Responsive Polymeric Nanoparticles for Biofilm-infection Control

Lin-Zhu Su; Yong Liu; Yuan-Feng Li; Ying-Li An; Lin-Qi Shi

doi:10.1007/s10118-021-2610-3

Your Location：

Home >

Browse articles >

Responsive Polymeric Nanoparticles for Biofilm-infection Control

FEATURE ARTICLE | Updated：2021-07-25

- Responsive Polymeric Nanoparticles for Biofilm-infection Control
- Responsive Polymeric Nanoparticles for Biofilm-infection Control
- Chinese Journal of Polymer Science 2021年39卷第11期页码：1376-1391
- Affiliations：
  
  a.State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Functional Polymer Materials, Ministry of Education, Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China
  b.Engineering Research Center of Clinical Functional Materials and Diagnosis & Treatment Devices of Zhejiang Province, Wenzhou Institute, University of Chinese Academy of Sciences; Oujiang Laboratory, Wenzhou 325000, China
- Author bio：
  
  y.liu@ucas.ac.cn (Y.L.)
  shilinqi@nankai.edu.cn (L.Q.S.)
- Funds：
  
  This work was financially supported by the National Natural Science Foundation of China (Nos. 21620102005, 51933006, and 52003184).
- DOI：10.1007/s10118-021-2610-3
  中图分类号：
- 收稿：2021-04-25，
  
  修回：2021-5-17，
  
  录用：2021-5-18，
  
  网络首发：2021-07-25，
  
  纸质出版：2021-09-18
- Accepted：
Scan QR Code
Su, L. Z.; Liu, Y.; Li, Y. F.; An, Y. L.; Shi, L. Q. Responsive Polymeric Nanoparticles for biofilm-infection control. Chinese J. Polym. Sci. 2021, 39, 1376–1391

Lin-Zhu Su, Yong Liu, Yuan-Feng Li, et al. Responsive Polymeric Nanoparticles for Biofilm-infection Control[J]. Chinese Journal of Polymer Science, 2021, 39(11): 1376-1391.
Su, L. Z.; Liu, Y.; Li, Y. F.; An, Y. L.; Shi, L. Q. Responsive Polymeric Nanoparticles for biofilm-infection control. Chinese J. Polym. Sci. 2021, 39, 1376–1391 DOI： 10.1007/s10118-021-2610-3.

Lin-Zhu Su, Yong Liu, Yuan-Feng Li, et al. Responsive Polymeric Nanoparticles for Biofilm-infection Control[J]. Chinese Journal of Polymer Science, 2021, 39(11): 1376-1391. DOI： 10.1007/s10118-021-2610-3.

摘要

Abstract

With the emergence of multidrug resistance (MDR) in many pathogens

bacterial infections are becoming a growing threat to public health. The frightening scenario is due largely to the formation of biofilms

in which the bacteria are extremely recalcitrant to the conventional antibiotic regimens. To address the emergence of MDR and biofilm-associated infections

numerous polymer-based materials have been designed and prepared recently. The subject of this perspective is the recent development of polymer-based materials that have been applied to combat multidrug-resistant pathogens

to prevent the formation of biofilms

or enhance the eradication efficacy to mature biofilms

via

killing biofilm-bacteria or dispersing biofilms. The advantages and shortcomings of these polymer-based materials are discussed

as well as the challenges we are facing in the clinical translation of these systems.

关键词

Keywords

references

Howard, S. J.; Hopwood, S.; Davies, S. C. . Antimicrobial resistance: a global challenge . Sci. Transl. Med. , 2014 . 6 236ed10 DOI: 10.1126/scitranslmed.3009315 http://doi.org/10.1126/scitranslmed.3009315 .

Humphreys, G.; Fleck, F. In United Nations meeting on antimicrobial resistance , Bull. World Health Organ., Sep 1; Bull. World Health Organ: 2016 ; pp 638−639.

Davies, D. . Understanding biofilm resistance to antibacterial agents . Nat. Rev. Drug Discov. , 2003 . 2 114 - 122 . DOI: 10.1038/nrd1008 http://doi.org/10.1038/nrd1008 .

Hall-Stoodley, L.; Costerton, J. W.; Stoodley, P. . Bacterial biofilms: from the natural environment to infectious diseases . Nat. Rev. Microbiol. , 2004 . 2 95 - 108 . DOI: 10.1038/nrmicro821 http://doi.org/10.1038/nrmicro821 .

Flemming, H. C.; Wingender, J. . The biofilm matrix . Nat. Rev. Microbiol. , 2010 . 8 623 - 633 . DOI: 10.1038/nrmicro2415 http://doi.org/10.1038/nrmicro2415 .

Van Acker, H.; Coenye, T. . The role of efflux and physiological adaptation in biofilm tolerance and resistance . J. Biol. Chem. , 2016 . 291 12565 - 12572 . DOI: 10.1074/jbc.R115.707257 http://doi.org/10.1074/jbc.R115.707257 .

Ramirez, M. S.; Tolmasky, M. E. . Aminoglycoside modifying enzymes . Drug Resistance Update. , 2010 . 13 151 - 171 . DOI: 10.1016/j.drup.2010.08.003 http://doi.org/10.1016/j.drup.2010.08.003 .

Hoiby, N.; Bjarnsholt, T.; Givskov, M.; Molin, S.; Ciofu, O. . Antibiotic resistance of bacterial biofilms . Int. J. Antimicrob. Agents. , 2010 . 35 322 - 332 . DOI: 10.1016/j.ijantimicag.2009.12.011 http://doi.org/10.1016/j.ijantimicag.2009.12.011 .

Piddock, L. J. V. . The crisis of no new antibiotics-what is the way forward? . Lancet Infect. Dis. , 2012 . 12 249 - 253 . DOI: 10.1016/S1473-3099(11)70316-4 http://doi.org/10.1016/S1473-3099(11)70316-4 .

Liu, Y.; Shi, L.; Su, L.; van der Mei, H. C.; Jutte, P. C.; Ren, Y.; Busscher, H. J. . Nanotechnology-based antimicrobials and delivery systems for biofilm-infection control . Chem. Soc. Rev. , 2019 . 48 428 - 446 . DOI: 10.1039/C7CS00807D http://doi.org/10.1039/C7CS00807D .

Zheng, C, X.; Zhao, Y.; Liu, Y. . Recent advances in self-assembled nano-therapeutics . Chinese J. Polym. Sci. , 2018 . 36 322 - 346 . DOI: 10.1007/s10118-018-2078-y http://doi.org/10.1007/s10118-018-2078-y .

Matyjaszewski, K.; Tsarevsky, N. V. . Macromolecular engineering by atom transfer radical polymerization . J. Am. Chem. Soc. , 2014 . 136 6513 - 6533 . DOI: 10.1021/ja408069v http://doi.org/10.1021/ja408069v .

Xu, F. J.; Yang, W. T. . Polymer vectors via controlled/living radical polymerization for gene delivery . Prog. Polym. Sci. , 2011 . 36 1099 - 1131 . DOI: 10.1016/j.progpolymsci.2010.11.005 http://doi.org/10.1016/j.progpolymsci.2010.11.005 .

Lutz, J. F.; Neugebauer, D.; Matyjaszewski, K. . Stereoblock copolymers and tacticity control in controlled/living radical polymerization . J. Am. Chem. Soc. , 2003 . 125 6986 - 6993 . DOI: 10.1021/ja029517w http://doi.org/10.1021/ja029517w .

Wu, Y. M.; Zhang, W. W.; Zhou, R. Y.; Chen, Q.; Xie, C. Y.; Xiang, H. X.; Sun, B.; Zhu, M. F.; Liu, R. H. . Facile synthesis of high molecular weight polypeptides via fast and moisture insensitive polymerization of α -amino acid n -carboxyanhydrides . Chinese J. Polym. Sci. , 2020 . 38 1131 - 1140 . DOI: 10.1007/s10118-020-2471-1 http://doi.org/10.1007/s10118-020-2471-1 .

Ding, X.; Wang, A.; Tong, W.; Xu, F. J. . Biodegradable antibacterial polymeric nanosystems: a new hope to cope with multidrug-resistant bacteria . Small , 2019 . 15 e1900999 DOI: 10.1002/smll.201900999 http://doi.org/10.1002/smll.201900999 .

Chin, W.; Yang, C. A.; Ng, V. W. L.; Huang, Y.; Cheng, J. C.; Tong, Y. W.; Coady, D. J.; Fan, W. M.; Hedrick, J. L.; Yang, Y. Y. . Biodegradable broad-spectrum antimicrobial polycarbonates: investigating the role of chemical structure on activity and selectivity . Macromolecules , 2013 . 46 8797 - 8807 . DOI: 10.1021/ma4019685 http://doi.org/10.1021/ma4019685 .

Gupta, A.; Landis, R. F.; Li, C. H.; Schnurr, M.; Das, R.; Lee, Y. W.; Yazdani, M.; Liu, Y.; Kozlova, A.; Rotello, V. M. . Engineered polymer nanoparticles with unprecedented antimicrobial efficacy and therapeutic indices against multidrug-resistant bacteria and biofilms . J. Am. Chem. Soc. , 2018 . 140 12137 - 12143 . DOI: 10.1021/jacs.8b06961 http://doi.org/10.1021/jacs.8b06961 .

