Star-shaped Block Copolymers of Poly-2-alkyl-5,6-dihydrooxazines: Synthesis, Conformational Characteristics, Thermoresponsiveness and Complexation with Curcumin

Tatyana U. Kirila; Serafim V. Rodchenko; Nina D. Kozina; Andrey V. Tenkovtsev; Alexander P. Filippov

doi:10.1007/s10118-025-3490-8

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Star-shaped Block Copolymers of Poly-2-alkyl-5,6-dihydrooxazines: Synthesis, Conformational Characteristics, Thermoresponsiveness and Complexation with Curcumin

RESEARCH ARTICLE | Updated：2026-01-30

- Star-shaped Block Copolymers of Poly-2-alkyl-5,6-dihydrooxazines: Synthesis, Conformational Characteristics, Thermoresponsiveness and Complexation with Curcumin
- Star-shaped Block Copolymers of Poly-2-alkyl-5,6-dihydrooxazines: Synthesis, Conformational Characteristics, Thermoresponsiveness and Complexation with Curcumin
- Chinese Journal of Polymer Science 2026年44卷第2期页码：423-436
- Affiliations：
  
  Branch of Petersburg Nuclear Physics Institute named by B.P. Konstantinov of National Research Centre «Kurchatov Institute»-Institute of Macromolecular Compounds, Saint Petersburg 199004, Russia
- Author bio：
  
  tatyana_pyx@mail.ru
- Funds：
  
  This study was financially supported by the Russian Science Foundation (No. 23-13-00205);Electronic supplementary information (ESI) is available free of charge in the online version of this article at http://doi.org/10.1007/s10118-025-3490-8.
- DOI：10.1007/s10118-025-3490-8
  中图分类号：
- 收稿：2025-10-06，
  
  录用：2025-10-27，
  
  网络首发：2026-01-16，
  
  纸质出版：2026-02-05
- Accepted：
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Kirila, T. U.; Rodchenko, S. V.; Kozina, N. D.; Tenkovtsev, A. V.; Filippov, A. P. Star-shaped block copolymers of poly-2-alkyl-5,6-dihydrooxazines: synthesis, conformational characteristics, thermoresponsiveness and complexation with curcumin. Chinese J. Polym. Sci. 2026, 44, 423–436

Tatyana U. Kirila, Serafim V. Rodchenko, Nina D. Kozina, et al. Star-shaped Block Copolymers of Poly-2-alkyl-5,6-dihydrooxazines: Synthesis, Conformational Characteristics, Thermoresponsiveness and Complexation with Curcumin[J]. Chinese Journal of Polymer Science, 2026, 44(2): 423-436.
Kirila, T. U.; Rodchenko, S. V.; Kozina, N. D.; Tenkovtsev, A. V.; Filippov, A. P. Star-shaped block copolymers of poly-2-alkyl-5,6-dihydrooxazines: synthesis, conformational characteristics, thermoresponsiveness and complexation with curcumin. Chinese J. Polym. Sci. 2026, 44, 423–436 DOI： 10.1007/s10118-025-3490-8.

Tatyana U. Kirila, Serafim V. Rodchenko, Nina D. Kozina, et al. Star-shaped Block Copolymers of Poly-2-alkyl-5,6-dihydrooxazines: Synthesis, Conformational Characteristics, Thermoresponsiveness and Complexation with Curcumin[J]. Chinese Journal of Polymer Science, 2026, 44(2): 423-436. DOI： 10.1007/s10118-025-3490-8.

摘要

Star-shaped polymers with hexaaza[2

]

orthoparacyclophane core and arms of block copolymers of poly-2-ethyl-5

6-dihydrooxazine with poly-2-isopropyl-5

6-dihydrooxazine were synthesized. The molecular conformation has been determined. Complexes of polymer stars with curcumin were obtained. The influence of the structure and molar mass of star copolymer on efficient binding and thermoresponsiveness of complexes was analyzed.

