pH Induced Self-assembly of AIE Fluorescent Probe for Tumor Imaging

Jing-Yuan Xiang; Wen-Long Zhang; He-Ting Li; Ya-Ning He

doi:10.1007/s10118-023-3000-9

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pH Induced Self-assembly of AIE Fluorescent Probe for Tumor Imaging

RESEARCH ARTICLE | Updated：2023-12-26

- pH Induced Self-assembly of AIE Fluorescent Probe for Tumor Imaging
- pH Induced Self-assembly of AIE Fluorescent Probe for Tumor Imaging
- 高分子科学（英文版） 2024年42卷第1期页码：7-13
- Affiliations：
  
  Department of Chemical Engineering, Key Laboratory of Advanced Materials (MOE), Tsinghua University, Beijing 100084, China
- Author bio：
  
  heyaning@mail.tsinghua.edu.cn
- Funds：
  
  This work was financially supported by the National Key Research and Development Program of China (No. 2021YFC2103100) and the National Natural Science Foundation of China (Nos. 51873097 and 21674058).;Electronic supplementary information (ESI) is available free of charge in the online version of this article at http://doi.org/10.1007/s10118-023-3000-9.
- DOI：10.1007/s10118-023-3000-9
  中图分类号：
- 收稿：2023-04-07，
  
  修回：2023-5-5，
  
  录用：2023-5-8，
  
  网络首发：2023-06-15，
  
  纸质出版：2024-01-01
- Accepted：
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Xiang, J. Y.; Zhang, W. L.; Li, H. T.; He, Y. N. pH induced self-assembly of AIE fluorescent probe for tumor imaging. Chinese J. Polym. Sci. 2024, 42, 7–13

Jing-Yuan Xiang, Wen-Long Zhang, He-Ting Li, et al. pH Induced Self-assembly of AIE Fluorescent Probe for Tumor Imaging[J]. Chinese Journal of Polymer Science, 2024, 42(1): 7-13.
Xiang, J. Y.; Zhang, W. L.; Li, H. T.; He, Y. N. pH induced self-assembly of AIE fluorescent probe for tumor imaging. Chinese J. Polym. Sci. 2024, 42, 7–13 DOI： 10.1007/s10118-023-3000-9.

Jing-Yuan Xiang, Wen-Long Zhang, He-Ting Li, et al. pH Induced Self-assembly of AIE Fluorescent Probe for Tumor Imaging[J]. Chinese Journal of Polymer Science, 2024, 42(1): 7-13. DOI： 10.1007/s10118-023-3000-9.

摘要

This work reported an AIE fluorescent probe for tumor imaging based on the pH induced self-assembly strategy. Under acidic tumor microenvironment

the transition of AIE molecules from dispersed state to aggregated state will lead to an obvious increase in fluorescence intensity.

Abstract

This work reported an AIE fluorescent probe for tumor imaging based on the pH induced self-assembly strategy. The fluorescent probe was composed of an acid-responsive soluble copolymer PEG-

-PAMA-DMMA with a maleic acid amide group and an anionic soluble aggregation-induced emission fluorogen (AIEgen) TPE-2SO

−

. The polymer could be transformed into a protonated amine-containing polymer after the hydrolysis of maleic acid amide in acidic tumor microenvironment

which would be further self-assembled with TPE-2SO

−

to form aggregated nanoparticles. The transition of TPE-2SO

−

from dispersed state to aggregated state led to an obvious increase in fluorescence intensity due to its AIE characteristics.

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references

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