Construction of PAMAM-based Nanocomplex Conjugated with Pt(IV)-complex and Lauric Acid Exerting Both Anti-tumor and Antibacterial Effects

You-Tao Xin; Lu-Yao Wang; Huan-Huan Chang; Fei-He Ma; Ming-Lei Sun; Li Chen; Hui Gao

doi:10.1007/s10118-023-2890-x

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Construction of PAMAM-based Nanocomplex Conjugated with Pt(IV)-complex and Lauric Acid Exerting Both Anti-tumor and Antibacterial Effects

RESEARCH ARTICLE | Updated：2023-05-26

- Construction of PAMAM-based Nanocomplex Conjugated with Pt(IV)-complex and Lauric Acid Exerting Both Anti-tumor and Antibacterial Effects
- Construction of PAMAM-based Nanocomplex Conjugated with Pt(IV)-complex and Lauric Acid Exerting Both Anti-tumor and Antibacterial Effects
- 高分子科学（英文版） 2023年41卷第6期页码：887-896
- Affiliations：
  
  a.State Key Laboratory of Separation Membranes and Membrane Processes, School of Materials Science and Engineering, Tiangong University, Tianjin 300387, China
  b.School of Chemistry and Chemical Engineering, Tianjin Key Laboratory of Drug Targeting and Bioimaging, Tianjin Enterprise Key Laboratory for Application Research of Hyaluronic Acid, Tianjin University of Technology, Tianjin 300384, China
- Author bio：
  
  feihema@tiangong.edu.cn (F.H.M.)
  huigao@tiangong.edu.cn (H.G.)
- Funds：
  
  This work was financially supported by the National Natural Science Foundation of China (Nos. 22075209, U20A20260 and 52103180); a distinguished professor of Tianjin, the Leading Talents Program of the Tianjin Educational Committee; the Key program of Tianjin Municipal Natural Science Foundation (Nos. 18JCZDJC37700 and 18JCQNJC72300); the Training Project of Innovation Team of Colleges and Universities in Tianjin (No. TD13-5020); and the Tianjin Enterprise Key Laboratory for Application Research of Hyaluronic Acid (No. KTRDHA-Z201901) for the financial support. We would like to thank the Analytical & Testing Center of Tiangong University for Thermal Field-Emission Scanning Electron Microscope work.;Electronic supplementary information (ESI) is available free of charge in the online version of this article at http://doi.org/10.1007/s10118-023-2890-x.
- DOI：10.1007/s10118-023-2890-x
  中图分类号：
- 收稿：2022-09-17，
  
  修回：2022-10-19，
  
  录用：2022-10-20，
  
  网络首发：2022-12-12，
  
  纸质出版：2023-06-01
- Accepted：
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Xin, Y. T.; Wang, L. Y.; Chang, H. H.; Ma, F. H.; Sun, M. L.; Chen, L.; Gao, H. Construction of PAMAM-based nanocomplex conjugated with Pt(IV)-complex and lauric acid exerting both anti-tumor and antibacterial effects. Chinese J. Polym. Sci. 2023, 41, 887–896

You-Tao Xin, Lu-Yao Wang, Huan-Huan Chang, et al. Construction of PAMAM-based Nanocomplex Conjugated with Pt(IV)-complex and Lauric Acid Exerting Both Anti-tumor and Antibacterial Effects[J]. Chinese Journal of Polymer Science, 2023, 41(6): 887-896.
Xin, Y. T.; Wang, L. Y.; Chang, H. H.; Ma, F. H.; Sun, M. L.; Chen, L.; Gao, H. Construction of PAMAM-based nanocomplex conjugated with Pt(IV)-complex and lauric acid exerting both anti-tumor and antibacterial effects. Chinese J. Polym. Sci. 2023, 41, 887–896 DOI： 10.1007/s10118-023-2890-x.

You-Tao Xin, Lu-Yao Wang, Huan-Huan Chang, et al. Construction of PAMAM-based Nanocomplex Conjugated with Pt(IV)-complex and Lauric Acid Exerting Both Anti-tumor and Antibacterial Effects[J]. Chinese Journal of Polymer Science, 2023, 41(6): 887-896. DOI： 10.1007/s10118-023-2890-x.

摘要

A novel polymeric nanocomplex with anti-tumour and antibacterial dual-functions was synthesized to treat Fusobacterium nucleatum (

)-infected colorectal cancer. This novel nanocomplex effectively reverses

-induced drug resistance

providing a powerful strategy for the treatment of bacterial related cancers.

Abstract

Oxaliplatin is the common chemotherapy drug for the treatment of colorectal cancer (CRC)

however

the harmful Fusobacterium nucleatum (

) that existed in the CRC tumor tissues leads to extreme drug resistance to oxaliplatin

which reduces the anticancer efficiency. Here we fabricated a new dendrimer-based nanocomplex with anti-tumor and antibacterial dual-functions through conjugating Pt(IV)-complex and lauric acid (LA) to the dendritic carrier PAMAM (G=3). The synthesized PAMAM-Pt-LA nanoparticle was further coated with hyaluronic acid (HA) on its surface through electrostatically interaction in order to enhance biocompatibility and tumor targeting. The biocompatibility

anti-tumor activity and antibacterial activity of PAMAM-Pt-LA@HA nanocomplex were evaluated

in vitro

. The results showed that the PAMAM-Pt-LA@HA nanocomplex ehxibited a good biocompatibility

high anti-colorectal cancer activity and high anti-

activity. This dual-functional nanocomplex provides a new method to develop anticancer nanomedicines that will be more therapeutically efficacious and less toxic than oxaliplatin for the treatment of CRC.

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references

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