Controlled Fabrication of Uniform Digital Nanorods from Precise Sequence-Defined Amphiphilic Polymers in Aqueous Media

Qiang-Qiang Shi; Xin Zhou; Jie Xu; Ning Wang; Jia-Lin Zhang; Xiang-Long Hu; Shi-Yong Liu

doi:10.1007/s10118-023-2946-y

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Controlled Fabrication of Uniform Digital Nanorods from Precise Sequence-Defined Amphiphilic Polymers in Aqueous Media

RESEARCH ARTICLE | Updated：2023-04-21

- Controlled Fabrication of Uniform Digital Nanorods from Precise Sequence-Defined Amphiphilic Polymers in Aqueous Media
- Controlled Fabrication of Uniform Digital Nanorods from Precise Sequence-Defined Amphiphilic Polymers in Aqueous Media
- 高分子科学（英文版） 2023年41卷第5期页码：768-777
- Affiliations：
  
  a.CAS Key Laboratory of Soft Matter Chemistry, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei 230026, China
  b.School of Biomedical Engineering and Suzhou Institute for Advanced Research, University of Science and Technology of China, Suzhou 215123, China
- Author bio：
  
  huxlong@ustc.edu.cn(X.L.H.)
  sliu@ustc.edu.cn(S.Y.L.)
- Funds：
  
  This work was financially supported by the National Key R&D Program of China (No. 2020YFA0710700) and the National Natural Science Foundation of China (Nos. 52021002, 52233009, U19A2094, 52073270 and 51973071).;Electronic supplementary information (ESI) is available free of charge in the online version of this article athttp://doi.org/10.1007/s10118-023-2946-y.
- DOI：10.1007/s10118-023-2946-y
  中图分类号：
- 收稿：2022-12-11，
  
  修回：2022-12-29，
  
  录用：2023-1-4，
  
  网络首发：2023-03-03，
  
  纸质出版：2023-05-01
- Accepted：
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Shi, Q. Q.; Zhou, X.; Xu, J.; Wang, N.; Zhang, J. L.; Hu, X. L.; Liu, S. Y. Controlled fabrication of uniform digital nanorods from precise sequence-defined amphiphilic polymers in aqueous media.Chinese J. Polym. Sci.2023,41, 768–777

Qiang-Qiang Shi, Xin Zhou, Jie Xu, et al. Controlled Fabrication of Uniform Digital Nanorods from Precise Sequence-Defined Amphiphilic Polymers in Aqueous Media[J]. Chinese Journal of Polymer Science, 2023, 41(5): 768-777.
Shi, Q. Q.; Zhou, X.; Xu, J.; Wang, N.; Zhang, J. L.; Hu, X. L.; Liu, S. Y. Controlled fabrication of uniform digital nanorods from precise sequence-defined amphiphilic polymers in aqueous media.Chinese J. Polym. Sci.2023,41, 768–777 DOI： 10.1007/s10118-023-2946-y.

Qiang-Qiang Shi, Xin Zhou, Jie Xu, et al. Controlled Fabrication of Uniform Digital Nanorods from Precise Sequence-Defined Amphiphilic Polymers in Aqueous Media[J]. Chinese Journal of Polymer Science, 2023, 41(5): 768-777. DOI： 10.1007/s10118-023-2946-y.

摘要

Controlled fabrication of uniform nanorods have remained a considerable challenge. We report the formation of helical nanorods with controlled handedness and uniform lengths in aqueous media

via

self-assembly of digital amphiphiles and subsequent thermal annealing. We also explored the precise synthesis and controlled self-assembly of digital dendrimers with discrete molecular weights.

Abstract

Compared with spherical micelles

rod/worm-like micelles not only have extended blood circulation duration

but also exhibit favorable cellular uptake behavior

which is promising for next-generation nanomedicine and biomaterials. However

the controllable fabrication of narrowly dispersed nanorods in aqueous media is still challenging. Herein

the methodology of thermal annealing was developed for the fabrication of helical nanorods as well as a series of nanorods with different lengths. The thermal annealing process generally consisted of adding a percentage of organic solvent (10%(

) or 20%(

)) to the digital micellar aqueous dispersion

followed by heating at 90 °C for 1 h

then cooling naturally to room temperature

and dialyzing against water to remove the organic solvent. Right-handed helical nanorods were afforded by the treatment of 45 nm digital micelles in the presence of 10%(

) dioxane

while left-handed helical nanorods were obtained in the presence of 20%(

) dioxane. Meanwhile

the controlled growth of rod-like digital micelles was achieved after thermal annealing in the presence of different types of organic solvents

and the length of the annealed nanorods was correlated with the types of organic solvent. Furthermore

no matter the size of initial digital micelles

they all exhibited similar trend of rod growth in the presence of a certain amount of organic solvent

allowing for controllable formulation of narrowly dispersed nanorods. In addition

supramolecular self-assembly by amphiphilic dendritic oligourethane readily fabricated diverse uniform nanorods in aqueous media. Overall

this work provided an attractive methodology to fabricate uniform digital nanorods.

关键词

Keywords

references

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