H<sub>2</sub>O<sub>2</sub>-Responsive Injectable Polymer Dots Hydrogel for Long-term Photodynamic Therapy of Tumors

Jian Wang; Ke Liang; Jian Li; Yun-Xiu Zhang; Xiao-Kuang Xue; Tie-Jin Chen; Yong-Liang Hao; Jia-Sheng Wu; Jie-Chao Ge

doi:10.1007/s10118-024-3155-z

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H₂O₂-Responsive Injectable Polymer Dots Hydrogel for Long-term Photodynamic Therapy of Tumors

RESEARCH ARTICLE | Updated：2024-11-04

- H₂O₂-Responsive Injectable Polymer Dots Hydrogel for Long-term Photodynamic Therapy of Tumors
- H₂O₂-Responsive Injectable Polymer Dots Hydrogel for Long-term Photodynamic Therapy of Tumors
- 高分子科学（英文版） 2024年42卷第11期页码：1690-1698
- Affiliations：
  
  a.Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China
  b.School of Future Technology, University of Chinese Academy of Sciences, Beijing 100049, China
- Author bio：
  
  wujs@mail.ipc.ac.cn (J.S.W.)
  jchge2010@mail.ipc.ac.cn (J.C.G.)
- Funds：
  
  This work was financially supported by the National Natural Science Foundation of China (Nos. 52272052 and 51972315).;Electronic supplementary information (ESI) is available free of charge in the online version of this article at http://doi.org/10.1007/s10118-024-3155-z.
- DOI：10.1007/s10118-024-3155-z
  中图分类号：
- 收稿：2024-03-27，
  
  修回：2024-04-26，
  
  录用：2024-05-04，
  
  网络首发：2024-06-26，
  
  纸质出版：2024-11-30
- Accepted：
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Wang, J.; Liang, K.; Li, J.; Zhang, Y. X.; Xue, X. K.; Chen, T. J.; Hao, Y. L.; Wu, J. S.; Ge, J. C. H₂O₂-responsive injectable polymer dots hydrogel for long-term photodynamic therapy of tumors. Chinese J. Polym. Sci. 2024, 42, 1690–1698 DOI: 10.1007/s10118-024-3155-z.

Jian Wang, Ke Liang, Jian Li, et al. H₂O₂-Responsive Injectable Polymer Dots Hydrogel for Long-term Photodynamic Therapy of Tumors[J]. Chinese Journal of Polymer Science, 2024, 42(11): 1690-1698. DOI: 10.1007/s10118-024-3155-z.
Wang, J.; Liang, K.; Li, J.; Zhang, Y. X.; Xue, X. K.; Chen, T. J.; Hao, Y. L.; Wu, J. S.; Ge, J. C. H₂O₂-responsive injectable polymer dots hydrogel for long-term photodynamic therapy of tumors. Chinese J. Polym. Sci. 2024, 42, 1690–1698 DOI: 10.1007/s10118-024-3155-z. DOI：

Jian Wang, Ke Liang, Jian Li, et al. H₂O₂-Responsive Injectable Polymer Dots Hydrogel for Long-term Photodynamic Therapy of Tumors[J]. Chinese Journal of Polymer Science, 2024, 42(11): 1690-1698. DOI: 10.1007/s10118-024-3155-z. DOI：

摘要

Here

a H

-responsive injectable hydrogel containing polythiophene quaternary ammonium salt polymer dots photosensitizers was fabricated. The obtained hydrogel realized a sustained photosensitizers retention for 7 days

in vivo

thus facilitating efficient tumor inhibition with 3 times light irridiation. This work presents an innovative delivery system for long-term PDT.

Abstract

Photodynamic therapy (PDT) has been emerged as a promising modality for cancer treatment. However

the development of drug delivery system enabling continuous release of photosensitizers (PSs) for long-term PDT treatment still remains challenges. Herein

a H

-responsive injectable hydrogel

covalently crosslinked by N

-(4-boronobenzyl)-N

-(4-boronophenyl)-N

-tetramethylpropane-1

3-diaminium (TSPBA) with PVA containing polythiophene quaternary ammonium salt (PT2) polymer dots (PDots) as a photos

ensitizer was fabricated. Under the stimulation of H

the obtained injectable hydrogel gradually degrades and releases PDots.

In vitro

experiments suggested that the released PDots could realize efficient tumor cells inhibition through its robust singlet oxygen generation capability upon 577 nm laser irradiation.

In vivo

studies demonstrated a sustained retention of PDots for at least 7 days following single-dose administration

facilitating efficient tumor inhibition with light treatments for 3 times without apparent biotoxicity. This work presents an innovative polymer dots-based composite local drug delivery system for long-term PDT in cancer treatment.

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Keywords

references

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H2O2-Responsive Injectable Polymer Dots Hydrogel for Long-term Photodynamic Therapy of Tumors

H2O2-Responsive Injectable Polymer Dots Hydrogel for Long-term Photodynamic Therapy of Tumors

DOI：10.1007/s10118-024-3155-z

摘要

Abstract

关键词

Keywords

references

H₂O₂-Responsive Injectable Polymer Dots Hydrogel for Long-term Photodynamic Therapy of Tumors

H₂O₂-Responsive Injectable Polymer Dots Hydrogel for Long-term Photodynamic Therapy of Tumors