pH/Glutathione Dual-stimuli-responsive Poly(acrylic acid)-coated Hollow Mesoporous Organosilica Nanospheres for Smart Pesticide Delivery

Peng Xu; Jia-Wei Bao; Qun Li; Wei-Shan Shi; Gang Xing; Lei Yu

doi:10.1007/s10118-025-3485-5

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pH/Glutathione Dual-stimuli-responsive Poly(acrylic acid)-coated Hollow Mesoporous Organosilica Nanospheres for Smart Pesticide Delivery

RESEARCH ARTICLE | Updated：2026-01-13

- pH/Glutathione Dual-stimuli-responsive Poly(acrylic acid)-coated Hollow Mesoporous Organosilica Nanospheres for Smart Pesticide Delivery
- pH/Glutathione Dual-stimuli-responsive Poly(acrylic acid)-coated Hollow Mesoporous Organosilica Nanospheres for Smart Pesticide Delivery
- Chinese Journal of Polymer Science 2026年44卷第1期页码：162-172
- Affiliations：
  
  a.Co-Innovation Center for Efficient Processing and Utilization of Forest Products, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China
  b.Jiangsu Aijin Crop Science and Technology Group Co., Ltd., Nanjing 210000, China
  c.School of Environmental Engineering, Nanjing Institute of Technology, Nanjing 211167, China
- Author bio：
  
  xupeng@njfu.edu.cn (P.X.)
  lyu@njfu.edu.cn (L.Y.)
- Funds：
  
  This work was financially supported by the Jiangsu Forestry Science and Technology Innovation and Promotion Project (No. LYKJ-Nanjing [2022]02) and the Jiangsu Agricultural Science and Technology Innovation Fund (No. CX (23)3090).;Electronic supplementary information (ESI) is available free of charge in the online version of this article at http://doi.org/10.1007/s10118-025-3485-5.
- DOI：10.1007/s10118-025-3485-5
  中图分类号：
- 收稿：2025-09-09，
  
  录用：2025-10-20，
  
  网络首发：2026-01-04，
  
  纸质出版：2026-01-15
- Accepted：
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Xu, P.; Bao, J. W.; Li, Q.; Shi, W. S.; Xing, G.; Yu, L. pH/glutathione dual-stimuli-responsive poly(acrylic acid)-coated hollow mesoporous organosilica nanospheres for smart pesticide delivery. Chinese J. Polym. Sci. 2026, 44, 162–172

Peng Xu, Jia-Wei Bao, Qun Li, et al. pH/Glutathione Dual-stimuli-responsive Poly(acrylic acid)-coated Hollow Mesoporous Organosilica Nanospheres for Smart Pesticide Delivery[J]. Chinese Journal of Polymer Science, 2026, 44(1): 162-172.
Xu, P.; Bao, J. W.; Li, Q.; Shi, W. S.; Xing, G.; Yu, L. pH/glutathione dual-stimuli-responsive poly(acrylic acid)-coated hollow mesoporous organosilica nanospheres for smart pesticide delivery. Chinese J. Polym. Sci. 2026, 44, 162–172 DOI： 10.1007/s10118-025-3485-5.

Peng Xu, Jia-Wei Bao, Qun Li, et al. pH/Glutathione Dual-stimuli-responsive Poly(acrylic acid)-coated Hollow Mesoporous Organosilica Nanospheres for Smart Pesticide Delivery[J]. Chinese Journal of Polymer Science, 2026, 44(1): 162-172. DOI： 10.1007/s10118-025-3485-5.

摘要

A pH/GSH dual-responsive nanopesticide system (Abamectin-HMONs@PAA) was developed for smart delivery. It exhibits enhanced photostability

controlled release in acidic/reducing environments

improved leaf adhesion

and superior insecticidal efficacy against Plutella xylostella

promoting sustainable crop protection.

Abstract

Smart pesticide delivery systems based on stimuli-responsive nanocarriers have attracted considerable attention because of their potential to enhance pesticide efficiency while reducing environmental risks. In this study

a novel pH/glutathione dual-responsive pesticide delivery s

ystem was constructed through the synthesis of disulfide-bridged hollow mesoporous organosilica nanospheres (HMONs)

via

the Stöber method

followed by poly(acrylic acid) (PAA) coating through distillation-precipitation polymerization to form HMONs@PAA nanocomposites. The resulting abamectin-loaded system (Abamectin-HMONs@PAA) demonstrated a 12.73% pesticide loading capacity and significantly improved photostability

retaining twice as much active ingredient as free abamectin after 250 h of UV irradiation (36 W). Release studies revealed pH- and glutathione-dependent characteristics

with cumulative releases in acidic conditions exceeding those in neutral and alkaline environments by 18.66% and 40.98%

respectively

and a 14.2% increase in glutathione-containing solution (0.2 mmol·L

–1

in 70% ethanol) after 97 h. Bioassays showed superior performance against

Plutella xylostella

with a 13.33% reduction in survival rate compared to conventional suspension at equivalent dosage (40 mg·L

–1

)

while maintaining efficacy after extensive rainfall simulation (20 events over 10 days). This study provides a promising approach for developing environmentally responsive nanopesticides with enhanced durability and controlled-release properties

offering significant potential for sustainable crop protection.

关键词

Keywords

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