Pu, Y. J.; Hou, Z.; Khin, M. M.; Zamudio-Vazquez, R.; Poon, K. L.; Duan, H. W.; Chan-Park, M. B. . Synthesis and antibacterial study of sulfobetaine/quaternary ammonium-modified star-shaped poly[2-(dimethylamino)ethyl methacrylate]-based copolymers with an inorganic core . Biomacromolecules , 2017 . 18 44 - 55 . DOI: 10.1021/acs.biomac.6b01279 http://doi.org/10.1021/acs.biomac.6b01279 .

Tan, J. P. K.; Coady, D. J.; Sardon, H.; Yuen, A.; Gao, S. J.; Lim, S. W.; Liang, Z. C.; Tan, E. W.; Venkataraman, S.; Engler, A. C.; Fevre, M.; Ono, R.; Yang, Y. Y.; Hedrick, J. L. . Broad spectrum macromolecular antimicrobials with biofilm disruption capability and in vivo efficacy . Adv. Healthc. Mater. , 2017 . 6 1601420 DOI: 10.1002/adhm.201601420 http://doi.org/10.1002/adhm.201601420 .

Patel, M.; Patel, R.; Chi, W. S.; Kim, J. H.; Sung, J. S. . Antibacterial behaviour of quaternized poly(vinyl chloride)- g -poly(4-vinyl pyridine) graft copolymers . Chinese J. Polym. Sci. , 2015 . 33 265 - 274 . DOI: 10.1007/s10118-015-1577-3 http://doi.org/10.1007/s10118-015-1577-3 .

Wang, M.; Zhou, C.; Chen, J.; Xiao, Y.; Du, J. . Multifunctional biocompatible and biodegradable folic acid conjugated poly( ε -caprolactone)-polypeptide copolymer vesicles with excellent antibacterial activities . Bioconjug. Chem. , 2015 . 26 725 - 734 . DOI: 10.1021/acs.bioconjchem.5b00061 http://doi.org/10.1021/acs.bioconjchem.5b00061 .

Xi, Y.; Song, T.; Tang, S.; Wang, N.; Du, J. . Preparation and antibacterial mechanism insight of polypeptide-based micelles with excellent antibacterial activities . Biomacromolecules , 2016 . 17 3922 - 3930 . DOI: 10.1021/acs.biomac.6b01285 http://doi.org/10.1021/acs.biomac.6b01285 .

Takahashi, H.; Nadres, E. T.; Kuroda, K. . Cationic amphiphilic polymers with antimicrobial activity for oral care applications: eradication of S. mutans biofilm . Biomacromolecules , 2017 . 18 257 - 265 . DOI: 10.1021/acs.biomac.6b01598 http://doi.org/10.1021/acs.biomac.6b01598 .

Nimmagadda, A.; Liu, X.; Teng, P.; Su, M.; Li, Y.; Qiao, Q.; Khadka, N. K.; Sun, X.; Pan, J.; Xu, H.; Li, Q.; Cai, J. . Polycarbonates with potent and selective antimicrobial activity toward gram-positive bacteria . Biomacromolecules , 2017 . 18 87 - 95 . DOI: 10.1021/acs.biomac.6b01385 http://doi.org/10.1021/acs.biomac.6b01385 .

Zou, Y. J.; He, S. S.; Du, J. Z. . ε -Poly(L-lysine)-based hydrogels with fast-acting and prolonged antibacterial activities . Chinese J. Polym. Sci. , 2018 . 36 1239 - 1250 . DOI: 10.1007/s10118-018-2156-1 http://doi.org/10.1007/s10118-018-2156-1 .

Xia, G. X.; Wu, Y. M.; Bi, Y. F.; Chen, K.; Zhang, W. W.; Liu, S. Q.; Zhang, W. J.; Liu, R. H. . Antimicrobial properties and application of polysaccharides and their derivatives . Chinese J. Polym. Sci. , 2021 . 39 133 - 146 . DOI: 10.1007/s10118-021-2506-2 http://doi.org/10.1007/s10118-021-2506-2 .

Ibrahim, H. R.; Thomas, U.;Pellegrini, A. . A helix-loop-helix peptide at the upper lip of the active site cleft of lysozyme confers potent antimicrobial activity with membrane permeabilization action . J. Biol. Chem. , 2001 . 276 43767 - 43774 . DOI: 10.1074/jbc.M106317200 http://doi.org/10.1074/jbc.M106317200 .

Wang, J.; Chen, X. Y.; Zhao, Y.; Yang, Y.; Wang, W.; Wu, C.; Yang, B.; Zhang, Z.; Zhang, L.; Liu, Y.; Du, X.; Li, W.; Qiu, L.; Jiang, P.; Mou, X. Z.;Li, Y. Q. . pH-Switchable antimicrobial nanofiber networks of hydrogel eradicate biofilm and rescue stalled healing in chronic wounds . ACS Nano , 2019 . 13 11686 - 11697 . DOI: 10.1021/acsnano.9b05608 http://doi.org/10.1021/acsnano.9b05608 .

Xiong, M.; Lee, M. W.; Mansbach, R. A.; Song, Z.; Bao, Y.; Peek, R. M.; Yao, C.; Chen, L. F.; Ferguson, A. L.; Wong, G. C. L.; Cheng, J. J. . Helical antimicrobial polypeptides with radial amphiphilicity . Proc. Natl. Acad. Sci. U. S. A. , 2015 . 112 13155 - 13160 . DOI: 10.1073/pnas.1507893112 http://doi.org/10.1073/pnas.1507893112 .

Liu, Y.; Li, Y.; Shi, L. . Controlled drug delivery systems in eradicating bacterial biofilm-associated infections . J. Control. Release , 2021 . 329 1102 - 1116 . DOI: 10.1016/j.jconrel.2020.10.038 http://doi.org/10.1016/j.jconrel.2020.10.038 .

Matsumura, Y.; Maeda, H. . A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs . Cancer Res. , 1986 . 46 6387 - 6392 . .

Shi, J.; Kantoff, P. W.; Wooster, R.; Farokhzad, O. C. . Cancer nanomedicine: progress, challenges and opportunities . Nat. Rev. Cancer , 2017 . 17 20 - 37 . DOI: 10.1038/nrc.2016.108 http://doi.org/10.1038/nrc.2016.108 .

Gerlowski, L. E.; Jain, R. K. . Microvascular permeability of normal and neoplastic tissues . Microvasc. Res. , 1986 . 31 288 - 305 . DOI: 10.1016/0026-2862(86)90018-X http://doi.org/10.1016/0026-2862(86)90018-X .

Maeda, H. . The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting . Adv. Enzyme Regul. , 2001 . 41 189 - 207 . DOI: 10.1016/S0065-2571(00)00013-3 http://doi.org/10.1016/S0065-2571(00)00013-3 .

Ding, Y.; Xu, Y.; Yang, W.; Niu, P.; Li, X.; Chen, Y.; Li, Z.; Liu, Y.; An, Y.; Liu, Y.; Shen, W.; Shi, L. . Investigating the EPR effect of nanomedicines in human renal tumors via ex vivo perfusion strategy . Nano Today , 2020 . 35 100970 DOI: 10.1016/j.nantod.2020.100970 http://doi.org/10.1016/j.nantod.2020.100970 .

Liu, Y.; Sun, D.; Fan, Q.; Ma, Q.; Dong, Z.; Tao, W.; Tao, H.; Liu, Z.; Wang, C. . The enhanced permeability and retention effect based nanomedicine at the site of injury . Nano Res. , 2020 . 13 564 - 569 . DOI: 10.1007/s12274-020-2655-6 http://doi.org/10.1007/s12274-020-2655-6 .

Maeda, H. . The 35 th anniversary of the discovery of EPR effect: a new wave of nanomedicines for tumor-targeted drug delivery-personal remarks and future prospects . J. Pers Med. , 2021 . 11 229 DOI: 10.3390/jpm11030229 http://doi.org/10.3390/jpm11030229 .

Maruo, K.; Akaike, T.; Inada, Y.; Ohkubo, I.; Ono, T.; Maeda, H. . Effect of microbial and mite proteases on low and high molecular weight kininogens. Generation of kinin and inactivation of thiol protease inhibitory activity . J. Biol. Chem. , 1993 . 268 17711 - 17715 . DOI: 10.1016/S0021-9258(17)46762-7 http://doi.org/10.1016/S0021-9258(17)46762-7 .

Molla, A.; Yamamoto, T.; Akaike, T.; Miyoshi, S.; Maeda, H. . Activation of hageman factor and prekallikrein and generation of kinin by various microbial proteinases . J. Biol. Chem. , 1989 . 264 10589 - 10594 . DOI: 10.1016/S0021-9258(18)81661-1 http://doi.org/10.1016/S0021-9258(18)81661-1 .

