Unconventional Fluorescent and Multi-responsive Polysiloxane: Synthesis, Characterization and Biological Applications

Xiao-Di Li; Shu-Sheng Li; Xu-Bao Jiang; Xiao-Li Zhu; Xiang Zheng Kong

doi:10.1007/s10118-024-3091-y

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Unconventional Fluorescent and Multi-responsive Polysiloxane: Synthesis, Characterization and Biological Applications

RESEARCH ARTICLE | Updated：2024-04-12

- Unconventional Fluorescent and Multi-responsive Polysiloxane: Synthesis, Characterization and Biological Applications
- Unconventional Fluorescent and Multi-responsive Polysiloxane: Synthesis, Characterization and Biological Applications
- 高分子科学（英文版） 2024年42卷第5期页码：579-590
- Affiliations：
  
  a.College of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, China
  b.College of Chemical Engineering, Tianjin University, Tianjin 300072, China
  c.Foshan (Southern China) Institute for New Materials, Foshan 528200, China
- Author bio：
  
  chm_liss@ujn.edu.cn (S.S.L.)
  chm_zhuxl@ujn.edu.cn (X.L.Z.)
- Funds：
  
  This work was financially supported by Nature Science Foundation of Shandong Province, China (Nos. ZR2021MB112 and ZR2022MB051), Science and Technology Bureau of Jinan City (No. 2021GXRC105), Postdoctoral Science Foundation of China (No. 2022M712343), as well as by Basic and Applied Basic Research Foundation (No. 2020A1515110374) of Guangdong Province, China.;Electronic supplementary information (ESI) is available free of charge in the online version of this article at http://doi.org/10.1007/s10118-024-3091-y.
- DOI：10.1007/s10118-024-3091-y
  中图分类号：
- 收稿：2023-11-17，
  
  修回：2023-12-22，
  
  录用：2023-12-27，
  
  网络首发：2024-02-23，
  
  纸质出版：2024-05-01
- Accepted：
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Li, X. D.; Li, S. S.; Jiang, X. B.; Zhu, X. L.; Kong, X. Z. Unconventional fluorescent and multi-responsive polysiloxane: synthesis, characterization and biological applications. Chinese J. Polym. Sci. 2024, 42, 579–590

Xiao-Di Li, Shu-Sheng Li, Xu-Bao Jiang, et al. Unconventional Fluorescent and Multi-responsive Polysiloxane: Synthesis, Characterization and Biological Applications[J]. Chinese Journal of Polymer Science, 2024, 42(5): 579-590.
Li, X. D.; Li, S. S.; Jiang, X. B.; Zhu, X. L.; Kong, X. Z. Unconventional fluorescent and multi-responsive polysiloxane: synthesis, characterization and biological applications. Chinese J. Polym. Sci. 2024, 42, 579–590 DOI： 10.1007/s10118-024-3091-y.

Xiao-Di Li, Shu-Sheng Li, Xu-Bao Jiang, et al. Unconventional Fluorescent and Multi-responsive Polysiloxane: Synthesis, Characterization and Biological Applications[J]. Chinese Journal of Polymer Science, 2024, 42(5): 579-590. DOI： 10.1007/s10118-024-3091-y.

摘要

Fluorescent and multi-responsive polysiloxane (FRPS) is synthesized. FRPS is not only highly sensitive to temperature

pH and CO

in water

but also showed an enhanced and stimuli-adjustable fluorescence emission. FRPS is used as physiological indicator for cell imaging

and for controlled release and trace detection of doxorubicin (DOX).

Abstract

Owing to their high significance in fundamental study and diverse applications

stimuli-responsive and fluorescent polymers

particularly those with cluster-triggered emission (CTE) featured by non-conjugated chromophores

have drawn tremendous attention in recent years. In this work

fluorescent and multi-responsive polysiloxane (FRPS) was synthesized by hydrolytic condensation polymerization of 3-aminopropyl methyl diethoxysilane (APMS) with 3-(

-isopropyl propionamide) iminopropyl methyl diethoxysilane (APMS-NIP)

which was formed

in situ

through aza-Michael addition between APMS and

-isopropyl acrylamide. FRPS was not only highly sensitive to temperature

pH and CO

in water

but also showed an enhanced and stimuli-adjustable fluorescence emission. The effects of monomer feeding

pH and CO

on its lower critical solution temperature and fluorescent property were investigated. FRPS fluorescence emission was ascribed to CTE mechanism. In addition

FRPS was shown to be highly potential as physiological indicator for cell imaging

and for controlled release and trace detection of doxorubicin. This study provides therefore a type of stimuli-responsive and fluorescent material for potential applications in biomedical fields

and it is also of great significance for understanding of the fluorescence mechanism of polysiloxane-based stimuli-responsive polymers.

关键词

Keywords

references

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