Glucose-sensitive Membrane with PBA-based Contraction-type Linear Polymer as Chemical Valves Prepared by Surface Grafting

Chun-Peng Zhang; Si-Jia Gao; Ying Luo; Lei Zou; Yong-Jun Zhang

doi:10.1007/s10118-024-3135-3

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Glucose-sensitive Membrane with PBA-based Contraction-type Linear Polymer as Chemical Valves Prepared by Surface Grafting

RESEARCH ARTICLE | Updated：2024-08-06

- Glucose-sensitive Membrane with PBA-based Contraction-type Linear Polymer as Chemical Valves Prepared by Surface Grafting
- Glucose-sensitive Membrane with PBA-based Contraction-type Linear Polymer as Chemical Valves Prepared by Surface Grafting
- 高分子科学（英文版） 2024年42卷第8期页码：1067-1076
- Affiliations：
  
  a.State Key Laboratory of Separation Membranes and Membrane Processes, School of Material Science and Engineering, Tiangong University, Tianjin 300387, China
  b.State Key Laboratory of Separation Membranes and Membrane Processes, School of Pharmaceutical Sciences, Tiangong University, Tianjin 300387, China
  c.Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, Institute of Hepatobiliary Disease, Nankai University Affiliated Third Center Hospital, Tianjin 300170, China
  d.Cangzhou Institute of Tiangong University, Cangzhou 061000, China
- Author bio：
  
  gaosijia@tiangong.edu.cn (S.J.G.)
  zhangyj@tiangong.edu.cn (Y.J.Z.)
- Funds：
  
  This work was financially supported by the National Natural Science Foundation of China (Nos. 52033004, 52273109 and 22275137), Cangzhou Institute of Tiangong University (No. TGCYY-F-0203) and Hebei Province Natural Science Foundation (No. E2023110007).;Electronic supplementary information (ESI) is available free of charge in the online version of this article at http://doi.org/10.1007/s10118-024-3135-3.
- DOI：10.1007/s10118-024-3135-3
  中图分类号：
- 收稿：2024-01-18，
  
  修回：2024-04-02，
  
  录用：2024-04-07，
  
  网络首发：2024-05-17，
  
  纸质出版：2024-08-01
- Accepted：
Scan QR Code
Zhang, C. P.; Gao, S. J.; Luo, Y.; Zou, L.; Zhang, Y. J. Glucose-sensitive membrane with PBA-based contraction-type linear polymer as chemical valves prepared by surface grafting. Chinese J. Polym. Sci. 2024, 42, 1067–1076

Chun-Peng Zhang, Si-Jia Gao, Ying Luo, et al. Glucose-sensitive Membrane with PBA-based Contraction-type Linear Polymer as Chemical Valves Prepared by Surface Grafting[J]. Chinese Journal of Polymer Science, 2024, 42(8): 1067-1076.
Zhang, C. P.; Gao, S. J.; Luo, Y.; Zou, L.; Zhang, Y. J. Glucose-sensitive membrane with PBA-based contraction-type linear polymer as chemical valves prepared by surface grafting. Chinese J. Polym. Sci. 2024, 42, 1067–1076 DOI： 10.1007/s10118-024-3135-3.

Chun-Peng Zhang, Si-Jia Gao, Ying Luo, et al. Glucose-sensitive Membrane with PBA-based Contraction-type Linear Polymer as Chemical Valves Prepared by Surface Grafting[J]. Chinese Journal of Polymer Science, 2024, 42(8): 1067-1076. DOI： 10.1007/s10118-024-3135-3.

摘要

Glucose-sensitive membrane was prepared by grafting PBA-based contraction-type glucose-sensitive linear polymer on the membrane surface. When glucose concentration increases

the polymer chain shrinks and insulin release increases. Conversely

insulin release is reduced. The membrane has potential application in self-regulating insulin release.

Abstract

Glucose-sensitive membrane has potential application in self-regulating insulin release. Phenylboronic acid (PBA) is a well-known glucose reporter. Unfortunately

most PBA-based glucose-sensitive materials are expansion-type

which are not suitable as chemical valves in membrane pores for self-regulating insulin release. According to a new glucose-sensitive mechanism

we synthesized PBA-based contraction-type glucose-sensitive liner polymer and microgels. Herein

a glucose-sensitive membrane was prepared by grafting PBA-based contraction-type glucose-sensitive linear polymer on the membrane surface. Through adjusting the chain length and chain density

the glucose-sensitivity of the membrane was optimized. The membrane can reversibly regulate insulin release at physiologically relevant glucose concentrations in simulates body fluids and fetal bovine serum. The membrane also has good stability

anti-fouling and biocompatibility. It has potential application in self-regulating insulin release.

