POSS-modified PEG Adhesives for Wound Closure

Ya-zhong Bu; Guo-fei Sun; Li-cheng Zhang; Jian-heng Liu; Fei Yang; Pei-fu Tang; De-cheng Wu

doi:10.1007/s10118-017-1958-x

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POSS-modified PEG Adhesives for Wound Closure

Papers | Updated：2021-02-18

- POSS-modified PEG Adhesives for Wound Closure
- Chinese Journal of Polymer Science Vol. 35, Issue 10, Pages: 1231-1242(2017)
- Affiliations：
  
  a.Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Polymer Physics & Chemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China
  b.University of Chinese Academy of Sciences, Beijing 100049, China
  c.Department of Orthopaedics, Chinese PLA General Hospital, Beijing 100853, China
- Author bio：
  
  Pei-fu Tang (唐佩福), E-mail:pftang301@126.com
  De-cheng Wu (吴德成), E-mail:dcwu@iccas.ac.cn
- Funds：
- DOI：10.1007/s10118-017-1958-x
  CLC：
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Ya-zhong Bu, Guo-fei Sun, Li-cheng Zhang, et al. POSS-modified PEG Adhesives for Wound Closure. [J]. Chinese Journal of Polymer Science 35(10):1231-1242(2017)
DOI：

Ya-zhong Bu, Guo-fei Sun, Li-cheng Zhang, et al. POSS-modified PEG Adhesives for Wound Closure. [J]. Chinese Journal of Polymer Science 35(10):1231-1242(2017) DOI： 10.1007/s10118-017-1958-x.

摘要

Abstract

PEG-related adhesives are limited in clinical use because they are easy to swell and cannot support the cell growth. In this study, we produced a series of POSS-modified PEG adhesives with high adhesive strength. Introduction of inorganic hydrophobic POSS units decreased the swelling of the adhesives and enhanced cell adhesion and growth. The ,in vitro, cytotoxicity and ,in vitro, inflammatory response experiments clearly demonstrated that the adhesives were nontoxic and possessed excellent biocompatibility. Compared with the sutured wounds, the adhesive-treated wounds showed an accelerated healing process in wounded skin model of the Bama miniature pig, demonstrating that the POSS-modified PEG adhesive is a promising candidate for wound closure.

关键词

Keywords

AdhesivesPEGPOSSHydrogelWound closure

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