Nanoparticle Induces Membrane Fusion in a State-wise and Property-sensitive Mode

Chi-Yun Ma; Xue-Wei Dong; Xue-Mei Lu; Bing Yuan; Kai Yang

doi:10.1007/s10118-024-3222-5

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Nanoparticle Induces Membrane Fusion in a State-wise and Property-sensitive Mode

RESEARCH ARTICLE | Updated：2024-12-31

- Nanoparticle Induces Membrane Fusion in a State-wise and Property-sensitive Mode
- Nanoparticle Induces Membrane Fusion in a State-wise and Property-sensitive Mode
- 高分子科学（英文） 2025年43卷第1期页码：235-244
- Affiliations：
  
  a.Center for Soft Condensed Matter Physics and Interdisciplinary Research & School of Physical Science and Technology, Soochow University, Suzhou 215006, China
  b.State Key Laboratory of Surface Physics and Department of Physics, Fudan University, Shanghai 200433, China
  c.School of Optical and Electronic Information, Suzhou City University, Suzhou 215104, China
  d.School of Physical Science and Technology, Jiangsu Key Laboratory of Thin Films, Soochow University, Suzhou 215006, China
  e.Songshan Lake Materials Laboratory, Dongguan 523808, China
- Author bio：
  
  dongxuewei@suda.edu.cn (X.W.D.)
  yangkai@suda.edu.cn (K.Y.)
- Funds：
  
  This work was financially supported by the National Natural Science Foundation of China (Nos. 22303060, 12274307, 32230063, 12347102 and 22203059), Natural Science Foundation of Jiangsu Province (Nos. BK20230470 and BK20210100), the Natural Science Foundation of Guangdong Province of China (No. 2023A1515011610), the Program of Jiangsu Provincial Key Lab of Thin Films (No. KJS2131) and the open research fund of State Key Laboratory of Surface Physics of Fudan University (No. KF2023_03).;Electronic supplementary information (ESI) is available free of charge in the online version of this article at http://doi.org/10.1007/s10118-024-3222-5.
- DOI：10.1007/s10118-024-3222-5
  中图分类号：
- 收稿：2024-07-18，
  
  修回：2024-08-15，
  
  录用：2024-08-19，
  
  网络首发：2024-11-07，
  
  纸质出版：2025-01-01
- Accepted：
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Ma, C. Y.; Dong, X. W.; Lu, X. M.; Yuan B.; Yang, K. Nanoparticle induces membrane fusion in a state-wise and property-sensitive mode. Chinese J. Polym. Sci. 2025, 43, 235–244

Chi-Yun Ma, Xue-Wei Dong, Xue-Mei Lu, et al. Nanoparticle Induces Membrane Fusion in a State-wise and Property-sensitive Mode[J]. Chinese Journal of Polymer Science, 2025, 43(1): 235-244.
Ma, C. Y.; Dong, X. W.; Lu, X. M.; Yuan B.; Yang, K. Nanoparticle induces membrane fusion in a state-wise and property-sensitive mode. Chinese J. Polym. Sci. 2025, 43, 235–244 DOI： 10.1007/s10118-024-3222-5.

Chi-Yun Ma, Xue-Wei Dong, Xue-Mei Lu, et al. Nanoparticle Induces Membrane Fusion in a State-wise and Property-sensitive Mode[J]. Chinese Journal of Polymer Science, 2025, 43(1): 235-244. DOI： 10.1007/s10118-024-3222-5.

摘要

NP-induced membrane fusion behaviors are systematically investigated by performing extensive CG-MD simulations. The vesicle-bilayer fusion induced by a hydrophobic NP is an intricately state-wise process. Moreover

NP properties (size

hydrophobicity and hydrophilicity) have distinct effects on membrane fusion and thus the optimal NP conditions for facilitating membrane fusion are obtained.

Abstract

Membrane fusion is essential for many cellular physiological functions

which is modulated by highly precise molecular mechanism involving multiple energy barriers. Nanoparticles (NPs)

which exhibit immense potential in the field of biomedical applications

can act as fusogen proteins to initiate and regulate membrane fusion. However

the underlying mechanisms of NP-induced membrane fusion and the molecular details involved remain largely elusive. Here

using coarse-grained molecular dynamics simulations

we systematically investigate the NP-induced membrane fusion behaviors and the influences of NP properties (size

hydrophobicity and hydrophilicity). Our results show that the vesicle-bilayer fusion induced by a hydrophobic NP is an intricately state-wise process

involving the approach and local deformation of the vesicle and bilayer bridging by the NP

the flip-flop of lipids from proximal leaflets and the formation of a fusion stalk

as well as further lipid interactions between distal leaflets and complete fusion. Moreover

we find that NP properties have distinct effects on membrane fusion and thus the optimal NP conditions for facilitating membrane fusion are obtained. Our work provides a mechanistic understanding of NP-induced membrane fusion and offers useful insights for efficient and controlled regulation of membrane fusion.

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references

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