Antibacterial Sutures Coated with Smooth Chitosan Layer by Gradient Deposition

Ying-Ge Chen; Chu-Xin Li; Yu Zhang; Yong-Dan Qi; Jun Feng; Xian-Zheng Zhang

doi:10.1007/s10118-022-2770-9

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Antibacterial Sutures Coated with Smooth Chitosan Layer by Gradient Deposition

RESEARCH ARTICLE | Updated：2022-08-19

- Antibacterial Sutures Coated with Smooth Chitosan Layer by Gradient Deposition
- Chinese Journal of Polymer Science Vol. 40, Issue 9, Pages: 1050-1061(2022)
- Affiliations：
  
  Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University, Wuhan 430072, China
- Author bio：
  
  fengjun@whu.edu.cn (J.F.)
  xz-zhang@whu.edu.cn (X.Z.Z.)
- Funds：
- DOI：10.1007/s10118-022-2770-9
  CLC：
- Published：01 September 2022，
  
  Published Online：12 July 2022，
  
  Received：30 March 2022，
  
  Revised：20 April 2022，
  
  Accepted：09 May 2022
- Accepted：
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Chen, Y. G.; Li, C. X.; Zhang, Y.; Qi, Y. D.; Feng, J.; Zhang, X. Z. Antibacterial sutures coated with smooth chitosan layer by gradient deposition. Chinese J. Polym. Sci. 2022, 40, 1050–1061

Ying-Ge Chen, Chu-Xin Li, Yu Zhang, et al. Antibacterial Sutures Coated with Smooth Chitosan Layer by Gradient Deposition. [J]. Chinese Journal of Polymer Science, 2022,40(9):1050-1061.
Chen, Y. G.; Li, C. X.; Zhang, Y.; Qi, Y. D.; Feng, J.; Zhang, X. Z. Antibacterial sutures coated with smooth chitosan layer by gradient deposition. Chinese J. Polym. Sci. 2022, 40, 1050–1061 DOI： 10.1007/s10118-022-2770-9.

Ying-Ge Chen, Chu-Xin Li, Yu Zhang, et al. Antibacterial Sutures Coated with Smooth Chitosan Layer by Gradient Deposition. [J]. Chinese Journal of Polymer Science, 2022,40(9):1050-1061. DOI： 10.1007/s10118-022-2770-9.

摘要

We developed a "gradient deposition" technique to coat a continuous and smooth layer of chitosan onto the surface of absorbable sutures. The coated sutures exhibited excellent anti-bacterial and anti-inflammation activities for significantly enhanced wound healing effect.

Abstract

Owing to the significant importance in clinics

antibacterial activity is thought as one indispensable feature of the next generation of absorbable sutures. It is challenging but imperative to arm the existing absorbable sutures with antibacterial functions. The present study describes a "gradient deposition" technique to coat a continuous and smooth layer of chitosan on the surface of absorbable sutures. Specifically

chitosan solution is arranged to undergo gradient pH decline step by step while during each pH interval

the solution is allowed to stand for a predetermined period of time in order to control gradual chitosan deposition. Chitosan nanoparticles are found to be first generated on suture surface and finally developed into a smooth chitosan layer as the antibacterial surface.

In vitro

and

in vivo

results demonstrated that coating chitosan on sutures by our technique could relieve wound inflammation

stimulate collagen deposition

regenerate blood vessels

and assist tissue repairing

consequently leading to a significant enhancement of wound healing effect. This technique is highlighted with low cost

extreme convenience and excellent safety without organic solvents. Furthermore

the "gradient deposition" technique would not affect the fundamental properties of matrix and thus hold promises as a universal way for superficial antibacterial modification towards almost all the surgical implanted materials

including but not limited to absorbable sutures.

关键词

Keywords

Antibacterial suturesGradient depositionChitosan coatingWound healingBacterial infection

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