Glucose-sensitive Membrane with PBA-based Contraction-type Linear Polymer as Chemical Valves Prepared by Surface Grafting

Chun-Peng Zhang; Si-Jia Gao; Ying Luo; Lei Zou; Yong-Jun Zhang

doi:10.1007/s10118-024-3135-3

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Glucose-sensitive Membrane with PBA-based Contraction-type Linear Polymer as Chemical Valves Prepared by Surface Grafting

RESEARCH ARTICLE | Updated：2024-08-06

- Glucose-sensitive Membrane with PBA-based Contraction-type Linear Polymer as Chemical Valves Prepared by Surface Grafting
- Glucose-sensitive Membrane with PBA-based Contraction-type Linear Polymer as Chemical Valves Prepared by Surface Grafting
- 高分子科学（英文版） 2024年42卷第8期页码：1067-1076
- Affiliations：
  
  a.State Key Laboratory of Separation Membranes and Membrane Processes, School of Material Science and Engineering, Tiangong University, Tianjin 300387, China
  b.State Key Laboratory of Separation Membranes and Membrane Processes, School of Pharmaceutical Sciences, Tiangong University, Tianjin 300387, China
  c.Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, Institute of Hepatobiliary Disease, Nankai University Affiliated Third Center Hospital, Tianjin 300170, China
  d.Cangzhou Institute of Tiangong University, Cangzhou 061000, China
- Author bio：
  
  gaosijia@tiangong.edu.cn (S.J.G.)
  zhangyj@tiangong.edu.cn (Y.J.Z.)
- Funds：
  
  This work was financially supported by the National Natural Science Foundation of China (Nos. 52033004, 52273109 and 22275137), Cangzhou Institute of Tiangong University (No. TGCYY-F-0203) and Hebei Province Natural Science Foundation (No. E2023110007).;Electronic supplementary information (ESI) is available free of charge in the online version of this article at http://doi.org/10.1007/s10118-024-3135-3.
- DOI：10.1007/s10118-024-3135-3
  中图分类号：
- 纸质出版日期：2024-08-01，
  
  网络出版日期：2024-05-17，
  
  收稿日期：2024-01-18，
  
  修回日期：2024-04-02，
  
  录用日期：2024-04-07
- Accepted：
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Zhang, C. P.; Gao, S. J.; Luo, Y.; Zou, L.; Zhang, Y. J. Glucose-sensitive membrane with PBA-based contraction-type linear polymer as chemical valves prepared by surface grafting. Chinese J. Polym. Sci. 2024, 42, 1067–1076

Chun-Peng Zhang, Si-Jia Gao, Ying Luo, et al. Glucose-sensitive Membrane with PBA-based Contraction-type Linear Polymer as Chemical Valves Prepared by Surface Grafting[J]. Chinese Journal of Polymer Science, 2024,42(8):1067-1076.
Zhang, C. P.; Gao, S. J.; Luo, Y.; Zou, L.; Zhang, Y. J. Glucose-sensitive membrane with PBA-based contraction-type linear polymer as chemical valves prepared by surface grafting. Chinese J. Polym. Sci. 2024, 42, 1067–1076 DOI： 10.1007/s10118-024-3135-3.

Chun-Peng Zhang, Si-Jia Gao, Ying Luo, et al. Glucose-sensitive Membrane with PBA-based Contraction-type Linear Polymer as Chemical Valves Prepared by Surface Grafting[J]. Chinese Journal of Polymer Science, 2024,42(8):1067-1076. DOI： 10.1007/s10118-024-3135-3.

摘要

Glucose-sensitive membrane was prepared by grafting PBA-based contraction-type glucose-sensitive linear polymer on the membrane surface. When glucose concentration increases

the polymer chain shrinks and insulin release increases. Conversely

insulin release is reduced. The membrane has potential application in self-regulating insulin release.

Abstract

Glucose-sensitive membrane has potential application in self-regulating insulin release. Phenylboronic acid (PBA) is a well-known glucose reporter. Unfortunately

most PBA-based glucose-sensitive materials are expansion-type

which are not suitable as chemical valves in membrane pores for self-regulating insulin release. According to a new glucose-sensitive mechanism

we synthesized PBA-based contraction-type glucose-sensitive liner polymer and microgels. Herein

a glucose-sensitive membrane was prepared by grafting PBA-based contraction-type glucose-sensitive linear polymer on the membrane surface. Through adjusting the chain length and chain density

the glucose-sensitivity of the membrane was optimized. The membrane can reversibly regulate insulin release at physiologically relevant glucose concentrations in simulates body fluids and fetal bovine serum. The membrane also has good stability

anti-fouling and biocompatibility. It has potential application in self-regulating insulin release.

关键词

Keywords

Phenylboronic acidGlucose-sensitiveMembraneSurface graftingInsulin

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