Improvement on the Mechanical Performance and Resistance Towards Hydrolysis of Poly(glycolic acid) <italic style="font-style: italic">via</italic> Solid-state Drawing

Jia-Xuan Li; De-Yu Niu; Bo Liu; Peng-Wu Xu; Wei-Jun Yang; Pieter Jan Lemstra; Pi-Ming Ma

doi:10.1007/s10118-022-2760-y

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Improvement on the Mechanical Performance and Resistance Towards Hydrolysis of Poly(glycolic acid) via Solid-state Drawing

RESEARCH ARTICLE | Updated：2022-12-19

- Improvement on the Mechanical Performance and Resistance Towards Hydrolysis of Poly(glycolic acid) via Solid-state Drawing
- Improvement on the Mechanical Performance and Resistance Towards Hydrolysis of Poly(glycolic acid) via Solid-state Drawing
- 高分子科学（英文版） 2023年41卷第1期页码：14-23
- Affiliations：
  
  a.The Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, Jiangnan University, Wuxi 214122, China
  b.PlemPolco B.V., Roek 24, 5508 KE Veldhoven, the Netherlands
- Author bio：
  
  p.ma@jiangnan.edu.cn
- Funds：
  
  This work was financially supported by the National Natural Science Foundation of China (Nos. 52073123 and 51873082), the Distinguished Young Natural Science Foundation of Jiangsu Province (No. BK20200027). The authors would also like to acknowledge Shanghai Pujing Chemical Industry Co., Ltd. for supplying the PGA raw materials.;Electronic supplementary information (ESI) is available free of charge in the online version of this article at http://doi.org/10.1007/s10118-022-2760-y.
- DOI：10.1007/s10118-022-2760-y
  中图分类号：
- 收稿：2022-03-18，
  
  修回：2022-4-3，
  
  录用：2022-4-18，
  
  网络首发：2022-07-20，
  
  纸质出版：2023-01-01
- Accepted：
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Li, J. X.; Niu, D. Y.; Liu, B.; Xu, P. W.; Yang, W. J.; Lemstra, P. J.; Ma, P. M. Improvement on the mechanical performance and resistance towards hydrolysis of poly(glycolic acid) via solid-state drawing. Chinese J. Polym. Sci. 2023, 41, 14–23

Jia-Xuan Li, De-Yu Niu, Bo Liu, et al. Improvement on the Mechanical Performance and Resistance Towards Hydrolysis of Poly(glycolic acid) via Solid-state Drawing[J]. Chinese Journal of Polymer Science, 2023, 41(1): 14-23. DOI: 10.1007/s10118-022-2760-y.
Li, J. X.; Niu, D. Y.; Liu, B.; Xu, P. W.; Yang, W. J.; Lemstra, P. J.; Ma, P. M. Improvement on the mechanical performance and resistance towards hydrolysis of poly(glycolic acid) via solid-state drawing. Chinese J. Polym. Sci. 2023, 41, 14–23 DOI： 10.1007/s10118-022-2760-y.

Jia-Xuan Li, De-Yu Niu, Bo Liu, et al. Improvement on the Mechanical Performance and Resistance Towards Hydrolysis of Poly(glycolic acid) via Solid-state Drawing[J]. Chinese Journal of Polymer Science, 2023, 41(1): 14-23. DOI: 10.1007/s10118-022-2760-y. DOI：

摘要

In this work

a solid-state drawing process after melt extrusion was carried out on poly(glycolic acid) (PGA) to form oriented crystal structures and tightly arranged rigid amorphous fraction which strongly improved the mechanical properties and the resistance to hydrolysis of PGA.

Abstract

Poly(glycolic acid) is a biocompatible as well as biocomposable polymer with superior mechanical and barrier properties and

consequently

has found important applications in both medical and packaging fields. However

the high hydrolysis rate in a high humidity environment restricts its application. In this work

a solid-state drawing process after melt extrusion is applied in order to produce fibrous PGA with enhanced mechanical properties and a much better resistance towards hydrolysis. The crystal structure of PGA gradually transformed from spherulites into oriented fibrous crystals in the stretching direction upon solid-state drawing. Meanwhile

both the length of microfibril and the size of lamellae increased initially with the drawing ratio (DR)

while the chain-folded lamellae transformed into extended-chain fibrils at high(er) DR. The oriented structures lead to an overall improvement of the mechanical properties of PGA

e.g.