Kamata, R.; Yamamoto, T.; Matsumoto, K.; Maeda, H. . A serratial protease causes vascular permeability reaction by activation of the Hageman factor-dependent pathway in guinea pigs . Infect. Immun. , 1985 . 48 747 - 753 . DOI: 10.1128/iai.48.3.747-753.1985 http://doi.org/10.1128/iai.48.3.747-753.1985 .

Matsumoto, K.; Yamamoto, T.; Kamata, R.; Maeda, H. . Pathogenesis of serratial infection: activation of the Hageman factor-prekallikrein cascade by serratial protease . J. Biochem. , 1984 . 96 739 - 749 . DOI: 10.1093/oxfordjournals.jbchem.a134892 http://doi.org/10.1093/oxfordjournals.jbchem.a134892 .

von Ohle, C.; Gieseke, A.; Nistico, L.; Decker, E. M.; deBeer, D.; Stoodley, P. . Real-time microsensor measurement of local metabolic activities in ex vivo dental biofilms exposed to sucrose and treated with chlorhexidine . Appl. Environ. Microbiol. , 2010 . 76 2326 - 2334 . DOI: 10.1128/AEM.02090-09 http://doi.org/10.1128/AEM.02090-09 .

Simmen, H. P.; Battaglia, H.; Giovanoli, P.; Blaser, J. . Analysis of pH, pO 2 and pCO 2 in drainage fluid allows for rapid detection of infectious complications during the follow-up period after abdominal surgery . Infection , 1994 . 22 386 - 389 . DOI: 10.1007/BF01715494 http://doi.org/10.1007/BF01715494 .

Su, L.; Li, Y.; Liu, Y.; Ma, R.; Liu, Y.; Huang, F.; An, Y.; Ren, Y.; van der Mei, H. C.; Busscher, H. J.; Shi, L. . Antifungal-inbuilt metal-organic-frameworks eradicate Candida albicans biofilms . Adv. Funct. Mater. , 2020 . 30 2000537 DOI: 10.1002/adfm.202000537 http://doi.org/10.1002/adfm.202000537 .

Simmen, H. P.; Blaser, J. . Analysis of pH and pO 2 in abscesses, peritoneal fluid, and drainage fluid in the presence or absence of bacterial infection during and after abdominal surgery . Am. J. Surg. , 1993 . 166 24 - 27 . DOI: 10.1016/S0002-9610(05)80576-8 http://doi.org/10.1016/S0002-9610(05)80576-8 .

Su, L.; Li, Y.; Liu, Y.; An, Y.; Shi, L. . Recent advances and future prospects on adaptive biomaterials for antimicrobial applications . Macromol. Biosci. , 2019 . 19 1900289 DOI: 10.1002/mabi.201900289 http://doi.org/10.1002/mabi.201900289 .

Stewart, P. S.; Franklin, M. J. . Physiological heterogeneity in biofilms . Nat. Rev. Microbiol. , 2008 . 6 199 - 210 . DOI: 10.1038/nrmicro1838 http://doi.org/10.1038/nrmicro1838 .

Flemming, H. C.; Wingender, J.; Szewzyk, U.; Steinberg, P.; Rice, S. A.; Kjelleberg, S. . Biofilms: an emergent form of bacterial life . Nat. Rev. Microbiol. , 2016 . 14 563 - 575 . DOI: 10.1038/nrmicro.2016.94 http://doi.org/10.1038/nrmicro.2016.94 .

Thambi, T.; Park, J. H.; Lee, D. S. . Hypoxia-responsive nanocarriers for cancer imaging and therapy: recent approaches and future perspectives . Chem. Commun. , 2016 . 52 8492 - 8500 . DOI: 10.1039/C6CC02972H http://doi.org/10.1039/C6CC02972H .

Kumari, R.; Sunil, D.; Ningthoujam, R. S. . Hypoxia-responsive nanoparticle based drug delivery systems in cancer therapy: an up-to-date review . J. Control. Release , 2020 . 319 135 - 156 . DOI: 10.1016/j.jconrel.2019.12.041 http://doi.org/10.1016/j.jconrel.2019.12.041 .

Hu, D.; Zou, L.; Yu, W.; Jia, F.; Han, H.; Yao, K.; Jin, Q.; Ji, J. . Relief of biofilm hypoxia using an oxygen nanocarrier: a new paradigm for enhanced antibiotic therapy . Adv. Sci. , 2020 . 7 2000398 DOI: 10.1002/advs.202000398 http://doi.org/10.1002/advs.202000398 .

Devnarain, N.; Osman, N.; Fasiku, V. O.; Makhathini, S.; Salih, M.; Ibrahim, U. H.; Govender, T. . Intrinsic stimuli-responsive nanocarriers for smart drug delivery of antibacterial agents-An in-depth review of the last two decades . WIREs-Nanomed. Nanobiotechnol. , 2021 . 13 e1664 DOI: 10.1002/wnan.1664 http://doi.org/10.1002/wnan.1664 .

Legigan, T.; Clarhaut, J.; Tranoy-Opalinski, I.; Monvoisin, A.; Renoux, B.; Thomas, M.; Le Pape, A.; Lerondel, S.; Papot, S. . The first generation of β -galactosidase-responsive prodrugs designed for the selective treatment of solid tumors in prodrug monotherapy . Angew. Chem. Int. Ed. , 2012 . 51 11606 - 11610 . DOI: 10.1002/anie.201204935 http://doi.org/10.1002/anie.201204935 .

DeVinney, R.; Steele-Mortimer, O.; Finlay, B. B. . Phosphatases and kinases delivered to the host cell by bacterial pathogens . Trends Microbiol. , 2000 . 8 29 - 33 . DOI: 10.1016/S0966-842X(99)01657-1 http://doi.org/10.1016/S0966-842X(99)01657-1 .

Xu, S.; Wang, Q.; Zhang, Q.; Zhang, L.; Zuo, L.; Jiang, J. D.; Hu, H. Y. . Real time detection of ESKAPE pathogens by a nitroreductase-triggered fluorescence turn-on probe . Chem. Commun. , 2017 . 53 11177 - 11180 . DOI: 10.1039/C7CC07050K http://doi.org/10.1039/C7CC07050K .

Kumar Shukla, S.; Rao, T. S. . Dispersal of bap-mediated Staphylococcus aureus biofilm by proteinase K . J. Antibiotics , 2013 . 66 55 - 60 . DOI: 10.1038/ja.2012.98 http://doi.org/10.1038/ja.2012.98 .

Gupta, R.; Gupta, N.; Rathi, P. . Bacterial lipases: an overview of production, purification and biochemical properties . Appl. Microbiol. Biotechnol. , 2004 . 64 763 - 781 . DOI: 10.1007/s00253-004-1568-8 http://doi.org/10.1007/s00253-004-1568-8 .

Songer, J. G. . Bacterial phospholipases and their role in virulence . Trends Microbiol. , 1997 . 5 156 - 161 . DOI: 10.1016/S0966-842X(97)01005-6 http://doi.org/10.1016/S0966-842X(97)01005-6 .

Gill, D. M. . Bacterial toxins: a table of lethal amounts . Microbiol. Rev. , 1982 . 46 86 - 94 . DOI: 10.1128/mr.46.1.86-94.1982 http://doi.org/10.1128/mr.46.1.86-94.1982 .

Middlebrook, J. L.; Dorland, R. B. . Bacterial toxins: cellular mechanisms of action . Microbiol. Rev. , 1984 . 48 199 - 221 . DOI: 10.1128/mr.48.3.199-221.1984 http://doi.org/10.1128/mr.48.3.199-221.1984 .

Li, Y.; Liu, G.; Wang, X.; Hu, J.; Liu, S. . Enzyme-responsive polymeric vesicles for bacterial-strain-selective delivery of antimicrobial agents . Angew. Chem. In. Ed. , 2016 . 55 1760 - 1764 . DOI: 10.1002/anie.201509401 http://doi.org/10.1002/anie.201509401 .

Pulendran, B.; Kumar, P.; Cutler, C. W.; Mohamadzadeh, M.; Van Dyke, T.; Banchereau, J. . Lipopolysaccharides from distinct pathogens induce different classes of immune responses in vivo . J. Immunol. , 2001 . 167 5067 - 5076 . DOI: 10.4049/jimmunol.167.9.5067 http://doi.org/10.4049/jimmunol.167.9.5067 .

Murphy, M. P.; Holmgren, A.; Larsson, N. G.; Halliwell, B.; Chang, C. J.; Kalyanaraman, B.; Rhee, S. G.; Thornalley, P. J.; Partridge, L.; Gems, D.; Nystrom, T.; Belousov, V.; Schumacker, P. T.; Winterbourn, C. C. . Unraveling the biological roles of reactive oxygen species . Cell Metab. , 2011 . 13 361 - 366 . DOI: 10.1016/j.cmet.2011.03.010 http://doi.org/10.1016/j.cmet.2011.03.010 .

