Characterization of a Multi-responsive Magnetic Graphene Oxide Nanocomposite Hydrogel and Its Application for DOX Delivery

M. Kurdtabar; S. Saif Heris; M. Dezfulian

doi:10.1007/s10118-021-2613-0

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Characterization of a Multi-responsive Magnetic Graphene Oxide Nanocomposite Hydrogel and Its Application for DOX Delivery

ARTICLE | Updated：2021-07-30

- Characterization of a Multi-responsive Magnetic Graphene Oxide Nanocomposite Hydrogel and Its Application for DOX Delivery
- Characterization of a Multi-responsive Magnetic Graphene Oxide Nanocomposite Hydrogel and Its Application for DOX Delivery
- Chinese Journal of Polymer Science 2021年39卷第12期页码：1597-1608
- Affiliations：
  
  a.Department of Chemistry, Karaj Branch, Islamic Azad University, Karaj 31485-313, Iran
  b.Department of Microbiology, Karaj Branch, Islamic Azad University, Karaj 31485-313, Iran
- Author bio：
  
  m.kurdtabar@kiau.ac.ir
- Funds：
- DOI：10.1007/s10118-021-2613-0
  中图分类号：
- 收稿：2021-04-11，
  
  录用：2021-5-25，
  
  网络首发：2021-07-30，
  
  纸质出版：2021-10-18
- Accepted：
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Kurdtabar, M.; Saif Heris, S.; Dezfulian, M. Characterization of a multi-responsive magnetic graphene oxide nanocomposite hydrogel and its application for DOX delivery. Chinese J. Polym. Sci. 2021, 39, 1597–1608

M. Kurdtabar, S. Saif Heris, M. Dezfulian. Characterization of a Multi-responsive Magnetic Graphene Oxide Nanocomposite Hydrogel and Its Application for DOX Delivery[J]. Chinese Journal of Polymer Science, 2021, 39(12): 1597-1608.
Kurdtabar, M.; Saif Heris, S.; Dezfulian, M. Characterization of a multi-responsive magnetic graphene oxide nanocomposite hydrogel and its application for DOX delivery. Chinese J. Polym. Sci. 2021, 39, 1597–1608 DOI： 10.1007/s10118-021-2613-0.

M. Kurdtabar, S. Saif Heris, M. Dezfulian. Characterization of a Multi-responsive Magnetic Graphene Oxide Nanocomposite Hydrogel and Its Application for DOX Delivery[J]. Chinese Journal of Polymer Science, 2021, 39(12): 1597-1608. DOI： 10.1007/s10118-021-2613-0.

摘要

Abstract

Nanocomposite hydrogels are one of the most important types of biomaterials which can be used in many different applications such as drug delivery and tissue engineering. Incorporation of nanoparticles within a hydrogel matrix can provide unique characteristics like remote stimulate and improved mechanical strength. In this study

the synthesis of graphene oxide and graphene oxide nanocomposite hydrogel has been studied. Nanocomposite hydrogel was synthesized using carboxymethyl cellulose as a natural base

acrylic acid as a comonomer

graphene oxide as a filler

ammonium persulfate as an initiator

and iron nanoparticles as a crosslinking agent. The effect of reaction variables such as the iron nanoparticles

graphene oxide

ammonium persulfate

and acrylic acid were examined to achieve a hydrogel with maximum absorbency. Doxorubicin

an anti-cancer chemotherapy drug

was loaded into this hydrogel and its release behaviors were examined in the phosphate buffer solutions with different pH values. The structure of the graphene oxide and the optimized hydrogel were confirmed by Fourier-transform infrared spectroscopy

Raman spectroscopy

X-ray diffraction

scanning electron microscopy

and atomic force microscopy.

关键词

Keywords

references

Kurdtabar, M.; Rezanejade Bardajee, G. . Drug release and swelling behavior of magnetic iron oxide nanocomposite hydrogels based on poly(acrylic acid) grafted onto sodium alginate . Polym. Bull. , 2020 . 77 3001 - 3015 . DOI: 10.1007/s00289-019-02894-w http://doi.org/10.1007/s00289-019-02894-w .

