Paclitaxel Prodrug Nanomedicine for Potential CT-imaging Guided Breast Cancer Therapy

Jia-Wei Chen; Yi Shen; Qing-Song Yu; Zhi-Hua Gan

doi:10.1007/s10118-023-2958-7

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Paclitaxel Prodrug Nanomedicine for Potential CT-imaging Guided Breast Cancer Therapy

RESEARCH ARTICLE | Updated：2023-11-10

- Paclitaxel Prodrug Nanomedicine for Potential CT-imaging Guided Breast Cancer Therapy
- Chinese Journal of Polymer Science Vol. 41, Issue 11, Pages: 1747-1759(2023)
- Affiliations：
  
  State Key Laboratory of Organic-Inorganic Composite Materials, Beijing Laboratory of Biomedical Materials, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China
- Author bio：
  
  yuqs@mail.buct.edu.cn
- Funds：
- DOI：10.1007/s10118-023-2958-7
  CLC：
- Received：31 December 2022，
  
  Revised：2023-02-07，
  
  Accepted：08 February 2023，
  
  Online First：23 March 2023，
  
  Published：01 November 2023
- Accepted：
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Chen, J. W.; Shen, Y.; Yu, Q. S.; Gan, Z. H. Paclitaxel prodrug nanomedicine for potential CT-imaging guided breast cancer therapy. Chinese J. Polym. Sci. 2023, 41, 1747–1759

Jia-Wei Chen, Yi Shen, Qing-Song Yu, et al. Paclitaxel Prodrug Nanomedicine for Potential CT-imaging Guided Breast Cancer Therapy[J]. Chinese Journal of Polymer Science, 2023, 41(11): 1747-1759.
Chen, J. W.; Shen, Y.; Yu, Q. S.; Gan, Z. H. Paclitaxel prodrug nanomedicine for potential CT-imaging guided breast cancer therapy. Chinese J. Polym. Sci. 2023, 41, 1747–1759 DOI： 10.1007/s10118-023-2958-7.

Jia-Wei Chen, Yi Shen, Qing-Song Yu, et al. Paclitaxel Prodrug Nanomedicine for Potential CT-imaging Guided Breast Cancer Therapy[J]. Chinese Journal of Polymer Science, 2023, 41(11): 1747-1759. DOI： 10.1007/s10118-023-2958-7.

摘要

The prodrug strategy significantly increased the encapsulation efficiency and cancer cell selectivity of paclitaxel. The iodination endows the nanoparticles with CT-imaging capacity. The GSH-responsiveness of polymer further facilitates the intracellular drug release. Therefore

efficient antitumor therapy and real-time monitoring of the therapeutic efficacy might be simultaneously achieved.

Abstract

Nanotheranostics

which combine the therapeutic and diagnostic functions in one integrated system

have received extensive attentions in cancer treatments because they enable non-invasive diagnosis

tumor-targeted drug delivery

and real-time monitoring of therapeutic response. However

due to the high systemic toxicity of commonly used chemotherapeutics

current treatment still has limitations. Herein

to simultaneously achieve safe cancer therapy and therapeutic response monitoring

an iodinated prodrug strategy was proposed. 2

5-Triiodobenzoic acid (TIBA) was used to modify both paclitaxel (PTX) and the polymeric vehicle

so that the encapsulation efficiency of PTX could be increased and the systemic toxicity could be reduced. As-prepared prodrug nanoparticles could accumulate passively in the tumor site and promptly release loaded drugs in response to the overexpressed GSH in cancer cells

which then caused efficient cell cycle arrest and apoptosis like that of the parent PTX. With this rational design

safe and efficient antitumor therapy and real-time computer tomography (CT) imaging could be simultaneously realized

facilitating potential CT imaging-guided therapy of metastatic breast cancer.

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references

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