Design of Biologically Active Macromolecular Ligands and Their Luminescent Complexes with Terbium Ions

Тatiana N. Nekrasova; Аndrei I. Fischer; Natalia А. Nesterova; Anatoliy V. Dobrodumov; Anzhelika V. Garshinina; Оlga D. Shuvaeva; Natalya V. Zakharova; Evgenii F. Panarin

doi:10.1007/s10118-024-3081-0

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Design of Biologically Active Macromolecular Ligands and Their Luminescent Complexes with Terbium Ions

RESEARCH ARTICLE | Updated：2024-04-12

- Design of Biologically Active Macromolecular Ligands and Their Luminescent Complexes with Terbium Ions
- Design of Biologically Active Macromolecular Ligands and Their Luminescent Complexes with Terbium Ions
- 高分子科学（英文版） 2024年42卷第5期页码：604-611
- Affiliations：
  
  a.Institute of Macromolecular Compounds, Russian Academy of Sciences, 31 Bolshoy pr., St Petersburg 199004, Russia
  b.Smorodintsev Research Institute of Influenza, Russian Ministry of Health, 15/17 ul. prof. Popova, St Petersburg 197376, Russia
- Author bio：
  
  polar@macro.ru (T.N.N.)
  andreasfischer@mail.ru (A.I.F.)
- Funds：
  
  The work was carried out as part of a State Assignment 12212100171-8.;Electronic supplementary information (ESI) is available free of charge in the online version of this article at http://doi.org/10.1007/s10118-024-3081-0.
- DOI：10.1007/s10118-024-3081-0
  中图分类号：
- 收稿：2023-11-17，
  
  修回：2023-12-2，
  
  录用：2023-12-15，
  
  网络首发：2024-01-25，
  
  纸质出版：2024-05-01
- Accepted：
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Nekrasova, Т. N.; Fischer, А. I.; Nesterova, N. А.; Dobrodumov, A. V.; Garshinina, A. V.; Shuvaeva, О. D.; Zakharova, N. V.; Panarin, E. F. Design of biologically active macromolecular ligands and their luminescent complexes with terbium ions. Chinese J. Polym. Sci. 2024, 42, 604–611

Тatiana N. Nekrasova, Аndrei I. Fischer, Natalia А. Nesterova, et al. Design of Biologically Active Macromolecular Ligands and Their Luminescent Complexes with Terbium Ions[J]. Chinese Journal of Polymer Science, 2024, 42(5): 604-611.
Nekrasova, Т. N.; Fischer, А. I.; Nesterova, N. А.; Dobrodumov, A. V.; Garshinina, A. V.; Shuvaeva, О. D.; Zakharova, N. V.; Panarin, E. F. Design of biologically active macromolecular ligands and their luminescent complexes with terbium ions. Chinese J. Polym. Sci. 2024, 42, 604–611 DOI： 10.1007/s10118-024-3081-0.

Тatiana N. Nekrasova, Аndrei I. Fischer, Natalia А. Nesterova, et al. Design of Biologically Active Macromolecular Ligands and Their Luminescent Complexes with Terbium Ions[J]. Chinese Journal of Polymer Science, 2024, 42(5): 604-611. DOI： 10.1007/s10118-024-3081-0.

摘要

In the Tb

complexes with the vinylamide copolymers of pmethacrylamidobenzoic acid

water molecules located in the vicinity of carbonyl groups C=O and strongly bound by hydrogen bonds are partially included in the coordination sphere of Tb

. As a result

OH vibrations of the coordinated water molecules

which are the main process of luminescence quenching

are difficult. This leads to a significant increase in luminescence in compared with other copolymers.

