Metal-Organic Framework/Polyimide-Electrochemiluminescence Sensor for Enantioselective Detection of Histidine

Ye-Qian Ruan; Xuan Kuang; Rui Kuang

doi:10.1007/s10118-025-3425-4

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Metal-Organic Framework/Polyimide-Electrochemiluminescence Sensor for Enantioselective Detection of Histidine

RESEARCH ARTICLE | Updated：2025-10-30

- Metal-Organic Framework/Polyimide-Electrochemiluminescence Sensor for Enantioselective Detection of Histidine
- Metal-Organic Framework/Polyimide-Electrochemiluminescence Sensor for Enantioselective Detection of Histidine
- 高分子科学（英文） 2025年43卷第11期页码：2110-2117
- Affiliations：
  
  a.Key Laboratory of Interfacial Reaction & Sensing Analysis in Universities of Shandong, School of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, China
  b.College of Traffic Civil Engineering, Shandong Jiaotong University, Jinan 250023, China
- Author bio：
  
  chm_kuangx@ujn.edu.cn (X.K.)
  kuangr1985@foxmail.com (R.K.)
- Funds：
  
  This work was financially supported by the Natural Science Foundation of Shandong Province, China (Nos. ZR2020QB065 and ZR2021MB121).;Electronic supplementary information (ESI) is available free of charge in the online version of this article at http://doi.org/10.1007/s10118-025-3425-4.
- DOI：10.1007/s10118-025-3425-4
  中图分类号：
- 收稿：2025-06-09，
  
  录用：2025-08-02，
  
  网络首发：2025-10-16，
  
  纸质出版：2025-11-05
- Accepted：
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Ruan, Y. Q.; Kuang, X.; Kuang, R. Metal-organic framework/polyimide-electrochemiluminescence sensor for enantioselective detection of histidine. Chinese J. Polym. Sci. 2025, 43, 2110–2117

Ye-Qian Ruan, Xuan Kuang, Rui Kuang. Metal-Organic Framework/Polyimide-Electrochemiluminescence Sensor for Enantioselective Detection of Histidine[J]. Chinese Journal of Polymer Science, 2025, 43(11): 2110-2117.
Ruan, Y. Q.; Kuang, X.; Kuang, R. Metal-organic framework/polyimide-electrochemiluminescence sensor for enantioselective detection of histidine. Chinese J. Polym. Sci. 2025, 43, 2110–2117 DOI： 10.1007/s10118-025-3425-4.

Ye-Qian Ruan, Xuan Kuang, Rui Kuang. Metal-Organic Framework/Polyimide-Electrochemiluminescence Sensor for Enantioselective Detection of Histidine[J]. Chinese Journal of Polymer Science, 2025, 43(11): 2110-2117. DOI： 10.1007/s10118-025-3425-4.

摘要

This study introduces a novel chiral MOF/PI-ECL sensor

utilizing a linear polyimide chain and ferrocene as key components for highly sensitive and enantioselective detection of histidine. The sensor demonstrates an impressive LOD of 8 μM and excellent recovery rates in real samples.

Abstract

In this study

a novel linear polyimide chain (PTCDA-DCH) was used as an electrochemiluminescence (ECL) emitter

employing a chiral metal-organic framework (MOF) (Zn-Dcam-dabco) as the chiral selector and ferrocene (Fc) as a quencher to construct a chiral sensor for detecting histidine (His) enantiomers. Competitive interactions between Fc and His induce partial Fc desorption from the sensor surface

leading to ECL signal recovery. Differential Fc release due to the distinct binding affinities of Zn-Dcam-dabco for His enantiomers enabled precise chiral discrimination. Notably

the sensor achieved the quantitative detection of His enantiomers with an limits of detection (LOD) of 8 μmol/L. Furthermore

the sensor demonstrated excellent recovery rates of 98.0%–104% for l-histidine (L-His) and 92.0%–95.9% for D-His in spiked milk samples

validating its reliability for real-sample analysis. This study provides a promising platform for ECL-based chiral recognition

bioanalysis

and the rapid assessment of amino acids in food products.

关键词

Keywords

references

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