Polymer Vesicles with Upper Critical Solution Temperature for Near-infrared Light-triggered Transdermal Delivery of Metformin in Diabetic Rats

Wei Hu; Ya-Wei Su; Yi-Kun Jiang; Wen-Di Fan; Song-Yue Cheng; Zai-Zai Tong; Chao Cen; Guo-Hua Jiang

doi:10.1007/s10118-021-2640-x

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Polymer Vesicles with Upper Critical Solution Temperature for Near-infrared Light-triggered Transdermal Delivery of Metformin in Diabetic Rats

Papers | Updated：2021-11-04

- Polymer Vesicles with Upper Critical Solution Temperature for Near-infrared Light-triggered Transdermal Delivery of Metformin in Diabetic Rats
- Polymer Vesicles with Upper Critical Solution Temperature for Near-infrared Light-triggered Transdermal Delivery of Metformin in Diabetic Rats
- Chinese Journal of Polymer Science 2022年40卷第2期页码：157-165
- Affiliations：
  
  a.College of Materials Science and Engineering and Institute of Smart Biomedical Materials, Zhejiang Sci-Tech University, Hangzhou 310018, China
  b.Department of Hepatobiliary and Pancreatic Surgery, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
- Author bio：
  
  tongzz@zstu.edu.cn (Z.Z.T.)
  cenchao@zju.edu.cn (C.C.)
- Funds：
  
  This work was financially supported by the Natural Science Foundation of Zhejiang Province (No. LY20E030005) and the Opening Project of Jiangxi Province Key Laboratory of Polymer Micro/Nano Manufacturing and Devices (No. PMND201905).
- DOI：10.1007/s10118-021-2640-x
  中图分类号：
- 收稿：2021-07-08，
  
  修回：2021-8-11，
  
  录用：2021-8-19，
  
  网络首发：2021-11-04，
  
  纸质出版：2022-02-01
- Accepted：
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Hu, W.; Su, Y. W.; Jiang, Y. K.; Fan, W. D.; Cheng, S. Y.; Tong, Z. Z.; Cen, C.; Jiang, G. H. Polymer vesicles with upper critical solution temperature for near-infrared light-triggered transdermal delivery of metformin in diabetic rats. Chinese J. Polym. Sci. 2022, 40, 157–165

Wei Hu, Ya-Wei Su, Yi-Kun Jiang, et al. Polymer Vesicles with Upper Critical Solution Temperature for Near-infrared Light-triggered Transdermal Delivery of Metformin in Diabetic Rats[J]. Chinese Journal of Polymer Science, 2022, 40(2): 157-165.
Hu, W.; Su, Y. W.; Jiang, Y. K.; Fan, W. D.; Cheng, S. Y.; Tong, Z. Z.; Cen, C.; Jiang, G. H. Polymer vesicles with upper critical solution temperature for near-infrared light-triggered transdermal delivery of metformin in diabetic rats. Chinese J. Polym. Sci. 2022, 40, 157–165 DOI： 10.1007/s10118-021-2640-x.

Wei Hu, Ya-Wei Su, Yi-Kun Jiang, et al. Polymer Vesicles with Upper Critical Solution Temperature for Near-infrared Light-triggered Transdermal Delivery of Metformin in Diabetic Rats[J]. Chinese Journal of Polymer Science, 2022, 40(2): 157-165. DOI： 10.1007/s10118-021-2640-x.

摘要

Abstract

Near-infrared light (NIR) triggered transdermal drug delivery systems are of great interest due to their on-demand drug release

which enable to enhance drug treatment efficiency as well as reduce side effect. Herein

a NIR-triggered microneedle (MN) patch array has been fabricated through depositing the photothermal conversion agent and anti-diabetic drug-loaded polymer vesicles with upper critical solution temperature (UCST) into dissolvable polymer matrix. The UCST-type polymer has a clearing point temperature of 41 °C and the drug-loaded polymer vesicles present excellent NIR-triggered and temperature responsive drug release behavior

in vitro

due to the disassociation of polymer vesicles upon NIR irradiation. After applying MNs to diabetic rats

significant hypoglycemic effect is achieved upon interval NIR irradiation and the blood glucose concentration can decrease to normal state for several hours

which enables to achieve the goal of on-demand drug release. This work suggests that the NIR-triggered MN drug release device has a potential application in the treatment of diabetes

especially for those requiring an active drug release manner.

关键词

Keywords

references

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