Ionic Hyper Crosslinked Polymers as High Performance Hemoperfusion Adsorbent for Efficient Removal of Excessive Bilirubin

Hong-Xiang Yin; Yue-Yuan Xiao; Yu-Cheng Cai; Shuai-Lin He; Yang Wang; Gang-Shen Zhang; Cheng Zhang; Bi-En Tan; Irshad Hussain; Wei Yan

doi:10.1007/s10118-025-3484-6

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Ionic Hyper Crosslinked Polymers as High Performance Hemoperfusion Adsorbent for Efficient Removal of Excessive Bilirubin

RESEARCH ARTICLE | Updated：2026-01-13

- Ionic Hyper Crosslinked Polymers as High Performance Hemoperfusion Adsorbent for Efficient Removal of Excessive Bilirubin
  Enhanced Publication
- Ionic Hyper Crosslinked Polymers as High Performance Hemoperfusion Adsorbent for Efficient Removal of Excessive Bilirubin
- Chinese Journal of Polymer Science 2026年44卷第1期页码：154-161
- Affiliations：
  
  a.Key Laboratory of Green Preparation and Application for Functional Materials of Ministry of Education, Hubei Key Laboratory of Polymer Materials, School of Material Science and Engineering, Hubei University, Wuhan 430062, China
  b.Shenzhen Huazhong University of Science and Technology Research institute, Shenzhen 518038, China
  c.School of Life Science, Hubei University, Wuhan 430062, China
  d.School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China
  e.Department of Chemistry and Chemical Engineering, SBA School of Science and Engineering, Lahore University of Management Sciences (LUMS), DHA, Lahore 54792, Pakistan
- Author bio：
  
  20041222@hubu.edu.cn (G.S.Z.)
  ihussain@lums.edu.pk (I.H.)
  willieyan2003@hubu.edu.cn (W.Y.)
- Funds：
  
  This work was financially supported by the International Cooperation Program of the Ministry of Science and Technology of Hubei Province (No. 2023EHA069), Shenzhen Science and Technology Program (No. JCYJ20230807143702005) and the National Foreign Experts Program (No. G2022027015L).;Electronic supplementary information (ESI) is available free of charge in the online version of this article at http://doi.org/10.1007/s10118-025-3484-6.
- DOI：10.1007/s10118-025-3484-6
  中图分类号：
- 收稿：2025-09-30，
  
  录用：2025-10-27，
  
  网络首发：2025-12-25，
  
  纸质出版：2026-01-15
- Accepted：
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Yin, H. X.; Xiao, Y. Y.; Cai, Y. C.; He, S. L.; Wang, Y.; Zhang, G. S.; Zhang, C.; Tan, B. E.; Hussain, I.; Yan, W. Ionic hyper crosslinked polymers as high performance hemoperfusion adsorbent for efficient removal of excessive bilirubin. Chinese J. Polym. Sci. 2026, 44, 154–161

Hong-Xiang Yin, Yue-Yuan Xiao, Yu-Cheng Cai, et al. Ionic Hyper Crosslinked Polymers as High Performance Hemoperfusion Adsorbent for Efficient Removal of Excessive Bilirubin[J]. Chinese Journal of Polymer Science, 2026, 44(1): 154-161.
Yin, H. X.; Xiao, Y. Y.; Cai, Y. C.; He, S. L.; Wang, Y.; Zhang, G. S.; Zhang, C.; Tan, B. E.; Hussain, I.; Yan, W. Ionic hyper crosslinked polymers as high performance hemoperfusion adsorbent for efficient removal of excessive bilirubin. Chinese J. Polym. Sci. 2026, 44, 154–161 DOI： 10.1007/s10118-025-3484-6.

Hong-Xiang Yin, Yue-Yuan Xiao, Yu-Cheng Cai, et al. Ionic Hyper Crosslinked Polymers as High Performance Hemoperfusion Adsorbent for Efficient Removal of Excessive Bilirubin[J]. Chinese Journal of Polymer Science, 2026, 44(1): 154-161. DOI： 10.1007/s10118-025-3484-6.

摘要

By incorporating a cationic monomer into the cross-linked polymer framework

we introduced electrostatic interactions that enhance the polymer’s affinity for bilirubin

resulting in outstanding adsorption performance and demonstrating its potential as an effective hemoperfusion adsorbent.