Kurdtabar, M.; Peyvand Kermani, Z.; Bagheri Marandi, G. . Synthesis and characterization of collagen-based hydrogel nanocomposites for adsorption of Cd 2+ , Pb 2+ , methylene green and crystal violet . Iran Polym. J. , 2015 . 24 791 - 803 . DOI: 10.1007/s13726-015-0368-6 http://doi.org/10.1007/s13726-015-0368-6 .

Abd El-Mohdy, H.; Hegazy, E.; El-Nesr, E.; El-Wahab, M. . Synthesis, characterization and properties of radiation-induced Starch/(EG- co -MAA) hydrogels . Arab. J. Chem. , 2016 . 9 S1627 - S1635 . DOI: 10.1016/j.arabjc.2012.04.022 http://doi.org/10.1016/j.arabjc.2012.04.022 .

Rivero, R. E.; Capella, V.; Liaudat, A.C.; Bosch, P.; Barbero, C. A.; Rodríguez, N. . Mechanical and physicochemical behavior of a 3D hydrogel scaffold during cell growth and proliferation . RSC Adv. , 2020 . 10 5827 - 5837 . DOI: 10.1039/C9RA08162C http://doi.org/10.1039/C9RA08162C .

Tirumala, V. R.; Tominaga, T.; Lee, S.; Butler, P. D.; Lin, E. K.; Gong, J. P. . Molecular model for toughening in double-network hydrogels . J. Phys. Chem. B , 2008 . 112 8024 - 8031 . .

Haraguchi, K. . Nanocomposite hydrogels . Curr. Opin. Solid. State. Mater. Sci. , 2007 . 11 47 - 54 . DOI: 10.1016/j.cossms.2008.05.001 http://doi.org/10.1016/j.cossms.2008.05.001 .

Zhang, H.; Zhai, D.; He, Y. . Graphene oxide/polyacrylamide/carboxymethyl cellulose sodium nanocomposite hydrogel with enhanced mechanical strength: preparation, characterization and the swelling behavior . RSC Adv. , 2014 . 4 44600 - 46609 . DOI: 10.1039/C4RA07576E http://doi.org/10.1039/C4RA07576E .

Liu, R.; Liang, S.; Tang, X. Z.; Yan, D.; Li, X.; Yu, Z. Z. . Tough and highly stretchable graphene oxide/polyacrylamide nanocomposite hydrogels . J. Mater. Chem. , 2012 . 22 14160 - 14167 . DOI: 10.1039/c2jm32541a http://doi.org/10.1039/c2jm32541a .

Su, J.; Cao, M.; Ren, L.; Hu, C. . Fe 3 O 4 -graphene nanocomposites with improved lithium storage and magnetism properties . J. Phys. Chem. C , 2011 . 115 14469 - 14477 . .

Moon, Y. E.; Jung, G.; Yun, J.; Kim, H. I. . Poly(vinyl alcohol)/poly (acrylic acid)/TiO 2 /graphene oxide nanocomposite hydrogels for pH-sensitive photocatalytic degradation of organic pollutants . Mater. Sci. Eng. B , 2013 . 178 1097 - 1103 . DOI: 10.1016/j.mseb.2013.07.002 http://doi.org/10.1016/j.mseb.2013.07.002 .

Shen, J.; Yan, B.; Li, T.; Long, Y.; Li, N.; Ye, M. . Study on graphene-oxide-based polyacrylamide composite hydrogels . Compos. Part A Appl. Sci. Manuf. , 2012 . 43 1476 - 1481 . DOI: 10.1016/j.compositesa.2012.04.006 http://doi.org/10.1016/j.compositesa.2012.04.006 .

Oh, J. K.; Park, J. M. . Iron oxide-based superparamagnetic polymeric nanomaterials: design, preparation, and biomedical application . Prog. Polym. Sci. , 2011 . 36 168 - 189 . DOI: 10.1016/j.progpolymsci.2010.08.005 http://doi.org/10.1016/j.progpolymsci.2010.08.005 .