Abstract

Star-shaped six-arm polymers with hexaaza[2

]

orthoparacyclophane core and arms of block copolymers of poly-2-ethyl-5

6-dihydrooxazine with poly-2-isopropyl-5

6-dihydrooxazine were synthesized successfully using cationic ring-opening polymerization. The ratio of blocks

the order of their attachment to the core

and arm length were varied. Conformation of synthesized stars was determined by methods of molecular hydrodynamics and optics. It has been shown that star-shaped molecules were characterized by high intramolecular density

and the arm folding increased with their lengthening. The influence of the structure of block copolymers and their molar mass on the critical micelle concentration has been established. Complexes of synthesized star-shaped block copolymers with curcumin were obtained and the efficient binding of curcumin to polymer molecules was demonstrated. The behavior of the aqueous solutions of the prepared polymer stars and their complexes with curcumin was investigated by light scattering and turbidimetry methods. The influence of the structure and mola

r mass of star polymers on their thermoresponsiveness and the phase separation temperatures in aqueous solutions was analyzed. A slight increase in the phase separation temperature was found on passage from polymer solutions to solutions of polymer complexes with hydrophobic curcumin.

关键词

Keywords

references

Gil, E. S.; Hudson, S. M. Stimuli-reponsive polymers and their bioconjugates. Prog. Polym. Sci. 2004 , 29 , 1173−1222..

Liu, R.; Fraylich, M.; Saunders, B. R. Thermoresponsive copolymers: from fundamental studies to applications. Colloid Polym. Sci . 2009 , 287 , 627−643..

Liu, F.; Urban, M. W. Recent advances and challenges in designing stimuli-responsive polymers. Prog. Polym. Sci. 2010 , 35 , 3−23..

Theato, P.; Sumerlin, B. S.; O’Reilly, R. K.; Epps T. H. Stimuli responsive materials. Chem. Soc. Rev. 2013 , 42 , 7055−7056..

Hoogenboom, R.; Schlaad, H. Thermoresponsive poly(2-oxazoline)s, polypeptoids, and polypeptides. Polym. Chem. 2017 , 8 , 24−40..

Hu, J.; Zhang, G.; Ge, Z.; Liu, S. Stimuli-responsive tertiary amine methacrylate-based block copolymers: synthesis, supramolecular self-assembly and functional applications. Prog. Polym. Sci. 2013 , 39 , 1096−1143..

Ge, Z.; Liu, H.; Zhang, Y.; Liu. S. Supramolecular thermoresponsive hyperbranched polymers constructed from poly( N -isopropylacrylamide) containing one adamantyl and two β -cyclodextrin terminal Moieties a . Macromol. Rapid Commun . 2011 , 32 , 68−73..

[Hosseini, M.; Makhlouf, A. S. H. in Industrial Applications for Intelligent Polymers and Coatings , Switzerland: Springer Nature, 2016 , p. 2016..

Liu, G.; Zhang, G.; Hu, J.; Wang, X.; Zhu, M.; Liu, S. Hyperbranched self-immolative polymers ( h SIPs) for programmed payload delivery and ultrasensitive detection. J. Am. Chem. Soc . 2015 , 137 , 11645−11655..

Hu, X.; Liu, G.; Li, Y.; Wang, X.; Liu, S. Cell-penetrating hyperbranched polyprodrug amphiphiles for synergistic reductive milieu-triggered drug release and enhanced magnetic resonan ce signals. J. Am. Chem. Soc. 2015 , 137 , 362−368..

Hu, J.; Liu, S. Recent advances on stimuli-responsive macromolecular magnetic resonance imaging (MRI) contrast agents. Sci. China Chem. 2018 , 61 , 1110−1122..

Murphy, E. B.; Wudl, F. The world of smart healable materials. Prog. Polym. Sci. 2010 , 35 , 223−251..

Ward, M. A.; Georgiou, T. K. Thermoresponsive polymers for biomedical applications. Polymers 2011 , 3 , 1215−1242..

Mei, L.; Jiang, Y. Y.; Feng, S. S. Star-shaped block polymers as a molecular biomaterial for nanomedicine development. Nanomedicine 2014 , 9 , 9−12..

Yao, C.; Wang, X.; Liu, G.; Hu, J.; Liu, S. Distinct morphological transitions of photoreactive and thermoresponsive vesicles for controlled release and nanoreactors. Macromolecules 2016 , 49 , 8282−8295..

Sedlacek, O.; Hoogenboom, R. Drug delivery systems based on poly(2-oxazoline)s and poly(2-oxazine)s. Adv. Ther. 2019 , 3 , 1900168..