Abstract

Liver is a vital organ in the human body and plays a central role in the metabolism and detoxification of endotoxins and exotoxins. Bilirubin is an endotoxin derived from hemoglobin (Hb). Removing excess bilirubin in the blood is crucial for the treatment of liver diseases. Hemoperfusion

which relies on adsorbents to efficiently adsorb toxins

is a widely applied procedure for the removal of blood toxins. To broaden and improve the range and performance of hemoperfusion adsorbents

we synthesized cationic hyper crosslinked polymers (HCPs) with strong affinity for bilirubin. This material exhibited outstanding adsorption performance

with a maximum adsorption capacity of 934 mg/g and a removal efficiency of 96%. Further investigation confirmed their excellent selectivity

reusability

and biocompatibility. These findings expand the potential applications of HCPs and provide insight into strategies for constructing promising hemoperfusion adsorbent materials.

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references

Hamoud, A. R.; Weaver, L.; Stec, D. E.; Hinds, T. D., Jr. Bilirubin in the liver-gut signaling axis. Trends Endocrinol. Metab. 2018 , 29 , 140−150..

Soppert, J.; Brandt, E. F.; Heussen, N. M.; Barzakova, E.; Blank, L. M.; Kuepfer, L.; Hornef, M. W.; Trebicka, J.; Janko wski, J.; Berres, M.-L.; Noels, H. Blood endotoxin levels as biomarker of nonalcoholic fatty liver disease: a systematic review and meta-analysis. Clin. Gastroenterology H 2023 , 21 , 2746−2758..

Ramírez-Mejía, M. M.; Castillo-Castañeda, S. M.; Pal, S. C.; Qi, X.; Méndez-Sánchez, N. The multifaceted role of bilirubin in liver disease: a literature review. J. Clin. Transl. Hepato. 2024 , 12 , 939−948..

Liu, H. W.; Gong, L. N.; Lai, K.; Yu, X. F.; Liu, Z. Q.; Li, M. X.; Yin, X. L.; Liang, M.; Shi, H. S.; Jiang, L. H.; Yang, W.; Shi, H. B.; Wang, L. Y.; Yin, S. K. Bilirubin gates the TRPM2 channel as a direct agonist to exacerbate ischemic brain damage. Neuron 2023 , 111 , 1609−1625.e6..

Vitek, L.; Hubacek, J. A.; Pajak, A.; Doryńska, A.; Kozela, M.; Eremiasova, L.; Danzig, V.; Stefler, D.; Bobak, M. Association between plasma bilirubin and mortality. Ann. Hepatol. 2019 , 18 , 379−385..

Wang, L.; Han, K.; Jiang, X.; Mao, C.; Li, X.; Zhou, M. Recent advances in blood toxin removal technology. Sustain. Mater. Technol. 2024 , 39 , e00828..

Wu, S.; Yue, P.; Ma, Y.; Zou, Y.; Liang, W.; Ye, Q. Hemoperfusion adsorbents for removal of common toxins in liver and kidney failure: recent progress, challenges, and prospects. Adv. Mater. 2023 , 37 , 2305152..

Guo, C.; Jiang, X.; Guo, X.; Ou, L. An evolutionary review of hemoperfusion adsorbents: materials, preparation, functionalization, and outlook. ACS Biomater. Sci. Eng. 2024 , 10 , 3599−3611..

Dou, W.; Wang, J.; Yao, Z.; Xiao, W.; Huang, M.; Zhang, L. A critical review of hemoperfusion adsorbents: materials, functionalization and matrix structure selection. Mater. Adv. 2022 , 3 , 918−930..

Li, M.; Wang, X.; Gong, G.; Li, X.; Tang, Y.; Wang, Q.; Zhou, J.; Guo, J.; Liao, X.; Shi, B. Engineered liver-inspired collagen matrix as a high-performance hemoperfusion adsorbent for bilirubin removal. Chem. Eng. J. 2021 , 426 , 130791..

Liu, J.; Shu, G.; Lu, X.; Li, K.; Kong, X.; Zheng, S.; Ma, R.; Li, T. Alginate/HSA double-sided functional pvdf multifunctional composite membrane for bilirubin removal. Sep. Purif. Technol. 2020 , 252 , 117295..