Abstract

Water-soluble copolymers of

-methacrylamidobenzoic acid (MABA) with neutral comonomers (

-vinylpyrrolidone (VP)

-methyl-

-vinylacetamide (MVAA)

-methacryloyl glucosamine (MAG)) and anionic comononer sodium styrene sulfonate (NaSS) were synthesized by radical copolymerization. The interactions between the prepared copolymers and Tb

ions in aqueous solutions were studied; the significant influence of chemical structure of a comonomer on luminescence intensity of Tb

complexes with the copolymers was revealed. The luminescence intensity of Tb

complexes with the copolymers containing

-vinylamide units (VP

MVAA) is three times more intense than that observed for the complexes between Tb

and MAG-containing copolymers. In the case of NaSS-containing copolymers

the luminescence intensity is controlled by the values of binding constants between Tb

and MABA and the content of MABA units in a copolymer. The studied copolymers and their complexes with Tb

have low cytotoxicity and a pronounced antiviral activity against human respiratory syncytial virus.

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references

Panarin, E. F.; Fischer, A. I.; Nesterova, N. A.; Shtro, A. A.; Dobrodumov, A. V.; Gavrilova, I. I.; Manakhov, V. A.; Nekrasova, T. N. Luminescent polyelectrolytes with antiviral activity. Russ. Chem. Bull. 2022 , 71 , 2352−2357..

Zarubaev, V. V.; Buchkov, E. V.; Nazarova, O. V.; Zolotovа, Yu. I.; Panarin, E. F. Synthesis and anti-influenza activity of vinylphosphonic acid (co)polymers. Dokl. Biochem. Biophys. 2022 , 506 , 227−230..

Kaczmarek, M. T.; Zabiszak, M.; Nowak, M.; Jastrzab, R. Lanthanides: Schiff base complexes, applications in cancer diagnosis, therapy, and antibacterial activity. Coord. Chem. Rev. 2018 , 370 , 42−54..

Bünzli, J. C. G. Lanthanide light for biology and medical diagnosis. J. Lumin. 2016 , 170 , 866−878..

Bünzli, J. C. G. Lanthanide coordination chemistry: from old concepts to coordination polymers. J. Coord. Chem . 2014 , 67 , 3706−3733..

Liu, M.; Li, Z.; Xiong, J.; Jiang, Y.; Tang, T.; Qiu, J.; Yao, J.; Ng, S. W.; Zeng, C. Structure regulation for ultra-high luminescence quantum yield lanthanide complex and simultaneous detection of cancer marker and ferrous ion. J. Rare Earths 2021 , 39 , 1194−1203..

Tripier, R.; Tircsó, G.; Platas-Iglesias, C.; Harriswangler C. Chapter 325 - Importance of ligand design in lanthanide azamacrocyclic complexes relevant to biomedical applications. Handbook on the Physics and Chemistry of Rare Earths 2022 , 61 , 129−220..

Zhang, Q.; O’Brien, S.; Grimm, J. Biomedical applications of lanthanide nanomaterials, for imaging, sensing and therapy. Nanotheranostics 2022 , 6 , 184−194..

Tamanna; Mutreja, V. Biomedical applications of lanthanide complexes. Mater. Today: Proc. 2022 , DOI: 10.1016/j.matpr.2022.12.065.

Utochnikova, V. V.; Kusmina, N. P. Photoluminescence of lanthanide aromatic carboxylates. Russ. J. Coord. Chem . 2016 , 42 , 679−694..

Zhang, A. Q.; Yang, Y. M.; Li, L. P.; Zhai, G. M.; Jia, H. S.; Liu, X. G.; Xu, B. S. Syntheses and luminescent properties of a copolymer of terbium p aminobenzoic acid-methacrylic acid and styrene. Luminescence 2015 , 30 , 1020−1025..

Kalyakina, A. S.; Utochnikova, V. V.; Bushmarinov, I. S.; Le-Deygen, I. M.; Volz, D.; Weis, P.; Schepers, U.; Kuzmina, N. P.; Bräse, S. Lanthanide fluorobenzoates as bio-probes: a quest for the optimal ligand fluorination degree. Chem. Eur. J. 2017 , 23 , 14944−14953..

