A Brief Review on Ultrasound Induced Drug Activation Systems

Jia-Ning Zhang; Yu-Ru Ma; Liu-Tian-Yun Yuan; Shang Jia; Xiao-Miao Yu; Yuan Yuan; Zhi-Yuan Shi

doi:10.1007/s10118-025-3398-3

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A Brief Review on Ultrasound Induced Drug Activation Systems

REVIEW | Updated：2025-10-30

- A Brief Review on Ultrasound Induced Drug Activation Systems
- A Brief Review on Ultrasound Induced Drug Activation Systems
- 高分子科学（英文） 2025年43卷第11期页码：1950-1972
- Affiliations：
  
  a.School of Pharmaceutical Science and Technology, Faculty of Medicine, Tianjin University, Tianjin 300072, China
  b.State Key Laboratory of Advanced Materials for Intelligent Sensing, Ministry of Science and Technology & Key Laboratory of Organic Integrated Circuit, Ministry·of Education & Tianjin Key Laboratory of Molecular Optoelectronic Sciences, Department of Chemistry, School of Science, Tianjin University, Tianjin 300072, China
- Author bio：
  
  yyuan@tju.edu.cn (Y.Y.)
  zhiyuan_shi2023@tju.edu.cn (Z.Y.S.)
- Funds：
  
  This work was financially supported by the Young Scientists Fund of the National Natural Science Foundation of China (No. 22305173), Young Scientists Fund of the Natural Science Foundation of Tianjin (No. S25QNM009), Tianjin University Independent Innovation Fund (No. 2025XSU-0008), the National Natural Science Foundation of China (No. 22475151), and Xiaomi Young Talents Program.;Yuan Yuan is an associate professor in the Department of Chemistry at Tianjin University (China). She received her B.S. and Ph.D. degrees in Chemistry from Tianjin University (China). Her research interests include mechano-responsive polymer materials and stretchable electronic encapsulation materials.Zhi-Yuan Shi is a professor and principal investigator (PI) at the School of Pharmaceutical Science and Technology, Tianjin University. She completed her undergraduate studies in Biology at the University of Göttingen, Germany, and subsequently obtained a Master's degree in Biomedical Engineering and Ph.D. in Chemistry from the RWTH Aachen University, Germany. From 2020 to the end of 2022, she worked on the development of bispecific antibodies at the University of Cologne, Germany. In 2023, she joined Tianjin University full time to conduct independent scientific research. Dr. Shi has been dedicated to research in sonopharmacology and sonogenetics. She pioneered the introduction of mechanical switch structures into drug systems using ultrasound and other mechanical forces to regulate the chemical properties of drugs, thereby achieving precise control of their pharmacodynamics and pharmacokinetics. She developed various mechanochemical prodrug activation systems, providing a novel theoretical and technical framework for drug development.
- DOI：10.1007/s10118-025-3398-3
  中图分类号：
- 收稿：2025-05-01，
  
  修回：2025-06-06，
  
  录用：2025-06-15，
  
  网络首发：2025-09-25，
  
  纸质出版：2025-11-05
- Accepted：
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Zhang, J. N.; Ma, Y. R.; Yuan, L. T. Y.; Jia, S.; Yu, X. M.; Yuan, Y.; Shi, Z. Y. A brief review on ultrasound induced drug activation systems. Chinese J. Polym. Sci. 2025, 43, 1950–1972

Jia-Ning Zhang, Yu-Ru Ma, Liu-Tian-Yun Yuan, et al. A Brief Review on Ultrasound Induced Drug Activation Systems[J]. Chinese Journal of Polymer Science, 2025, 43(11): 1950-1972.
Zhang, J. N.; Ma, Y. R.; Yuan, L. T. Y.; Jia, S.; Yu, X. M.; Yuan, Y.; Shi, Z. Y. A brief review on ultrasound induced drug activation systems. Chinese J. Polym. Sci. 2025, 43, 1950–1972 DOI： 10.1007/s10118-025-3398-3.

Jia-Ning Zhang, Yu-Ru Ma, Liu-Tian-Yun Yuan, et al. A Brief Review on Ultrasound Induced Drug Activation Systems[J]. Chinese Journal of Polymer Science, 2025, 43(11): 1950-1972. DOI： 10.1007/s10118-025-3398-3.

摘要

This review systematically investigates the mechanisms of ultrasound-induced cleavage of covalent/non-covalent bonds and ultrasound-induced generation of ROS through nanocarriers. We emphasize the role of ultrasound in drug molecule activation and its unique advantages. Finally

current challenges and future directions are discussed to broaden the application of ultrasound mechanochemistry.

Abstract

Ultrasound (US)

as an efficient and non-invasive trigger

has been extensively explored in drug delivery and has many advantages

such as deep penetration

low invasiveness

and high biochemical precision. These advantages demonstrate the immense clinical potential of ultrasound. This study aimed to provide a comprehensive analysis of ultrasound-induced shear forces that exhibit covalent/non-covalent bond cleavage and reactive oxygen species (ROS)-mediated remote control of nanocarriers. By doing so

we can gain a deeper understanding of the vital role

significant advantages

and untapped potential of ultrasound in molecular-level drug activation. Furthermore

clinical translation faces challenges such as the low drug-loading capacity of polymer chains

frequency compatibility between ultrasound parameters and biological systems

insufficient ROS generation

and biocompatibility of current sonosensitizers. To solve these problems

ultrasound mechanochemistry has emerged as a versatile therapeutic modality to promote the development of medical treatments.

关键词

Keywords

references

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