Ye, H.; Zhou, Y.; Liu, X.; Chen, Y.; Duan, S.; Zhu, R.; Liu, Y.; Yin, L. . Recent advances on reactive oxygen species-responsive delivery and diagnosis system . Biomacromolecules. , 2019 . 20 2441 - 2463 . DOI: 10.1021/acs.biomac.9b00628 http://doi.org/10.1021/acs.biomac.9b00628 .

Li, C.; Liu, X.; Liu, Y.; Huang, F.; Wu, G.; Liu, Y.; Zhang, Z.; Ding, Y.; Lv, J.; Ma, R.; An, Y.; Shi, L. . Glucose and H 2 O 2 dual-sensitive nanogels for enhanced glucose-responsive insulin delivery . Nanoscale , 2019 . 11 9163 - 9175 . DOI: 10.1039/C9NR01554J http://doi.org/10.1039/C9NR01554J .

Li, Y.; Hu, J.; Liu, X.; Liu, Y.; Lv, S.; Dang, J.; Ji, Y.; He, J.; Yin, L. . Photodynamic therapy-triggered on-demand drug release from ROS-responsive core-cross-linked micelles toward synergistic anti-cancer treatment . Nano Res. , 2019 . 12 999 - 1008 . DOI: 10.1007/s12274-019-2330-y http://doi.org/10.1007/s12274-019-2330-y .

Dalsin, J. L.; Messersmith, P. B. . Bioinspired antifouling polymers . Mater. Today , 2005 . 8 38 - 46 . DOI: 10.1016/S1369-7021(05)71079-8 http://doi.org/10.1016/S1369-7021(05)71079-8 .

Gong, Y. K.; Liu, L. P.; Messersmith, P. B. . Doubly biomimetic catecholic phosphorylcholine copolymer: a platform strategy for fabricating antifouling surfaces . Macromol. Biosci. , 2012 . 12 979 - 985 . DOI: 10.1002/mabi.201200074 http://doi.org/10.1002/mabi.201200074 .

Cao, Z.; Mi, L.; Mendiola, J.; Ella-Menye, J. R.; Zhang, L.; Xue, H.; Jiang, S. . Reversibly switching the function of a surface between attacking and defending against bacteria . Angew. Chem. Int. Ed. , 2012 . 51 2602 - 2605 . DOI: 10.1002/anie.201106466 http://doi.org/10.1002/anie.201106466 .

Khoo, X.; Grinstaff, M. W. . Novel infection-resistant surface coatings: a bioengineering approach . MRS Bull. , 2011 . 36 357 - 366 . DOI: 10.1557/mrs.2011.66 http://doi.org/10.1557/mrs.2011.66 .

Ramstedt, M.; Ekstrand-Hammarstrom, B.; Shchukarev, A. V.; Bucht, A.; Osterlund, L.; Welch, M.; Huck, W. T. S . Bacterial and mammalian cell response to poly(3-sulfopropyl methacrylate) brushes loaded with silver halide salts . Biomaterials , 2009 . 30 1524 - 1531 . DOI: 10.1016/j.biomaterials.2008.12.008 http://doi.org/10.1016/j.biomaterials.2008.12.008 .

Zhang, L.; Pornpattananangkul, D.; Hu, C. M. J.; Huang, C. M. . Development of nanoparticles for antimicrobial drug delivery . Curr. Med. Chem. , 2010 . 17 585 - 594 . DOI: 10.2174/092986710790416290 http://doi.org/10.2174/092986710790416290 .

Epand, R. F.; Savage, P. B.; Epand, R. M. . Bacterial lipid composition and the antimicrobial efficacy of cationic steroid compounds (Ceragenins) . Biochim. Biophys. Acta-Biomembr. , 2007 . 1768 2500 - 2509 . DOI: 10.1016/j.bbamem.2007.05.023 http://doi.org/10.1016/j.bbamem.2007.05.023 .

Nagasaki, Y. . Construction of a densely poly(ethylene glycol)-chain-tethered surface and its performance . Polym. J. , 2011 . 43 949 - 958 . DOI: 10.1038/pj.2011.93 http://doi.org/10.1038/pj.2011.93 .

Jiang, S.; Cao, Z. . Ultralow-fouling, functionalizable, and hydrolyzable zwitterionic materials and their derivatives for biological applications . Adv. Mater. , 2010 . 22 920 - 932 . DOI: 10.1002/adma.200901407 http://doi.org/10.1002/adma.200901407 .

Mi, L.; Bernards, M. T.; Cheng, G.; Yu, Q.; Jiang, S. . pH responsive properties of non-fouling mixed-charge polymer brushes based on quaternary amine and carboxylic acid monomers . Biomaterials , 2010 . 31 2919 - 2925 . DOI: 10.1016/j.biomaterials.2009.12.038 http://doi.org/10.1016/j.biomaterials.2009.12.038 .

Cao, Z.; Brault, N.; Xue, H.; Keefe, A.; Jiang, S. . Manipulating sticky and non-sticky properties in a single material . Angew. Chem. Int. Ed. , 2011 . 50 6102 - 6104 . DOI: 10.1002/anie.201100004 http://doi.org/10.1002/anie.201100004 .

Cheng, Y.; Feng, G.; Moraru, C. I. . Micro- and nanotopography sensitive bacterial attachment mechanisms: a review . Front. Microbiol. , 2019 . 10 191 DOI: 10.3389/fmicb.2019.00191 http://doi.org/10.3389/fmicb.2019.00191 .

Lee, S. W.; Phillips, K. S.; Gu, H.; Kazemzadeh-Narbat, M.; Ren, D. . How microbes read the map: effects of implant topography on bacterial adhesion and biofilm formation . Biomaterials , 2021 . 268 120595 DOI: 10.1016/j.biomaterials.2020.120595 http://doi.org/10.1016/j.biomaterials.2020.120595 .

Keskin, D.; Zu, G.; Forson, A. M.; Tromp, L.; Sjollema, J.; van Rijn, P. . Nanogels: a novel approach in antimicrobial delivery systems and antimicrobial coatings . Bioactive Mater. , 2021 . 6 3634 - 3657 . DOI: 10.1016/j.bioactmat.2021.03.004 http://doi.org/10.1016/j.bioactmat.2021.03.004 .

Keskin, D.; Mergel, O.; van der Mei, H. C.; Busscher, H. J.; van Rijn, P. . Inhibiting bacterial adhesion by mechanically modulated microgel coatings . Biomacromolecules , 2019 . 20 243 - 253 . DOI: 10.1021/acs.biomac.8b01378 http://doi.org/10.1021/acs.biomac.8b01378 .

Jiang, R. J.; Yan, S. J.; Tian, L. M.; Xu, S. A.; Xin, Z. R.; Luan, S. F.; Yin, J. H.; Ren, L. Q.; Zhao, J. . A biomimetic surface for infection-resistance through assembly of metal-phenolic networks . Chinese J. Polym. Sci. , 2018 . 36 576 - 583 . DOI: 10.1007/s10118-018-2032-z http://doi.org/10.1007/s10118-018-2032-z .

Jin, X.; Xiong, Y. H.; Zhang, X. Y.; Wang, R.; Xing, Y.; Duan, S.; Chen, D.; Tian, W.; Xu, F. J. . Self-adaptive antibacterial porous implants with sustainable responses for infected bone defect therapy . Adv. Funct. Mater. , 2019 . 29 1807915 DOI: 10.1002/adfm.201807915 http://doi.org/10.1002/adfm.201807915 .

Zhao, C. J.; An, Y. L.; Yin, F. F.; Zhang, W. Q.; Shi, L. Q. . The self-assembly of polystyrene- b -poly(acrylic acid)/polystyrene in water . Acta Polymerica Sinica (in Chinese) , 2005 . 379 - 383 . .

He, Z.; Sun, P.; Xiong, D. A.; Ma, R.; Lin, H.; Shi, L . Investigation of the micellization process of diblock copolymers containing pH sensitive poly(4-vinylpyridine) by NMR . Acta Polymerica Sinica (in Chinese) , 2008 . 691 - 696 . DOI: 10.3724/SP.J.1105.2008.00691 http://doi.org/10.3724/SP.J.1105.2008.00691 .

Chai, Z. H.; Ma, R. J.; Zhang, Z. K.; Shi, L. Q. . Recent progress in biomimetic light-harvesting materials . Acta Polymerica Sinica (in Chinese) , 2012 . 1108 - 1117 . DOI: 10.3724/SP.J.1105.2012.12128 http://doi.org/10.3724/SP.J.1105.2012.12128 .

Xiong, J.; Wang, J. Z.; Ran, Q. P.; An, Y. L.; Zhang, Z. K.; Shi, L. Q. . Solution behavior of comb-like copolymer dispersants probed by laser light scattering . Acta Polymerica Sinica (in Chinese) , 2013 . 750 - 754 . DOI: 10.3724/SP.J.1105.2013.12435 http://doi.org/10.3724/SP.J.1105.2013.12435 .

Hao, J.; Li, A.; Liu, Y.; Ma, R. J.; Shi, L. Q.; An, Y. L. . Tpps aggregates with chirality induced by hydrogen bonds from polycationic glycoconjugate . Acta Polymerica Sinica (in Chinese) , 2014 . 1378 - 1385 . DOI: 10.11777/j.issn1000-3304.2014.14029 http://doi.org/10.11777/j.issn1000-3304.2014.14029 .