Zhou, W.; Hu, W.; Zhan, Q.; Zhang, M.; Liu, X.; Hussain, W.; Yu, H.; Wang, S.; Zhou, L. Novel hemoperfusion adsorbents based on collagen for efficient bilirubin removal – a thought from yellow skin of patients with hyperbilirubinemia. Int. J. Biol. Macromol. 2023 , 253 , 127321..

Zhang, M.; Wang, Y.; Zhou, W.; Zheng, X.; Liu, X.; Zhu, B.; Wang, S.; Zhou, L. Ordered mesoporous SiO 2 as hemoperfusion adsorbents for enhanced selectivity of bilirubin removal from blood. Sep. Purif. Technol. 2025 , 359 , 130640..

Im, P.; Jeong, H. G.; Kim, D.; Song, J.; Phan, N. M.; Choi, E.-s.; Kim, Y. M.; Jeong, S. H.; Park, J.; Park, I.; Kim, J. Extracorporeal catalytic hemoperfusion therapy for refractory septic shock using ceria nanoparticle-embedded porous microbeads. Adv. Funct. Mater. 2025 , 35 , 2415949..

Li, K.; Wang, C.; Gao, Y.; Xu, B.; Zhao, X.; Xu, Z.; Hou, M.; Qi, R.; Gan, J.; Huang, Y.; Yang, M.; Zhao, M.; Zhuang, D.; Li, Y.; Gong, Q. Preparation of zwitterion-decorated carbon nanotubes/ZIF-8 composite aerogel beads as an effective adsorbent for protein-bound uremic toxins removal in hemoperfusion. Carbon 2025 , 244 , 120689..

Weng, R.; Zhang, L.; Cao, Y.; Wang, Z.; Zhao, C.; Wang, J.; Zhao, C. Two-dimensional borocarbonitrides nanosheets engineered sulfonated polyether sulfone microspheres as highly efficient and photothermally recyclable adsorbents for hemoperfusion. Chem. Eng. J. 2023 , 463 , 142365..

Liu, Y.; Wang, Z. K.; Liu, C. Z.; Liu, Y. Y.; Li, Q.; Wang, H.; Cui, F.; Zhang, D. W.; Li, Z. T. Supramolecular organic frameworks as adsorbents for efficient removal of excess bilirubin in hemoperfusion. ACS Appl. Mater. Interfaces 2022 , 14 , 47397−47408..

Zhao, R.; Ma, T.; Cui, F.; Tian, Y.; Zhu, G. Porous aromatic framework with tailored binding sites and pore sizes as a high-performance hemoperfusion adsorbent for bilirubin removal. Adv. Sci. 2020 , 7 , 2001899..

Li, Q.; Zhao, W.; Guo, H.; Yang, J.; Zhang, J.; Liu, M.; Xu, T.; Chen, Y.; Zhang, L. Metal-organic framework traps with record-high bilirubin removal capacity for hemoperfusion therapy. ACS Appl. Mater. Interfaces 2020 , 12 , 25546−25556..

Yang, J.; Yuan, Y.; Hou, J.; Xu, Z.; Du, Y.; Yang, J.; Shan, S.; Hu, T.; Wang, C.; Su, H. Cyclodextrin metal-organic framework derived na no-cubic gel particles for the efficient removal of bilirubin. Sep. Purif. Technol. 2025 , 360 , 131071..

Li, Q.; Zhu, Y.; Li, Y.; Yang, J.; Bao, Z.; Tian, S.; Wang, X.; Zhang, L. Reusable zwitterionic porous organic polymers for bilirubin removal in serum. ACS Appl. Mater. Interfaces 2023 , 15 , 56665−56677..

Hu, X. L.; Li, H. G.; Tan, B. E. COFs-based porous materials for photocatalytic applications. Chinese J. Polym. Sci. 2020 , 38 , 673−684..

Wu, H. M.; Ma, W. C.; Cai, Y. F.; Huang, X.; Li, J. H.; Kai, X.; Zhang, Q. H.; Jia, X. D. Boroxine crystalline covalent organic frameworks based single-ion quasi-solid-state conductor in lithium-ion battery. Chinese J. Polym. Sci. 2025 , 43 , 177−187..

Zhang, X.; Wang, X.; Li, C.; Hu, T.; Fan, L. Nanoporous {Co 3 }-organic framework for efficiently seperating gases and catalyzing cycloaddition of epoxides with CO 2 and knoevenagel condensation. J. Colloid Interface Sci. 2024 , 656 , 127−136..