Zahoranová, A.; Luxenhofer, R. Poly(2-oxazoline)- and poly(2-oxazine)-based self-assemblies, polyplexes, and drug nanoformulations—an update. Adv. Healthc. Mater. 2021 , 10 , 2001382..

Varanaraja, Z.; Kim, J.; Remzi Becer, C. Poly(2-oxazine)s: a comprehensive overview of thepolymer structures, physical properties and applications. Eur. Polym. J . 2021 , 147 , 110299..

Levy, A. J.; Litt, M. H. Polymerization of cyclic imino ethers. Oxazines. J. Polym. Sci. Part B: Polym.Lett . 1967 , 5 , 881−886..

Lambermont-Thijs, H. M. L.; Fijten, M. W. M.; van der Linden, A. J. T.; van Lankvelt, B. M.; Bloksma, M. M.; Schubert, U. S.; Hoogenboom, R. Efficient cationic ring-opening polymerization of diverse cyclic imino ethers: unexpected copolymerization behavior. Macromolecules 2011 , 44 , 4320−4325..

Kappe, C. O. The use of microwave irradiation in organic synthesis. From laboratory curiosity to standard practice in twenty years. Chimia 2006 , 60 , 308−312..

Sinnwell, S.; Ritter, H. Microwave accelerated polymerization of 2-phenyl5,6-dihydro-4 H -1,3-oxazine: kinetics and influence of end-groups on gass transition temperature. Macromol. Rapid Commun . 2006 , 27 , 1335−1340..

Bloksma, M. M.; Paulus, R. M.; van Kuringen, H. P. C.; van der Woerdt, F.; Lambermont-Thijs, H. M. L.; Schubert, U. S.; Hoogenboom, R. Thermoresponsive poly(2-oxazine)s. Macromol. Rapid Commun . 2012 , 33 , 92−96..

Smirnova, A.; Kirila, T.; Blokhin, A.; Kozina, N.; Kurlykin, M.; Tenkovtsev, A.; Filippov, A. Linear and star-shaped poly(2-ethyl-2-oxazine)s. Synthesis, characterization and conformation in solution. Eur. Polym. J. 2021 , 156 , 110637..

Morgese, G.; Verbraeken, B.; Ramakrishna, N. R.; Gombert, Y.; Cavalli, E.; Rosenboom, J. G.; Zenobi-Wong, M.; Spencer, N. D.; Hoogenboom, R.; Benetti, E. M. Chemical design of non-ionic polymer brushes as biointerfaces: poly(2-oxazine)s outperform both poly(2-oxazoline)s and PEG. Angew. Chem. Int. Ed . 2018 , 57 , 11667−11672..

Bloksma, M. M.; Schubert, U. S.; Hoogenboom, R. Poly(cyclic imino ether)s beyond 2-substituted-2-oxazolines. Macromol. Rapid Commun . 2011 , 32 , 1419−1441..

Zhang, J.; Zhou, H., Liu H.; Hu, J.; Liu, S. Fabrication of pH- and thermoresponsive three-layered micelles via host-guest interactions. Macromol. Rapid Commun. 2018 , 39 , 1700225,.

Wang, C.; Zhang, G.; Liu, G.; Hu, J.; Liu S. Photo- and thermo-responsive multicompartment hydrogels for synergistic delivery of gemcitabine and doxorubicin. J. Control. Rel. 2017 , 259 , 149−159.

Sedlacek, O.; Lava, K.; Verbraeken, B.; Kasmi, S.; De Geest, B.G.; Hoogenboom, R. Unexpected reactivity switch in the statistical copolymerization of 2-oxazolines and 2-oxazines enabling the one-step synthesis of amphiphilic gradient copolymers. J. Am. Chem. Soc. 2019 , 141 , 9617−9622..

Haider, M. S.; Lübtow, M. M.; Endres, S.; Forster, S.; Flegler, V.J.; Böttcher, B.; Aseyev, V.; Pöppler, A. C.; Luxenhofer, R. Think beyond the core: the impact of the hydrophilic corona on the drug solubilization using polymer micelles . ACS Appl. Mat. Interf. 2020 , 12 , 24531−24543..

Lübtow, M. M.; Hahn, L.; Haider, M. S.; Luxenhofer, R. Drug specificity, synergy and antagonism in ultra-high capacity poly(2-oxazoline)/poly(2-oxazine) based formulations. J. Am. Chem. Soc. 2017 , 139 , 10980−10983..

