Shear-thinning Catechol-modified Chitosan Hydrogel Loaded with Silver Nanoparticles for Endoscopic Submucosal Dissection

Wen-Jun Feng; Yan-He Wu; Xiao-Yang Liu; Zheng-Ke Wang

doi:10.1007/s10118-024-3146-0

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Shear-thinning Catechol-modified Chitosan Hydrogel Loaded with Silver Nanoparticles for Endoscopic Submucosal Dissection

RESEARCH ARTICLE | Updated：2024-08-06

- Shear-thinning Catechol-modified Chitosan Hydrogel Loaded with Silver Nanoparticles for Endoscopic Submucosal Dissection
- Shear-thinning Catechol-modified Chitosan Hydrogel Loaded with Silver Nanoparticles for Endoscopic Submucosal Dissection
- 高分子科学（英文版） 2024年42卷第8期页码：1147-1155
- Affiliations：
  
  MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310058, China
- Author bio：
  
  wangzk@zju.edu.cn
- Funds：
  
  This work was financially supported by Science Fund for Distinguished Young Scholars of Zhejiang Province (No. LR20E030004), the National Natural Science Foundation of China (No. 51873187) and National Basic Research Program of China (No. 2018YFC1004803).;Electronic supplementary information (ESI) is available free of charge in the online version of this article at http://doi.org/10.1007/s10118-024-3146-0.
- DOI：10.1007/s10118-024-3146-0
  中图分类号：
- 收稿：2024-03-05，
  
  修回：2024-04-21，
  
  录用：2024-04-24，
  
  网络首发：2024-06-26，
  
  纸质出版：2024-08-01
- Accepted：
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Feng, W. J.; Wu, Y. H.; Liu, X. Y.; Wang, Z. K. Shear-thinning catechol-modified chitosan hydrogel loaded with silver nanoparticles for endoscopic submucosal dissection. Chinese J. Polym. Sci. 2024, 42, 1147–1155

Wen-Jun Feng, Yan-He Wu, Xiao-Yang Liu, et al. Shear-thinning Catechol-modified Chitosan Hydrogel Loaded with Silver Nanoparticles for Endoscopic Submucosal Dissection[J]. Chinese Journal of Polymer Science, 2024, 42(8): 1147-1155.
Feng, W. J.; Wu, Y. H.; Liu, X. Y.; Wang, Z. K. Shear-thinning catechol-modified chitosan hydrogel loaded with silver nanoparticles for endoscopic submucosal dissection. Chinese J. Polym. Sci. 2024, 42, 1147–1155 DOI： 10.1007/s10118-024-3146-0.

Wen-Jun Feng, Yan-He Wu, Xiao-Yang Liu, et al. Shear-thinning Catechol-modified Chitosan Hydrogel Loaded with Silver Nanoparticles for Endoscopic Submucosal Dissection[J]. Chinese Journal of Polymer Science, 2024, 42(8): 1147-1155. DOI： 10.1007/s10118-024-3146-0.

摘要

A kind of injectable shear-thinning hydrogel for endoscopic submucosal dissection was developed

which has excellent shear-thinning and self-healing properties. And it can maintain more durable submucosal cushion height than normal saline. Integrated with good antibacterial activity

hemocompatibility and cytocompatibility

the hydrogel demonstrates a superiority in accelerating wound healing after operation.

Abstract

Shear-thinning hydrogels have emerged for endoscopic submucosal dissection

while wound intervention after surgery has rarely been mentioned. Herein

a catechol-modified chitosan hydrogel with shear-thinning property was developed for simultaneously facilitating endoscopic submucosal dissection and postoperative wound healing. Benefiting from the shear-thinning and self-healing characteristics

the as-prepared hydrogel showed easily endoscopic injectability. It also performed very well as submucosal cushion

which could remain above 70% after injection for 120 min in

ex vivo

porcine large intestine model. In fact

the cushion height of normal saline dramatically decreased to 46% of the initial height at 30 min. Ag nanoparticles encapsulated into the network endowed the hydrogel with almost reached 100% antibacterial effect against

E. coli

and

S. aureus.

The hemolysis ratio of the hydrogel was calculated to be as low as 0.8%. Combined with good hemocompatibility and cytocompatibility

the as-prepared hyd

rogel displayed much higher

in vivo

wound closure and healing efficacy than normal saline. These results demonstrated the superiority of the shear-thinning chitosan hydrogel in facilitating clinical endoscopic submucosal dissection surgery.

关键词

Keywords

references

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