Sharifi, S.; Seyednejad, H.; Laurent, S.; Atyabi, F.; Saei, A. A.; Mahmoudi, M. . Superparamagnetic iron oxide nanoparticles for in vivo molecular and cellular imaging . Contrast Media Mol. Imaging , 2015 . 10 329 - 355 . DOI: 10.1002/cmmi.1638 http://doi.org/10.1002/cmmi.1638 .

Dias, A.; Hussain, A.; Marcos, A.; Roque, A. . A biotechnological perspective on the application of iron oxide magnetic colloids modified with polysaccharides . Biotechnol. Adv. , 2011 . 29 142 - 155 . DOI: 10.1016/j.biotechadv.2010.10.003 http://doi.org/10.1016/j.biotechadv.2010.10.003 .

Ruzene, D. S.; Gonçalves, A. R.; Teixeira, J. A.; De Amorim, M. T. P. Carboxymethylcellulose obtained by ethanol/water organosolv process under acid conditions. Appl. Biochem. 2007 , 573−582.

Marcano, D. C.; Kosynkin, D. V.; Berlin, J. M.; Sinitskii, A.; Sun, Z.; Slesarev, A. . Improved synthesis of graphene oxide . ACS Nano , 2010 . 4 4806 - 4814 . DOI: 10.1021/nn1006368 http://doi.org/10.1021/nn1006368 .

Pourjavadi, A.; Kurdtabar, M.; Ghasemzadeh, H. . Salt- and pH-resisting collagen-based highly porous hydrogel . Polym. J. , 2008 . 40 94 - 103 . DOI: 10.1295/polymj.PJ2007042 http://doi.org/10.1295/polymj.PJ2007042 .

Pourjavadi, A.; Kurdtabar, M. . Effect of different bases and neutralization steps on porosity and properties of collagen-based hydrogels . Polym. Int. , 2010 . 59 36 - 42 . DOI: 10.1002/pi.2685 http://doi.org/10.1002/pi.2685 .

Pourjavadi, A.; Mazaheri Tehrani, Z.; Jokar, S. . Functionalized mesoporous silica-coated magnetic graphene oxide by polyglycerol- g -polycaprolactone with pH-responsive behavior: designed for targeted and controlled doxorubicin delivery . J. Ind. Eng. Chem. , 2015 . 28 45 - 53 . DOI: 10.1016/j.jiec.2015.01.021 http://doi.org/10.1016/j.jiec.2015.01.021 .

Kurdtabar, M.; Nezam, H.; Rezanejade Bardajee, G.; Dezfulian, M.; Salimi, H. . Biocompatible magnetic hydrogel nanocomposite based on carboxymethylcellulose: synthesis, cell culture property and drug delivery . Polym. Sci. Ser. B. , 2018 . 60 231 - 242 . DOI: 10.1134/S1560090418020021 http://doi.org/10.1134/S1560090418020021 .

Jiao, T.; Guo, H.; Zhang, Q.; Peng, Q.; Tang, Y.; Yan, X. . Reduced graphene oxide-based silver nanoparticle-containing composite hydrogel as highly efficient dye catalysts for wastewater treatment . Sci. Rep. , 2015 . 5 11873 DOI: 10.1038/srep11873 http://doi.org/10.1038/srep11873 .

Su, C. Y.; Lu, A. Y.; Xu, Y.; Chen, F. R.; Khlobystov, A. N.; Li, L. J. . High-quality thin graphene films from fast electrochemical exfoliation . ACS Nano , 2011 . 5 2332 - 2339 . DOI: 10.1021/nn200025p http://doi.org/10.1021/nn200025p .

Fu, L.; Zhu, D.; Yu, A. . Galvanic replacement synthesis of silver dendrites-reduced graphene oxide composites and their surface-enhanced Raman scattering characteristics . Spectrochim. Acta A Mol. Biomol. Spectrosc. , 2015 . 149 396 - 401 . DOI: 10.1016/j.saa.2015.04.049 http://doi.org/10.1016/j.saa.2015.04.049 .