Schlaad, H.; Diehl, C.; Gress, A.; Meyer, M.; Demirel, A. L.; Nur, Y.; Bertin, A. Poly(2-oxazoline)s as smart bioinspired polymers. Macromol. Rapid Commun . 2010 , 31 , 511−525..

Roy, D.; Brooks, W. L. A.; Sumerlin, B. S. New directions in thermoresponsive polymers. Chem. Soc. Rev . 2013 , 42 , 7214−7243..

Schenk, V.; Rossegger, E.; Ebner, C.; Bangerl, F.; Reichmann, K.; Hoffmann, B.; Höpfner, M.; Wiesbrock, F. RGD-Functionalization of poly(2-oxazoline)-based networks for enhanced adhesion to cancer cells. Polymers 2014 , 6 , 264..

Wu, W.; Wang, W.; Li, J. Star polymers: advances in biomedical applications. Prog. Polym. Sci. 2015 , 46 , 55−85..

Luef, K. P.; Petit, C.; Ottersböck, B.; Oreski, G.; Ehrenfeld, F.; Grassl, B.; Reynaud, S.; Wiesbrock, F. UV-mediated thiol-ene click reactions for the synthesis of drugloadable and degradable gels based on copoly(2-oxazoline)s. Eur. Polym. J . 2017 , 88 , 701..

Lou, L.; Jiang, L.; Liu, J.; Sun, W.; Shen, Z. Synthesis and characterization of optically active star-shaped poly( N -phenylmaleimide)s with a calixarene core. Polym. Inter. 2007 , 56 , 796−802..

Terashima, T.; Kojima, H.; Sawamoto, M. Core-imprinted star polymers via living radical polymerization: precision cavity microgels for selective molecular recognition. Chem. Lett. 2014 , 43 , 1690−1692..

Kirila, T.; Smirnova, A.; Razina, A.; Tenkovtsev, A.; Filippov, A. Synthesis and conformational characteristics of thermosensitive star-shaped six-arm polypeptoids. Polymers 2020 , 12 , 800..

Kirila, T.; Smirnova, A.; Razina, A.; Tenkovtsev, A.; Filippov, A. Influence of salt on the self-organization in solutions of star-shaped poly-2-alkyl-2-oxazoline and poly-2-alkyl-2-o xazine on heating. Polymers 2021 , 13 , 1152..

Kirila, T.; Smirnova, A.; Aseyev, V.; Tenkovtsev, A.; Tenhu, H.; Filippov, A. Self-organization in dilute aqueous solutions of thermoresponsive star-shaped six-arm poly-2-alkyl-2-oxazines and poly-2-alkyl-2-oxazolines. Polymers 2021 , 13 , 1429..

Kowalczuk, A.; Kronek, J.; Bosowska, K.; Trzebicka, B.; Dworak, A. Star poly(2-ethyl-2-oxazoline)s—synthesis and thermosensitivity. Polym. Int . 2011 , 60 , 1001−1009..

Pereira, G.; Huin, C.; Morariu, S.; Bennevault-Celton, V.; Guegan, P. Synthesis of poly(2-methyl-2-oxazoline) star polymers with a b-cyclodextrin core. Austr. J. Chem . 2012 , 65 , 1145−1155..

Zhang, N.; Luxenhofer, R.; Jordan, R. Thermoresponsive poly(2-oxazoline) molecular brushes by living ionic polymerization: modulation of the cloud point by random and block copolymer pendant chains. Macromol. Chem. Phys . 2012 , 213 , 1963−1969..

Glassner, M.; Lava, K.; de la Rosa, V. R.; Hoogenboom, R. Tuning the LCST of poly(2-cycloprop yl-2-oxazoline) via gradient copolymerization with 2-ethyl-2-oxazoline. J. Polym. Sci. Part A: Polym. Chem . 2014 , 52 , 3118−3122..

Gao, H.; Min, K.; Matyjaszewski, K. Synthesis of 3-arm star block copolymers by combination of ‘‘core-first’’ and ‘‘coupling-onto’’ methods using ATRP and click reactions. Macromol. Chem. Phys . 2007 , 208 , 1370−1378..

