybrid Poly(vinyl alcohol) Hydrogel Membranes with Embedded Microgels as Valves

Zi-Lin Wang; Di Huang; Mei-Yu Zhang; Xin-Xin Fu; Ying Luo; Lei Zou; Si-Jia Gao; Zhuo Zhao; Ya-Fei Wang; Yan Zhang; Yong-Jun Zhang

doi:10.1007/s10118-023-2995-2

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Responsive Hybrid Poly(vinyl alcohol) Hydrogel Membranes with Embedded Microgels as Valves

RESEARCH ARTICLE | Updated：2023-09-21

- Responsive Hybrid Poly(vinyl alcohol) Hydrogel Membranes with Embedded Microgels as Valves
- Chinese Journal of Polymer Science Vol. 41, Issue 10, Pages: 1646-1655(2023)
- Affiliations：
  
  a.State Key Laboratory of Separation Membranes and Membrane Processes, School of Material Science and Engineering, Tiangong University, Tianjin 300387, China
  b.Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, Institute of Hepatobiliary Disease, Nankai University Affiliated Third Center Hospital, Tianjin 300170, China
  c.School of Chemistry, Tiangong University, Tianjin 300387, China
- Author bio：
  
  zoulei@tiangong.edu.cn (L.Z.)
  zhangyj@tiangong.edu.cn (Y.J.Z.)
- Funds：
- DOI：10.1007/s10118-023-2995-2
  CLC：
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Zi-Lin Wang, Di Huang, Mei-Yu Zhang, et al. Responsive Hybrid Poly(vinyl alcohol) Hydrogel Membranes with Embedded Microgels as Valves. [J]. Chinese Journal of Polymer Science 41(10):1646-1655(2023)
DOI：

Zi-Lin Wang, Di Huang, Mei-Yu Zhang, et al. Responsive Hybrid Poly(vinyl alcohol) Hydrogel Membranes with Embedded Microgels as Valves. [J]. Chinese Journal of Polymer Science 41(10):1646-1655(2023) DOI： 10.1007/s10118-023-2995-2.

摘要

Poly(vinyl alcohol) hydrogel hybrid membranes with embedded poly(Nisopropylacrylamide-acrylic acid) microgels were constructed by simple mixing and subsequent freezing-thawing process. The temperature and pH responsiveness of the P(NIPAM-AA) microgels in the membranes matrix were retained and the obtained hydrogel membranes exhibited extraordinary responsiveness to temperature and pH, with microgels functioning as the responsive valves.

Abstract

The research and application of responsive materials have long been hampered by their complicated designs and tedious construction processes. Besides, many current responsive materials show retard or weak responsiveness. In this study, responsive hybrid poly(vinyl alcohol) hydrogel membranes with embedded poly(,N,-isopropylacrylamide-acrylic acid) microgels as valves were constructed by simple mixing and subsequent freezing-thawing process. In the structure of the membranes, the matrix poly(vinyl alcohol) chains thread through and entangle with the microgels, and the microgels are firmly constrained within the hybrid hydrogel network. The fast and sharp temperature responsiveness of the embedded microgels was largely retained and endowed the hydrogel membrane with excellent temperature and pH responsiveness. Moreover, the hydrogel membrane showed excellent fatigue resistance in both temperature and pH-responsive flux examination. This study presented the great potential of these hybrid hydrogel membranes in biomedical applications and provided a new strategy for the future design and construction of responsive biomaterials.

关键词

Keywords

Poly(vinyl alcohol) hydrogelMicrogelsHydrogel membrane

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