Huang, Y.; Zeng, M.; Ren, J.; Wang, J.; Fan, L.; Xu, Q. . Preparation and swelling properties of graphene oxide/poly(acrylic acid- co -acrylamide) super-absorbent hydrogel nanocomposites . Colloids Surf. A Physicochem. Eng. Asp. , 2012 . 401 97 - 106 . DOI: 10.1016/j.colsurfa.2012.03.031 http://doi.org/10.1016/j.colsurfa.2012.03.031 .

Ho, C. Y.; Wang, H. W. . Characteristics of thermally reduced graphene oxide and applied for dye-sensitized solar cell counter electrode . Appl. Surf. Sci. , 2015 . 357 147 - 154 . DOI: 10.1016/j.apsusc.2015.09.016 http://doi.org/10.1016/j.apsusc.2015.09.016 .

Abd El-Mohdy, H. . Radiation initiated synthesis of 2-acrylamidoglycolic acid grafted carboxymethyl cellulose as pH-sensitive hydrogel . Polym. Eng. Sci. , 2014 . 54 2753 - 2761 . DOI: 10.1002/pen.23831 http://doi.org/10.1002/pen.23831 .

Naebe, M.; Wang, J.; Amini, A.; Khayyam, H.; Hameed, N.; Li, L. H. . Mechanical property and structure of covalent functionalised graphene/epoxy nanocomposites . Sci. Rep. , 2014 . 4 4375 .

Oh, J.; Lee, J. H.; Koo, J. C.; Choi, H. R.; Lee, Y.; Kim, T. . Graphene oxide porous paper from amine-functionalized poly(glycidyl methacrylate)/graphene oxide core-shell microspheres . J. Mater. Chem. , 2010 . 20 9200 - 9204 . DOI: 10.1039/c0jm00107d http://doi.org/10.1039/c0jm00107d .

Braihi, A. J.; Salih, S. I.; Hashem, F. A.; Ahmed, J. K. . Proposed cross-linking model for carboxymethyl cellulose/starch superabsorbent polymer blend . Int. J. Mater. Sci. Appl. , 2014 . 3 363 - 369 . .

Mohkami, M.; Talaeipour, M. . Investigation of the chemical structure of carboxylated and carboxymethylated fibers from waste paper via XRD and FTIR analysis . Bioresources , 2011 . 6 1988 - 2003 . .

Zarnegar, Z.; Safari, J. . The novel synthesis of magnetically chitosan/carbon nanotube composites and their catalytic applications . Int. J. Biol. Macromol. , 2015 . 75 21 - 31 . DOI: 10.1016/j.ijbiomac.2015.01.013 http://doi.org/10.1016/j.ijbiomac.2015.01.013 .

Piao, Y.; Chen, B. . Self-assembled graphene oxide–gelatin nanocomposite hydrogels: Characterization, formation mechanisms, and pH-sensitive drug release behavior . J. Polym. Sci., Part B: Polym. Phys. , 2015 . 53 356 - 367 . DOI: 10.1002/polb.23636 http://doi.org/10.1002/polb.23636 .

Stankovich, S.; Dikin, D.A.; Piner, R.D.; Kohlhaas, K.A.; Kleinhammes, A.; Jia, Y. . Synthesis of graphene-based nanosheets via chemical reduction of exfoliated graphite oxide . Carbon , 2007 . 45 1558 - 1565 . DOI: 10.1016/j.carbon.2007.02.034 http://doi.org/10.1016/j.carbon.2007.02.034 .

Bao, Y.; Ma, J.; Li, N. . Synthesis and swelling behaviors of sodium carboxymethyl cellulose- g -poly(AA- co -AM- co -AMPS)/MMT superabsorbent hydrogel . Carbohydr. Polym. , 2011 . 84 76 - 82 . DOI: 10.1016/j.carbpol.2010.10.061 http://doi.org/10.1016/j.carbpol.2010.10.061 .

El-Sayed, S.; Mahmoud, K.; Fatah, A.; Hassen, A. . TGA and dielectric properties of carboxymethyl cellulose/polyvinyl alcohol blends . Physica B , 2011 . 406 4068 - 4076 . DOI: 10.1016/j.physb.2011.07.050 http://doi.org/10.1016/j.physb.2011.07.050 .