the tensile strength increased from 62.0±1.4 MPa to 910±54 MPa and the elongation at break increased from around 7% to 50%. Meanwhile

the heat capacity of totally mobile amorphous PGA (Δ

=0.64 J∙g

−1

∙°C

−1

) was reported for the first time

which was used to analyze the content of mobile amorphous fraction (

MAF

) and rigid amorphous fraction (

RAF

). Both the oriented chain-folded lamellae crystals and the tightly arranged RAF are beneficial to prevent water molecules from penetrating the matrix

thus improving the resistance towards hydrolysis. As a consequence

the fibrous PGA with a DR of 5 showed a tensile strength retention rate of 17.3% higher in comparison with the undrawn sample after 7-days accelerated hydrolysis. Therefore

this work provides a feasible method to improve the mechanical and resistance towards hydrolysis performance of PGA

which may broaden its application and prolong the shelf-life of PGA products.

关键词

Keywords

references

Yu, C.; Bao, J.; Xie, Q.; Shan, G . Crystallization behavior and crystalline structural changes of poly(glycolic acid) investigated via temperature-variable WAXD and FTIR analysis . CrystEngComm , 2016 . 18 7894 - 7902 . DOI: 10.1039/C6CE01623E http://doi.org/10.1039/C6CE01623E .

Chatani, Y.; Suehiro, K.; Okita, Y.; Tadokoro, H . H. Structural studies of polyesters. I. Crystal structure of polyglycolide . Macromol. Chem. Phys. , 1968 . 113 215 - 229 . DOI: 10.1002/macp.1968.021130119 http://doi.org/10.1002/macp.1968.021130119 .

Yamane, K.; Kawakami, Y. Polyhydroxycarboxylic acid and its production process , US, 2006 .

Shawe, S.; Buchanan, F.; Harkin-Jones, E.; Farrar, D . A study on the rate of degradation of the bioabsorbable polymer polyglycolic acid (PGA) . J. Mater. Sci. , 2006 . 41 4832 - 4838 . DOI: 10.1007/s10853-006-0064-1 http://doi.org/10.1007/s10853-006-0064-1 .

Stloukal, P.; Jandikova, G.; Koutny, M.; Sedlařík, V . Carbodiimide additive to control hydrolytic stability and biodegradability of PLA . Polym. Test. , 2016 . 54 19 - 28 . DOI: 10.1016/j.polymertesting.2016.06.007 http://doi.org/10.1016/j.polymertesting.2016.06.007 .

Nishino, K.; Shindo, Y.; Takayama, T.; Ito, H . Improvement of impact strength and hydrolytic stability of PC/ABS blend using reactive polymer . J. Appl. Polym. Sci. , 2017 . 134 1 - 6 . .

Rodriguez, E.; Shahbikian, S.; Marcos, B.; Huneault, M. A . Hydrolytic stability of polylactide and poly(methyl methacrylate) blends . J. Appl. Polym. Sci. , 2018 . 135 1 - 14 . .

Špírková, M.; Hodan, J.; Kobera, L.; Kredatusová, J . The influence of the length of the degradable segment on the functional properties and hydrolytic stability of multi-component polyurethane elastomeric films . Polym. Degrad. Stabil. , 2017 . 137 216 - 228 . DOI: 10.1016/j.polymdegradstab.2017.01.021 http://doi.org/10.1016/j.polymdegradstab.2017.01.021 .

Mazurek-Budzyńska, M.; Behl, M.; Razzaq, M. Y.; Nöchel, U . Hydrolytic stability of aliphatic poly(carbonate-urea-urethane)s: Influence of hydrocarbon chain length in soft segment . Polym. Degrad. Stabil. , 2019 . 161 283 - 297 . DOI: 10.1016/j.polymdegradstab.2019.01.032 http://doi.org/10.1016/j.polymdegradstab.2019.01.032 .

Park, T. G . Degradation of poly(lactic- co -glycolic acid) microspheres: effect of copolymer composition . Biomaterials , 1995 . 16 1123 - 1130 . DOI: 10.1016/0142-9612(95)93575-X http://doi.org/10.1016/0142-9612(95)93575-X .

Li, Y.; Yuan, L.; Ming, H.; Li, X . Enhanced hydrolytic resistance of fluorinated silicon-containing polyether urethanes . Biomacromolecules , 2020 . 21 1460 - 1470 . DOI: 10.1021/acs.biomac.9b01768 http://doi.org/10.1021/acs.biomac.9b01768 .