Liu, G.; Yang, H.; Ma, R. J.; Shi, L. Q. . Phenylboronic acid based glucose-responsive polymeric materials for insulin delivery and glucose monitoring . Acta Polymerica Sinica (in Chinese) , 2014 . 1161 - 1173 . DOI: 10.11777/j.issn1000-3304.2014.14079 http://doi.org/10.11777/j.issn1000-3304.2014.14079 .

Zhang, H. X.; Song, Y. Q.; An, Y. L.; Wang, Y.; Shi, L. Q. . Protein refolding assisted by thermosensitive complex micelles . Acta Polymerica Sinica (in Chinese) , 2014 . 1561 - 1567 . DOI: 10.11777/j.issn1000-3304.2014.14096 http://doi.org/10.11777/j.issn1000-3304.2014.14096 .

Liu, Y.; Busscher, H. J.; Zhao, B.; Li, Y.; Zhang, Z.; van der Mei, H. C.; Ren, Y.; Shi, L. . , Surface-adaptive, antimicrobially loaded, micellar nanocarriers with enhanced penetration and killing efficiency in staphylococcal biofilms . ACS Nano , 2016 . 10 4779 - 4789 . DOI: 10.1021/acsnano.6b01370 http://doi.org/10.1021/acsnano.6b01370 .

Huang, F.; Gao, Y.; Zhang, Y.; Cheng, T.; Ou, H.; Yang, L.; Liu, J.; Shi, L.; Liu, J. . Silver-decorated polymeric micelles combined with curcumin for enhanced antibacterial activity . ACS Appl. Mater. Interfaces , 2017 . 9 16880 - 16889 . DOI: 10.1021/acsami.7b03347 http://doi.org/10.1021/acsami.7b03347 .

Praphakar, R. A.; Ebenezer, R. S.; Vignesh, S.; Shakila, H.; Rajan, M. . Versatile pH-responsive chitosan-g-polycaprolactone/maleic anhydride-isoniazid polymeric micelle to improve the bioavailability of tuberculosis multidrugs . ACS Appl. Bio Mater. , 2019 . 2 1931 - 1943 . DOI: 10.1021/acsabm.9b00003 http://doi.org/10.1021/acsabm.9b00003 .

Soria-Carrera, H.; Lucia, A.; De Matteis, L.; Ainsa, J. A.; de la Fuente, J. M.; Martin-Rapun, R. . Polypeptidic micelles stabilized with sodium alginate enhance the activity of encapsulated bedaquiline . Macromol. Biosci. , 2019 . 19 1800397 DOI: 10.1002/mabi.201800397 http://doi.org/10.1002/mabi.201800397 .

Liu, Y.; Li, Y.; Keskin, D.; Shi, L. . Poly( β -amino esters): synthesis, formulations, and their biomedical applications . Adv. Healthc. Mater. , 2019 . 8 1801359 DOI: 10.1002/adhm.201801359 http://doi.org/10.1002/adhm.201801359 .

Liu, Y.; van der Mei, H. C.; Zhao, B.; Zhai, Y.; Cheng, T.; Li, Y.; Zhang, Z.; Busscher, H. J.; Ren, Y.; Shi, L. . Eradication of multidrug-resistant staphylococcal infections by light-activatable micellar nanocarriers in a murine model . Adv. Funct. Mater. , 2017 . 27 1701974 DOI: 10.1002/adfm.201701974 http://doi.org/10.1002/adfm.201701974 .

Elsabahy, M.; Wooley, K. L. . Design of polymeric nanoparticles for biomedical delivery applications . Chem. Soc. Rev. , 2012 . 41 2545 - 2561 . DOI: 10.1039/c2cs15327k http://doi.org/10.1039/c2cs15327k .

Pelgrift, R. Y.; Friedman, A. J. . Nanotechnology as a therapeutic tool to combat microbial resistance . Adv. Drug Del. Rev. , 2013 . 65 1803 - 1815 . DOI: 10.1016/j.addr.2013.07.011 http://doi.org/10.1016/j.addr.2013.07.011 .

Liu, Y.; Ren, Y.; Li, Y.; Su, L.; Zhang, Y.; Huang, F.; Liu, J.; Liu, J.; van Kooten, T. G.; An, Y.; Shi, L.; van der Mei, H. C.; Busscher, H. J. . Nanocarriers with conjugated antimicrobials to eradicate pathogenic biofilms evaluated in murine in vivo and human ex vivo infection models . Acta Biomater. , 2018 . 79 331 - 343 . DOI: 10.1016/j.actbio.2018.08.038 http://doi.org/10.1016/j.actbio.2018.08.038 .

Ferrer, M. C. C.; Dastghey, S.; Hickok, N. J.; Eckrnann, D. M.; Composto, R. J. . Designing nanogel carriers for antibacterial applications . Acta Biomater. , 2014 . 10 2105 - 2111 . DOI: 10.1016/j.actbio.2014.01.009 http://doi.org/10.1016/j.actbio.2014.01.009 .

Liu, T.; Liu, H. X.; Wu, Z. M.; Chen, T.; Zhou, L.; Liang, Y. Y.; Me, B.; Huang, H. X.; Jiang, Z. Y.; Xie, M. Q.; Wu, T. . The use of poly(methacrylic acid) nanogel to control the release of amoxycillin with lower cytotoxicity . Mater. Sci. Eng. C-Mater. Biol. Appl. , 2014 . 43 622 - 629 . DOI: 10.1016/j.msec.2014.07.067 http://doi.org/10.1016/j.msec.2014.07.067 .

Chen, T.; Chen, L.; Li, H. C.; Chen, Y. H.; Guo, H. X.; Shu, Y.; Chen, Z. Y.; Cai, C. H.; Guo, L. N.; Zhang, X. N.; Zhou, L.; Zhong, Q. . Design and in vitro evaluation of a novel poly(methacrylic acid)/metronidazole antibacterial nanogel as an oral dosage form . Colloid. Surf. B , 2014 . 118 65 - 71 . DOI: 10.1016/j.colsurfb.2014.02.011 http://doi.org/10.1016/j.colsurfb.2014.02.011 .

Peppas, N. A.; Hilt, J. Z.; Khademhosseini, A.; Langer, R. . Hydrogels in biology and medicine: from molecular principles to bionanotechnology . Adv. Mater. , 2006 . 18 1345 - 1360 . DOI: 10.1002/adma.200501612 http://doi.org/10.1002/adma.200501612 .

Oh, J. K.; Drumright, R.; Siegwart, D. J.; Matyjaszewski, K. . The development of microgels/nanogels for drug delivery applications . Prog. Polym. Sci. , 2008 . 33 448 - 477 . DOI: 10.1016/j.progpolymsci.2008.01.002 http://doi.org/10.1016/j.progpolymsci.2008.01.002 .

Molina, M.; Asadian-Birjand, M.; Balach, J.; Bergueiro, J.; Miceli, E.; Calderon, M. . Stimuli-responsive nanogel composites and their application in nanomedicine . Chem. Soc. Rev. , 2015 . 44 6161 - 6186 . DOI: 10.1039/C5CS00199D http://doi.org/10.1039/C5CS00199D .

Hu, Y.; Zhang, Z. Y.; Li, Y.; Ding, X. K.; Li, D. W.; Shen, C. N.; Xu, F. J. . Dual-crosslinked amorphous polysaccharide hydrogels based on chitosan/alginate for wound healing applications . Macromol. Rapid Commun. , 2018 . 39 1800069 DOI: 10.1002/marc.201800069 http://doi.org/10.1002/marc.201800069 .

Liu, J. Y.; Li, Y.; Hu, Y.; Cheng, G.; Ye, E. Y.; Shen, C. A.; Xu, F. J. . Hemostatic porous sponges of cross-linked hyaluronic acid/cationized dextran by one self-foaming process . Mater. Sci. Eng. C-Mater. Biol. Appl. , 2018 . 83 160 - 168 . DOI: 10.1016/j.msec.2017.10.007 http://doi.org/10.1016/j.msec.2017.10.007 .

Li, L. L.; Xu, J. H.; Qi, G. B.; Zhao, X. Z.; Yu, F. Q.; Wang, H. . Core-shell supramolecular gelatin nanoparticles for adaptive and "on-demand" antibiotic delivery . ACS Nano , 2014 . 8 4975 - 4983 . DOI: 10.1021/nn501040h http://doi.org/10.1021/nn501040h .

Wang, D. Y.; van der Mei, H. C.; Ren, Y.; Busscher, H. J.; Shi, L. . Lipid-based antimicrobial delivery-systems for the treatment of bacterial infections . Front. Chem. , 2020 . 7 872 DOI: 10.3389/fchem.2019.00872 http://doi.org/10.3389/fchem.2019.00872 .