关键词

Keywords

references

Liu, Z; Wang, W; Xie, R; Ju, X. J; Chu, L. Y. Stimuli-responsive smart gating membranes. Chem. Soc. Rev. 2015 , 45 , 460−475..

Gholami, S; Zarkesh, I; Ghanian, M. H; Hajizadeh-Saffar, E; Hassan-Aghaei, F; Mohebi, M. M; Baharvand, H. Dynamically capped hierarchically porous microneedles enable post-fabrication loading and self-regulated transdermal delivery of insulin. Chem. Eng. J. 2020 , 421 , 127823..

Yu, J; Wang, J; Zhang, Y; Chen, G; Mao, W; Ye, Y; Kahkoska, A. R; Buse, J. B; Langer, R; Gu, Z. Glucose-responsive insulin patch for the regulation of blood glucose in mice and minipigs. Nat. Biomed. Eng. 2020 , 4 , 499−506..

Shen, D; Yu, H; Wang, L; Khan, A; Haq, F; Chen, X; Huang, Q; Teng, L. Recent progress in design and preparation of glucose-responsive insulin delivery systems. J. Control. Rel. 2020 , 321 , 236−258..

Yin, R; Tong, Z; Yang, D; Nie, J. Glucose and pH dual-responsive concanavalin a based microhydrogels for insulin delivery. Int. J. Biol. Macromol. 2011 , 49 , 1137−1142..

Wang, X; Li, Q; Guan, Y; Zhang, Y. Glucose oxidase-incorporated hydrogel thin film for fast optical glucose detecting under physiological conditions. Mater. Today. Chem . 2016 , 1−2 , 7−14..

Guan, Y; Zhang, Y. Boronic acid-containing hydrogels: Synthesis and their applications. Chem. Soc. Rev. 2013 , 42 , 8106−8121..

Tang, Y. J; Cheng, K; Tan, L. F; Xie, X. T; Zhang, B; Su, W. M; Zhao, Y. D; Xu, Q. R. pH and non-enzymatic glucose response at ultra-low concentration using sub-microchannel heterogeneous membrane. Chem. Eng. J. 2023 , 463 , 142438..

Huang, Q; Wang, L; Yu, H; Ur-Rahman, K. Advances in phenylboronic acid-based closed-loop smart drug delivery system for diabetic therapy. J. Control. Rel. 2019 , 305 , 50−64..

Chu, L. Y; Li, Y; Zhu, J. H; Wang, H. D; Liang, Y. J. Control of pore size and permeability of a glucose-responsive gating membrane for insulin delivery. J. Control. Release 2004 , 97 , 43−53..

Sun, X; Ji, W; Zhang, B; Ma, L; Fu, W; Qian, W; Zhang, X; Li, J; Sheng, E; Tao, Y; Zhu, D. A theranostic microneedle array patch for integrated glycemia sensing and self-regulated release of insulin. Biomater. Sci. 2022 , 10 , 1209−1216..

Hu, D. N; Ju, X. J; Pu, X. Q; Xie, R; Wang, W; Liu, Z; Chu, L. Y. Injectable temperature/glucose dual-responsive hydrogels for controlled release of insulin. Ind. Eng. Chem. Res. 2021 , 22 , 8147−8158..

Matsumoto, A; Tanaka, M; Matsumoto, H; Ochi, K; Moro-oka, Y; Kuwata, H; Yamada, H; Shirakawa, I; Miyazawa, T; Ishii, H; Kataoka, K; Ogawa, Y; Miyahara, Y; Suganami, T. Synthetic “smart gel” provides glucose-responsive insulin delivery in diabetic mice. Sci. Adv. 2017 , 3 , 0723..

Xing, S; Guan, Y; Zhang, Y. Kinetics of glucose-induced swelling of P(NIPAM-AAPBA) microgels. Macromolecules 2011 , 11 , 4479−4486..