Takahashi, R.; Sato, T.; Terao, K.; Qiu, X. P.; Winnik, F. M. Self-association of a thermosensitive poly(alkyl-2-oxazoline) block copolymer in aqueous solution. Macromolecules 2012 , 45 , 6111−6119..

Smirnova, A. V.; Kirila, T. U.; Kurlykin, M. P.; Tenkovtsev, A. V.; Filippov, A. P. Behavior of aqueous solutions of polymer star with block-copolymer poly(2-ethyl-2-oxazoline) and poly(2-isopropyl-2-oxazoline) arms. Int. J. Polym. Anal. Charact . 2017 , 22 , 677−684..

Kirila, T.; Amirova, A.; Blokhin, A.; Tenkovtsev, A.; Filippov, A. Features of solution behavior of polymer stars with arms of poly-2-alkyl-2-oxazolines copolymers grafted to the upper rim of calix[8 ] aren. Polymers 2021 , 13 , 2507..

Sheng, Y. J.; Nung, C. H.; Tsao, H. K. Morphologies of star-block copolymers in dilute solutions. J. Phys. Chem . 2006 , 110 , 21643−21650..

Li, J.; Zhu, Y.; Hazeldine, S. T.; Firestine, S. M.; Oupický, D. Cyclam-based polymeric copper chelators for gene delivery and potential PET imaging. Biomacromolecules 2012 , 13 , 3220−3227..

Singh, M.; Singh, N. Molecular mechanism of curcumin induced cytotoxicity in human cervical carcinoma cells. Mol. Cell. Biochem. 2009 , 325 , 107−119..

Kitani, K.; Osawa, T.; Yokozawa, T. The effects of tetrahydrocurcumin and green tea polyphenol on the survival of male C57BL/6 mice. Biogerontology 2007 , 8 , 567−573..

Granata, G.; Consoli, G. M. L.; Nigro, R. L.; Malandrino, G.; Geraci, C. Supramolecular assembly of a succinylcalix[4 ] arene derivative in multilamellar vesicles. Supramolec. Chem. 2016 , 28 , 377−383..

Rogers, N. M.; Kireta, S.; Coates, P. T. H. Curcumin induces maturation-a rrested dendritic cells that expand regulatory T cells in vitro and in vivo . Clin. Exp. Immun . 2010 , 162 , 460−473..

Chen, J.; Qin, X.; Zhong, S.; Chen, S.; Su, W.; Liu, Y. Characterization of curcumin/cyclodextrin polymer inclusion complex and investigation on its antioxidant and antiproliferative activities. Molecules 2018 , 23 , 1179..

de Azevedo, L. A.; da Luz, L. L.; de Souza Ferro, J. N.; Barreto, E.; Silva, R. O.; Junior, S. A.; Alves, I. B. V. The new supramolecular nano-aggregate curcumin-cucurbit[7 ] uril: synthesis, photophysical properties and biocompatibility evaluation. Photochem. Photobiolog. Sci. 2017 , 16 , 663−671..

Jelezova, I.; Drakalska, E.; Momekova, D.; Shalimova, N.; Momekov, G.; Konstantinov, S.; Rangelov, S.; Pispas, S. Curcumin loaded pH-sensitive hybrid lipid/block copolymer nanosized drug delivery systems. Eur. J. Pharm. Sci. 2015 , 78 , 67−78..

Zhao, L.; Kang, L.; Chen, Y.; Li, G.; Wang, L.; Hu, C.; Yang, P. Spectral study on conformation switchable cationic calix[4 ] carbazole serving as curcumin container, stabilizer and sustained-delivery carrier. Spectrochim. Acta Part A: Molec. Biomolec. Spectr. 2018 , 193 , 276−282..

Chen, W.; Li, L.; Zhang, X.; Liang, Y.; Pu, Z.; Wang, L.; Mo, J. Curcumin: a calixarene derivative micelle potentiates anti-breast cancer stem cells effects in xenografted, triple-negative breast cancer mouse models. Drug Deliv. 2017 , 24 , 1470−1481..

Filippov, A. P.; Kirila, T. Y.; Rodchenko, S. V.; Smirnova, A. V.; Kozina, N. D.; Tenkovtsev, A. V. Self-organization of macromolecules of block copolymers of poly-2-alkyl-5,6-dihydrooxazines in aqueous and water-salt solutions. Nanobiotechnol. Rep . 2023 , 18 , S136−S143..