Mugabe, C.; Halwani, M.; Azghani, A. O.; Lafrenie, R. M.; Omri, A. . Mechanism of enhanced activity of liposome-entrapped aminoglycosides against resistant strains of Pseudomonas aeruginosa . Antimicrob. Agents Chemother. , 2006 . 50 2016 - 2022 . DOI: 10.1128/AAC.01547-05 http://doi.org/10.1128/AAC.01547-05 .

Mugabe, C.; Azghani, A. O.; Omri, A. . Liposome-mediated gentamicin delivery: development and activity against resistant strains of Pseudomonas aeruginosa isolated from cystic fibrosis patients . J. Antimicrob. Chemother. , 2005 . 55 269 - 271 . DOI: 10.1093/jac/dkh518 http://doi.org/10.1093/jac/dkh518 .

Sachetelli, S.; Khalil, H.; Chen, T.; Beaulac, C.; Senechal, S.; Lagace, J. . Demonstration of a fusion mechanism between a fluid bactericidal liposomal formulation and bacterial cells . Biochim. Biophys. Acta-Biomembr. , 2000 . 1463 254 - 266 . DOI: 10.1016/S0005-2736(99)00217-5 http://doi.org/10.1016/S0005-2736(99)00217-5 .

Marier, J. F.; Lavigne, J.; Ducharme, M. P. . Pharmacokinetics and efficacies of liposomal and conventional formulations of tobramycin after intratracheal administration in rats with pulmonary Burkholdefia cepacia infection . Antimicrob. Agents Chemother. , 2002 . 46 3776 - 3781 . DOI: 10.1128/AAC.46.12.3776-3781.2002 http://doi.org/10.1128/AAC.46.12.3776-3781.2002 .

Messiaen, A. S.; Forier, K.; Nelis, H.; Braeckmans, K.; Coenye, T. . Transport of nanoparticles and tobramycin-loaded liposomes in Burkholderia cepacia complex biofilms . PLoS One , 2013 . 8 e79220 DOI: 10.1371/journal.pone.0079220 http://doi.org/10.1371/journal.pone.0079220 .

Nicolosi, D.; Scalia, M.; Nicolosi, V. M.; Pignatello, R. . Encapsulation in fusogenic liposomes broadens the spectrum of action of vancomycin against Gram-negative bacteria . Int. J. Antimicrob. Agents , 2010 . 35 553 - 558 . DOI: 10.1016/j.ijantimicag.2010.01.015 http://doi.org/10.1016/j.ijantimicag.2010.01.015 .

Chakraborty, S. P.; Sahu, S. K.; Pramanik, P.; Roy, S. . In vitro antimicrobial activity of nanoconjugated vancomycin against drug resistant Staphylococcus aureus . Int. J. Pharm. , 2012 . 436 659 - 676 . DOI: 10.1016/j.ijpharm.2012.07.033 http://doi.org/10.1016/j.ijpharm.2012.07.033 .

Solleti, V. S.; Alhariri, M.; Halwani, M.; Omri, A. . Antimicrobial properties of liposomal azithromycin for Pseudomonas infections in cystic fibrosis patients . J. Antimicrob. Chemother. , 2015 . 70 784 - 796 . DOI: 10.1093/jac/dku452 http://doi.org/10.1093/jac/dku452 .

Vyas, S. P.; Sihorkar, V.; Dubey, P. K. . Preparation, characterization and in vitro antimicrobial activity of metronidazole bearing lectinized liposomes for intra-periodontal pocket delivery . Pharmazie , 2001 . 56 554 - 560 . .

Meers, P.; Neville, M.; Malinin, V.; Scotto, A. W.; Sardaryan, G.; Kurumunda, R.; Mackinson, C.; James, G.; Fisher, S.; Perkins, W. R. . Biofilm penetration, triggered release and in vivo activity of inhaled liposomal amikacin in chronic Pseudomonas aeruginosa lung infections . J. Antimicrob. Chemother. , 2008 . 61 859 - 868 . DOI: 10.1093/jac/dkn059 http://doi.org/10.1093/jac/dkn059 .

Hu, F.; Zhou, Z.; Xu, Q.; Fan, C.; Wang, L.; Ren, H.; Xu, S.; Ji, Q.; Chen, X. . A novel pH-responsive quaternary ammonium chitosan-liposome nanoparticles for periodontal treatment . Int. J. Biol. Macromol. , 2019 . 129 1113 - 1119 . DOI: 10.1016/j.ijbiomac.2018.09.057 http://doi.org/10.1016/j.ijbiomac.2018.09.057 .

Zhou, Z.; Hu, F.; Hu, S.; Kong, M.; Feng, C.; Liu, Y.; Cheng, X.; Ji, Q.; Chen, X. . pH-Activated nanoparticles with targeting for the treatment of oral plaque biofilm . J. Mater. Chem. B , 2018 . 6 586 - 592 . DOI: 10.1039/C7TB02682J http://doi.org/10.1039/C7TB02682J .

Rozenbaum, R. T.; Su, L.; Umerska, A.; Eveillard, M.; Hakansson, J.; Mahlapuu, M.; Huang, F.; Liu, J.; Zhang, Z.; Shi, L.; van der Mei, H. C.; Busscher, H. J.; Sharma, P. K. . Antimicrobial synergy of monolaurin lipid nanocapsules with adsorbed antimicrobial peptides against Staphylococcus aureus biofilms in vitro is absent in vivo . J. Control. Release , 2019 . 293 73 - 83 . DOI: 10.1016/j.jconrel.2018.11.018 http://doi.org/10.1016/j.jconrel.2018.11.018 .

Akbarzadeh, A.; Rezaei-Sadabady, R.; Davaran, S.; Joo, S. W.; Zarghami, N.; Hanifehpour, Y.; Samiei, M.; Kouhi, M.; Nejati-Koshki, K. . Liposome: classification, preparation, and applications . Nanoscale Res. Lett , 2013 . 8 102 DOI: 10.1186/1556-276X-8-102 http://doi.org/10.1186/1556-276X-8-102 .

Liu, D. Q.; Sun, H.; Xiao, Y. F.; Chen, S.; Cornel, E. J.; Zhu, Y. Q.; Du, J. Z. . Design principles, synthesis and biomedical applications of polymer vesicles with inhomogeneous membranes . J. Control. Release , 2020 . 326 365 - 386 . DOI: 10.1016/j.jconrel.2020.07.018 http://doi.org/10.1016/j.jconrel.2020.07.018 .

Xi, Y.; Wang, Y.; Gao, J.; Xiao, Y.; Du, J. . Dual corona vesicles with intrinsic antibacterial and enhanced antibiotic delivery capabilities for effective treatment of biofilm-induced periodontitis . ACS Nano , 2019 . 13 13645 - 13657 . DOI: 10.1021/acsnano.9b03237 http://doi.org/10.1021/acsnano.9b03237 .

Gao, Y.; Wang, J.; Chai, M.; Li, X.; Deng, Y.; Jin, Q.; Ji, J. . Size and charge adaptive clustered nanoparticles targeting the biofilm microenvironment for chronic lung infection management . ACS Nano , 2020 . 14 5686 - 5699 . DOI: 10.1021/acsnano.0c00269 http://doi.org/10.1021/acsnano.0c00269 .

Zhang, L. J.; Parente, J.; Harris, S. A.; Woods, D. E.; Hancock, R. E. W.; Fallal, T. J. . Antimicrobial peptide therapeutics for cystic fibrosis . Antimicrob. Agents Chemother. , 2005 . 49 2921 - 2927 . DOI: 10.1128/AAC.49.7.2921-2927.2005 http://doi.org/10.1128/AAC.49.7.2921-2927.2005 .

Karlsson, A. J.; Pomerantz, W. C.; Weisblum, B.; Gellman, S. H.; Palecek, S. P. . Antifungal activity from 14-helical β -peptides . J. Am. Chem. Soc. , 2006 . 128 12630 - 12631 . DOI: 10.1021/ja064630y http://doi.org/10.1021/ja064630y .

Hancock, R. E. W.; Sahl, H. G. . Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies . Nat. Biotechnol. , 2006 . 24 1551 - 1557 . DOI: 10.1038/nbt1267 http://doi.org/10.1038/nbt1267 .

Hancock, R. E. . Cationic peptides: effectors in innate immunity and novel antimicrobials . Lancet Infect. Dis. , 2001 . 1 156 - 164 . DOI: 10.1016/S1473-3099(01)00092-5 http://doi.org/10.1016/S1473-3099(01)00092-5 .

Epand, R. M.; Vogel, H. J. . Diversity of antimicrobial peptides and their mechanisms of action . Biochim. Biophys. Acta-Biomembr. , 1999 . 1462 11 - 28 . DOI: 10.1016/S0005-2736(99)00198-4 http://doi.org/10.1016/S0005-2736(99)00198-4 .

Aliferis, T.; Iatrou, H.; Hadjichristidis, N. . Living polypeptides . Biomacromolecules , 2004 . 5 1653 - 1656 . DOI: 10.1021/bm0497217 http://doi.org/10.1021/bm0497217 .

Zasloff, M. . Antimicrobial peptides of multicellular organisms . Nature , 2002 . 415 389 - 395 . DOI: 10.1038/415389a http://doi.org/10.1038/415389a .

