Biocompatible, Hemocompatible and Antibacterial Acylated Dextran-<italic style="font-style: italic">g</italic>-polyisobutylene Graft Copolymers with Silver Nanoparticles

Cong-Lei Zhao; Yu-Zhuang Gao; Meng-Ying Wu; Hang-Tian Zhang; Yi-Xian Wu

doi:10.1007/s10118-021-2621-0

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Biocompatible, Hemocompatible and Antibacterial Acylated Dextran-g-polyisobutylene Graft Copolymers with Silver Nanoparticles

ARTICLE | Updated：2021-08-26

- Biocompatible, Hemocompatible and Antibacterial Acylated Dextran-g-polyisobutylene Graft Copolymers with Silver Nanoparticles
- Biocompatible, Hemocompatible and Antibacterial Acylated Dextran-g-polyisobutylene Graft Copolymers with Silver Nanoparticles
- Chinese Journal of Polymer Science 2021年39卷第12期页码：1550-1561
- Affiliations：
  
  State Key Laboratory of Chemical Resource Engineering, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing 100029, China
- Author bio：
  
  wuyx@mail.buct.edu.cn
- Funds：
  
  This work was financially supported by the National Natural Science Foundation of China (Nos. 51521062 and 21574007).
- DOI：10.1007/s10118-021-2621-0
  中图分类号：
- 收稿：2021-03-25，
  
  修回：2021-5-12，
  
  录用：2021-6-14，
  
  网络首发：2021-08-26，
  
  纸质出版：2021-10-18
- Accepted：
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Zhao, C. L.; Gao, Y. Z.; Wu, M. Y.; Zhang, H. T.; Wu, Y. X. Biocompatible, hemocompatible and antibacterial acylated dextran-g-polyisobutylene graft copolymers with silver nanoparticles. Chinese J. Polym. Sci. 2021, 39, 1550–1561

Cong-Lei Zhao, Yu-Zhuang Gao, Meng-Ying Wu, et al. Biocompatible, Hemocompatible and Antibacterial Acylated Dextran-g-polyisobutylene Graft Copolymers with Silver Nanoparticles[J]. Chinese Journal of Polymer Science, 2021, 39(12): 1550-1561. DOI: 10.1007/s10118-021-2621-0.
Zhao, C. L.; Gao, Y. Z.; Wu, M. Y.; Zhang, H. T.; Wu, Y. X. Biocompatible, hemocompatible and antibacterial acylated dextran-g-polyisobutylene graft copolymers with silver nanoparticles. Chinese J. Polym. Sci. 2021, 39, 1550–1561 DOI： 10.1007/s10118-021-2621-0.

Cong-Lei Zhao, Yu-Zhuang Gao, Meng-Ying Wu, et al. Biocompatible, Hemocompatible and Antibacterial Acylated Dextran-g-polyisobutylene Graft Copolymers with Silver Nanoparticles[J]. Chinese Journal of Polymer Science, 2021, 39(12): 1550-1561. DOI: 10.1007/s10118-021-2621-0. DOI：

摘要

Abstract

The novel amphiphilic acylated dextran-

-polyisobutylene (AcyDex-

-PIB) graft copolymers with different branch lengths (

PIB

2600–5800 g/mol) and grafting numbers (

5–28 per 1000 Dex monosaccharide) were successfully synthesized

via

the nucleophilic substitution of the hydroxyl (―OH) side groups along AcyDex backbone by the living PIB-THF

chains prepared through cationic polymerization. The crystallization of AcyDex backbone in AcyDex-

-PIB graft copolymers was confined due to the presence of PIB branches and the morphology changed from short rod-like crystals to fragment-like crystals with increasing

PIB

and

. The obvious microphase separation occurred due to the incompatibility between hard AcyDex backbone and soft PIB branches. AcyDex-

-PIB graft copolymers exhibit excellent biocompatibility towards HeLa cells and good hemocompatibility with red blood cells (RBCs)

both of which increase with increasing

. The increases of water contact angle and roughness on the surface of the graft copolymers with increasing

PIB

and

manifest the anti-protein adsorption performance. The amphiphilic AcyDex-

-PIB graft copolymers could self-assemble in aqueous solution into nanospheres

which can be used as pH-sensitive drug carriers and can release 100% of the loaded drug within 72 h at pH=7.4. AcyDex-

-PIB graft copolymers bearing silver nanoparticles (Ag-NPs

0.8 wt%–3.9 wt%

4.5–9.5 nm) show good antibacterial properties. This kind of amphiphilic graft copolymer would have a promising prospect in biological and medical fields.

关键词

Keywords

references

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Biocompatible, Hemocompatible and Antibacterial Acylated Dextran-g-polyisobutylene Graft Copolymers with Silver Nanoparticles

DOI：10.1007/s10118-021-2621-0

摘要

Abstract

关键词

Keywords

references