Filippov, A. P.; Kirila, T. Y.; Rodchenko, S. V.; Smirnova, A. V.; Kozina, N. D.; Tenkovtsev, A. V. Influence of the composition of block copolymers of poly-2-alkyl-5,6-dihydroxazines on their behavior in solutions. Nanobiotechnol. Rep . 2024 , 19 , 979−986..

Filippov, A. P.; Rodchenko, S. V.; Kirila, T. Y.; Kozina, N. D.; Tenkovtsev A. V. Behavior of complexes of poly-2-alkyl-5,6-dihydrooxazine block copolymers with curcumin in aqueous solutions. Nanobiotechnol. Rep . 2025 , 20 , 64−69..

Witte, H.; Seeliger, W. Cyclische imidsaureester aus nitrilen und aminoalkoholen. Justus Liebigs Ann. Chem. 1974 , 1974 , 996−1009..

Gawronski, J., Gawronska, K., Grajewski, J., Kwit, M., Plutecka, A., Rychlewska, U. Trianglamines—readily prepared, conformationally flexible inclusion-forming chiral hexamines. Chem. A Eur. J. 2006 , 12 , 1807−1817..

[Tsvetkov, V. N. in Plenum Press (in New York), 1989 ..

Rueb, C. J., Zukoski, C. F. Rheology of suspensions of weakly attractive particles: approach to gelation. J. Rheol. 1998 , 42 , 1451−1476..

[Yamakawa, H. in Harper and Row (in New York), 1971 ..

Filippov, A. P.; Belyaeva, E. V.; Tarabukina, E.B.; Amirova, A.I. Behavior of hyperbranched polymers in solutions. Polym. Sci. Ser. C 2011 , 53 , 107−117..

Bodnár, I.; Silva, A.S.; Deitcher, R. W.; Weisman, N.E.; Kim, Y.H.; Wagner, N. J. Structure and rheology of hyperbranched and dendritic polymers. II. Effects of blending acetylated and hydroxy-terminated poly(propyleneimine) dendrimers with aqueous poly(ethylene oxide) solutions. J. Polym. Sci. Part B: Polym. Phys. 2000 , 38 , 857−873..

Jeong, M.; Mackay, M.E.; Vestberg, R.; Hawker, C.J. Intrinsic viscosity variation in different solvents for dendrimers and their hybrid copolymers with linear polymers. Macromolecules 2001 , 34 , 4927−4936..

Terao, K.; Hokajo, T.; Nakamura, Y.; Norisuye, T. Solution properties of polymacromonomers consisting of polystyrene. 3. Viscosity behavior in cyclohexane and toluene. Macromolecules 1999 , 32 , 3690−3694..

Kuhnert, N.; Strassnig, C.; Lopez-Periago, A. M. Synthesis of novel enantiomerically pure trianglimine and trianglamine macrocycles. Tetrahedron: Asymmetry 2002 , 13 , 123−128..

Kurlykin, M.; Kozina, N.; Kirila, T.; Filippov, A.; Tenkovtsev, A. Star-shaped thermosensitive poly- N -acyl-1,3-propylenimines with trianglamine core. Mendeleev Commun . 2024 , 34 , 743−744..

Tsvetkov, V. N.; Lavrenko, P. N.; Bushin, S. V. A Hydrodynamic Invariant of Polymeric Molecules. Russ. Chem. Rev . 1982 , 51 , 975−993..

Tsvetkov, V. N.; Lavrenko, P. N.; Bushin, S. V. Hydrodynamic invariant of polymer molecules. J. Polym. Sci.: Polym.Chem. Ed . 1984 , 22 , 3447−3486..

Pavlov, G. M.; Korneeva, E. V.; Roy, R.; Michailova, N. A.; Ortega, P. C.; Perez, M. A. Sedimentation, translational diffusion, and viscosity of lactosylated polyamidoamine dendrimers. Progr Colloid Polym. Sci . 1999 , 113 , 150−157..

Filippov, A. P.; Zamyshlyayeva, O. G.; Tarabukina, E. B.; Simonova, M. A.; Kozlov, A. V.; Semchikov, Yu. D. Structural and conformational properties of hyperbranched copolymers based on perfluorinated germanium hydrides. Polym. Sci. Ser. A 2012 , 54 , 319−329..