Zhang, S. Y.; Gong, W. T.; Qu, W. D.; Deng, X. R.; Dong, K. X.; Zhang, S. G.; Ning, G. L. Construction of ionic porous organic polymers (iPOPs) via pyrylium mediated transformation. Chinese J. Polym. Sci. 2020 , 38 , 958−964..

Fuchs, A.; Mannhardt, P.; Hirschle, P.; Wang, H.; Zaytseva, I.; Ji, Z.; Yaghi, O.; Wuttke, S.; Ploetz, E. Single crystals heterogeneity impacts the intrinsic and extrinsic properties of metal-organic frameworks. Adv. Mater. 2022 , 34 , 2104530..

Tan, L.; Tan, B. Hypercrosslinked porous polymer materials: design, synthesis, and applications. Chem. Soc. Rev. 2017 , 46 , 3322−3356..

Gu, Y.; Son, S. U.; Li, T.; Tan, B. Low-cost hypercrosslinked polymers by direct knitting strategy for catalytic applications. Adv. Funct. Mater. 2021 , 31 , 2008265..

Peng, M.; Gao, H.; Gu, Y.; Tan, B. Hyper-cross-linked pyridine-functionalized bis(imino)acenaphthene-n-heterocyclic carbene (BIAN-NHC) palladium catalysts for superior Suzuki-Miyaura and buchwald-hartwig coupling reactions. ACS Appl. Polym. Mater. 2025 , 7 , 2226−2236..

Tian, K.; Zhu, T. T.; Lan, P.; Wu, Z. C.; Hu, W.; Xie, F. F.; Li, L. Massive preparation of coumarone-indene resin-based hyper-crosslinked polymers for gas adsorption. Chinese J. Polym. Sci. 2018 , 36 , 1168−1174..

Cheng, Y.; Razzaque, S.; Zhan, Z.; Tan, B. Construction and gas uptake performance of cyano-functional hypercrosslinked polymers via knitting strategy. Chem. Eng. J. 2021 , 426 , 130731..

Hou, S.; Hu, J.; Liang, X.; Zhang, D.; Tan, B. Carbonate-based hyper-cross-linked polymers with pendant versatile electron-withdrawing functional groups for CO 2 adsorption and separation. J. Mater. Chem. A 2022 , 10 , 15062−15073..

Hu, J.; Gao, H.; Wang, X.; Tan, B. High-capacity volumetric methane storage in hyper-cross-linked porous polymers via flexibility engineering of building units. Adv. Mater. 2025 , 37 , 2418005..

Zhang, L.; Yao, L.; Ye, L.; Long, B.; Dai, Y.; Ding, Y. Benzimidazole-based hyper-cross-linked polymers for effective adsorption of chlortetracycline from aqueous solution. J. Environ. Chem. Eng. 2020 , 8 , 104562..

Han, L.; Peng, Y.; Ma, J.; Shi, Z.; Jia, Q. Construction of hypercrosslinked polymers with styrene-based copolymer precursor for adsorption of rare earth elements. Sep. Purif. Technol. 2022 , 285 , 120378..

Cai, Y.; Wen, X.; Wang, Y.; Song, H.; Li, Z.; Cui, Y.; Li, C. Preparation of hyper-crosslinked polymers with hierarchical porous structure from hyperbranched polymers for adsorption of naphthalene and 1-naphthylamine. Sep. Purif. Technol. 2021 , 266 , 118542..

Liu, A.; Wei, X.; Lin, S.; Ding, L.; Huang, Y.; Fan, X.; Li, P.; Lau, C. H. Photo-modulated regeneration of hypercrosslinked polymer adsorbents for water treatment. Sep. Purif. Technol. 2024 , 329 , 125142..

Yang, S.; Zhong, Z.; Hu, J.; Wang, X.; Tan, B. Dibromomethane knitted highly porous hyper-cross-linked polymers for efficient high-pressure methane storage. Adv. Mater. 2024 , 36 , 2307579..

Ghasemi, S.; Harandi,Z. A. Thermo-responsive poly( N -isopropylacrylamide)-block-poly(ionic liquid) of pyridinium sulfonate immobilized Pd nanoparticles in C–C coupling re actions. RSC Adv. 2018 , 8 , 14570−14578..

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