Injectable Polymeric Hemostats for Non-compressible Hemorrhage Control

Zheng Pan; Gang He; De-Cheng Wu; Chong Zhang

doi:10.1007/s10118-026-3794-3

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Injectable Polymeric Hemostats for Non-compressible Hemorrhage Control

REVIEW | Updated：2026-09-16

- Injectable Polymeric Hemostats for Non-compressible Hemorrhage Control
- Injectable Polymeric Hemostats for Non-compressible Hemorrhage Control
- Chinese Journal of Polymer Science 2026年44卷页码：1-24
- Affiliations：
  
  Guangdong Provincial Key Laboratory of Advanced Biomaterials, Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen 518055, China
- Author bio：
  
  wudc@sustech.edu.cn (D.C.W.)
  zhangc9@sustech.edu.cn (C.Z.)
- Funds：
  
  This work was financially supported by the Shenzhen Medical Research Fund (No. D2404007), the National Natural Science Foundation of China (No. 22405118), Shenzhen Science and Technology Program (Nos. JCYJ20220818100601003 and JCYJ20240813100111016), Guangdong Basic and Applied Basic Research Foundation (No. 2024A1515011621), and Guangdong Provincial Key Laboratory of Advanced Biomaterials (No. 2022B1212010003).;De-Cheng Wu received his Ph.D. degree from the National University of Singapore (NUS) in 2006. From 2005 to 2010, he worked at the Institute of Materials Research and Engineering (IMRE), A*STAR, Singapore, as a research engineer. He joined the Institute of Chemistry, Chinese Academy of Sciences (ICCAS) as a professor in 2011. He has been a Professor at the University of Chinese Academy of Sciences (UCAS) since 2015 and a Chair Professor in the Department of Biomedical Engineering at the Southern University of Science and Technology (SUSTech) since 2019. Prof. Wu received the National Science Fund for Distinguished Young Scholars in 2017, the Innovative Talent Promotion Plan of the Ministry of Science and Technology in 2018, and the National Special Support Program for High-level Personnel Recruitment in 2019. His research focuses on the fundamental and applied studies of biomedical polymers, particularly their applications in hemostatic and wound dressings, high-performance medical devices, drug delivery, and tissue engineering.Chong Zhang received his Ph.D. degree from the University of Science and Technology of China (USTC) in 2016. He joined the Department of Biomedical Engineering at the Southern University of Science and Technology (SUSTech) in 2021 and was appointed as a Research Associate Professor in 2025. He conducted postdoctoral research at Peking University with Prof. Hua Lu and at The University of Tokyo with Prof. Takashi Kato. He is now working on high-performance biomedical dressings.The authors declare no interest conflict.
- DOI：10.1007/s10118-026-3794-3
  中图分类号：
- 收稿：2026-05-25，
  
  录用：2026-06-23，
  
  网络首发：2026-09-16，
  
  纸质出版：2026-08
- Accepted：
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Pan, Z.; He, G.; Wu, D. C.; Zhang C. Injectable polymeric hemostats for non-compressible hemorrhage control. Chinese J. Polym. Sci. https://doi.org/10.1007/s10118-026-3794-3

Zheng Pan, Gang He, De-Cheng Wu, et al. Injectable Polymeric Hemostats for Non-compressible Hemorrhage Control[J/OL]. Chinese Journal of Polymer Science, 2026, 441-24.
Pan, Z.; He, G.; Wu, D. C.; Zhang C. Injectable polymeric hemostats for non-compressible hemorrhage control. Chinese J. Polym. Sci. https://doi.org/10.1007/s10118-026-3794-3 DOI：

Zheng Pan, Gang He, De-Cheng Wu, et al. Injectable Polymeric Hemostats for Non-compressible Hemorrhage Control[J/OL]. Chinese Journal of Polymer Science, 2026, 441-24. DOI： 10.1007/s10118-026-3794-3.

摘要

Abstract

Non-compressible hemorrhage arising from torso

junctional

or intracavitary injuries remains a major cause of preventable trauma-related mortality owing to anatomically difficult-to-access bleeding sites

rapid high-pressure blood flow

and the limitations of conventional hemostatic approaches. Injectable polymeric hemostats enable minimally invasive delivery into narrow or irregular wound tracts and conformal adaptation to complex wound geometries

representing a promising strategy for effective hemorrhage control. This review summarizes the recent advances in three classes of injectable polymeric hemostats

including hydrogels

gelable powders

and expandable hemostatic materials

with particular emphasis on material design strategies

hemostatic mechanisms

and performance characteristics. Current challenges and future perspectives are also discussed

providing insights to guide the rational design and clinical translation of advanced polymeric hemostats for safer and more effective management of non-compressible hemorrhage.

关键词

Keywords

references

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