Superparamagnetic Iron Oxide Nanoparticles Prepared with Multidentate Thioether Polymer Ligand for Magnetic Resonance Imaging

Chang Gao; Chen-Yang Xiang; Jiao-Jiao Guo; Peng-Rui Song; Zhi-Yan Lu; Chun-Sheng Xiao; Irshad Hussain; Wen Fan; Xiu-Dong Shi; Wei Yan

doi:10.1007/s10118-025-3537-x

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Superparamagnetic Iron Oxide Nanoparticles Prepared with Multidentate Thioether Polymer Ligand for Magnetic Resonance Imaging

RESEARCH ARTICLE | Updated：2026-02-13

- Superparamagnetic Iron Oxide Nanoparticles Prepared with Multidentate Thioether Polymer Ligand for Magnetic Resonance Imaging
- Superparamagnetic Iron Oxide Nanoparticles Prepared with Multidentate Thioether Polymer Ligand for Magnetic Resonance Imaging
- Chinese Journal of Polymer Science 2026年44卷第3期页码：688-695
- Affiliations：
  
  a.Key Laboratory of Green Preparation and Application for Functional Materials of Ministry of Education, Hubei Key Laboratory of Polymer Materials, School of Material Science and Engineering, Hubei University, Wuhan 430062, China
  b.Manchester Metropolitan Joint Institute, Hubei University, Wuhan 430062, China
  c.Shenzhen Huazhong University of Science and Technology Research Institute, Shenzhen 518038, China
  d.Department of Radiology, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China
  e.Department of Radiology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China
  f.State Key Laboratory of Polymer Science and Technology, Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
  g.Department of Chemistry and Chemical Engineering, SBA School of Science and Engineering, Lahore University of Management Sciences (LUMS). DHA, Lahore 54792, Pakistan
- Author bio：
  
  fanwen@hubu.edu.cn (W.F.)
  shixd006@foxmail.com (X.D.S.)
  willieyan2003@hubu.edu.cn (W.Y.)
- Funds：
  
  This work was financially supported by the International Cooperation Program of the Ministry of Science and Technology of Hubei Province (No. 2023EHA069), Shenzhen Science and Technology Program (No. JCYJ20230807143702005), National Foreign Experts Program (No. G2022027015L), and the National Natural Science Foundation of China (No. 82302265).;Electronic supplementary information (ESI) is available free of charge in the online version of this article at http://doi.org/10.1007/s10118-025-3537-x.
- DOI：10.1007/s10118-025-3537-x
  中图分类号：
- 收稿：2025-10-30，
  
  录用：2025-12-16，
  
  网络首发：2026-02-04，
  
  纸质出版：2026-03-15
- Accepted：
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Gao, C.; Xiang, C. Y.; Guo, J. J.; Song, P. R.; Lu, Z. Y.; Xiao, C. S.; Hussain, I.; Fan, W.; Shi, X. D.; Yan, W. Superparamagnetic iron oxide nanoparticles prepared with multidentate thioether polymer ligand for magnetic resonance imaging. Chinese J. Polym. Sci. 2026, 44, 688–695

Chang Gao, Chen-Yang Xiang, Jiao-Jiao Guo, et al. Superparamagnetic Iron Oxide Nanoparticles Prepared with Multidentate Thioether Polymer Ligand for Magnetic Resonance Imaging[J]. Chinese Journal of Polymer Science, 2026, 44(3): 688-695.
Gao, C.; Xiang, C. Y.; Guo, J. J.; Song, P. R.; Lu, Z. Y.; Xiao, C. S.; Hussain, I.; Fan, W.; Shi, X. D.; Yan, W. Superparamagnetic iron oxide nanoparticles prepared with multidentate thioether polymer ligand for magnetic resonance imaging. Chinese J. Polym. Sci. 2026, 44, 688–695 DOI： 10.1007/s10118-025-3537-x.

Chang Gao, Chen-Yang Xiang, Jiao-Jiao Guo, et al. Superparamagnetic Iron Oxide Nanoparticles Prepared with Multidentate Thioether Polymer Ligand for Magnetic Resonance Imaging[J]. Chinese Journal of Polymer Science, 2026, 44(3): 688-695. DOI： 10.1007/s10118-025-3537-x.

摘要

Herein

the synthesis of magnetic iron oxide nanoparticles (MIONs) functionalized with the multidentate thioether polymer ligand PTMP-PMAA is reported. The obtained biocompatible

low toxic MIONs@PTMP-PMAA exhibit strong negative contrast enhancement and present great potential as

-weighted contrast agents for magnetic resonance imaging (MRI).

Abstract

Cancer has been recognized as one of the leading causes of mortality for decades. Magnetic resonance imaging (MRI) is a powerful imaging technology that has been widely applied in tumor diagnosis. Herein

we report the synthesis of magnetic iron oxide nanoparticles (MIONs) functionalized with multidentate thioether polymer ligand pentaerythritol tetrakis 3-mercaptopropionate-poly(methacrylic acid) (PTMP-PMAA). Cytotoxicity assessment

via

the CCK-8 assay confirmed the low toxicity of the nanoparticles. MRI results showed excellent negative contrast enhancement. Bio-distribution study indicated gradual excretion of the nanoparticles. These MIONs@PTMP-PMAA exhibit strong negative contrast enhancement and present great potential as

-weighted contrast agents for MRI.

关键词

Keywords

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