Doga, P. G.; Meshkova, S. B.; Shul’gin, V. F.; Gusev, A. N.; Lobko, E. V.; Kozak, N. V.; Smola, S. S. Synthesis and luminescent properties of europium(III) and terbium(III) complexes with acylated derivatives of 2-aminobenzoic acid. Russ. J. Inorg. Chem. 2013 , 58 , 1341−1348..

Gao, B.; Zhang, W.; Zhang, Z.; Lei, Q. Preparation of polymer–rare earth complex using salicylic acid-containing polystyrene and its fluorescence emission property. J. Lumin. 2012 , 132 , 2005−2011..

Anderson, R. A.; Feathergill, K.; Diao, X.; Cooper, M.; Kirkpatrick, R.; Spear, P.; Waller, D. P.; Chany, C.; Doncel, G. F.; Herold, B.; Zaneveld, L. J. D. Evaluation of poly(styrene-4-sulfonate) as a preventive agent for conception and sexually transmitted diseases. J. Androl. 2000 , 21 , 862−875..

Schandock, F.; Riber, C. F.; Röcker, A.; Müller, J. A.; Harms, M.; Gajda, P.; Zuwala, K.; Andersen, A. H. F.; Løvschall, K. B.; Tolstrup, M.; Kreppel, F.; Münch, J.; Zelikin, A. N. Macromolecular antiviral agents against Zika, Ebola, SARS, and other pathogenic viruses. Adv. Healthc. Mater. 2017 , 6 , 1700748..

Koton, M. M.; Sokolova, T. A.; Chetyrkina, G. M. Synthesis of N substituted methacrylamides. Zhurnal Obshchei Khimii 1957 , 27 , 185..

Zakharova, N. V.; Filippov, A. P.; Zelinskii, S. N.; Danilovtseva, E. N.; Annenkov, V. V. The influence of composition of thermo- and pHsensitive copolymers of N -(3(diethylamino)propyl)- N -methylacrylamide and N,N diethylacrylamide on their behavior in aqueous solutions. Polymer Science, Ser. A 2019 , 61 , 1−8..

Nikš, M.; Otto, M. Towards an optimized MTT assay. J. Immunol. Methods 1990 , 130 , 149−151..

Reed, L. J.; Muench, H. A simple method of estimating fifty per cent endpoints. Am. J. Epidemiol. 1938 , 27 , 493−497..

Bünzli, J. C. G. On the design of highly luminescent lanthanide complexes. Coord. Chem. Rev . 2015 , 293–294 , 19−47..

Wang, P.; Ma, J. P.; Dong, Y. B. Guest-driven luminescence: lanthanide-based host-guest systems with bimodal emissive properties based on a guest-driven approach. Chem. Eur. J . 2009 , 15 , 10432−10445..

Kirsh, Yu. E., in Poly-N-vinylpyrrolidone and other poly-Nvinylamides: synthesis and physicochemical properties (in Russian), Nauka, Moscow, 1998 . ISBN 5020044989..

Ikada, Y.; Suzuki, M.; Iwata, H. Water in mucopolysaccharides, in: Water in Polymers , ed. by Rowland, S. P., ACS Symposium Series 1980 . 127 , Ch. 17, 287–305..

Gorbunova, M. N.; Vorobyeva, A. I.; Tolstikov, A. G.; Monakov, Yu. B. N vinylpyrrolidone in radical copolymerization reactions. Izvestiya Vysshikh Uchebnykh Zavedenii, Seriya Khimiya i Khimicheskaya Tekhnologiya 2006 , 49 , 3–22..

Qi, X.; Wang, Z.; Ma, S.; Wu, L.; Yang, S.; Xu, J. Complexation behavior of poly(acrylic acid) and lanthanide ions. Polymer 2014 , 55 , 1183−1189..

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