Recent Advances on Surface-modified Biomaterials Promoting Selective Adhesion and Directional Migration of Cells

Chen-Xi Tu; Chang-You Gao

doi:10.1007/s10118-021-2564-5

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Recent Advances on Surface-modified Biomaterials Promoting Selective Adhesion and Directional Migration of Cells

REVIEW | Updated：2021-05-13

- Recent Advances on Surface-modified Biomaterials Promoting Selective Adhesion and Directional Migration of Cells
- Recent Advances on Surface-modified Biomaterials Promoting Selective Adhesion and Directional Migration of Cells
- Chinese Journal of Polymer Science 2021年39卷第7期页码：815-823
- Affiliations：
  
  MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China
- Author bio：
  
  cygao@zju.edu.cn
- Funds：
  
  This study was financially supported by the National Key Research and Development Program of China (No. 2016YFC1100403), the National Natural Science Foundation of China (No. 21434006), and the Fundamental Research Funds for the Central Universities of China (No. 2020XZZX004-01).
- DOI：10.1007/s10118-021-2564-5
  中图分类号：
- 收稿：2021-01-12，
  
  修回：2021-2-4，
  
  录用：2021-2-9，
  
  网络首发：2021-05-13，
  
  纸质出版：2021-05-14
- Accepted：
Scan QR Code
Tu, C. X.; Gao, C. Y. Recent advances on surface-modified biomaterials promoting selective adhesion and directional migration of cells. Chinese J. Polym. Sci. 2021, 39, 815–823

Chen-Xi Tu, Chang-You Gao. Recent Advances on Surface-modified Biomaterials Promoting Selective Adhesion and Directional Migration of Cells[J]. Chinese Journal of Polymer Science, 2021, 39(7): 815-823.
Tu, C. X.; Gao, C. Y. Recent advances on surface-modified biomaterials promoting selective adhesion and directional migration of cells. Chinese J. Polym. Sci. 2021, 39, 815–823 DOI： 10.1007/s10118-021-2564-5.

Chen-Xi Tu, Chang-You Gao. Recent Advances on Surface-modified Biomaterials Promoting Selective Adhesion and Directional Migration of Cells[J]. Chinese Journal of Polymer Science, 2021, 39(7): 815-823. DOI： 10.1007/s10118-021-2564-5.

摘要

Abstract

The surfaces and interfaces of biomaterials interact with the biological systems in multi-scale levels

and thereby influence the biological functions and comprehensive performance

in vitro

and

in vivo

. In particular

a surface promoting the selective adhesion and directional migration of desired types of cells in complex environment is extremely important in the repair and regeneration of tissues such as peripheral nerve and blood vessel

and long-term application of intracorporal devices such as intravascular implants. Therefore

surface modification of biomaterials is a facile and effective method to achieve the desired cell-biomaterials interactions. In this short review

recent advances on the surface modification of biomaterials to regulate selective cell adhesion and migration are briefly summarized. In particular

the surface properties of biomaterials are manipulated

via

the convenient introduction of amino groups to the ester-based polymers

the formation of polyelectrolyte multilayers

and the fabrication of topology and gradient cues

etc

followed by the association of chemical and biological signals such as collagen

heparin

hyaluronic acid

peptides and cell growth factors. The selective adhesion and directional migration of various types of cells such as endothelial cells (ECs)

smooth muscle cells (SMCs)

hepatocytes and Schwann cells (SCs) are achieved over the competitive counterpart cells by the use of cell-resisting substances and cell-selective motifs on gradient substrates in most cases. Recent advances on cell behaviors in three-dimensional (3D) cell-extracellular matrix (ECM)-mimicking substrates are also reviewed.

关键词

Keywords

references

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