Li, W.; Sun, B.; Wu, P. . Study on hydrogen bonds of carboxymethyl cellulose sodium film with two-dimensional correlation infrared spectroscopy . Carbohydr. Polym. , 2009 . 78 454 - 461 . DOI: 10.1016/j.carbpol.2009.05.002 http://doi.org/10.1016/j.carbpol.2009.05.002 .

Davaran, S.; Alimirzalu, S.; Nejati-Koshki, K.; Nasrabadi, H. T.; Akbarzadeh, A.; Khandaghi, A. A. . Physicochemical characteristics of Fe . Asian Pac. J. Cancer Prev. , 2014 . 15 49 - 54 . DOI: 10.7314/APJCP.2014.15.1.49 http://doi.org/10.7314/APJCP.2014.15.1.49 .

Khosroshahi, M.E.; Ghazanfari, L.; Hassannejad, Z.; Lenhert, S. . In-vitro application of doxorubicin loaded magnetoplasmonic thermosensitive liposomes for laser hyperthermia and chemotherapy of breast cancer . J. Nanomed. Nanotechnol. , 2015 . 6 298 .

Zhang, H.; Xie, A.; Wang, C.; Wang, H.; Shen, Y.; Tian, X. . Novel rGO/ α -Fe 2 O 3 composite hydrogel: synthesis, characterization and high performance of electromagnetic wave absorption . J. Mater. Chem. A , 2013 . 1 8547 - 8552 . DOI: 10.1039/c3ta11278k http://doi.org/10.1039/c3ta11278k .

Pourjavadi, A, Ghasemzadeh, H, Soleyman, R. . characterization, and swelling behavior of alginate- g -poly (sodium acrylate)/kaolin superabsorbent hydrogel composites . J. Appl. Polym. Sci. , 2007 . 105 2631 - 2639 . DOI: 10.1002/app.26345 http://doi.org/10.1002/app.26345 .

Hayati, M.; Rezanejade Bardajee, G.; Ramezani, M.; Mizani, F. . Temperature/pH/magnetic triple sensitive nanogel for doxorubicin anticancer drug delivery . Inorg. Nano-Met. Chem. , 2020 . 50 1189 - 1200 . DOI: 10.1080/24701556.2020.1737821 http://doi.org/10.1080/24701556.2020.1737821 .

McCarty, M. F.; Whitaker, J. . Manipulating tumor acidification as a cancer treatment strategy . Altern. Med. Rev. , 2010 . 15 264 - 272 . .

Neumann, A.; Jahnke, K.; Maier, H.; Ragoss, C. . Biocompatibilty of silicon nitride ceramic in vitro. A comparative fluorescence-microscopic and scanning electron-microscopic study . Laryngo-rhino-otologie. , 2004 . 83 845 - 851 . DOI: 10.1055/s-2004-825739 http://doi.org/10.1055/s-2004-825739 .

El-Ghalbzouri, A.; Gibbs, S.; Lamme, E.; Van Blitterswijk, C. A.; Ponec, M. . Effect of fibroblasts on epidermal regeneration . Br. J. Dermatol. , 2002 . 147 230 - 243 . DOI: 10.1046/j.1365-2133.2002.04871.x http://doi.org/10.1046/j.1365-2133.2002.04871.x .

Falanga, V.; Margolis, D.; Alvarez, O.; Auletta, M.; Maggiacomo, F.; Altman, M. . Rapid healing of venous ulcers and lack of clinical rejection with an allogeneic cultured human skin equivalent . Arch. Dermatol. , 1998 . 134 293 - 300 . DOI: 10.1001/archderm.134.3.293 http://doi.org/10.1001/archderm.134.3.293 .

Slany, A.; Meshcheryakova, A.; Beer, A.; Ankersmit, H. J.; Paulitschke, V.; Gerner, C. . Plasticity of fibroblasts demonstrated by tissue-specific and function-related proteome profiling . Clin. Proteom. , 2014 . 11 1 - 13 . DOI: 10.1186/1559-0275-11-1 http://doi.org/10.1186/1559-0275-11-1 .

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