PLG-<italic style="font-style: italic">g</italic>-mPEG Mediated Multifunctional Nanoparticles for Photoacoustic Imaging Guided Combined Chemo/Photothermal Antitumor Therapy

Chong Liu; Ling Li; Zhao-Pei Guo; Lin Lin; Yan-Hui Li; Hua-Yu Tian

doi:10.1007/s10118-022-2857-3

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PLG-g-mPEG Mediated Multifunctional Nanoparticles for Photoacoustic Imaging Guided Combined Chemo/Photothermal Antitumor Therapy

RESEARCH ARTICLE | Updated：2023-03-07

- PLG-g-mPEG Mediated Multifunctional Nanoparticles for Photoacoustic Imaging Guided Combined Chemo/Photothermal Antitumor Therapy
- PLG-g-mPEG Mediated Multifunctional Nanoparticles for Photoacoustic Imaging Guided Combined Chemo/Photothermal Antitumor Therapy
- 高分子科学（英文版） 2023年41卷第4期页码：538-546
- Affiliations：
  
  a.School of Materials Science and Engineering, Changchun University of Science and Technology, Changchun 130022, China
  b.Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
  c.College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China
  d.School of Materials Science and Engineering, Xiamen University of Technology, Xiamen 361024, China
- Author bio：
  
  lyh2008@cust.edu.cn (Y.H.L.)
  thy@ciac.ac.cn (H.Y.T.)
- Funds：
  
  This work was financially supported by the National Natural Science Foundation of China (Nos. 52173115, 52073278, 51925305 and 51873208), Jilin province science and technology development program (No. 20200201103JC) and Foundation of Department of Education of Jilin Province of China (No. JJKH20210828KJ).;Electronic supplementary information (ESI) is available free of charge in the online version of this article at http://doi.org/10.1007/s10118-022-2857-3.
- DOI：10.1007/s10118-022-2857-3
  中图分类号：
- 收稿：2022-07-14，
  
  修回：2022-8-15，
  
  录用：2022-8-23，
  
  网络首发：2022-10-10，
  
  纸质出版：2023-04-01
- Accepted：
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Liu, C.; Li, L.; Guo, Z. P.; Lin, L.; Li, Y. H.; Tian, H. Y. PLG-g-mPEG mediated multifunctional nanoparticles for photoacoustic imaging guided combined chemo/photothermal antitumor therapy. Chinese J. Polym. Sci. 2023, 41, 538–546

Chong Liu, Ling Li, Zhao-Pei Guo, et al. PLG-g-mPEG Mediated Multifunctional Nanoparticles for Photoacoustic Imaging Guided Combined Chemo/Photothermal Antitumor Therapy[J]. Chinese Journal of Polymer Science, 2023, 41(4): 538-546. DOI: 10.1007/s10118-022-2857-3.
Liu, C.; Li, L.; Guo, Z. P.; Lin, L.; Li, Y. H.; Tian, H. Y. PLG-g-mPEG mediated multifunctional nanoparticles for photoacoustic imaging guided combined chemo/photothermal antitumor therapy. Chinese J. Polym. Sci. 2023, 41, 538–546 DOI： 10.1007/s10118-022-2857-3.

Chong Liu, Ling Li, Zhao-Pei Guo, et al. PLG-g-mPEG Mediated Multifunctional Nanoparticles for Photoacoustic Imaging Guided Combined Chemo/Photothermal Antitumor Therapy[J]. Chinese Journal of Polymer Science, 2023, 41(4): 538-546. DOI: 10.1007/s10118-022-2857-3. DOI：

摘要

PLG-g-mPEG was synthesized to co-loaded GA and IR783 to obtain GI@P NPs to perform photoacoustic imaging guided combined chemo/photothermal antitumor therapy. In GI@P NPs

GA inhibited HSP90 expression to overcome the thermotolerance of tumors to endow IR783 achieve mild-temperature photothermal therapy and reducing thermal damage to healthy tissue.

Abstract

Under laser irradiation

photothermal therapy (PTT) effectively ablates tumors above 50 °C. However

hyperthermia can cause additional damage due to the inevitable heat spread to surrounding healthy tissue. Herein

nanoparticles named as GI@P NPs were designed for enhanced PTT with heat shock protein 90 (HSP90) inhibition at temperatures below 50 °C to achieve optimal cancer therapy and avoid surrounding damage. GI@P NPs were done by co-loading Garcinia cambogia acid (GA) and photosensitizer IR783 in polymer PLG-

-mPEG to form a nanomedicine

where IR783 with excellent photoacoustic (PA) signal acted as an excellent photothermal therapeutic agent that converted the laser energy into heat to kill tumor cells

GA was used as antitumor drug for chemotherapy and an inhibitor of HSP90 to overcome the heat resistance of tumors for efficient cryo-photothermal therapy

and PLG-

-mPEG can encapsulate IR783 and GA to increase biocompatibility and accumulate effectively in the tumor. After GI@P NPs were injected into the mice

we could observe that the PA signals gradually increased in the tumor region and showed the strongest PA signals at 12 h. Under laser irradiation

the tumor temperature of the mice could raise to about 43.5 °C

and the tumor was significantly inhibited after long-term monitoring by PA imaging. As a result

gentle PTT produced by GI@P NPs exhibited good antitumor effects at relatively low temperature and minimized nonspecific thermal damage to normal tissues. The GI@P NPs as nanomedicine enriched our understanding of various applications of polymeric carriers

especially in the biomedical field.

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PLG-g-mPEG Mediated Multifunctional Nanoparticles for Photoacoustic Imaging Guided Combined Chemo/Photothermal Antitumor Therapy

PLG-g-mPEG Mediated Multifunctional Nanoparticles for Photoacoustic Imaging Guided Combined Chemo/Photothermal Antitumor Therapy

DOI：10.1007/s10118-022-2857-3

摘要

Abstract

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