Antibacterial Thermoplastic Polyurethane/PL-DOSS Composite Films

Xiao Liu; Jian-Wei Guo; Ya-Dong Liu; Ming Liu; Hui Liu; Miao-Miao Han; Sheng-Xiang Ji

doi:10.1007/s10118-021-2578-z

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Antibacterial Thermoplastic Polyurethane/PL-DOSS Composite Films

ARTICLE | Updated：2021-05-27

- Antibacterial Thermoplastic Polyurethane/PL-DOSS Composite Films
- Antibacterial Thermoplastic Polyurethane/PL-DOSS Composite Films
- Chinese Journal of Polymer Science 2021年39卷第8期页码：1020-1028
- Affiliations：
  
  a.Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
  b.School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei 230026, China
- Author bio：
  
  hanmiaomiao@ciac.ac.cn (M.M.H.)
  sji@ciac.ac.cn (S.X.J.)
- Funds：
  
  This work was financially supported by the National Natural Science Foundation of China (Nos. 51773201 and 51973212), the Bureau of Science and Technology of Changchun (No. 19SS005), the Department of Science and Technology of Jilin Province (No. 20200301017RQ) and the Joint Program of CAS-Jilin Province (No. 2019SYHZ0002).
- DOI：10.1007/s10118-021-2578-z
  中图分类号：
- 收稿：2021-02-08，
  
  修回：2021-3-9，
  
  录用：2021-3-10，
  
  网络首发：2021-05-27，
  
  纸质出版：2021-06-18
- Accepted：
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Liu, X.; Guo, J. W.; Liu, Y. D.; Liu, M.; Liu, H.; Han, M. M.; Ji, S. X. Antibacterial thermoplastic polyurethane/PL-DOSS composite films. Chinese J. Polym. Sci. 2021, 39, 1020–1028

Xiao Liu, Jian-Wei Guo, Ya-Dong Liu, et al. Antibacterial Thermoplastic Polyurethane/PL-DOSS Composite Films[J]. Chinese Journal of Polymer Science, 2021, 39(8): 1020-1028.
Liu, X.; Guo, J. W.; Liu, Y. D.; Liu, M.; Liu, H.; Han, M. M.; Ji, S. X. Antibacterial thermoplastic polyurethane/PL-DOSS composite films. Chinese J. Polym. Sci. 2021, 39, 1020–1028 DOI： 10.1007/s10118-021-2578-z.

Xiao Liu, Jian-Wei Guo, Ya-Dong Liu, et al. Antibacterial Thermoplastic Polyurethane/PL-DOSS Composite Films[J]. Chinese Journal of Polymer Science, 2021, 39(8): 1020-1028. DOI： 10.1007/s10118-021-2578-z.

摘要

Abstract

Medical devices-related infections pose a great threat to patients and cause an increased morbidity and mortality. Herein

we prepare an antibacterial composite (TPU-

) through blending medical grade thermoplastic polyurethane (TPU) and the complex (PL-DOSS) of

-polylysine (

-PL) and docusate sodium (DOSS).

99% reduction of colony forming unit (CFU) can be obtained in TPU-

composite films even at relatively low content of PL-DOSS

e.g.

0.13% for Methicillin resistant

S. aureus

(MRSA) and 0.5% for

E. coli

. The excellent antibacterial activity is mainly attributed to the formation of PL-DOSS nanoparticles that are uniformly dispersed in the TPU matrix with a size of ~100 nm. TPU-

composite films exhibit long-term stability in saline and good biocompatibility

and retain mechanical properties of TPU.

关键词

Keywords

references

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