Layered Gradient-structured Coating with Sustained Lubricating Performance for the Surface Functionalization of Implant Materials

Xiao-Bo Deng; Hong-Xiu Wei; Lin Yang; Feng Luo; Zhen Li; Hong Tan; Yan-Chao Wang; Jie-Hua Li

doi:10.1007/s10118-025-3328-4

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Layered Gradient-structured Coating with Sustained Lubricating Performance for the Surface Functionalization of Implant Materials

RESEARCH ARTICLE | Updated：2025-07-14

- Layered Gradient-structured Coating with Sustained Lubricating Performance for the Surface Functionalization of Implant Materials
- Layered Gradient-structured Coating with Sustained Lubricating Performance for the Surface Functionalization of Implant Materials
- 高分子科学（英文） 2025年43卷第6期页码：1050-1058
- Affiliations：
  
  a.College of Polymer Science and Engineering, National Key Laboratory of Advanced Polymer Materials, Sichuan University, Chengdu 610065, China
  b.Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu 610000, China
- Author bio：
  
  wangyanchao@scu.edu.cn (Y.C.W.)
  jiehua_li@scu.edu.cn (J.H.L.)
- Funds：
  
  This study was financially supported by the National Natural Science Foundation of China (Nos. 52373296 and 52173287). We thank Xiaomei Zhang from the Laboratory Animal Center of Sichuan University for the animal experiments.;Electronic supplementary information (ESI) is available free of charge in the online version of this article at http://doi.org/10.1007/s10118-025-3328-4.
- DOI：10.1007/s10118-025-3328-4
  中图分类号：
- 收稿：2025-01-24，
  
  修回：2025-02-19，
  
  录用：2025-02-26，
  
  网络首发：2025-04-24，
  
  纸质出版：2025-05-20
- Accepted：
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Deng, X. B.; Wei, H. X.; Yang, L.; Luo, F.; Li, Z.; Tan, H.; Wang, Y. C.; Li, J. H. Layered gradient-structured coating with sustained lubricating performance for the surface functionalization of implant materials. Chinese J. Polym. Sci. 2025, 43, 1050–1058

Xiao-Bo Deng, Hong-Xiu Wei, Lin Yang, et al. Layered Gradient-structured Coating with Sustained Lubricating Performance for the Surface Functionalization of Implant Materials[J]. Chinese Journal of Polymer Science, 2025, 43(6): 1050-1058.
Deng, X. B.; Wei, H. X.; Yang, L.; Luo, F.; Li, Z.; Tan, H.; Wang, Y. C.; Li, J. H. Layered gradient-structured coating with sustained lubricating performance for the surface functionalization of implant materials. Chinese J. Polym. Sci. 2025, 43, 1050–1058 DOI： 10.1007/s10118-025-3328-4.

Xiao-Bo Deng, Hong-Xiu Wei, Lin Yang, et al. Layered Gradient-structured Coating with Sustained Lubricating Performance for the Surface Functionalization of Implant Materials[J]. Chinese Journal of Polymer Science, 2025, 43(6): 1050-1058. DOI： 10.1007/s10118-025-3328-4.

摘要

By immersing the initiator on the material surface and enabling the concurrent polymerization reaction of AA and SBMA on the surface under ultraviolet initiation

followed by Q8C in the same manner

a coating with a stratified structure that exhibits persistent lubrication and antibacterial properties is obtained.

Abstract

Enhancing the lubricating properties and antibacterial adhesion resistance of implantable medical materials is critical to prevent soft tissue injury during implantation and the formation of bacterial biofilms. Prior studies may have exhibited limitations in the preparation methodologies and long-term stability of coatings for implantable medical materials. In this study

we developed a multilayered hybrid hydrogel coating method based on the rate difference of polymerization initiation on the material surface. The acquired coating with persistent lubrication capability retained its functionality after 2×10

cycles of friction and 21 days of PBS immersion. A quaternary ammonium salt coating with antibacterial properties was introduced to further functionalize the coating. Animal experiments demonstrated that this coating exhibited remarkable effects on delaying encrustation and bacterial colonization. These studies indicate that this simple method of introducing lubricating and antibacterial coatings on catheters is likely to enhance the biocompatibility of medical devices and has broad application prospects in this field of medical devices.

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references

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