One-pot and One-step Cu(0)-mediated Reversible-Deactivation Radical Polymerization of <italic style="font-style: italic">N</italic>-Isopropylacrylamide (NIPAM) in Water

Zi-Shan Li; Jing Lyu; Bei Qiu; Ying-Hao Li; Ruth Foley; Ri-Jian Song; Melissa Johnson; Qiang Geng; Wen-Xin Wang

doi:10.1007/s10118-024-3065-0

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One-pot and One-step Cu(0)-mediated Reversible-Deactivation Radical Polymerization of N-Isopropylacrylamide (NIPAM) in Water

RAPID COMMUNICATION | Updated：2023-12-26

- One-pot and One-step Cu(0)-mediated Reversible-Deactivation Radical Polymerization of N-Isopropylacrylamide (NIPAM) in Water
- One-pot and One-step Cu(0)-mediated Reversible-Deactivation Radical Polymerization of N-Isopropylacrylamide (NIPAM) in Water
- 高分子科学（英文版） 2024年42卷第1期页码：1-6
- Affiliations：
  
  a.Institute of Precision Medicine (AUST-IPM), Anhui University of Science and Technology, Huainan 232001, China
  b.Charles Institute of Dermatology, School of Medicine, University College Dublin, Dublin D04 V1W8, Ireland
- Author bio：
  
  jing.lyu@ucd.ie (J.L.)
  wenxin.wang@ucd.ie (W.X.W.)
- Funds：
  
  This work was financially supported by the Science Foundation Ireland (SFI) Frontiers for the Future 2019 call (No. 19/FFP/6522), the National Natural Science Foundation of China (NSFC) (No. 51873179) and Irish Research Council (IRC) Government of Ireland Postdoctoral Fellowship (No. GOIPD/2022/209).;Electronic supplementary information (ESI) is available free of charge in the online version of this article at http://doi.org/10.1007/s10118-024-3065-0.
- DOI：10.1007/s10118-024-3065-0
  中图分类号：
- 收稿：2023-09-16，
  
  修回：2023-10-20，
  
  录用：2023-11-2，
  
  网络首发：2023-11-21，
  
  纸质出版：2024-01-01
- Accepted：
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Li, Z. S.; Lyu, J.; Qiu, B.; Li, Y. H.; Foley, R.; Song, R. J.; Johnson, M.; Geng, Q.; Wang, W. X. One-pot and one-step Cu(0)-mediated reversible-deactivation radical polymerization of N-isopropylacrylamide (NIPAM) in water. Chinese J. Polym. Sci. 2024, 42, 1–6

Zi-Shan Li, Jing Lyu, Bei Qiu, et al. One-pot and One-step Cu(0)-mediated Reversible-Deactivation Radical Polymerization of N-Isopropylacrylamide (NIPAM) in Water[J]. Chinese Journal of Polymer Science, 2024, 42(1): 1-6. DOI: 10.1007/s10118-024-3065-0.
Li, Z. S.; Lyu, J.; Qiu, B.; Li, Y. H.; Foley, R.; Song, R. J.; Johnson, M.; Geng, Q.; Wang, W. X. One-pot and one-step Cu(0)-mediated reversible-deactivation radical polymerization of N-isopropylacrylamide (NIPAM) in water. Chinese J. Polym. Sci. 2024, 42, 1–6 DOI： 10.1007/s10118-024-3065-0.

Zi-Shan Li, Jing Lyu, Bei Qiu, et al. One-pot and One-step Cu(0)-mediated Reversible-Deactivation Radical Polymerization of N-Isopropylacrylamide (NIPAM) in Water[J]. Chinese Journal of Polymer Science, 2024, 42(1): 1-6. DOI: 10.1007/s10118-024-3065-0. DOI：

摘要

The well-controlled NIPAM polymerization was realized in water with narrow MWDs and varied MWs via a facile one-pot and one-step Cu(0)-mediated RDRP. Sufficient CuI at the very beginning is the key for kicking off the Cu(0)-mediated NIPAM RDRPs

and adequate deactivation strength during the polymerization process is the key to achieve a well-controlled chain growth.

Abstract

Copper(0)-mediated reversible-deactivation radical polymerization (Cu(0)-mediated RDRP) of the water-soluble monomer

-isopropylacrylamide (NIPAM) has been challenging with the problems of high dispersity

poor control over the molecular weights (MWs) or complex or multi reaction steps

etc

. In this work

we report the well-controlled polymerization of NIPAM in water

via

a facile one-pot and one-step Cu(0)-mediated RDRP. The results of this approach show that the key for kicking off the Cu(0)-mediated NIPAM RDRPs is to ensure sufficient Cu

at the very beginning

and the key to achieve a well-controlled chain growth is to provide adequate deactivation strength during the polymerization process. For NIPAM

which has a high propagation rate constant

the deactivation control can be effectively enhanced by extra adding deactivator (

i.e.

) to the system. Moreover

a low reaction temperature (4 °C) is necessary in the controlled synthesis of higher MW poly(

-isopropylacrylamide) (PNIPAM) to avoid the compromise in control caused by the phase transition from its lower critical solution temperature (LCST). Through this new kinetically controlled strategy

PNIPAMs with well-defined structure

narrow molecular weight distributions (MWDs) and varied MWs were successfully achieved.

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One-pot and One-step Cu(0)-mediated Reversible-Deactivation Radical Polymerization of N-Isopropylacrylamide (NIPAM) in Water

One-pot and One-step Cu(0)-mediated Reversible-Deactivation Radical Polymerization of N-Isopropylacrylamide (NIPAM) in Water

DOI：10.1007/s10118-024-3065-0

摘要

Abstract

关键词

Keywords

references