Unconventional Fluorescent and Multi-responsive Polyethyleneimine with LCST and UCST Behavior: Synthesis, Characterization and Biological Applications

Feng-Ming Yin; Li-Li Wu; Shu-Sheng Li; Xiao-Na Pan; Xiao-Li Zhu; Xu-Bao Jiang; Xiang Zheng Kong

doi:10.1007/s10118-024-3120-x

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Unconventional Fluorescent and Multi-responsive Polyethyleneimine with LCST and UCST Behavior: Synthesis, Characterization and Biological Applications

RESEARCH ARTICLE | Updated：2024-05-11

- Unconventional Fluorescent and Multi-responsive Polyethyleneimine with LCST and UCST Behavior: Synthesis, Characterization and Biological Applications
- Unconventional Fluorescent and Multi-responsive Polyethyleneimine with LCST and UCST Behavior: Synthesis, Characterization and Biological Applications
- 高分子科学（英文版） 2024年42卷第6期页码：826-837
- Affiliations：
  
  a.College of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, China
  b.Shandong Institute for Product Quality Inspection, Jinan 250102, China
  c.College of Chemical Engineering, Tianjin University, Tianjin 300072, China
- Author bio：
  
  chm_liss@ujn.edu.cn (S.S.L.)
  chm_zhuxl@ujn.edu.cn (X.L.Z.)
- Funds：
  
  This work was financially supported by Nature Science Foundation of Shandong Province, China (Nos. ZR2021MB112 and ZR2022MB051), Science and Technology Bureau of Jinan City (2021GXRC105), Postdoctoral Science Foundation of China (2022M712343), as well as by Basic and Applied Basic Research Foundation (2020A1515110374) of Guangdong Province, China.;Electronic supplementary information (ESI) is available free of charge in the online version of this article at http://doi.org/10.1007/s10118-024-3120-x.
- DOI：10.1007/s10118-024-3120-x
  中图分类号：
- 收稿：2024-01-31，
  
  修回：2024-2-24，
  
  录用：2024-3-6，
  
  网络首发：2024-04-15，
  
  纸质出版：2024-06-01
- Accepted：
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Yin, F. M.; Wu, L. L.; Li, S. S.; Pan, X. N.; Zhu, X. L.; Jiang, X. B.; Kong, X. Z. Unconventional fluorescent and multi-responsive polyethyleneimine with LCST and UCST behavior: synthesis, characterization and biological applications. Chinese J. Polym. Sci. 2024, 42, 826–837

Feng-Ming Yin, Li-Li Wu, Shu-Sheng Li, et al. Unconventional Fluorescent and Multi-responsive Polyethyleneimine with LCST and UCST Behavior: Synthesis, Characterization and Biological Applications[J]. Chinese Journal of Polymer Science, 2024, 42(6): 826-837.
Yin, F. M.; Wu, L. L.; Li, S. S.; Pan, X. N.; Zhu, X. L.; Jiang, X. B.; Kong, X. Z. Unconventional fluorescent and multi-responsive polyethyleneimine with LCST and UCST behavior: synthesis, characterization and biological applications. Chinese J. Polym. Sci. 2024, 42, 826–837 DOI： 10.1007/s10118-024-3120-x.

Feng-Ming Yin, Li-Li Wu, Shu-Sheng Li, et al. Unconventional Fluorescent and Multi-responsive Polyethyleneimine with LCST and UCST Behavior: Synthesis, Characterization and Biological Applications[J]. Chinese Journal of Polymer Science, 2024, 42(6): 826-837. DOI： 10.1007/s10118-024-3120-x.

摘要

Synthesised fluorescent and multi-responsive polyethyleneimine (RFPEI) exhibits both LCST and UCST properties in water and stimuli-adjustable fluorescence emission. Its fluorescence properties and phase transition process are examined systematicly. RFPEI shows great potential for cell imaging

trace detection

and controlled release of doxorubicin.

Abstract

Non-aromatic fluorescent and multi-responsive materials

exhibiting inherent fluorescence emission and controlled phase change

have garnered significant attention in recent years. However

the underlying interaction between their fluorescent properties and phase transition remains unclear. In this study

we synthesized a series of catalyst-free aza-Michael addition-based polyethyleneimine (RFPEI) materials by reacting polyethyleneimine (PEI) with

-isopropyl acrylamide (NIPAM). The resulting RFPEI was comprehensively characterized

and demonstrated dual-phase transition behavior (LCST and UCST) in water

which could be finely tuned by adjusting its composition or external factors such as pH. Notably

upon UV irradiation (365 nm)

RFPEI exhibited strong fluorescence emission. We further investigated the effects of NIPAM grafting percentage to PEI

polymer concentration

and pH on the LCST/UCST and fluorescent properties of RFPEI aqueous solutions. Moreover

we showcased the great potential of RFPEI as a versatile tool for physiological cell imaging

trace detection

and controlled release of doxorubicin. Our study presents a novel class of stimuli-responsive fluorescent materials with promising applications in the field of biomedicine.

关键词

Keywords

references

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