Polymerization-Amplified Photoacoustic Signal by Enhancing Near-Infrared Light-Harvesting Capacity and Thermal-to-Acoustic Conversion

He-Qi Gao; Jing-Tian Zhang; Xin-Wen Qi; Di Jiao; Yu-Ning Hong; Ke Shan; Xiang-Long Kong; Dan Ding

doi:10.1007/s10118-022-2793-2

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Polymerization-Amplified Photoacoustic Signal by Enhancing Near-Infrared Light-Harvesting Capacity and Thermal-to-Acoustic Conversion

RESEARCH ARTICLE | Updated：2022-08-19

- Polymerization-Amplified Photoacoustic Signal by Enhancing Near-Infrared Light-Harvesting Capacity and Thermal-to-Acoustic Conversion
- Polymerization-Amplified Photoacoustic Signal by Enhancing Near-Infrared Light-Harvesting Capacity and Thermal-to-Acoustic Conversion
- 高分子科学（英文版） 2022年40卷第9期页码：1090-1100
- Affiliations：
  
  a.Key Laboratory of Bioactive Materials, Ministry of Education, and College of Life Sciences, Nankai University, Tianjin 300071, China
  b.Center for AIE Research, Shenzhen Key Laboratory of Polymer Science and Technology, Guangdong Research Center for Interfacial Engineering of Functional Materials, College of Materials Science and Engineering, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China
  c.Department of Chemistry and Physics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne Victoria 3086, Australia
  d.Shandong Artificial intelligence Institute and Shandong Computer Science Center, Qilu University of Technology, Jinan 250353, China
- Author bio：
  
  dingd@nankai.edu.cn
- Funds：
  
  All animal studies were performed according to the guidelines set by the Tianjin Committee of Use and Care of Laboratory Animals, and the overall project protocols were approved by the Animal Ethics Committee of Nankai University. The accreditation number of the laboratory is SYXK(Jin) 2019-0003 promulgated by the Tianjin Science and Technology Commission. This work was supported by the National Key R&D Program of China (Intergovernmental Cooperation Project, 2017YFE0132200), the National Natural Science of Fundation of China (Nos. 51961160730, 51873092, and 81921004), the Fundamental Research Funds for the Central Universities, the Tianjin Science Fund for Distinguished Young Scholars (19JCJQJC61200).
- DOI：10.1007/s10118-022-2793-2
  中图分类号： M
- 收稿：2022-04-01，
  
  修回：2022-05-02，
  
  录用：2022-05-17，
  
  网络首发：2022-07-12，
  
  纸质出版：2022-09-01
- Accepted：
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Gao, H. Q.; Zhang, J. T.; Qi, X. W.; Jiao, D.; Hong, Y. N.; Shan, K.; Kong, X. L.; Ding, D. Polymerization-amplified photoacoustic signal by enhancing near-infrared light-harvesting capacity and thermal-to-acoustic conversion. Chinese J. Polym. Sci. 2022, 40, 1090–1100

He-Qi Gao, Jing-Tian Zhang, Xin-Wen Qi, et al. Polymerization-Amplified Photoacoustic Signal by Enhancing Near-Infrared Light-Harvesting Capacity and Thermal-to-Acoustic Conversion[J]. Chinese Journal of Polymer Science, 2022, 40(9): 1090-1100.
Gao, H. Q.; Zhang, J. T.; Qi, X. W.; Jiao, D.; Hong, Y. N.; Shan, K.; Kong, X. L.; Ding, D. Polymerization-amplified photoacoustic signal by enhancing near-infrared light-harvesting capacity and thermal-to-acoustic conversion. Chinese J. Polym. Sci. 2022, 40, 1090–1100 DOI： 10.1007/s10118-022-2793-2.

He-Qi Gao, Jing-Tian Zhang, Xin-Wen Qi, et al. Polymerization-Amplified Photoacoustic Signal by Enhancing Near-Infrared Light-Harvesting Capacity and Thermal-to-Acoustic Conversion[J]. Chinese Journal of Polymer Science, 2022, 40(9): 1090-1100. DOI： 10.1007/s10118-022-2793-2.

摘要

Herein

we develop a new strategy in which photoacoustic (PA) imaging reagents with better properties can be easily optimized by polymerization. The polymerization strategy can effectively promote the PA signal by specifically increasing the thermal-to-acoustic conversion efficiency. The polymers with intense intramolecular motion exhibit an amplified PA signal by elevating thermal-to-acoustic conversion and its higher light-harvesting capability at redshifted region. This work highlights a simple and available design guideline of polymerization for amplifying the PA effect and optimizing existing materials.

Abstract

As a frontier imaging technique for biomedical applications

photoacoustic (PA) imaging has been developed rapidly. The development of new design strategies and excellent PA imaging reagents to boost PA conversion is eagerly desirable for high quality PA imaging but complicated to realize. Herein

we develop a new strategy in which PA imaging reagents with better properties can be easily optimized by polymerization. A series of new PA imaging reagents were designed and synthesized. The polymerization strategy can effectively promote the PA signal by specifically increasing the thermal-to-acoustic conversion efficiency. As these materials shared the same building units

the optimized effectiveness of polymerization strategy in terms of near-infrared light-harvesting capacity and thermal-to-acoustic conversion efficiency are discussed

rationally. The polymers with intense intramolecular motion exhibit an amplified PA signal by elevating thermal-to-acoustic conversion and its higher light-harvesting capability at redshifted region. The simultaneously strong PA signal and photothermal conversion efficiency of p-TT

B NPs enable precise PA imaging and effective photothermal therapy. This work highlights a simple and available design guideline of polymerization for amplifying the PA effect and optimizing existing materials.

关键词

Keywords

references

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