Nanocomposite from Alpha-Tocopheryl Succinate and Chitosan-modified-graphene for Efficient Inhibition on Choroidal Melanoma <italic style="font-style: italic">via</italic> a Chemotherapy-assisted-photothermal Therapy

Feng Yuan; Dan Lin; Yue Zhang; Kang Han; Qing Xu; He Ma; Ping-Ping Huang; Yong Liu; Ling-Dan Kong

doi:10.1007/s10118-025-3371-1

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Nanocomposite from Alpha-Tocopheryl Succinate and Chitosan-modified-graphene for Efficient Inhibition on Choroidal Melanoma via a Chemotherapy-assisted-photothermal Therapy

RESEARCH ARTICLE | Updated：2025-07-26

- Nanocomposite from Alpha-Tocopheryl Succinate and Chitosan-modified-graphene for Efficient Inhibition on Choroidal Melanoma via a Chemotherapy-assisted-photothermal Therapy
- Nanocomposite from Alpha-Tocopheryl Succinate and Chitosan-modified-graphene for Efficient Inhibition on Choroidal Melanoma via a Chemotherapy-assisted-photothermal Therapy
- 高分子科学（英文） 2025年43卷第8期页码：1387-1394
- Affiliations：
  
  a.Laboratory of Novel Optoelectronic Technology for Ophthalmic Devices (NOTOD), School of Ophthalmology and Optometry, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou 325027, China
  b.National Engineering Research Center of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou 325027, China
  c.National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou 325027, China
- Author bio：
  
  huangping2020@wmu.edu.cn (P.P.H.)
  yongliu@wmu.edu.cn (Y.L.)
  lingdankong@wmu.edu.cn (L.D.K.)
- Funds：
  
  This work was financially supported by the National Natural Science Foundation of China (Nos. 82202354, U20A20338), the Summit Advancement Disciplines of Zhejiang Province (Wenzhou Medical University Pharmaceutics), and Key R&D Program of Zhejiang Province (No. 2021C04019). We acknowledge the valuable consultation and instrument support from the Scientific Research Centre of Wenzhou Medical University.;Electronic supplementary information (ESI) is available free of charge in the online version of this article at http://doi.org/10.1007/s10118-025-3371-1.
- DOI：10.1007/s10118-025-3371-1
  中图分类号：
- 收稿：2024-12-25，
  
  修回：2025-04-27，
  
  录用：2025-05-02，
  
  网络首发：2025-07-03，
  
  纸质出版：2025-08-01
- Accepted：
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Yuan F.; Lin D.; Zhang Y.; Han K.; Xu Q.; Ma H.; Huang, P. P.; Liu, Y.; Kong, L. D. Nanocomposite from alpha-tocopheryl succinate and chitosan-modified-graphene for efficient inhibition on choroidal melanoma via a chemotherapy-assisted-photothermal therapy. Chinese J. Polym. Sci. 2025, 43, 1387–1394

Feng Yuan, Dan Lin, Yue Zhang, et al. Nanocomposite from Alpha-Tocopheryl Succinate and Chitosan-modified-graphene for Efficient Inhibition on Choroidal Melanoma via a Chemotherapy-assisted-photothermal Therapy[J]. Chinese Journal of Polymer Science, 2025, 43(8): 1387-1394. DOI: 10.1007/s10118-025-3371-1.
Yuan F.; Lin D.; Zhang Y.; Han K.; Xu Q.; Ma H.; Huang, P. P.; Liu, Y.; Kong, L. D. Nanocomposite from alpha-tocopheryl succinate and chitosan-modified-graphene for efficient inhibition on choroidal melanoma via a chemotherapy-assisted-photothermal therapy. Chinese J. Polym. Sci. 2025, 43, 1387–1394 DOI： 10.1007/s10118-025-3371-1.

Feng Yuan, Dan Lin, Yue Zhang, et al. Nanocomposite from Alpha-Tocopheryl Succinate and Chitosan-modified-graphene for Efficient Inhibition on Choroidal Melanoma via a Chemotherapy-assisted-photothermal Therapy[J]. Chinese Journal of Polymer Science, 2025, 43(8): 1387-1394. DOI: 10.1007/s10118-025-3371-1. DOI：

摘要

A multifunctional nanocomposite is prepared to efficiently inhibit choroidal melanoma (CM) using synergistic chemotherapy-assisted-photothermal therapy (CTH-PTT). This nanocomposite comprises alpha-tocopheryl succinate (

-TOS) and carboxylic chitosan-modified graphene (CG) to tackle the pivotal challenge of ocular malignancies such as CM.

Abstract

High mortality of choroidal melanoma (CM) is mainly attributed to the high likelihood of tumorous recurrence. The essential challenge lies in the presence of residual CM cells survived from the antitumor tr

eatment. These residual tumorous cells are most likely to cause tumorous recurrence. This article reports the preparation of a multifunctional nanocomposite which can be used to treat CM efficiently

via

a chemotherapy-assisted-photothermal therapy (CTH-PTT). The nanocomposite comprises of alpha-tocopheryl succinate (

-TOS) and carboxylic chitosan modified graphene (CG).

-TOS has been potentially seen as an efficient CTH antitumor drug while its deficiency such as easy being hydrolyzed by gastrointestinal esterase and poor hydrophilicity inevitable limits the clinic application of

-TOS. CG is introduced to overcome these shortcomings

offering additional advantages such as the PTT possibility for the antitumor application. The employment of CG-

-TOS on ocular CM cells caused more than 80% inhibition rates after irradiation under an 808 nm laser for 10 min. The outcomes of this work provide a facile and advantageous way to resolve the essential issue of the treatment of ocular tumors such as CM.

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Nanocomposite from Alpha-Tocopheryl Succinate and Chitosan-modified-graphene for Efficient Inhibition on Choroidal Melanoma via a Chemotherapy-assisted-photothermal Therapy

Nanocomposite from Alpha-Tocopheryl Succinate and Chitosan-modified-graphene for Efficient Inhibition on Choroidal Melanoma via a Chemotherapy-assisted-photothermal Therapy

DOI：10.1007/s10118-025-3371-1

摘要

Abstract

关键词

Keywords

references