Chen, S; Matsumoto, H; Moro-oka, Y; Tanaka, M; Miyahara, Y; Suganami, T; Matsumoto, A. Microneedle-array patch fabricated with enzyme-free polymeric components capable of on-demand insulin delivery. Adv. Funct. Mater. 2018 , 29 , 1807369..

Tang, Z; Guan, Y; Zhang, Y. The synthesis of a contraction-type glucose-sensitive microgel working at physiological temperature guided by a new glucose-sensing mechanism. Polym. Chem. 2018 , 9 , 1012−1021..

Wang, Q; Fu, M; Guan, Y; James, T. D; Zhang, Y. Mechanistic insights into the novel glucose-sensitive behavior of P(NIPAM- co -2-AAPBA). Sci. China Chem. 2020 , 63 , 377−385..

Yang, X; Lee, M. C; Sartain, F; Pan, X; Lowe, C. R. Designed boronate ligands for glucose-selective holographic sensors. Chem. Eur. J. 2006 , 33 , 8491−8497..

Tang, Z; Guan, Y; Zhang, Y. Contraction-type glucose-sensitive microgel functionalized with a 2-substituted phenylboronic acid ligand. Polym. Chem. 2013 , 5 , 1782−1790..

Tang, Z; Weng, J; Guan, Y; Zhang, Y. Unexpected large depression of VPTT of a PNIPAM microgel by low concentration of PVA. Macromol. Chem. Phys. 2017 , 218 , 1700364..

Liu, J; Gao, S; Luo, Y; Zhang, C; Zhang, P; Wang, Z; Zou, L; Zhao, Z; Zhang, Y. Glucose-sensitive poly(ether sulfone) composite membranes blended with phenylboronic acid-based amphiphilic block copolymer for self-regulated insulin release. J. Mater. Chem. B 2023 , 11 , 5000−5009..

Huang, D; Gao, S; Luo, Y; Zhou, X; Lu, Z; Zou, L; Hu, K; Zhao, Z; Zhang, Y. Glucose-sensitive membrane with phenylboronic acid-based contraction-type microgels as chemical valves. J. Membr. Sci. 2022 , 650 , 120406..

Zheng, Z; Gu, Z; Huo, R; Luo, Z. Fabrication of self-cleaning poly(vinylidene fluoride) membrane with micro/nanoscaled two-tier roughness. J. Appl. Polym. Sci. 2011 , 122 , 1268−1274..

Dong, L; Liu, X; Xiong, Z; Sheng, D; Lin, C; Zhou, Y; Yang, Y. Fabrication of highly efficient ultraviolet absorbing PVDF membranes via surface polydopamine deposition. J. Appl. Polym. Sci. 2017 , 135 , 45746..

Ye, J. L; Guo, M. Y; Han, C; Zhang, Y. F; Meng, J. Q. Multifunctionalization of RC membrane via combining surface initiated RAFT polymerization with thiolactone chemistry for enhanced antibody recovery. Polymer 2022 , 261 , 125414..

Chen, Y; Sun, W; Deng, Q; Chen, L. Controlled grafting from poly(vinylidene fluoride) films by surface-initia ted reversible addition-fragmentation chain transfer polymerization. J. Polym. Sci., Part A: Polym. Chem. 2006 , 44 , 3071−3082..

Shen, X; Yin, X; Zhao, Y; Chen, L. Improved protein fouling resistance of PVDF membrane grafted with the polyampholyte layers. Colloid. Polym. Sci. 2015 , 293 , 1205−1213..

Gaballa, H; Theato, P. Glucose-responsive polymeric micelles via boronic acid-diol complexation for insulin delivery at neutral pH. Biomacromolecules 2019 , 2 , 871−881..

Adelsberger, J; Kulkarni, A; Jain, A; Wang, W; Bivigou-Koumba, A. M; Busch, P; Pipich, V; Holderer, O; Hellweg, T; Laschewsky, A; Müller-Buschbaum, P; Papadakis, C. M. Thermoresponsive PS- b -PNIPAM- b -PS micelles: aggregation behavior, segmental dynamics, and thermal response. Macromolecules 2010 , 5 , 2490−2501..

Liu, J; Wang, N; Yu, L. J; Karton, A; Li, W; Zhang, W; Guo, F; Hou, L; Cheng, Q; Jiang, L; Weitz, D. A; Zhao, Y. Bioinspired graphene membrane with temperature tunable channels for water gating and molecular separation. Nat. Commun. 2017 , 5 , 02198..

