A Biosurfactant-containing TSD Strategy to Modify Bovine Pericardial Bioprosthetic Valves for Anticalcification

Cai-Yun Gao; Gang Wang; Lin Wang; Qun-Song Wang; Han-Cheng Wang; Lin Yu; Jian-Xiong Liu; Jian-Dong Ding

doi:10.1007/s10118-022-2843-9

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A Biosurfactant-containing TSD Strategy to Modify Bovine Pericardial Bioprosthetic Valves for Anticalcification

RESEARCH ARTICLE | Updated：2022-12-19

- A Biosurfactant-containing TSD Strategy to Modify Bovine Pericardial Bioprosthetic Valves for Anticalcification
  Enhanced Publication
- Chinese Journal of Polymer Science Vol. 41, Issue 1, Pages: 51-66(2023)
- Affiliations：
  
  a.State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai 200438, China
  b.R&D Center, Lifetech Scientific (Shenzhen) Co., Ltd., Shenzhen 518057, China
  c.R&D Center, Lifevalve Medical Scientific Co., Ltd., Shenzhen 518057, China
- Author bio：
  
  jdding1@fudan.edu.cn
- Funds：
- DOI：10.1007/s10118-022-2843-9
  CLC：
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Cai-Yun Gao, Gang Wang, Lin Wang, et al. A Biosurfactant-containing TSD Strategy to Modify Bovine Pericardial Bioprosthetic Valves for Anticalcification. [J]. Chinese Journal of Polymer Science 41(1):51-66(2023)
DOI：

Cai-Yun Gao, Gang Wang, Lin Wang, et al. A Biosurfactant-containing TSD Strategy to Modify Bovine Pericardial Bioprosthetic Valves for Anticalcification. [J]. Chinese Journal of Polymer Science 41(1):51-66(2023) DOI： 10.1007/s10118-022-2843-9.

摘要

The pseudo-color SEM image shows a calcified bovine pericardial valve with collagen fibrils in blue and calcium nodules in yellow. The calcification shortens the life of the bioprosthetic valve. A two-step decellularization (TSD) strategy was put forward for anticalcification. The ,in vivo, biomineralization extent was reduced two orders of magnitude.

Abstract

Bioprosthetic heart valves (BHVs) are important for transcatheter valve replacement. Current commercial BHVs on the market are basically porcine or bovine pericardium (BP) crosslinked with glutaraldehyde (GA). Simply applying GA to BHVs can enhance mechanical stability, but cannot alleviate ,in vivo, calcification. In this work, we developed a two-step decellularization (TSD) strategy to modify this biomacromolecular network, in which BP was post-treated, as the second step of decellularization, with a mild biosurfactant ,n,-dodecyl-,β,-D-maltoside in a mixture of isopropanol and phosphate-buffered saline after the first step of traditional decellularization and GA cross-linking. The TSD-treated BP exhibited not only low cytotoxicity and excellent mechanical properties ,in vitro, but also low immune responses and significant anticalcification ,in vivo,. After 60 days of subcutaneous implantation in the back of Wistar rats, the calcium content was, as quantified with an inductively coupled plasma optical emission spectrometer, only 1.1 μg/mg compared to 138.6 μg/mg in the control group without the post-treatment. In addition, collagen fibrils were observed with field emitting scanning electron microscopy (SEM), and the morphology and composition of the calcified sites resulting from ,in vivo, biomineralization were studied with SEM with energy dispersive spectroscopy and also X-ray diffraction. This study proposes a facile yet effective anticalcification strategy for the modification of the bovine pericardial bioprosthetic heart valve, a natural biomacromolecular network.

关键词

Keywords

Heart valveAnticalcificationCollagenIn vivo biomineralization Transcatheter aortic valve implantation (TAVI)Extracellular matrixBiomacromolecular networkBiosurfactantBovine pericardium

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