Polymeric Nanomedicines for Comprehensive Regulation of Tumor Microenvironment

Hui-Xin Li; Rui-Ying Wu; Xin-Tong Mao; Xiao-Rui Zhou; Kai Hao; Hua-Yu Tian

doi:10.1007/s10118-026-3678-6

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Polymeric Nanomedicines for Comprehensive Regulation of Tumor Microenvironment

REVIEW | Updated：2026-07-27

- Polymeric Nanomedicines for Comprehensive Regulation of Tumor Microenvironment
- Polymeric Nanomedicines for Comprehensive Regulation of Tumor Microenvironment
- Chinese Journal of Polymer Science 2026年44卷第8期页码：2427-2452
- Affiliations：
  
  a.College of Chemistry and Chemical Engineering, Institute of Flexible Electronics (IFE, Future Technologies), Xiamen University, Xiamen 361005, China
  b.Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province (IKKEM), Xiamen University, Xiamen 361005, China
  c.Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
  d.School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei 230026, China
- Author bio：
  
  kaihao@xmu.edu.cn (K.H.)
  thy@xmu.edu.cn (H.Y.T.)
- Funds：
  
  This work was financially supported by the National Natural Science Foundation of China (Nos. 52433006, 52495010, 52495015 and 52503178), Fundamental Research Funds for the Central Universities (No. 20720230008), and Talent Cultivation Project Funds for the Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province (HRTP-[2022] 52).;Kai Hao received his Ph.D. in Polymer Chemistry and Physics from the University of Science and Technology of China in 2021. Currently, he serves as an Assistant Professor at the Institute of Flexible Electronics (IFE, Future Technologies), Xiamen University. His research primarily focuses on the design of novel non-viral nucleic acid delivery vectors and their application in tumor immunotherapy.Hua-Yu Tian obtained his Ph.D. degree from the Changchun Institute of Applied Chemistry, Chinese Academy of Sciences in 2005. From 2006 to 2022, he conducted research at institutions including the Changchun Institute of Applied Chemistry, the Chinese Academy of Sciences, the Korea Advanced Institute of Science and Technology, Kyushu University, and the University of Utah. In 2022, he joined the College of Chemistry and Chemical Engineering at Xiamen University. His research topics include biomedical polymers, nanogene/drug carriers, biotherapy, nucleic acid vaccines, immunotherapy, and energy polymers.The authors declare no interest conflict.
- DOI：10.1007/s10118-026-3678-6
  中图分类号：
- 收稿：2026-02-28，
  
  录用：2026-03-18，
  
  网络首发：2026-06-10，
  
  纸质出版：2026-08-15
- Accepted：
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Li, H. X.; Wu, R. Y.; Mao, X. T.; Zhou, X. R.; Hao, K.; Tian, H. Y. Polymeric nanomedicines for comprehensive regulation of tumor microenvironment. Chinese J. Polym. Sci. 2026, 44, 2427–2452

Hui-Xin Li, Rui-Ying Wu, Xin-Tong Mao, et al. Polymeric Nanomedicines for Comprehensive Regulation of Tumor Microenvironment[J]. Chinese Journal of Polymer Science, 2026, 44(8): 2427-2452.
Li, H. X.; Wu, R. Y.; Mao, X. T.; Zhou, X. R.; Hao, K.; Tian, H. Y. Polymeric nanomedicines for comprehensive regulation of tumor microenvironment. Chinese J. Polym. Sci. 2026, 44, 2427–2452 DOI： 10.1007/s10118-026-3678-6.

Hui-Xin Li, Rui-Ying Wu, Xin-Tong Mao, et al. Polymeric Nanomedicines for Comprehensive Regulation of Tumor Microenvironment[J]. Chinese Journal of Polymer Science, 2026, 44(8): 2427-2452. DOI： 10.1007/s10118-026-3678-6.

摘要

Polymeric nanomedicines provide versatile platforms for comprehensive tumor microenvironment (TME) regulation. By coordinating immune cell modulation and stromal remodeling

these systems dismantle biological barriers and transform “cold” tumors into a “hot” state to maximize synergistic anti-tumor immune activation.

Abstract

Cancer immunotherapy

which harnesses the host immune system to combat cancer

has advanced into preclinical and clinical trials. However

the tumor microenvironment (TME) usually promotes tumor angiogenesis and induces immune tolerance. Recently

polymeric nanomedicines with comprehensive regulation of the TME have attracted research interest. Compared with others

polymeric nanomedicines have outstanding characteristics

including facile preparation

improved tumor penetration

longer blood circulation

and better bioavailability. In particular

polymeric nanomedicines hold great potential for integrating combined treatments and imaging methods to concurrently modulate and trace the functional processes of multiple immune cells. This review summarizes the advances in polymeric nanomedicine-based strategies for TME regulation

including the regulation of TME stromal cells

the immune microenvironment matrix

and vasculature. Furthermore

the development of comprehensive polymeric nanomedicine-based theragnostic platforms integrated with imaging segments is briefly introduced.

关键词

Keywords

references

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