Lin, Y. C; Tseng, H. H; Wang, D. K. Uncovering the effects of PEG porogen molecular weight and concentration on ultrafiltration membrane properties and protein purification performance. J. Membr. Sci. 2021 , 618 , 118729..

Sun, B; Lin, Y; Wu, P. Structure analysis of poly( N -isopropylacrylamide) using near-infrared spectroscopy and generalized two-dimensional correlation infrared spectroscopy. Appl. Spectrosc. 2007 , 61 , 765−771..

Chen, P. C; Wan, L. S; Ke, B. B; Xu, Z. K. Honeycomb-patterned film segregated with phenylboronic acid for glucose sensing. Langmuir 2011 , 20 , 12597−12605..

Lue, S. J; Hsu, J. J; Wei, T. C. Drug permeation modeling through the thermo-sensitive membranes of poly( N -isopropylacrylamide) brushes grafted onto micro-porous films. J. Membr. Sci. 2008 , 321 , 146−154..

Li, P. F; Xie, R; Jiang, J. C; Meng, T; Yang, M; Ju, X. J; Yang, L; Chu, L. Y. Thermo-responsive gating membranes with controllable length and density of poly( N -isopropylacrylamide) chains grafted by ATRP method. J. Membr. Sci. 2009 , 337 , 310−317..

Roghani-Mamaqani, H; Khezri, K. A grafting from approach to graft polystyrene chains at the surface of graphene nanolayers by RAFT polymerization: various graft densities from hydroxyl groups. Appl. Surf. Sci. 2016 , 360 , 373−382..

Takahashi, H; Nakayama, M; Yamato, M; Okano, T. Controlled chain length and graft density of thermoresponsive polymer brushes for optimizing cell sheet harvest. Biomacromolecules 2010 , 8 , 1991−1999..

Liu, H; Zhao, X; Jia, N; Sotto, A; Zhao, Y; Shen, J; Gao, C; van der Bruggen, B. Engineering of thermo-/pH-responsive membranes with enhanced gating coefficients, reversible behaviors and self-cleaning performance through acetic acid boosted microgel assembly. J. Mater. Chem. A 2018 , 6 , 11874−11883..

Liu, H; Yang, S; Liu, Y; Miao, M; Zhao, Y; Sotto, A; Gao, C; Shen, J. Fabricating a pH-responsive membrane through interfacial in-situ assembly of microgels for water gating and self-cleaning. J. Membr. Sci. 2019 , 579 , 230−239..

Shen, S; Hao, Y; Zhang, Y; Zhang, G; Zhou , X; Bai, R. B. Enhancing the antifouling properties of poly(vinylidene fluoride) (PVDF) membrane through a novel blending and surface-grafting modification approach. ACS Omega 2018 , 12 , 17403−17415..

Kavand, A; Blanck, C; Przybilla, F; Mély, Y; Anton, N; Vandamme, T; Serra, C. A; Chan-Seng, D. Investigating the growth of hyperbranched polymers by self-condensing vinyl RAFT copolymerization from the surface of upconversion nanoparticles. Polym. Chem. 2020 , 11 , 4313−4325..

Wang, W; Yu, Y; Wang, P; Wang, Q; Li, Y; Yuan, J; Fan, X. Controlled graft polymerization on the surface of filter paper via enzyme-initiated RAFT polymerization. Carbohydr. Polym. 2018 , 207 , 239−245..

Chang, C. C; Beltsios, K. G; Lin, J. D; Cheng, L. P. Nano-titania/polyethersulfone composite ultrafiltration membranes with optimized antifouling capacity. J. Taiwan Inst. Chem. E 2020 , 113 , 325−331..

Liu, F; Zhu, B. K; Xu, Y. Y. Improving the hydrophilicity of poly(vinylidene fluoride) porous membranes by electron beam initiated surface grafting of AA/SSS binary monomers. Appl. Surf. Sci. 2006 , 253 , 2096−2101..

Gordijo, C. R; Shuhendler, A. J; Wu, X. Y. Glucose-responsive bioinorganic nanohybrid membrane for self-regulated insulin release. Adv. Funct. Mater. 2010 , 20 , 1404−1412..

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