Madden, D.G.; Albadarin, A.B.; O'Nolan, D.; Cronin, P . Metal-organic material polymer coatings for enhanced gas sorption performance and hydrolytic stability under humid conditions . ACS Appl. Mater. Interfaces , 2020 . 12 33759 - 33764 . DOI: 10.1021/acsami.0c08078 http://doi.org/10.1021/acsami.0c08078 .

Xu, H.; Zhong, G. J.; Fu, Q.; Lei, J . Formation of shish-kebabs in injection-molded poly( l -lactic acid) by application of an intense flow field . ACS Appl. Mater. Interfaces , 2012 . 4 6774 - 6784 . DOI: 10.1021/am3019756 http://doi.org/10.1021/am3019756 .

Zhou, S.-Y.; Niu, B.; Xie, X. L.; Ji, X . Interfacial shish-kebabs lengthened by coupling effect of in situ flexible nanofibrils and intense shear flow: achieving hierarchy to conquer the conflicts between strength and toughness of polylactide . ACS Appl. Mater. Interfaces , 2017 . 9 10148 - 10159 . DOI: 10.1021/acsami.7b00479 http://doi.org/10.1021/acsami.7b00479 .

Zhang, Z. C.; Sang, Z. H.; Huang, Y. F.; Ru, J. F . Enhanced heat deflection resistance via shear flow-induced stereocomplex crystallization of polylactide systems . ACS Sustain. Chem. Eng. , 2017 . 5 1692 - 1703 . DOI: 10.1021/acssuschemeng.6b02438 http://doi.org/10.1021/acssuschemeng.6b02438 .

Browning, A.; Chu, C. C . The effect of annealing treatments on the tensile properties and hydrolytic degradative properties of polyglycolic acid sutures . J. Biomed. Mater. Res. Part A , 1986 . 20 613 - 632 . DOI: 10.1002/jbm.820200507 http://doi.org/10.1002/jbm.820200507 .

Sangroniz, A.; Chaos, A.; Iriarte, M.; del Río, J . Influence of the rigid amorphous fraction and crystallinity on polylactide transport properties . Macromolecules , 2018 . 51 3923 - 3931 . DOI: 10.1021/acs.macromol.8b00833 http://doi.org/10.1021/acs.macromol.8b00833 .

Nassar, S. F.; Domenek, S.; Guinault, A.; Stoclet, G . Structural and dynamic heterogeneity in the amorphous phase of poly(L,L-lactide) confined at the nanoscale by the coextrusion process . Macromolecules , 2018 . 51 128 - 136 . DOI: 10.1021/acs.macromol.7b02188 http://doi.org/10.1021/acs.macromol.7b02188 .

Montes de Oca, H.; Ward, I. M . Structure and mechanical properties of PGA crystals and fibres . Polymer , 2006 . 47 7070 - 7077 . DOI: 10.1016/j.polymer.2006.07.045 http://doi.org/10.1016/j.polymer.2006.07.045 .

Montes de Oca, H.; Ward, I. M.; Klein, P. G.; Ries, M. E . Solid state nuclear magnetic resonance study of highly oriented poly(glycolic acid) . Polymer , 2004 . 45 7261 - 7272 . DOI: 10.1016/j.polymer.2004.08.028 http://doi.org/10.1016/j.polymer.2004.08.028 .

Delpouve, N.; Stoclet, G.; Saiter, A.; Dargent, E . Water barrier properties in biaxially drawn poly(lactic acid) films . J. Phys. Chem. B , 2012 . 116 4615 - 4625 . DOI: 10.1021/jp211670g http://doi.org/10.1021/jp211670g .

Lee, S.; Hongo, C.; Nishino, T . Crystal modulus of poly(glycolic acid) and its temperature dependence . Macromolecules , 2017 . 50 5074 - 5079 . DOI: 10.1021/acs.macromol.7b00753 http://doi.org/10.1021/acs.macromol.7b00753 .

An, M.; Xu, H.; Lv, Y.; Gu, Q . An in situ small-angle X-ray scattering study of the structural effects of temperature and draw ratio of the hot-drawing process on ultra-high molecular weight polyethylene fibers . RSC Adv. , 2016 . 6 51125 - 51134 . DOI: 10.1039/C6RA09965C http://doi.org/10.1039/C6RA09965C .

