Interferometers Utilizing Reversible X-ray-induced Chemical Changes in Poly(<italic style="font-style: italic">N</italic>-isopropylacrylamide) Microgels

Ya-Jie Wang; Ping Zhang; Michael J Serpe; Hong Chen; Liang Hu

doi:10.1007/s10118-024-3223-4

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Interferometers Utilizing Reversible X-ray-induced Chemical Changes in Poly(N-isopropylacrylamide) Microgels

RESEARCH ARTICLE | Updated：2024-12-03

- Interferometers Utilizing Reversible X-ray-induced Chemical Changes in Poly(N-isopropylacrylamide) Microgels
- Interferometers Utilizing Reversible X-ray-induced Chemical Changes in Poly(N-isopropylacrylamide) Microgels
- 高分子科学（英文版） 2024年42卷第12期页码：1915-1924
- Affiliations：
  
  a.State Key Laboratory of Radiation Medicine and Protection, Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, and School for Radiological and Interdisciplinary Sciences (RAD-X), Soochow University, Suzhou 215123, China
  b.State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China
  c.Department of Chemistry, University of Alberta, Edmonton, AB, T6G 2G2, Canada
- Author bio：
  
  chenh@suda.edu.cn (H.C.)
  huliang@suda.edu.cn (L.H.)
- Funds：
  
  This work was financially supported by Natural Science Foundation of Jiangsu Province (No. BK20221359), Interdisciplinary Basic Frontier Innovation Program of Suzhou Medical College of Soochow University, State Key Laboratory of Radiation Medicine and Protection (No. GZC00501), the National Natural Science Foundation of China (No. 51873137), and the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD). We also acknowledged the University of Alberta, the Natural Sciences and Engineering Research Council of Canada (NSERC), the Canada Foundation for Innovation (CFI), the Alberta Advanced Education & Technology Small Equipment Grants Program (AET/SEGP), and Grand Challenges Canada.;Electronic supplementary information (ESI) is available free of charge in the online version of this article at http://doi.org/10.1007/s10118-024-3223-4.
- DOI：10.1007/s10118-024-3223-4
  中图分类号： M
- 收稿：2024-06-26，
  
  修回：2024-08-19，
  
  录用：2024-08-20，
  
  网络首发：2024-10-31，
  
  纸质出版：2024-12-01
- Accepted：
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Wang, Y. J.; Zhang, P.; Serpe, M. J.; Chen, H.; Hu, L. Interferometers utilizing reversible X-ray-induced chemical changes in poly(N-isopropylacrylamide) microgels. Chinese J. Polym. Sci. 2024, 42, 1915–1924

Ya-Jie Wang, Ping Zhang, Michael J Serpe, et al. Interferometers Utilizing Reversible X-ray-induced Chemical Changes in Poly(N-isopropylacrylamide) Microgels[J]. Chinese Journal of Polymer Science, 2024, 42(12): 1915-1924. DOI: 10.1007/s10118-024-3223-4.
Wang, Y. J.; Zhang, P.; Serpe, M. J.; Chen, H.; Hu, L. Interferometers utilizing reversible X-ray-induced chemical changes in poly(N-isopropylacrylamide) microgels. Chinese J. Polym. Sci. 2024, 42, 1915–1924 DOI： 10.1007/s10118-024-3223-4.

Ya-Jie Wang, Ping Zhang, Michael J Serpe, et al. Interferometers Utilizing Reversible X-ray-induced Chemical Changes in Poly(N-isopropylacrylamide) Microgels[J]. Chinese Journal of Polymer Science, 2024, 42(12): 1915-1924. DOI: 10.1007/s10118-024-3223-4. DOI：

摘要

X-ray responsive pNIPAm microgel-based interferometers are capable of showing tunable colors in response to 0-16 Gy X-rays. This feature enables interferometers to trigger drug release through X-ray stimulation.

Abstract

Photonic materials

which react to light

have garnered interest due to their capability to exhibit adjustable structural colors. Typically

light targets the UV

visible

or near-IR spectrums. In this study

microgel-based photonic materials that are capable of reversibly responding to X-rays have been engineered. To accomplish this

azobenzene (Azo)-containing poly(

-isopropylacrylamide) (pNIPAm)-based microgels are synthesized. Subsequently

ZnS scintillator and Cr/Au are applied on each side of the poly(methyl methacrylate (PMMA) substrate. Subsequently

the Azo MG monolayer is deposited onto the Au surface

followed by the deposition of an additional layer of Cr/Au. This process generates ZnS/PMMA/Cr/Au/Azo MG/Cr/Au or ZnS/Au-Azo MG-Au structure. Functioning as a typical interferometer

ZnS/Au-Azo MG-Au demonstrates tunable colors based on the separation distance between the two Au layers. The ZnS scintillator can absorb and convert X-rays into UV light

initiating the transition of the Azo groups from a

trans

to a

cis

state. Consequently

this transition causes the Azo MG to swell. As Azo MG swells

the distance between the two Au layers increases

resulting in a red-shift of approximately 350 nm in the optical signal of the ZnS/Au-Azo MG-Au interferometer. Remarkably

this X-ray responsivity of the interferometer is reversible

as it returns to its initial state after being stored in the dark for 24 h. To demonstrate its capabilities

the ZnS/Au-Azo MG-Au interferometer successfully releases a drug when triggered by X-ray stimulation

thus validating its potential

. The microgel-based interferometers hold significant promise for applications in chemoradiotherapy

radiobiology

and actuators in space.

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Keywords

references

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Interferometers Utilizing Reversible X-ray-induced Chemical Changes in Poly(N-isopropylacrylamide) Microgels

Interferometers Utilizing Reversible X-ray-induced Chemical Changes in Poly(N-isopropylacrylamide) Microgels

DOI：10.1007/s10118-024-3223-4

摘要

Abstract

关键词

Keywords

references