Lam, S. J.; O'Brien-Simpson, N. M.; Pantarat, N.; Sulistio, A.; Wong, E. H.; Chen, Y. Y.; Lenzo, J. C.; Holden, J. A.; Blencowe, A.; Reynolds, E. C.; Qiao, G. G. . Combating multidrug-resistant Gram-negative bacteria with structurally nanoengineered antimicrobial peptide polymers . Nat. Microbiol , 2016 . 1 16162 DOI: 10.1038/nmicrobiol.2016.162 http://doi.org/10.1038/nmicrobiol.2016.162 .

Zhou, C.; Wang, M.; Zou, K.; Chen, J.; Zhu, Y.; Du, J. . Antibacterial polypeptide-grafted chitosan-based nanocapsules as an “armed” carrier of anticancer and antiepileptic drugs . ACS Macro Lett. , 2013 . 2 1021 - 1025 . DOI: 10.1021/mz400480z http://doi.org/10.1021/mz400480z .

Ergene, C.; Yasuhara, K.; Palermo, E. F. . Biomimetic antimicrobial polymers: recent advances in molecular design . Polym. Chem. , 2018 . 9 2407 - 2427 . DOI: 10.1039/C8PY00012C http://doi.org/10.1039/C8PY00012C .

Rahman, M. A.; Bam, M.; Luat, E.; Jui, M. S.; Ganewatta, M. S.; Shokfai, T.; Nagarkatti, M.; Decho, A. W.; Tang, C. . Macromolecular-clustered facial amphiphilic antimicrobials . Nat. Commun. , 2018 . 9 5231 DOI: 10.1038/s41467-018-07651-7 http://doi.org/10.1038/s41467-018-07651-7 .

Xiong, M.; Han, Z.; Song, Z.; Yu, J.; Ying, H.; Yin, L.; Cheng, J. . Bacteria-assisted activation of antimicrobial polypeptides by a random-coil to helix transition . Angew. Chem. Int. Ed. , 2017 . 56 10826 - 10829 . DOI: 10.1002/anie.201706071 http://doi.org/10.1002/anie.201706071 .

Xiong, M. H.; Bao, Y.; Xu, X.; Wang, H.; Han, Z. Y.; Wang, Z. Y.; Liu, Y. Q.; Huang, S. Y.; Song, Z. Y.; Chen, J. J.; Peek, R. M.; Yin, L. C.; Chen, L. F.; Cheng, J. J. . Selective killing of Helicobacter pylori with pH-responsive helix-coil conformation transitionable antimicrobial polypeptides . Proc. Natl. Acad. Sci. U. S. A. , 2017 . 114 12675 - 12680 . DOI: 10.1073/pnas.1710408114 http://doi.org/10.1073/pnas.1710408114 .

Davies, D. G. . Biofilm dispersion . Biofilm Highlights , 2011 . 5 571 DOI: 10.1007/978-3-642-19940-0_1 http://doi.org/10.1007/978-3-642-19940-0_1 .

Fleming, D.; Rumbaugh, K. P. . Approaches to dispersing medical biofilms . Microorganisms , 2017 . 5 15 DOI: 10.3390/microorganisms5020015 http://doi.org/10.3390/microorganisms5020015 .

Guilhen, C.; Forestier, C.; Balestrino, D. . Biofilm dispersal: multiple elaborate strategies for dissemination of bacteria with unique properties . Mol. Microbiol. , 2017 . 105 188 - 210 . DOI: 10.1111/mmi.13698 http://doi.org/10.1111/mmi.13698 .

Kaplan, J. B.; LoVetri, K.; Cardona, S. T.; Madhyastha, S.; Sadovskaya, I.; Jabbouri, S.; Izano, E. A. . Recombinant human DNase I decreases biofilm and increases antimicrobial susceptibility in staphylococci . J. Antibiot. , 2012 . 65 73 - 77 . DOI: 10.1038/ja.2011.113 http://doi.org/10.1038/ja.2011.113 .

Lister, J. L.; Horswill, A. R. . Staphylococcus aureus biofilms: recent developments in biofilm dispersal . Front. Cell. Infect. Microbiol. , 2014 . 4 178 DOI: 10.3389/fcimb.2014.00178 http://doi.org/10.3389/fcimb.2014.00178 .

Swartjes, J. J. T. M.; Das, T.; Sharifi, S.; Subbiahdoss, G.; Sharma, P. K.; Krom, B. P.; Busscher, H. J.; van der Mei, H. C. . A Functional DNase I coating to prevent adhesion of bacteria and the formation of biofilm . Adv. Funct. Mater. , 2013 . 23 2843 - 2849 . DOI: 10.1002/adfm.201202927 http://doi.org/10.1002/adfm.201202927 .

Al-Shabib, N. A.; Husain, F. M.; Ahmed, F.; Khan, R. A.; Khan, M. S.; Ansari, F. A.; Alam, M. Z.; Ahmed, M. A.; Khan, M. S.; Baig, M. H.; Khan, J. M.; Shahzad, S. A.; Arshad, M.; Alyousef, A.; Ahmad, I. . Low temperature synthesis of superparamagnetic iron oxide (Fe 3 O 4 ) nanoparticles and their ROS mediated inhibition of biofilm formed by food-associated bacteria . Front. Microbiol. , 2018 . 9 2567 DOI: 10.3389/fmicb.2018.02567 http://doi.org/10.3389/fmicb.2018.02567 .

Gao, L.; Giglio, K. M.; Nelson, J. L.; Sondermann, H.; Travis, A. J. . Ferromagnetic nanoparticles with peroxidase-like activity enhance the cleavage of biological macromolecules for biofilm elimination . Nanoscale , 2014 . 6 2588 - 2593 . DOI: 10.1039/C3NR05422E http://doi.org/10.1039/C3NR05422E .

Gao, L.; Liu, Y.; Kim, D.; Li, Y.; Hwang, G.; Naha, P. C.; Cormode, D. P.; Koo, H. . Nanocatalysts promote Streptococcus mutans biofilm matrix degradation and enhance bacterial killing to suppress dental caries in vivo . Biomaterials , 2016 . 101 272 - 284 . DOI: 10.1016/j.biomaterials.2016.05.051 http://doi.org/10.1016/j.biomaterials.2016.05.051 .

Yan, Z.; Bing, W.; Ding, C.; Dong, K.; Ren, J.; Qu, X. . A H 2 O 2 -free depot for treating bacterial infection: localized cascade reactions to eradicate biofilms in vivo . Nanoscale , 2018 . 10 17656 - 17662 . DOI: 10.1039/C8NR03963A http://doi.org/10.1039/C8NR03963A .

Diez-Castellnou, M.; Mancin, F.; Scrimin, P. . Efficient phosphodiester cleaving nanozymes resulting from multivalency and local medium polarity control . J. Am. Chem. Soc. , 2014 . 136 1158 - 1161 . DOI: 10.1021/ja411969e http://doi.org/10.1021/ja411969e .

Bleem, A.; Francisco, R.; Bryers, J. D.; Daggett, V. . Designed α -sheet peptides suppress amyloid formation in Staphylococcus aureus biofilms . Npj Biofilms and Microbiomes. , 2017 . 3 16 DOI: 10.1038/s41522-017-0025-2 http://doi.org/10.1038/s41522-017-0025-2 .

De la Fuente-Nunez, C.; Reffuveille, F.; Haney, E. F.; Straus, S. K.; Hancock, R. E. W. . Broad-spectrum anti-biofilm peptide that targets a cellular stress response . PLoS Path. , 2014 . 10 e1004152 DOI: 10.1371/journal.ppat.1004152 http://doi.org/10.1371/journal.ppat.1004152 .

Paranjapye, N.; Daggett, V. . De Novo designed α -sheet peptides inhibit functional amyloid formation of Streptococcus mutans biofilms . J. Mol. Biol. , 2018 . 430 3764 - 3773 . DOI: 10.1016/j.jmb.2018.07.005 http://doi.org/10.1016/j.jmb.2018.07.005 .

Zhang, S.; Xiao, X. M.; Qi, F.; Ma, P. C.; Zhang, W. W.; Dai, C. Z.; Zhang, D. F.; Liu, R. H. . Biofilm disruption utilizing α / β chimeric polypeptide molecular brushes . Chinese J. Polym. Sci. , 2019 . 37 1105 - 1112 . DOI: 10.1007/s10118-019-2278-0 http://doi.org/10.1007/s10118-019-2278-0 .

Frei, R.; Breitbach, A. S.; Blackwell, H. E. . 2-Aminobenzimidazole derivatives strongly inhibit and disperse Pseudomonas aeruginosa biofilms . Angew. Chem. Int. Ed. , 2012 . 51 5226 - 5229 . DOI: 10.1002/anie.201109258 http://doi.org/10.1002/anie.201109258 .

Ng, W.-L.; Bassler, B. L. . Bacterial quorum-sensing network architectures . Annu. Rev. Genet. , 2009 . 43 197 - 222 . DOI: 10.1146/annurev-genet-102108-134304 http://doi.org/10.1146/annurev-genet-102108-134304 .