Cao, T.; Chen, X.; Lin, Y.; Meng, L . Structural evolution of UHMWPE fibers during prestretching far and near melting temperature: an in situ synchrotron radiation small- and wide-angle X-ray scattering study . Macromol. Mater. Eng. , 2018 . 303 1700493 DOI: 10.1002/mame.201700493 http://doi.org/10.1002/mame.201700493 .

Chen, X.; Lv, F.; Su, F.; Ji, Y . Deformation mechanism of i PP under uniaxial stretching over a wide temperature range: an in-situ synchrotron radiation SAXS/WAXS study . Polymer , 2017 . 118 12 - 21 . DOI: 10.1016/j.polymer.2017.04.054 http://doi.org/10.1016/j.polymer.2017.04.054 .

Wang, Z.; Ma, Z.; Li, L . Flow-induced crystallization of polymers: molecular and thermodynamic considerations . Macromolecules , 2016 . 49 1505 - 1517 . DOI: 10.1021/acs.macromol.5b02688 http://doi.org/10.1021/acs.macromol.5b02688 .

Ruland, W . Small-angle scattering studies on carbonized cellulose fibers . J. Polym. Sci. Polym. Symp. , 2010 . 28 143 - 151 . .

Perret, R.; Ruland, W . Single and multiple X-ray small-angle scattering of carbon fibres . J. Appl. Crystallogr , 1969 . 2 209 - 218 . .

Perret, R.; Ruland, W . The microstructure of PAN-base carbon fibres . J. Appl. Crystallogr. , 1970 . 3 525 - 532 . DOI: 10.1107/S0021889870006805 http://doi.org/10.1107/S0021889870006805 .

Montes de Oca, H.; Farrar, D. F.; Ward, I. M . Degradation studies on highly oriented poly(glycolic acid) fibres with different lamellar structures . Acta Biomaterialia , 2011 . 7 1535 - 1541 . DOI: 10.1016/j.actbio.2010.12.023 http://doi.org/10.1016/j.actbio.2010.12.023 .

Czerniecka-Kubicka, A.; Janowski, G.; Pyda, M.; Frącz, W . Biocomposites based on the poly(3-hydroxybutyrate- co -3-hydroxyvalerate) matrix with the hemp fibers: thermal and mechanical properties . J. Therm. Anal. Calorimetry , 2021 . 147 1017 - 1029 . .

Cao, Y.; Xu, P.; Yang, W.; Zhu, X . UV resistant PBT nanocomposites by reactive compatibilization and selective distribution of tailor-made double-shelled TiO 2 nanohybrids . Compos. Part B: Eng. , 2021 . 205 108510 DOI: 10.1016/j.compositesb.2020.108510 http://doi.org/10.1016/j.compositesb.2020.108510 .

Fechine, G. J. M.; Rabello, M. S.; Souto Maior, R. M.; Catalani, L. H . Surface characterization of photodegraded poly(ethylene terephthalate). The effect of ultraviolet absorbers . Polymer , 2004 . 45 2303 - 2308 . DOI: 10.1016/j.polymer.2004.02.003 http://doi.org/10.1016/j.polymer.2004.02.003 .

King, E.; Robinson, S.; Cameron, R. E . Effect of hydrolytic degradation on the microstructure of quenched, amorphous poly(glycolic acid): an X-ray scattering study of hydrated samples . International , 1999 . 48 915 - 920 . .

Woodard, L. N.; Grunlan, M. A . Hydrolytic degradation and erosion of polyester biomaterials . ACS Macro Lett. , 2018 . 7 976 - 982 . DOI: 10.1021/acsmacrolett.8b00424 http://doi.org/10.1021/acsmacrolett.8b00424 .

Organ, S. J . Variation in melting point with molecular weight for hydroxybutyrate/hydroxyvalerate copolymers . Polymer , 1993 . 34 2175 - 2179 . DOI: 10.1016/0032-3861(93)90747-X http://doi.org/10.1016/0032-3861(93)90747-X .

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Improvement on the Mechanical Performance and Resistance Towards Hydrolysis of Poly(glycolic acid) via Solid-state Drawing

Improvement on the Mechanical Performance and Resistance Towards Hydrolysis of Poly(glycolic acid) via Solid-state Drawing

DOI：10.1007/s10118-022-2760-y

摘要

Abstract

关键词

Keywords

references