Daoud, M.; Cotton, J. P. Star shaped polymers: a model for the conformation and its concentration dependence. J. Phys . 1982 , 43 , 531−538..

[Kratochvil, P. in Elsevier (in Amsterdam), 1987 , p.330−p.345..

[Schärtl, W. L. in Springer (in Berlin), 2007 , p.191..

Amirova, A. I.; Golub, O. V.; Kirila, T. U.; Razina, A. B.; Tenkovtsev, A. V.; Filippov, A. P. The influence of arm length and number on starshaped poly(2-isopropyl-2-oxazoline) aggregation in aqueous solutions near cloud point. Soft Mater . 2016 , 14 , 15−26..

Simonova, M. A.; Tarasova, E. V.; Dudkina, M. M.; Tenkovtsev, A. V.; Filippov, A. P. Synthesis and hydrodynamic and conformation properties of star-shaped polystyrene with calix[8 ] arene core. Int. J. Polym. Anal. Charact . 2019 , 24 , 87−95..

Rossegger, E.; Schenk, V.; Wiesbrock, F. Design strategies for functionalized poly(2-oxazoline)s and derived materials. Polymers 2013 , 5 , 956−1011..

Weber, C.; Hoogenboom, R.; Schubert, U. S. Temperature responsive bio-compatible polymers based on poly(ethylene oxide) and poly(2-oxazoline)s. Progr. Polym. Sci . 2012 , 37 , 686−714..

Trinh, L. T. T.; Lambermont-Thijs, H. M. L.; Schubert, U. S.; Hoogenboom, R.; Kjøniksen, A. L. Thermoresponsive poly(2-oxazoline) block copolymers exhibiting two cloud points: complex multistep assembly behavior. Macromolecules 2012 , 45 , 4337−4345..

Steinschulte, A.A.; Schulte, B.; Rütten, S.; Eckert, T.; Okuda, J.; Möller, M.; Schneider, S.; Borisov, O.V.; Plamper, F. A. Effects of architecture on the stability of thermosensitive unimolecular micelles. Phys. Chem. Chem. Phys . 2014 , 16 , 4917−4932..

Kowalczuk, A.; Mendrek, B.; Zymełka-Miara, I.; Libera, M.; Marcinkowski, A.; Trzebicka, B.; Smet, M.; Dworak, A. Solution behavior of star polymers with oligo(ethylene glycol) methyl ether methacrylate arms. Polymer 2012 , 53 , 5619−5631..

Qiu, F.; Wang, D.; Wang, R.; Huan, X.; Tong, G.; Zhu, Q.; Yan, D.; Zhu, X. Temperature-induced emission enhancement of star conjugated copolymers with poly(2-(dimethylamino)ethyl methacrylate) coronas for detection of bacteria. Biomacromolecules 2013 , 14 , 1678−1686..

Le Dévédec, F.; Strandman, S.; Baille, W. E.; Zhu, X. X. Functional star block copolymers with a cholane core: Thermo-responsiveness and aggregation behavior. Polymer 2013 , 54 , 3898−3903..

Renny, J. S.; Tomasevich, L. L.; Tallmadge, E. H.; Collum, D. B. Method of continuous variations: applications of Job plots to the study of molecular associations in organometallic chemistry. Angew. Chem. Int. Ed . 2013 , 52 , 11998−12013..

Nafisi, S.; Adelzadeh, M.; Norouzi, Z.; Sarbolouki, M. N. Curcumin binding to DNA and RNA. DNA Cell Biol . 2009 , 28 , 201−208..

Mohammadi, F.; Bordbar, A. K.; Divsalar, A.; Mohammadi, K.; Saboury, A. A. Analysis of binding interaction of curcumin and diacetylcurcumin with human and bovine serum albumin using fluorescence and circular dichroism spectroscopy. Protein J . 2009 , 28 , 189−196..

Kozina, N. D.; Blokhin, A. N.; Kirila, T. U.; Razina, A. B.; Bursian, A. E.; Kurlykin, M. P.; Filippov, A. P.; Tenkovtsev, A. V. Synthesis of novel star-shaped calix[4 ] arene-bas ed poly(2-oxazoline)s and study of their complexation with curcumin. Mater. Today Commun. 2023 , 34 , 105403..

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