Hydrogen-Bonding Crosslinked Supramolecular Polymer Materials: From Design Evolution of Side-Chain Hydrogen-Bonding to Applications

Qian Zhang; Zi-Yang Xu; Wen-Guang Liu

doi:10.1007/s10118-024-3204-7

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Hydrogen-Bonding Crosslinked Supramolecular Polymer Materials: From Design Evolution of Side-Chain Hydrogen-Bonding to Applications

REVIEW | Updated：2024-11-04

- Hydrogen-Bonding Crosslinked Supramolecular Polymer Materials: From Design Evolution of Side-Chain Hydrogen-Bonding to Applications
- Hydrogen-Bonding Crosslinked Supramolecular Polymer Materials: From Design Evolution of Side-Chain Hydrogen-Bonding to Applications
- 高分子科学（英文版） 2024年42卷第11期页码：1619-1641
- Affiliations：
  
  School of Materials Science and Engineering, Tianjin Key Laboratory of Composite and Functional Materials, Tianjin University, Tianjin 300350, China
- Author bio：
  
  xu_zy@tju.edu.cn (Z.Y.X.)
  wgliu@tju.edu.cn (W.G.L.)
- Funds：
  
  This work was financially supported by National Key Research and Development Program (No. 2018YFA0703100), the National Natural Science Foundation of China (No. 51733006) and China Postdoctoral Science Foundation (No. 2023M732578).;Qian Zhang received her Bachelor of Science degree in materials science and engineering from Southwest Jiaotong University in 2019. She is now a Ph.D. candidate at Tianjin University under the guidance of Prof. Wen-Guang Liu. Her current research involves high-strength hydrogels, 3D printing and meniscus substitutes.Zi-Yang Xu is a postdoctoral fellow at Tianjin University. He received his Ph.D. in polymer materials science and engineering from Tianjin University in 2022. His current research focuses on 3D printing supramolecular polymer hydrogels.Wen-Guang Liu is a professor at the School of Materials Science and Engineering at Tianjin University. He received his Ph.D. in Biomedical Engineering from Tianjin University in 1999. Dr Liu was a visiting scholar at The University of Hong Kong from July 2003 to January 2004. He did postdoctoral research at the Department of Cellular and Molecular Medicine, University of Ottawa (Canada) from March 2005 to November 2006. His current research focuses on functional polymers, hydrogels, regenerative medicine and tissue engineering.
- DOI：10.1007/s10118-024-3204-7
  中图分类号：
- 收稿：2024-06-06，
  
  修回：2024-07-01，
  
  录用：2024-07-07，
  
  网络首发：2024-09-13，
  
  纸质出版：2024-11-30
- Accepted：
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Zhang, Q.; Xu, Z. Y.; Liu, W. G. Hydrogen-bonding crosslinked supramolecular polymer materials: from design evolution of side-chain hydrogen-bonding to applications. Chinese J. Polym. Sci. 2024, 42, 1619–1641

Qian Zhang, Zi-Yang Xu, Wen-Guang Liu. Hydrogen-Bonding Crosslinked Supramolecular Polymer Materials: From Design Evolution of Side-Chain Hydrogen-Bonding to Applications[J]. Chinese Journal of Polymer Science, 2024, 42(11): 1619-1641.
Zhang, Q.; Xu, Z. Y.; Liu, W. G. Hydrogen-bonding crosslinked supramolecular polymer materials: from design evolution of side-chain hydrogen-bonding to applications. Chinese J. Polym. Sci. 2024, 42, 1619–1641 DOI： 10.1007/s10118-024-3204-7.

Qian Zhang, Zi-Yang Xu, Wen-Guang Liu. Hydrogen-Bonding Crosslinked Supramolecular Polymer Materials: From Design Evolution of Side-Chain Hydrogen-Bonding to Applications[J]. Chinese Journal of Polymer Science, 2024, 42(11): 1619-1641. DOI： 10.1007/s10118-024-3204-7.

摘要

Recent advancements in hydrogen-bonding crosslinked supramolecular polymer materials are comprehensively reviewed

with a focus on the design principles of hydrogen-bonding units featuring distinct side-chain chemical structures and the extensive applications of hydrogen bonding crosslinked systems. This review highlights how subtle structural variations in these units enable the fabrication of H-bonded supramolecular polymer materials with significantly diverse performances.

Abstract

Hydrogen bonds (H-bonds) are the most essential non-covalent interactions in nature

playing a crucial role in stabilizing the secondary structures of proteins. Taking inspiration from nature

researchers have developed several multiple H-bonds crosslinked supramolecular polymer materials through the incorporation of H-bond side-chain units into the polymer chains.

-acryloyl glycinamide (NAGA) is a monomer with dual amides in the side group

which facilitates the formation of multiple dense intermolecular H-bonds within poly(

-acryloyl glycinamide) (PNAGA)

thereby exhibiting diverse properties dependent on concentration and meeting various requirements across different applications. Moreover

numerous attempts have been undertaken to synthesize diverse NAGA-derived units through meticulous chemical structure regulation and fabricate corresponding H-bonding crosslinked supramolecular polymer materials. Despite this

the systematic clarification of the impact of chemical structures of side moieties on intermolecular associations and material performances remains lacking. The present review will focus on the design principle f

or synthesizing NAGA-derived H-bond side-chain units and provide an overview of the recent advancements in multiple H-bonds crosslinked PNAGA-derived supramolecular polymer materials

which can be categorized into three groups based on the chemical structure of H-bonds units: (1) monomers with solely cooperative H-bonds; (2) monomers with synergistic H-bonds and other physical interactions; and (3) diol chain extenders with cooperative H-bonds. The significance of subtle structural variations in these NAGA-derived units

enabling the fabrication of hydrogen-bonded supramolecular polymer materials with significantly diverse performances

will be emphasized. Moreover

the extensive applications of multiple H-bonds crosslinked supramolecular polymer materials will be elucidated.

关键词

Keywords

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