Kolodkin-Gal, I.; Romero, D.; Cao, S.; Clardy, J.; Kolter, R.; Losick, R. . D-amino acids trigger biofilm disassembly . Science , 2010 . 328 627 - 629 . DOI: 10.1126/science.1188628 http://doi.org/10.1126/science.1188628 .

Bonnichsen, L.; Svenningsen, N. B.; Rybtke, M.; de Bruijn, I.; Raaijmakers, J. M.; Tolker-Nielsen, T.; Nybroe, O. . Lipopeptide biosurfactant viscosin enhances dispersal of Pseudomonas fluorescens SBW25 biofilms . Microbiology-Sgm. , 2015 . 161 2289 - 2297 . DOI: 10.1099/mic.0.000191 http://doi.org/10.1099/mic.0.000191 .

Davey, M. E.; Caiazza, N. C.; O'Toole, G. A. . Rhamnolipid surfactant production affects biofilm architecture in Pseudomonas aeruginosa PAO1 . J. Bacteriol. , 2003 . 185 1027 - 1036 . DOI: 10.1128/JB.185.3.1027-1036.2003 http://doi.org/10.1128/JB.185.3.1027-1036.2003 .

Engelsman, A. F.; Krom, B. P.; Busscher, H. J.; van Dam, G. M.; Ploeg, R. J.; van der Mei, H. C. . Antimicrobial effects of an NO-releasing poly(ethylene vinylacetate) coating on soft-tissue implants in vitro and in a murine model . Acta Biomater. , 2009 . 5 1905 - 1910 . DOI: 10.1016/j.actbio.2009.01.041 http://doi.org/10.1016/j.actbio.2009.01.041 .

Chen, M.; Wei, J.; Xie, S.; Tao, X.; Zhang, Z.; Ran, P.; Li, X. . Bacterial biofilm destruction by size/surface charge-adaptive micelles . Nanoscale , 2019 . 11 1410 - 1422 . DOI: 10.1039/C8NR05575K http://doi.org/10.1039/C8NR05575K .

Liu, C.; Zhao, Y.; Su, W.; Chai, J.; Xu, L.; Cao, J.; Liu, Y. . Encapsulated DNase improving the killing efficiency of antibiotics in staphylococcal biofilms . J. Mater. Chem. B , 2020 . 8 4395 - 4401 . DOI: 10.1039/D0TB00441C http://doi.org/10.1039/D0TB00441C .

Abenojar, E. C.; Wickramasinghe, S.; Ju, M.; Uppaluri, S.; Klika, A.; George, J.; Barsoum, W.; Frangiamore, S. J.; Higuera-Rueda, C. A.; Samia, A. C. S. . Magnetic glycol chitin-based hydrogel nanocomposite for combined thermal and D-amino-acid-assisted biofilrn disruption . ACS Infect. Dis. , 2018 . 4 1246 - 1256 . DOI: 10.1021/acsinfecdis.8b00076 http://doi.org/10.1021/acsinfecdis.8b00076 .

Duong, H. T. T.; Adnan, N. N. M.; Barraud, N.; Basuki, J. S.; Kutty, S. K.; Jung, K.; Kumar, N.; Davis, T. P.; Boyer, C. . Functional gold nanoparticles for the storage and controlled release of nitric oxide: applications in biofilm dispersal and intracellular delivery . J. Mater. Chem. B , 2014 . 2 5003 - 5011 . DOI: 10.1039/C4TB00632A http://doi.org/10.1039/C4TB00632A .

Hasan, N.; Cao, J.; Lee, J.; Naeem, M.; Hlaing, S. P.; Kim, J.; Jung, Y.; Lee, B. L.; Yoo, J. W. . PEI/NONOates-doped PLGA nanoparticles for eradicating methicillin-resistant Staphylococcus aureus biofilm in diabetic wounds via binding to the biofilm matrix . Mater. Sci. Eng. C-Mater. Biol. Appl. , 2019 . 103 109741 DOI: 10.1016/j.msec.2019.109741 http://doi.org/10.1016/j.msec.2019.109741 .

Nguyen, T. K.; Selvanayagam, R.; Ho, K. K. K.; Chen, R.; Kutty, S. K.; Rice, S. A.; Kumar, N.; Barraud, N.; Duong, H. T. T.; Boyer, C. . Co-delivery of nitric oxide and antibiotic using polymeric nanoparticles . Chem. Sci. , 2016 . 7 1016 - 1027 . DOI: 10.1039/C5SC02769A http://doi.org/10.1039/C5SC02769A .

Tan, Y.; Ma, S.; Liu, C.; Yu, W.; Han, F. . Enhancing the stability and antibiofilm activity of DspB by immobilization on carboxymethyl chitosan nanoparticles . Microbiol. Res. , 2015 . 178 35 - 41 . DOI: 10.1016/j.micres.2015.06.001 http://doi.org/10.1016/j.micres.2015.06.001 .

Patel, K. K.; Agrawal, A. K.; Anjum, M. M.; Tripathi, M.; Pandey, N.; Bhattacharya, S.; Tilak, R.; Singh, S. . DNase-I functionalization of ciprofloxacin-loaded chitosan nanoparticles overcomes the biofilm-mediated resistance of Pseudomonas aeruginosa . Appl. Nanosci. , 2020 . 10 563 - 575 . DOI: 10.1007/s13204-019-01129-8 http://doi.org/10.1007/s13204-019-01129-8 .

Hayden, S. C.; Zhao, G.; Saha, K.; Phillips, R. L.; Li, X.; Miranda, O. R.; Rotello, V. M.; El-Sayed, M. A.; Schmidt-Krey, I.; Bunz, U. H. . Aggregation and interaction of cationic nanoparticles on bacterial surfaces . J. Am. Chem. Soc. , 2012 . 134 6920 - 3 . DOI: 10.1021/ja301167y http://doi.org/10.1021/ja301167y .

Duan, X.; Li, Y. . Physicochemical characteristics of nanoparticles affect circulation, biodistribution, cellular internalization, and trafficking . Small , 2013 . 9 1521 - 1532 . DOI: 10.1002/smll.201201390 http://doi.org/10.1002/smll.201201390 .

Tian, S.; Su, L.; Liu, Y.; Cao, J.; Yang, G.; Ren, Y.; Huang, F.; Liu, J.; An, Y.; van der Mei, H. C.; Busscher, H. J.; Shi, L. . Self-targeting, zwitterionic micellar dispersants enhance antibiotic killing of infectious biofilms—an intravital imaging study in mice . Sci. Adv. , 2020 . 6 eabb1112 DOI: 10.1126/sciadv.abb1112 http://doi.org/10.1126/sciadv.abb1112 .

Hu, D.; Deng, Y.; Jia, F.; Jin, Q.; Ji, J. . Surface charge switchable supramolecular nanocarriers for nitric oxide synergistic photodynamic eradication of biofilms . ACS Nano. , 2020 . 14 347 - 359 . DOI: 10.1021/acsnano.9b05493 http://doi.org/10.1021/acsnano.9b05493 .

Zhao, Y.; Li, Q.; Chai, J.; Liu, Y. . Cargo-templated crosslinked polymer nanocapsules and their biomedical applications . Adv. NanoBiomed Res. , 2021 . 1 2000078 DOI: 10.1002/anbr.202000078 http://doi.org/10.1002/anbr.202000078 .

Li, Y.; Liu, Y.; Ren, Y.; Su, L.; Li, A.; An, Y.; Rotello, V.; Zhang, Z.; Wang, Y.; Liu, Y.; Liu, S.; Liu, J.; Laman, J. D.; Shi, L.; Mei, H. C.; Busscher, H. J. . Coating of a novel antimicrobial nanoparticle with a macrophage membrane for the selective entry into infected macrophages and killing of intracellular Staphylococci . Adv. Funct. Mater. , 2020 . 30 2004942 DOI: 10.1002/adfm.202004942 http://doi.org/10.1002/adfm.202004942 .

Li, Y.; Yang, G.; Ren, Y.; Shi, L.; Ma, R.; van der Mei, H. C.; Busscher, H. J. . Applications and perspectives of cascade reactions in bacterial infection control . Front. Chem. , 2020 . 7 861 DOI: 10.3389/fchem.2019.00861 http://doi.org/10.3389/fchem.2019.00861 .

浏览量

203

Downloads

CSCD

文章被引用时，请邮件提醒。

Submit

工具集

关联资源

Multicomponent Polymerization of Alkynes, Amines, and Benzaldehyde toward Main-chain Charged Aggregation-induced Emission Polyelectrolytes

Transparent Polyurethane Coating with Selenonium Salt-enhanced Healing and Antibacterial Properties

Swelling of Spherical Polyelectrolyte Gels

Manipulating Hierarchical Aggregation Structure via Film-forming Kinetics Enables Organic Photovoltaics over 20% Efficiency

Experimental Investigation of Graphene and TiO2 Reinforced Poly(vinyl alcohol)-based Fiber Metal Laminates